Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder / Ulrika ROINE in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-11 Titre : Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Pekka TANI, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Karen CAEYENBERGHS, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain’s wiring diagram, i.e., the connectome. En ligne : http://dx.doi.org/10.1186/s13229-015-0058-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Pekka TANI, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Karen CAEYENBERGHS, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-11 Index. décimale : PER Périodiques Résumé : Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain’s wiring diagram, i.e., the connectome. En ligne : http://dx.doi.org/10.1186/s13229-015-0058-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome / Ulrika ROINE in Molecular Autism, (January 2015)  

Public ISBD [article]  inMolecular Autism > (January 2015) . - p.1-12 Titre : Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Juha SALMI, Auteur ; Timo ROINE, Auteur ; Taina Nieminen-von WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The aim of this study was to investigate potential differences in neural structure in individuals with Asperger syndrome (AS), high-functioning individuals with autism spectrum disorder (ASD). The main symptoms of AS are severe impairments in social interactions and restricted or repetitive patterns of behaviors, interests or activities. En ligne : http://dx.doi.org/10.1186/2040-2392-6-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Juha SALMI, Auteur ; Timo ROINE, Auteur ; Taina Nieminen-von WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - p.1-12. Langues : Anglais (eng) in Molecular Autism > (January 2015) . - p.1-12 Index. décimale : PER Périodiques Résumé : The aim of this study was to investigate potential differences in neural structure in individuals with Asperger syndrome (AS), high-functioning individuals with autism spectrum disorder (ASD). The main symptoms of AS are severe impairments in social interactions and restricted or repetitive patterns of behaviors, interests or activities. En ligne : http://dx.doi.org/10.1186/2040-2392-6-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study / Ulrika ROINE in Autism Research, 6-6 (December 2013)  

Public ISBD [article]  inAutism Research > 6-6 (December 2013) . - p.642-650 Titre : Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Année de publication : 2013 Article en page(s) : p.642-650 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging (DTI)  clinical psychiatry  neuroimaging  autism spectrum disorder Index. décimale : PER Périodiques Résumé : To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging (DTI) in 14 male adults with Asperger syndrome (AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder (ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy (FA) and mean diffusivity (MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient (CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. En ligne : http://dx.doi.org/10.1002/aur.1332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - 2013 . - p.642-650. Langues : Anglais (eng) in Autism Research > 6-6 (December 2013) . - p.642-650 Mots-clés : diffusion tensor imaging (DTI)  clinical psychiatry  neuroimaging  autism spectrum disorder Index. décimale : PER Périodiques Résumé : To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging (DTI) in 14 male adults with Asperger syndrome (AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder (ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy (FA) and mean diffusivity (MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient (CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. En ligne : http://dx.doi.org/10.1002/aur.1332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

White Matter and Visuospatial Processing in Autism: A Constrained Spherical Deconvolution Tractography Study / Jane MCGRATH in Autism Research, 6-5 (October 2013)  

Public ISBD [article]  inAutism Research > 6-5 (October 2013) . - p.307-319 Titre : White Matter and Visuospatial Processing in Autism: A Constrained Spherical Deconvolution Tractography Study Type de document : Texte imprimé et/ou numérique Auteurs : Jane MCGRATH, Auteur ; Katherine JOHNSON, Auteur ; Erik O'HANLON, Auteur ; Hugh GARAVAN, Auteur ; Louise GALLAGHER, Auteur ; Alexander LEEMANS, Auteur Article en page(s) : p.307-319 Langues : Anglais (eng) Mots-clés : diffusion MRI  constrained spherical deconvolution  tractography  autism  visuospatial processing  inferior fronto-occipital fasciculus Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are associated with a marked disturbance of neural functional connectivity, which may arise from disrupted organization of white matter. The aim of this study was to use constrained spherical deconvolution (CSD)-based tractography to isolate and characterize major intrahemispheric white matter tracts that are important in visuospatial processing. CSD-based tractography avoids a number of critical confounds that are associated with diffusion tensor tractography, and to our knowledge, this is the first time that this advanced diffusion tractography method has been used in autism research. Twenty-five participants with ASD and aged 25, intelligence quotient-matched controls completed a high angular resolution diffusion imaging scan. The inferior fronto-occipital fasciculus (IFOF) and arcuate fasciculus were isolated using CSD-based tractography. Quantitative diffusion measures of white matter microstructural organization were compared between groups and associated with visuospatial processing performance. Significant alteration of white matter organization was present in the right IFOF in individuals with ASD. In addition, poorer visuospatial processing was associated in individuals with ASD with disrupted white matter in the right IFOF. Using a novel, advanced tractography method to isolate major intrahemispheric white matter tracts in autism, this research has demonstrated that there are significant alterations in the microstructural organization of white matter in the right IFOF in ASD. This alteration was associated with poorer visuospatial processing performance in the ASD group. This study provides an insight into structural brain abnormalities that may influence atypical visuospatial processing in autism. En ligne : http://dx.doi.org/10.1002/aur.1290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 [article] White Matter and Visuospatial Processing in Autism: A Constrained Spherical Deconvolution Tractography Study [Texte imprimé et/ou numérique] / Jane MCGRATH, Auteur ; Katherine JOHNSON, Auteur ; Erik O'HANLON, Auteur ; Hugh GARAVAN, Auteur ; Louise GALLAGHER, Auteur ; Alexander LEEMANS, Auteur . - p.307-319. Langues : Anglais (eng) in Autism Research > 6-5 (October 2013) . - p.307-319 Mots-clés : diffusion MRI  constrained spherical deconvolution  tractography  autism  visuospatial processing  inferior fronto-occipital fasciculus Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are associated with a marked disturbance of neural functional connectivity, which may arise from disrupted organization of white matter. The aim of this study was to use constrained spherical deconvolution (CSD)-based tractography to isolate and characterize major intrahemispheric white matter tracts that are important in visuospatial processing. CSD-based tractography avoids a number of critical confounds that are associated with diffusion tensor tractography, and to our knowledge, this is the first time that this advanced diffusion tractography method has been used in autism research. Twenty-five participants with ASD and aged 25, intelligence quotient-matched controls completed a high angular resolution diffusion imaging scan. The inferior fronto-occipital fasciculus (IFOF) and arcuate fasciculus were isolated using CSD-based tractography. Quantitative diffusion measures of white matter microstructural organization were compared between groups and associated with visuospatial processing performance. Significant alteration of white matter organization was present in the right IFOF in individuals with ASD. In addition, poorer visuospatial processing was associated in individuals with ASD with disrupted white matter in the right IFOF. Using a novel, advanced tractography method to isolate major intrahemispheric white matter tracts in autism, this research has demonstrated that there are significant alterations in the microstructural organization of white matter in the right IFOF in ASD. This alteration was associated with poorer visuospatial processing performance in the ASD group. This study provides an insight into structural brain abnormalities that may influence atypical visuospatial processing in autism. En ligne : http://dx.doi.org/10.1002/aur.1290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218

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