Common and unique multimodal covarying patterns in autism spectrum disorder subtypes / Shile QI in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Common and unique multimodal covarying patterns in autism spectrum disorder subtypes Type de document : texte imprimé Auteurs : Shile QI, Auteur ; Robin D. MORRIS, Auteur ; Jessica A. TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur Année de publication : 2020 Langues : Anglais (eng) Mots-clés : Asperger’s disorder  Autism spectrum disorder  Autistic disorder  Heterogeneity  Multimodal fusion  Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n = 79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n = 58) and Autistic disorder (n = 92) from ABIDE II were used as discovery cohort, and ABIDE I (n = 400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Common and unique multimodal covarying patterns in autism spectrum disorder subtypes [texte imprimé] / Shile QI, Auteur ; Robin D. MORRIS, Auteur ; Jessica A. TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur . - 2020. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : Asperger’s disorder  Autism spectrum disorder  Autistic disorder  Heterogeneity  Multimodal fusion  Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n = 79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n = 58) and Autistic disorder (n = 92) from ABIDE II were used as discovery cohort, and ABIDE I (n = 400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation / Jessica BRAMHAM in Autism, 13-3 (May 2009)  

Public ISBD [article]  inAutism > 13-3 (May 2009) . - p.245-264 Titre : Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation Type de document : texte imprimé Auteurs : Jessica BRAMHAM, Auteur ; Philip ASHERSON, Auteur ; Declan G.M. MURPHY, Auteur ; Ailsa RUSSELL, Auteur ; Fiona AMBERY, Auteur ; Robin D. MORRIS, Auteur ; Kiriakos XENITIDIS, Auteur ; Susan E. YOUNG, Auteur Année de publication : 2009 Article en page(s) : p.245-264 Langues : Anglais (eng) Mots-clés : ADHD adults ASD executive-functioning Index. décimale : PER Périodiques Résumé : Executive functioning deficits characterize the neuropsychological profiles of the childhood neurodevelopmental disorders of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). This study sought to determine whether similar impairments exist in adults with ADHD (N = 53) and ASD (N = 45) in comparison with a healthy control group (N = 31), whether the two disorders can be distinguished on the basis of their executive functioning features, and whether these impairments are related to symptom severity. Both clinical groups were found to exhibit executive functioning deficits. The ADHD group had difficulty withholding a response, with relative preservation of initiation and planning abilities. In contrast, the ASD group exhibited significant impairments in initiation, planning and strategy formation. The specific executive functioning deficits were related to severity of response inhibition impairments in ADHD and stereotyped, repetitive behaviours in ASD. These findings suggest the pattern of executive functioning deficits follows a consistent trajectory into adulthood. En ligne : http://dx.doi.org/10.1177/1362361309103790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=728 [article] Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation [texte imprimé] / Jessica BRAMHAM, Auteur ; Philip ASHERSON, Auteur ; Declan G.M. MURPHY, Auteur ; Ailsa RUSSELL, Auteur ; Fiona AMBERY, Auteur ; Robin D. MORRIS, Auteur ; Kiriakos XENITIDIS, Auteur ; Susan E. YOUNG, Auteur . - 2009 . - p.245-264. Langues : Anglais (eng) in Autism > 13-3 (May 2009) . - p.245-264 Mots-clés : ADHD adults ASD executive-functioning Index. décimale : PER Périodiques Résumé : Executive functioning deficits characterize the neuropsychological profiles of the childhood neurodevelopmental disorders of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). This study sought to determine whether similar impairments exist in adults with ADHD (N = 53) and ASD (N = 45) in comparison with a healthy control group (N = 31), whether the two disorders can be distinguished on the basis of their executive functioning features, and whether these impairments are related to symptom severity. Both clinical groups were found to exhibit executive functioning deficits. The ADHD group had difficulty withholding a response, with relative preservation of initiation and planning abilities. In contrast, the ASD group exhibited significant impairments in initiation, planning and strategy formation. The specific executive functioning deficits were related to severity of response inhibition impairments in ADHD and stereotyped, repetitive behaviours in ASD. These findings suggest the pattern of executive functioning deficits follows a consistent trajectory into adulthood. En ligne : http://dx.doi.org/10.1177/1362361309103790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=728

Healthcare Providers' Experiences with Autism: A Scoping Review / Robin D. MORRIS in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2374-2388 Titre : Healthcare Providers' Experiences with Autism: A Scoping Review Type de document : texte imprimé Auteurs : Robin D. MORRIS, Auteur ; Andrea GREENBLATT, Auteur ; Michael SAINI, Auteur Article en page(s) : p.2374-2388 Langues : Anglais (eng) Mots-clés : Autism  Healthcare  Patient-provider  Professional experience  Scoping review  Service provision Index. décimale : PER Périodiques Résumé : Gaps in research knowledge exist regarding patient-provider interactions with individuals with autism in healthcare settings. To address this, a scoping review was conducted focusing on the experiences of healthcare professionals working with individuals with autism. A systematic search and screen of the literature resulted in 27 relevant studies. Six key themes were found across these 27 studies including (1) complexity beyond usual role, (2) limited knowledge and resources, (3) training/prior experience, (4) communication and collaboration, (5) need for information and training, and (6) need for care coordination and systemic changes. The results of this review have implications for future research and practice and should be considered when reflecting on opportunities to enhance research and service provision with individuals with autism. En ligne : https://dx.doi.org/10.1007/s10803-019-03912-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Healthcare Providers' Experiences with Autism: A Scoping Review [texte imprimé] / Robin D. MORRIS, Auteur ; Andrea GREENBLATT, Auteur ; Michael SAINI, Auteur . - p.2374-2388. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2374-2388 Mots-clés : Autism  Healthcare  Patient-provider  Professional experience  Scoping review  Service provision Index. décimale : PER Périodiques Résumé : Gaps in research knowledge exist regarding patient-provider interactions with individuals with autism in healthcare settings. To address this, a scoping review was conducted focusing on the experiences of healthcare professionals working with individuals with autism. A systematic search and screen of the literature resulted in 27 relevant studies. Six key themes were found across these 27 studies including (1) complexity beyond usual role, (2) limited knowledge and resources, (3) training/prior experience, (4) communication and collaboration, (5) need for information and training, and (6) need for care coordination and systemic changes. The results of this review have implications for future research and practice and should be considered when reflecting on opportunities to enhance research and service provision with individuals with autism. En ligne : https://dx.doi.org/10.1007/s10803-019-03912-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS) / Giles MY TAN in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.42 Titre : Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS) Type de document : texte imprimé Auteurs : Giles MY TAN, Auteur ; Felix BEACHER, Auteur ; Eileen DALY, Auteur ; Jamie HORDER, Auteur ; Verinder PRASHER, Auteur ; Maria-Luisa HANNEY, Auteur ; Robin D. MORRIS, Auteur ; Simon LOVESTONE, Auteur ; Kieran C. MURPHY, Auteur ; Andrew SIMMONS, Auteur ; Declan G.M. MURPHY, Auteur Article en page(s) : p.42 Langues : Anglais (eng) Mots-clés : 1h mrs  Alzheimer's disease  Dementia  Down syndrome  Glutamate-glutamine (Glx)  Hippocampus  Intellectual disability  Magnetic resonance spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS), or trisomy 21, is one of the most common autosomal mutations. People with DS have intellectual disability (ID) and are at significantly increased risk of developing Alzheimer's disease (AD). The biological associates of both ID and AD in DS are poorly understood, but glutamate has been proposed to play a key role. In non-DS populations, glutamate is essential to learning and memory and glutamate-mediated excitotoxicity has been implicated in AD. However, the concentration of hippocampal glutamate in DS individuals with and without dementia has not previously been directly investigated. Proton magnetic resonance spectroscopy ((1)H MRS) can be used to measure in vivo the concentrations of glutamate-glutamine (Glx). The objective of the current study was to examine the hippocampal Glx concentration in non-demented DS (DS-) and demented DS (DS+) individuals. METHODS: We examined 46 adults with DS (35 without dementia and 11 with dementia) and 39 healthy controls (HC) using (1)H MRS and measured their hippocampal Glx concentrations. RESULTS: There was no significant difference in the hippocampal Glx concentration between DS+ and DS-, or between either of the DS groups and the healthy controls. Also, within DS, there was no significant correlation between hippocampal Glx concentration and measures of overall cognitive ability. Last, a sample size calculation based on the effect sizes from this study showed that it would have required 6,257 participants to provide 80% power to detect a significant difference between the groups which would indicate that there is a very low likelihood of a type 2 error accounting for the findings in this study. CONCLUSIONS: Individuals with DS do not have clinically detectable differences in hippocampal Glx concentration. Other pathophysiological processes likely account for ID and AD in people with DS. En ligne : http://dx.doi.org/10.1186/1866-1955-6-42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS) [texte imprimé] / Giles MY TAN, Auteur ; Felix BEACHER, Auteur ; Eileen DALY, Auteur ; Jamie HORDER, Auteur ; Verinder PRASHER, Auteur ; Maria-Luisa HANNEY, Auteur ; Robin D. MORRIS, Auteur ; Simon LOVESTONE, Auteur ; Kieran C. MURPHY, Auteur ; Andrew SIMMONS, Auteur ; Declan G.M. MURPHY, Auteur . - p.42. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.42 Mots-clés : 1h mrs  Alzheimer's disease  Dementia  Down syndrome  Glutamate-glutamine (Glx)  Hippocampus  Intellectual disability  Magnetic resonance spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS), or trisomy 21, is one of the most common autosomal mutations. People with DS have intellectual disability (ID) and are at significantly increased risk of developing Alzheimer's disease (AD). The biological associates of both ID and AD in DS are poorly understood, but glutamate has been proposed to play a key role. In non-DS populations, glutamate is essential to learning and memory and glutamate-mediated excitotoxicity has been implicated in AD. However, the concentration of hippocampal glutamate in DS individuals with and without dementia has not previously been directly investigated. Proton magnetic resonance spectroscopy ((1)H MRS) can be used to measure in vivo the concentrations of glutamate-glutamine (Glx). The objective of the current study was to examine the hippocampal Glx concentration in non-demented DS (DS-) and demented DS (DS+) individuals. METHODS: We examined 46 adults with DS (35 without dementia and 11 with dementia) and 39 healthy controls (HC) using (1)H MRS and measured their hippocampal Glx concentrations. RESULTS: There was no significant difference in the hippocampal Glx concentration between DS+ and DS-, or between either of the DS groups and the healthy controls. Also, within DS, there was no significant correlation between hippocampal Glx concentration and measures of overall cognitive ability. Last, a sample size calculation based on the effect sizes from this study showed that it would have required 6,257 participants to provide 80% power to detect a significant difference between the groups which would indicate that there is a very low likelihood of a type 2 error accounting for the findings in this study. CONCLUSIONS: Individuals with DS do not have clinically detectable differences in hippocampal Glx concentration. Other pathophysiological processes likely account for ID and AD in people with DS. En ligne : http://dx.doi.org/10.1186/1866-1955-6-42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Measuring autism with the ADOS-2 using a bifactor model / Phebe ALBERT in Autism Research, 17-12 (December 2024)  

Public ISBD [article]  inAutism Research > 17-12 (December 2024) . - p.2487-2502 Titre : Measuring autism with the ADOS-2 using a bifactor model Type de document : texte imprimé Auteurs : Phebe ALBERT, Auteur ; Gal KALDES, Auteur ; Erin TULLY, Auteur ; MaryAnn ROMSKI, Auteur ; Robin D. MORRIS, Auteur ; Rose A. SEVCIK, Auteur ; Laura DILLY, Auteur Article en page(s) : p.2487-2502 Langues : Anglais (eng) Mots-clés : autism diagnostic observation schedule, second edition  autism spectrum disorder  bifactor model  nonverbal cognition  verbal cognition Index. décimale : PER Périodiques Résumé : Abstract The measurement of autism characteristics can be challenging due to variability of social impairments and restricted and repetitive behaviors or interests (RRBs). Psychometrically strong measures such as the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) can improve our capacity for thorough autism assessment. The conceptualization of the ADOS-2 has been shaped by research exploring the structure of its items, which evaluate autism traits associated with social affect and RRBs. Continuously refining our understanding of these items and their relations to other characteristics, such as cognition, is crucial for more accurate autism assessment and diagnosis. This study used data from a sample of 188 school-age children with mostly average cognitive functioning referred for clinical autism evaluations to (1) test the dimensionality of the ADOS-2, Module 3 (appropriate for children with relatively higher verbal ability), across two sets of items (i.e., algorithm only, algorithm with three non-algorithm RRB items) using confirmatory factor analysis (CFA) and (2) examine the relations of cognition to the dimensions tested in the ADOS-2. A bifactor model, featuring a general autism trait and two subfactors (RRB and Social Affect), provided superior fit for algorithm-only and algorithm with three non-algorithm items. Cognitive functioning was not significantly related to the general or specific factors in the model with only algorithm items. While the findings support the validity of the ADOS-2, it may not fully capture RRBs among children referred for autism. This study enhances our understanding of the ADOS-2, highlighting the utility of a bifactor model for characterizing its dimensionality, measuring autism traits with minimal cognitive influence, and identifying its limitations in assessing RRBs. En ligne : https://dx.doi.org/10.1002/aur.3245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] Measuring autism with the ADOS-2 using a bifactor model [texte imprimé] / Phebe ALBERT, Auteur ; Gal KALDES, Auteur ; Erin TULLY, Auteur ; MaryAnn ROMSKI, Auteur ; Robin D. MORRIS, Auteur ; Rose A. SEVCIK, Auteur ; Laura DILLY, Auteur . - p.2487-2502. Langues : Anglais (eng) in Autism Research > 17-12 (December 2024) . - p.2487-2502 Mots-clés : autism diagnostic observation schedule, second edition  autism spectrum disorder  bifactor model  nonverbal cognition  verbal cognition Index. décimale : PER Périodiques Résumé : Abstract The measurement of autism characteristics can be challenging due to variability of social impairments and restricted and repetitive behaviors or interests (RRBs). Psychometrically strong measures such as the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) can improve our capacity for thorough autism assessment. The conceptualization of the ADOS-2 has been shaped by research exploring the structure of its items, which evaluate autism traits associated with social affect and RRBs. Continuously refining our understanding of these items and their relations to other characteristics, such as cognition, is crucial for more accurate autism assessment and diagnosis. This study used data from a sample of 188 school-age children with mostly average cognitive functioning referred for clinical autism evaluations to (1) test the dimensionality of the ADOS-2, Module 3 (appropriate for children with relatively higher verbal ability), across two sets of items (i.e., algorithm only, algorithm with three non-algorithm RRB items) using confirmatory factor analysis (CFA) and (2) examine the relations of cognition to the dimensions tested in the ADOS-2. A bifactor model, featuring a general autism trait and two subfactors (RRB and Social Affect), provided superior fit for algorithm-only and algorithm with three non-algorithm items. Cognitive functioning was not significantly related to the general or specific factors in the model with only algorithm items. While the findings support the validity of the ADOS-2, it may not fully capture RRBs among children referred for autism. This study enhances our understanding of the ADOS-2, highlighting the utility of a bifactor model for characterizing its dimensionality, measuring autism traits with minimal cognitive influence, and identifying its limitations in assessing RRBs. En ligne : https://dx.doi.org/10.1002/aur.3245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Reading, Laterality, and the Brain: Early Contributions on Reading Disabilities by Sara S. Sparrow / Jack M. FLETCHER in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

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Visual perception and processing in children with 22q11.2 deletion syndrome: associations with social cognition measures of face identity and emotion recognition / Kathryn L. MCCABE in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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