Autistic Traits and Abnormal Sensory Experiences in Adults / Jamie HORDER in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1461-1469 Titre : Autistic Traits and Abnormal Sensory Experiences in Adults Type de document : Texte imprimé et/ou numérique Auteurs : Jamie HORDER, Auteur ; C. Ellie WILSON, Auteur ; M. Andreina MENDEZ, Auteur ; Declan G. M. MURPHY, Auteur Article en page(s) : p.1461-1469 Langues : Anglais (eng) Mots-clés : Adults  Anxiety  Autism  Comorbidities  Sensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities are common in autism spectrum disorders (ASD), and now form part of the Diagnostic and Statistical Manual 5th Edition (DSM-5) diagnostic criteria, but it is unclear whether they characterize the ‘broader phenotype’ of the disorder. We recruited adults (n = 772) with and without an ASD and administered the Autism Quotient (AQ) along with the Adult/Adolescent Sensory Profile (AASP), the Cardiff Anomalous Perceptions Scale (CAPS), and the Glasgow Sensory Questionnaire (GSQ), all questionnaire measures of abnormal sensory responsivity. Autism traits were significantly correlated with scores on all three sensory scales (AQ/GSQ r = 0.478; AQ/AASP r = 0.344; AQ/CAPS r = 0.333; all p 0.001). This relationship was linear across the whole range of AQ scores and was true both in those with, and without, an ASD diagnosis. It survived correction for anxiety trait scores, and other potential confounds such as mental illness and migraine. En ligne : http://dx.doi.org/10.1007/s10803-013-2012-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Autistic Traits and Abnormal Sensory Experiences in Adults [Texte imprimé et/ou numérique] / Jamie HORDER, Auteur ; C. Ellie WILSON, Auteur ; M. Andreina MENDEZ, Auteur ; Declan G. M. MURPHY, Auteur . - p.1461-1469. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1461-1469 Mots-clés : Adults  Anxiety  Autism  Comorbidities  Sensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities are common in autism spectrum disorders (ASD), and now form part of the Diagnostic and Statistical Manual 5th Edition (DSM-5) diagnostic criteria, but it is unclear whether they characterize the ‘broader phenotype’ of the disorder. We recruited adults (n = 772) with and without an ASD and administered the Autism Quotient (AQ) along with the Adult/Adolescent Sensory Profile (AASP), the Cardiff Anomalous Perceptions Scale (CAPS), and the Glasgow Sensory Questionnaire (GSQ), all questionnaire measures of abnormal sensory responsivity. Autism traits were significantly correlated with scores on all three sensory scales (AQ/GSQ r = 0.478; AQ/AASP r = 0.344; AQ/CAPS r = 0.333; all p 0.001). This relationship was linear across the whole range of AQ scores and was true both in those with, and without, an ASD diagnosis. It survived correction for anxiety trait scores, and other potential confounds such as mental illness and migraine. En ligne : http://dx.doi.org/10.1007/s10803-013-2012-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

Cortical and subcortical glutathione levels in adults with autism spectrum disorder / Alice M. S. DURIEUX in Autism Research, 9-4 (April 2016)  

Public ISBD [article]  inAutism Research > 9-4 (April 2016) . - p.429-435 Titre : Cortical and subcortical glutathione levels in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur Article en page(s) : p.429-435 Langues : Anglais (eng) Mots-clés : autism  magnetic resonance spectroscopy  glutathione  oxidative stress  redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 [article] Cortical and subcortical glutathione levels in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur . - p.429-435. Langues : Anglais (eng) in Autism Research > 9-4 (April 2016) . - p.429-435 Mots-clés : autism  magnetic resonance spectroscopy  glutathione  oxidative stress  redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287

GABA system dysfunction in autism and related disorders. From synapse to symptoms? / Jamie HORDER

Public ISBD in Autism imaging and Devices / Manuel F. CASANOVA Titre : GABA system dysfunction in autism and related disorders. From synapse to symptoms? Type de document : Texte imprimé et/ou numérique Auteurs : Jamie HORDER, Auteur Importance : p.219-244 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 in Autism imaging and Devices / Manuel F. CASANOVA GABA system dysfunction in autism and related disorders. From synapse to symptoms? [Texte imprimé et/ou numérique] / Jamie HORDER, Auteur . - [s.d.] . - p.219-244. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

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