Classification of Preschoolers with Low-Functioning Autism Spectrum Disorder Using Multimodal MRI Data / Johanna Inhyang KIM in Journal of Autism and Developmental Disorders, 53-1 (January 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.25-37 Titre : Classification of Preschoolers with Low-Functioning Autism Spectrum Disorder Using Multimodal MRI Data Type de document : Texte imprimé et/ou numérique Auteurs : Johanna Inhyang KIM, Auteur ; Sungkyu BANG, Auteur ; Jin-Ju YANG, Auteur ; Heejin KWON, Auteur ; Soomin JANG, Auteur ; Sungwon ROH, Auteur ; Seok Hyeon KIM, Auteur ; Mi Jung KIM, Auteur ; Hyun Ju LEE, Auteur ; Jong-Min LEE, Auteur ; Bung-Nyun KIM, Auteur Article en page(s) : p.25-37 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Multimodal imaging studies targeting preschoolers and low-functioning autism spectrum disorder (ASD) patients are scarce. We applied machine learning classifiers to parameters from T1-weighted MRI and DTI data of 58 children with ASD (age 3 “6 years) and 48 typically developing controls (TDC). Classification performance reached an accuracy, sensitivity, and specificity of 88.8%, 93.0%, and 83.8%, respectively. The most prominent features were the cortical thickness of the right inferior occipital gyrus, mean diffusivity of the middle cerebellar peduncle, and nodal efficiency of the left posterior cingulate gyrus. Machine learning-based analysis of MRI data was useful in distinguishing low-functioning ASD preschoolers from TDCs. Combination of T1 and DTI improved classification accuracy about 10%, and large-scale multi-modal MRI studies are warranted for external validation. En ligne : https://doi.org/10.1007/s10803-021-05368-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Classification of Preschoolers with Low-Functioning Autism Spectrum Disorder Using Multimodal MRI Data [Texte imprimé et/ou numérique] / Johanna Inhyang KIM, Auteur ; Sungkyu BANG, Auteur ; Jin-Ju YANG, Auteur ; Heejin KWON, Auteur ; Soomin JANG, Auteur ; Sungwon ROH, Auteur ; Seok Hyeon KIM, Auteur ; Mi Jung KIM, Auteur ; Hyun Ju LEE, Auteur ; Jong-Min LEE, Auteur ; Bung-Nyun KIM, Auteur . - p.25-37. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.25-37 Index. décimale : PER Périodiques Résumé : Multimodal imaging studies targeting preschoolers and low-functioning autism spectrum disorder (ASD) patients are scarce. We applied machine learning classifiers to parameters from T1-weighted MRI and DTI data of 58 children with ASD (age 3 “6 years) and 48 typically developing controls (TDC). Classification performance reached an accuracy, sensitivity, and specificity of 88.8%, 93.0%, and 83.8%, respectively. The most prominent features were the cortical thickness of the right inferior occipital gyrus, mean diffusivity of the middle cerebellar peduncle, and nodal efficiency of the left posterior cingulate gyrus. Machine learning-based analysis of MRI data was useful in distinguishing low-functioning ASD preschoolers from TDCs. Combination of T1 and DTI improved classification accuracy about 10%, and large-scale multi-modal MRI studies are warranted for external validation. En ligne : https://doi.org/10.1007/s10803-021-05368-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Different clinical courses of children exposed to a single incident of psychological trauma: a 30-month prospective follow-up study / Soon-Beom HONG in Journal of Child Psychology and Psychiatry, 55-11 (November 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-11 (November 2014) . - p.1226-1233 Titre : Different clinical courses of children exposed to a single incident of psychological trauma: a 30-month prospective follow-up study Type de document : Texte imprimé et/ou numérique Auteurs : Soon-Beom HONG, Auteur ; George J. YOUSSEF, Auteur ; Sook-Hyung SONG, Auteur ; Nam-Hee CHOI, Auteur ; Jeong RYU, Auteur ; Brett MCDERMOTT, Auteur ; Vanessa E. COBHAM, Auteur ; Subin PARK, Auteur ; Jae-Won KIM, Auteur ; Min-Sup SHIN, Auteur ; Hee-Jeong YOO, Auteur ; Soo-Churl CHO, Auteur ; Bung-Nyun KIM, Auteur Article en page(s) : p.1226-1233 Langues : Anglais (eng) Mots-clés : Children  growth mixture modeling  PTSD  resilience Index. décimale : PER Périodiques Résumé : Background We investigated the distinct longitudinal trajectories of posttraumatic stress symptoms in a sample of 167 children, who witnessed death of two mothers of their schoolmates. Methods The cohort was followed-up at 2 days (T1), 2 months (T2), 6 months (T3), and 30 months (T4) after the traumatic event. The children's posttraumatic stress symptoms (T1–T4), depression (T1, T3 and T4), state anxiety (T1, T3 and T4), and quality of life (T4) were assessed, along with parental stress related to child rearing (T4). Different trajectory patterns of the children's posttraumatic stress symptoms were identified using growth mixture modeling (GMM). Results Four different patterns of symptom change were identified, which were consistent with the prototypical model, and were named Recovery (19.9%), Resilience (72.7%), Chronic Dysfunction (1.8%), and Delayed Reactions (5.6%). Significant differences were found in depression and anxiety scores, children's quality of life, and parental rearing stress according to the distinct longitudinal trajectories of posttraumatic stress symptoms. Conclusions The present study suggests that individual differences should be taken into account in the clinical course and outcome of children exposed to psychological trauma. The two most common trajectories were the Resilience and the Recovery types, together suggesting that over 90% of children were evidenced with a favorable 30-month outcome. The latent classes were associated with significant mean differences in depression and anxiety scores, supporting the clinical validity of the distinct trajectories. En ligne : http://dx.doi.org/10.1111/jcpp.12241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Different clinical courses of children exposed to a single incident of psychological trauma: a 30-month prospective follow-up study [Texte imprimé et/ou numérique] / Soon-Beom HONG, Auteur ; George J. YOUSSEF, Auteur ; Sook-Hyung SONG, Auteur ; Nam-Hee CHOI, Auteur ; Jeong RYU, Auteur ; Brett MCDERMOTT, Auteur ; Vanessa E. COBHAM, Auteur ; Subin PARK, Auteur ; Jae-Won KIM, Auteur ; Min-Sup SHIN, Auteur ; Hee-Jeong YOO, Auteur ; Soo-Churl CHO, Auteur ; Bung-Nyun KIM, Auteur . - p.1226-1233. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-11 (November 2014) . - p.1226-1233 Mots-clés : Children  growth mixture modeling  PTSD  resilience Index. décimale : PER Périodiques Résumé : Background We investigated the distinct longitudinal trajectories of posttraumatic stress symptoms in a sample of 167 children, who witnessed death of two mothers of their schoolmates. Methods The cohort was followed-up at 2 days (T1), 2 months (T2), 6 months (T3), and 30 months (T4) after the traumatic event. The children's posttraumatic stress symptoms (T1–T4), depression (T1, T3 and T4), state anxiety (T1, T3 and T4), and quality of life (T4) were assessed, along with parental stress related to child rearing (T4). Different trajectory patterns of the children's posttraumatic stress symptoms were identified using growth mixture modeling (GMM). Results Four different patterns of symptom change were identified, which were consistent with the prototypical model, and were named Recovery (19.9%), Resilience (72.7%), Chronic Dysfunction (1.8%), and Delayed Reactions (5.6%). Significant differences were found in depression and anxiety scores, children's quality of life, and parental rearing stress according to the distinct longitudinal trajectories of posttraumatic stress symptoms. Conclusions The present study suggests that individual differences should be taken into account in the clinical course and outcome of children exposed to psychological trauma. The two most common trajectories were the Resilience and the Recovery types, together suggesting that over 90% of children were evidenced with a favorable 30-month outcome. The latent classes were associated with significant mean differences in depression and anxiety scores, supporting the clinical validity of the distinct trajectories. En ligne : http://dx.doi.org/10.1111/jcpp.12241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Increased use of lethal methods and annual increase of suicide rates in Korean adolescents: comparison with adolescents in the United States / Subin PARK in Journal of Child Psychology and Psychiatry, 55-3 (March 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-3 (March 2014) . - p.258-263 Titre : Increased use of lethal methods and annual increase of suicide rates in Korean adolescents: comparison with adolescents in the United States Type de document : Texte imprimé et/ou numérique Auteurs : Subin PARK, Auteur ; Soo-Churl CHO, Auteur ; Bung-Nyun KIM, Auteur ; Jae-Won KIM, Auteur ; Hee Jeong YOO, Auteur ; Jin Pyo HONG, Auteur Article en page(s) : p.258-263 Langues : Anglais (eng) Mots-clés : Adolescence  suicide Index. décimale : PER Périodiques Résumé : Background The lethality of the suicide method is a strong risk factor for completed suicide. We examined whether the annual change in the pattern of suicide methods was related to the annual change in suicide rates among adolescents in South Korea and the United States. Methods We analyzed annual data for the 2000–2009 period for South Korea and the 2000–2008 period for the United States to examine time trends in the suicide rates and suicide methods of adolescents aged 10–19 years in two countries. Data on suicide methods were obtained from the World Health Organization (WHO) mortality database. Results Suicide rates among adolescents in the United States have remained relatively steady since 2000, whereas the suicide among Korean adolescents has increased. Between 2000 and 2009, the most common suicide method among Korean adolescents was jumping for boys and girls, whereas it was hanging for girls and firearms for boys in the United States. Along with the annual increase in suicide rates in South Korea, the incidences of jumping among males and hanging (and recently jumping) among females have increased steadily, whereas suicide by self-poisoning steadily decreased. In the United States, between 2000 and 2008, the proportion of suicides committed by hanging increased, whereas those committed using firearms steadily decreased, particularly among adolescent females. Conclusions These findings suggest that the increased use of lethal suicide methods is reflected in the increase in suicide rates in Korean adolescents. The most fruitful approach to addressing the rises in jumping suicides among Korean adolescents and hanging suicides among adolescents in the United States may be through population-based initiatives to reduce the physical availability (e.g., limiting access to or fencing off tall structures) and the social acceptability (e.g., effective and responsible regulations for reporting suicide) of these methods. En ligne : http://dx.doi.org/10.1111/jcpp.12148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226 [article] Increased use of lethal methods and annual increase of suicide rates in Korean adolescents: comparison with adolescents in the United States [Texte imprimé et/ou numérique] / Subin PARK, Auteur ; Soo-Churl CHO, Auteur ; Bung-Nyun KIM, Auteur ; Jae-Won KIM, Auteur ; Hee Jeong YOO, Auteur ; Jin Pyo HONG, Auteur . - p.258-263. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-3 (March 2014) . - p.258-263 Mots-clés : Adolescence  suicide Index. décimale : PER Périodiques Résumé : Background The lethality of the suicide method is a strong risk factor for completed suicide. We examined whether the annual change in the pattern of suicide methods was related to the annual change in suicide rates among adolescents in South Korea and the United States. Methods We analyzed annual data for the 2000–2009 period for South Korea and the 2000–2008 period for the United States to examine time trends in the suicide rates and suicide methods of adolescents aged 10–19 years in two countries. Data on suicide methods were obtained from the World Health Organization (WHO) mortality database. Results Suicide rates among adolescents in the United States have remained relatively steady since 2000, whereas the suicide among Korean adolescents has increased. Between 2000 and 2009, the most common suicide method among Korean adolescents was jumping for boys and girls, whereas it was hanging for girls and firearms for boys in the United States. Along with the annual increase in suicide rates in South Korea, the incidences of jumping among males and hanging (and recently jumping) among females have increased steadily, whereas suicide by self-poisoning steadily decreased. In the United States, between 2000 and 2008, the proportion of suicides committed by hanging increased, whereas those committed using firearms steadily decreased, particularly among adolescent females. Conclusions These findings suggest that the increased use of lethal suicide methods is reflected in the increase in suicide rates in Korean adolescents. The most fruitful approach to addressing the rises in jumping suicides among Korean adolescents and hanging suicides among adolescents in the United States may be through population-based initiatives to reduce the physical availability (e.g., limiting access to or fencing off tall structures) and the social acceptability (e.g., effective and responsible regulations for reporting suicide) of these methods. En ligne : http://dx.doi.org/10.1111/jcpp.12148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226

A Randomized Controlled Trial of the Korean Version of the PEERS® Parent-Assisted Social Skills Training Program for Teens With ASD / Hee-Jeong YOO in Autism Research, 7-1 (February 2014)  

Public ISBD [article]  inAutism Research > 7-1 (February 2014) . - p.145-161 Titre : A Randomized Controlled Trial of the Korean Version of the PEERS® Parent-Assisted Social Skills Training Program for Teens With ASD Type de document : Texte imprimé et/ou numérique Auteurs : Hee-Jeong YOO, Auteur ; Geonho BAHN, Auteur ; In Hee CHO, Auteur ; Eun-Kyung KIM, Auteur ; Joo-Hyun KIM, Auteur ; Jung-Won MIN, Auteur ; Won-Hye LEE, Auteur ; Jun-Seong SEO, Auteur ; Sang-Shin JUN, Auteur ; Guiyoung BONG, Auteur ; Soochurl CHO, Auteur ; Min-Sup SHIN, Auteur ; Bung-Nyun KIM, Auteur ; Jae-Won KIM, Auteur ; Subin PARK, Auteur ; Elizabeth A. LAUGESON, Auteur Article en page(s) : p.145-161 Langues : Anglais (eng) Mots-clés : social skills intervention  intervention  clinical psychiatry  adolescents  pediatrics Index. décimale : PER Périodiques Résumé : Impaired social functioning is a hallmark feature of autism spectrum disorder (ASD), often requiring treatment throughout the life span. PEERS® (Program for the Education and Enrichment of Relational Skills) is a parent-assisted social skills training for teens with ASD. Although PEERS® has an established evidence base in improving the social skills of adolescents and young adults with ASD in North America, the efficacy of this treatment has yet to be established in cross-cultural validation trials. The objective of this study is to examine the feasibility and treatment efficacy of a Korean version of PEERS® for enhancing social skills through a randomized controlled trial (RCT).The English version of the PEERS® Treatment Manual (Laugeson Frankel, 2010) was translated into Korean and reviewed by 21 child mental health professionals. Items identified as culturally sensitive were surveyed by 447 middle school students, and material was modified accordingly. Participants included 47 teens between 12 and 18 years of age with a diagnosis of ASD and a verbal intelligence quotient (IQ)???65. Eligible teens were randomly assigned to a treatment group (TG) or delayed treatment control group (CG). Primary outcome measures included questionnaires and direct observations quantifying social ability and problems directly related to ASD. Secondary outcome measures included scales for depressive symptoms, anxiety, and other behavioral problems. Rating scales for parental depressive symptoms and anxiety were examined to detect changes in parental psychosocial functioning throughout the PEERS® treatment. Independent samples t-tests revealed no significant differences at baseline across the TG and CG conditions with regard to age (14.04?±?1.64 and 13.54?±?1.50 years), IQ (99.39?±?18.09 100.67?±?16.97), parental education, socioeconomic status, or ASD symptoms (p??0.05), respectively. Results for treatment outcome suggest that the TG showed significant improvement in communication and social interaction domain scores on the Autism Diagnostic Observation Schedule, interpersonal relationship and play/leisure time on the subdomain scores of the Korean version of the Vineland Adaptive Behavior Scale (p's??0.01), social skills knowledge total scores on the Test of Adolescent Social Skills Knowledge—Revised (p??0.01), and decreased depressive symptoms on the Child Depression Inventory following treatment (p??0.05). Analyses of parental outcome reveal a significant decrease in maternal state anxiety in the TG after controlling for potential confounding variables (p??0.05). Despite cultural and linguistic differences, the PEERS® social skills intervention appears to be efficacious for teens with ASD in Korea with modest cultural adjustment. In an RCT, participants receiving the PEERS® treatment showed significant improvement in social skills knowledge, interpersonal skills, and play/leisure skills, as well as a decrease in depressive symptoms and ASD symptoms. This study represents one of only a few cross-cultural validation trials of an established evidence-based treatment for adolescents with ASD. En ligne : http://dx.doi.org/10.1002/aur.1354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] A Randomized Controlled Trial of the Korean Version of the PEERS® Parent-Assisted Social Skills Training Program for Teens With ASD [Texte imprimé et/ou numérique] / Hee-Jeong YOO, Auteur ; Geonho BAHN, Auteur ; In Hee CHO, Auteur ; Eun-Kyung KIM, Auteur ; Joo-Hyun KIM, Auteur ; Jung-Won MIN, Auteur ; Won-Hye LEE, Auteur ; Jun-Seong SEO, Auteur ; Sang-Shin JUN, Auteur ; Guiyoung BONG, Auteur ; Soochurl CHO, Auteur ; Min-Sup SHIN, Auteur ; Bung-Nyun KIM, Auteur ; Jae-Won KIM, Auteur ; Subin PARK, Auteur ; Elizabeth A. LAUGESON, Auteur . - p.145-161. Langues : Anglais (eng) in Autism Research > 7-1 (February 2014) . - p.145-161 Mots-clés : social skills intervention  intervention  clinical psychiatry  adolescents  pediatrics Index. décimale : PER Périodiques Résumé : Impaired social functioning is a hallmark feature of autism spectrum disorder (ASD), often requiring treatment throughout the life span. PEERS® (Program for the Education and Enrichment of Relational Skills) is a parent-assisted social skills training for teens with ASD. Although PEERS® has an established evidence base in improving the social skills of adolescents and young adults with ASD in North America, the efficacy of this treatment has yet to be established in cross-cultural validation trials. The objective of this study is to examine the feasibility and treatment efficacy of a Korean version of PEERS® for enhancing social skills through a randomized controlled trial (RCT).The English version of the PEERS® Treatment Manual (Laugeson Frankel, 2010) was translated into Korean and reviewed by 21 child mental health professionals. Items identified as culturally sensitive were surveyed by 447 middle school students, and material was modified accordingly. Participants included 47 teens between 12 and 18 years of age with a diagnosis of ASD and a verbal intelligence quotient (IQ)???65. Eligible teens were randomly assigned to a treatment group (TG) or delayed treatment control group (CG). Primary outcome measures included questionnaires and direct observations quantifying social ability and problems directly related to ASD. Secondary outcome measures included scales for depressive symptoms, anxiety, and other behavioral problems. Rating scales for parental depressive symptoms and anxiety were examined to detect changes in parental psychosocial functioning throughout the PEERS® treatment. Independent samples t-tests revealed no significant differences at baseline across the TG and CG conditions with regard to age (14.04?±?1.64 and 13.54?±?1.50 years), IQ (99.39?±?18.09 100.67?±?16.97), parental education, socioeconomic status, or ASD symptoms (p??0.05), respectively. Results for treatment outcome suggest that the TG showed significant improvement in communication and social interaction domain scores on the Autism Diagnostic Observation Schedule, interpersonal relationship and play/leisure time on the subdomain scores of the Korean version of the Vineland Adaptive Behavior Scale (p's??0.01), social skills knowledge total scores on the Test of Adolescent Social Skills Knowledge—Revised (p??0.01), and decreased depressive symptoms on the Child Depression Inventory following treatment (p??0.05). Analyses of parental outcome reveal a significant decrease in maternal state anxiety in the TG after controlling for potential confounding variables (p??0.05). Despite cultural and linguistic differences, the PEERS® social skills intervention appears to be efficacious for teens with ASD in Korea with modest cultural adjustment. In an RCT, participants receiving the PEERS® treatment showed significant improvement in social skills knowledge, interpersonal skills, and play/leisure skills, as well as a decrease in depressive symptoms and ASD symptoms. This study represents one of only a few cross-cultural validation trials of an established evidence-based treatment for adolescents with ASD. En ligne : http://dx.doi.org/10.1002/aur.1354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

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