Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties / Tingfeng GU in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202722 Titre : Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties Type de document : texte imprimé Auteurs : Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur Article en page(s) : p.202722 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties [texte imprimé] / Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur . - p.202722. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202722 Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability / Ning PAN in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1348-1357 Titre : Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability Type de document : texte imprimé Auteurs : Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur Article en page(s) : p.1348-1357 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD+ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD+ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12 years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD+ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p?< 0.001). There was no difference in the EQ-C between children with ASD+ID and ASD-noID (16.59+5.53 vs. 16.23+5.85, p = 0.973), and the difference in the SQ-C attenuated to null when adjusting for intelligence between children with ASD-noID and TD children (18.89+7.80 vs. 24.15+6.73, p = 0.089). Children with ASD+ID scored higher on empathizing-systemizing difference than TD children but lower than children with ASD-noID (all p?< 0.05). Negative associations between EQ-C and all autistic traits, null associations between SQ-C and all autistic traits, and positive associations between empathizing-systemizing difference and all autistic traits were found in all groups. We observed differences in empathizing, systemizing, and empathizing-systemizing difference and the consistency of their associations with autistic traits among the three groups. Our findings provide implication that behavioral interventions of ASD should consider the balance of empathizing and systemizing. LAY SUMMARY: We examined the profiles of empathizing, systemizing, and empathizing-systemizing difference in children with autism spectrum disorder, with and without intellectual disability (ASD+ID; ASD-noID), and typically developing (TD) children aged 6-12 years. We observed differences in these profiles and the consistency of their associations with autistic traits among the three groups. Empathizing and empathizing-systemizing difference, rather than systemizing, were associated with autistic traits within the three groups. Our findings provide implication that behavioral interventions of ASD should consider these imbalance profiles. En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability [texte imprimé] / Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur . - p.1348-1357. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1348-1357 Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD+ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD+ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12 years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD+ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p?< 0.001). There was no difference in the EQ-C between children with ASD+ID and ASD-noID (16.59+5.53 vs. 16.23+5.85, p = 0.973), and the difference in the SQ-C attenuated to null when adjusting for intelligence between children with ASD-noID and TD children (18.89+7.80 vs. 24.15+6.73, p = 0.089). Children with ASD+ID scored higher on empathizing-systemizing difference than TD children but lower than children with ASD-noID (all p?< 0.05). Negative associations between EQ-C and all autistic traits, null associations between SQ-C and all autistic traits, and positive associations between empathizing-systemizing difference and all autistic traits were found in all groups. We observed differences in empathizing, systemizing, and empathizing-systemizing difference and the consistency of their associations with autistic traits among the three groups. Our findings provide implication that behavioral interventions of ASD should consider the balance of empathizing and systemizing. LAY SUMMARY: We examined the profiles of empathizing, systemizing, and empathizing-systemizing difference in children with autism spectrum disorder, with and without intellectual disability (ASD+ID; ASD-noID), and typically developing (TD) children aged 6-12 years. We observed differences in these profiles and the consistency of their associations with autistic traits among the three groups. Empathizing and empathizing-systemizing difference, rather than systemizing, were associated with autistic traits within the three groups. Our findings provide implication that behavioral interventions of ASD should consider these imbalance profiles. En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis / Guifeng XU in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.766-775 Titre : Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Guifeng XU, Auteur ; Jin JING, Auteur ; Katherine BOWERS, Auteur ; Buyun LIU, Auteur ; Wei BAO, Auteur Année de publication : 2014 Article en page(s) : p.766-775 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Diabetes  Pregnancy Index. décimale : PER Périodiques Résumé : We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1928-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis [texte imprimé] / Guifeng XU, Auteur ; Jin JING, Auteur ; Katherine BOWERS, Auteur ; Buyun LIU, Auteur ; Wei BAO, Auteur . - 2014 . - p.766-775. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.766-775 Mots-clés : Autism spectrum disorders  Diabetes  Pregnancy Index. décimale : PER Périodiques Résumé : We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1928-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era / Xin WANG in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3309-3312 Titre : Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era Type de document : texte imprimé Auteurs : Xin WANG, Auteur ; Xuchu WENG, Auteur ; Ning PAN, Auteur ; Xiuhong LI, Auteur ; Lizi LIN, Auteur ; Jin JING, Auteur Article en page(s) : p.3309-3312 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although the United States (US) have been monitoring the autism spectrum disorder (ASD) prevalence, whether the prevalence has continued to increase, decrease, fluctuate or reached a stable level remained unclear during the COVID-19 pandemic. We have requested the 2016-2021 National Survey of Children s Health (NSCH) data in the United States to estimate weighted ASD prevalence and assess linearity/nonlinearity in the time trend. We did not observe linear or nonlinear trends of the ASD prevalence during the 2016-2021 periods. The current ASD prevalence experienced a 0.3% drop from 2019 to 2020 but a 0.3% uptick in 2021, suggesting a stable trend during the COVID-19 pandemic. Our findings shed lights on the need for the modified strategy of monitor ASD prevalence during the COVID-19 era. En ligne : https://doi.org/10.1007/s10803-023-05915-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era [texte imprimé] / Xin WANG, Auteur ; Xuchu WENG, Auteur ; Ning PAN, Auteur ; Xiuhong LI, Auteur ; Lizi LIN, Auteur ; Jin JING, Auteur . - p.3309-3312. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3309-3312 Index. décimale : PER Périodiques Résumé : Although the United States (US) have been monitoring the autism spectrum disorder (ASD) prevalence, whether the prevalence has continued to increase, decrease, fluctuate or reached a stable level remained unclear during the COVID-19 pandemic. We have requested the 2016-2021 National Survey of Children s Health (NSCH) data in the United States to estimate weighted ASD prevalence and assess linearity/nonlinearity in the time trend. We did not observe linear or nonlinear trends of the ASD prevalence during the 2016-2021 periods. The current ASD prevalence experienced a 0.3% drop from 2019 to 2020 but a 0.3% uptick in 2021, suggesting a stable trend during the COVID-19 pandemic. Our findings shed lights on the need for the modified strategy of monitor ASD prevalence during the COVID-19 era. En ligne : https://doi.org/10.1007/s10803-023-05915-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years / Xin WANG in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1675-1685 Titre : Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years Type de document : texte imprimé Auteurs : Xin WANG, Auteur ; Mei-Xia DAI, Auteur ; Aja MURRAY, Auteur ; Si-Yu LIU, Auteur ; Jia-Jie CHEN, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur ; Bonnie AUYEUNG, Auteur Article en page(s) : p.1675-1685 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/psychology  Child  Empathy  Female  Humans  Intelligence  Male  Psychometrics  Reproducibility of Results  autism spectrum disorder  children  empathy quotient  gender differences  systemizing quotient Index. décimale : PER Périodiques Résumé : We aimed to validate the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in Mainland China, which can reflect the profiles of empathizing and systemizing, and describing specific characteristics of autism spectrum disorder (ASD) and gender-typical behaviors in general population. A total of 800 typically developing (TD) children, aged 4-12years was recruited initially with whose parents/guardians complete the measurements, and 782 TD children who met inclusion criteria were finally included. A 23-item three-factor EQ-C and a 22-item four-factor SQ-C was developed with good internal consistency (Omega total values of 0.87 and 0.86) and test-retest reliability (Pearson correlation coefficients of 0.82 and 0.69). In TD children, girls scored significantly higher on EQ-C (31.4Â+7.8 vs. 28.2Â+7.7) but there were no gender differences in SQ-C scores. TD children showed different cognitive styles (empathizing-dominant for girls with 42.6% identified as Type E; systemizing-dominant for boys with 40.7% identified as Type S). A further sample of 222 children with ASD indicated that they scored lower on EQ/SQ-C compared to TD children (13.2Â+5.1 vs. 29.7Â+7.9, 12.4Â+5.8 vs. 23.5Â+8.3) and were generally systemizing-dominant (Type S: 50.8% for boys and 64.0% for girls). Autistic children scored higher on the SQ-C in those without intellectual disability and with higher paternal education level and family income (14.2Â+6.1 vs. 10.9Â+5.0, 13.3Â+6.2 vs. 11.5Â+5.1, 13.7Â+5.6 vs. 11.9Â+5.8), while there were no differences in the EQ-C. This study indicated good reliability and validity of the Chinese version of EQ/SQ-C, which can be used in Chinese children with and without ASD. LAY SUMMARY: We developed the Chinese version of the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in 782 typically developing (TD) children aged 4-12years in Mainland China, yielding a 23-item, 3-factor EQ-C and a 22-item, 4-factor SQ-C with good psychometric properties. In TD children, we found gender difference only in scores of EQ-C. Further analyses of 222 autistic children indicated that differences were found in scores of SQ-C when considering their gender, intelligence and socio-economic status. En ligne : http://dx.doi.org/10.1002/aur.2743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years [texte imprimé] / Xin WANG, Auteur ; Mei-Xia DAI, Auteur ; Aja MURRAY, Auteur ; Si-Yu LIU, Auteur ; Jia-Jie CHEN, Auteur ; Li-Zi LIN, Auteur ; Jin JING, Auteur ; Bonnie AUYEUNG, Auteur . - p.1675-1685. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1675-1685 Mots-clés : Autism Spectrum Disorder/psychology  Child  Empathy  Female  Humans  Intelligence  Male  Psychometrics  Reproducibility of Results  autism spectrum disorder  children  empathy quotient  gender differences  systemizing quotient Index. décimale : PER Périodiques Résumé : We aimed to validate the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in Mainland China, which can reflect the profiles of empathizing and systemizing, and describing specific characteristics of autism spectrum disorder (ASD) and gender-typical behaviors in general population. A total of 800 typically developing (TD) children, aged 4-12years was recruited initially with whose parents/guardians complete the measurements, and 782 TD children who met inclusion criteria were finally included. A 23-item three-factor EQ-C and a 22-item four-factor SQ-C was developed with good internal consistency (Omega total values of 0.87 and 0.86) and test-retest reliability (Pearson correlation coefficients of 0.82 and 0.69). In TD children, girls scored significantly higher on EQ-C (31.4Â+7.8 vs. 28.2Â+7.7) but there were no gender differences in SQ-C scores. TD children showed different cognitive styles (empathizing-dominant for girls with 42.6% identified as Type E; systemizing-dominant for boys with 40.7% identified as Type S). A further sample of 222 children with ASD indicated that they scored lower on EQ/SQ-C compared to TD children (13.2Â+5.1 vs. 29.7Â+7.9, 12.4Â+5.8 vs. 23.5Â+8.3) and were generally systemizing-dominant (Type S: 50.8% for boys and 64.0% for girls). Autistic children scored higher on the SQ-C in those without intellectual disability and with higher paternal education level and family income (14.2Â+6.1 vs. 10.9Â+5.0, 13.3Â+6.2 vs. 11.5Â+5.1, 13.7Â+5.6 vs. 11.9Â+5.8), while there were no differences in the EQ-C. This study indicated good reliability and validity of the Chinese version of EQ/SQ-C, which can be used in Chinese children with and without ASD. LAY SUMMARY: We developed the Chinese version of the Children's Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C) in 782 typically developing (TD) children aged 4-12years in Mainland China, yielding a 23-item, 3-factor EQ-C and a 22-item, 4-factor SQ-C with good psychometric properties. In TD children, we found gender difference only in scores of EQ-C. Further analyses of 222 autistic children indicated that differences were found in scores of SQ-C when considering their gender, intelligence and socio-economic status. En ligne : http://dx.doi.org/10.1002/aur.2743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Socioeconomic factors and autism among 16- to 30-month-old children: Evidence from a national survey of China / Muqing CAO in Autism, 27-5 (July 2023)  

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The association between motor coordination impairment and restricted/repetitive behaviors in autistic children: The partial mediating effect of executive function / Chengkai JIN in Research in Autism Spectrum Disorders, 99 (November)  

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The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire / Si-Yu LIU in Autism Research, 15-9 (September 2022)  

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