Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties / Tingfeng GU in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202722 Titre : Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties Type de document : texte imprimé Auteurs : Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur Article en page(s) : p.202722 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties [texte imprimé] / Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur . - p.202722. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202722 Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability / Ning PAN in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1348-1357 Titre : Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability Type de document : texte imprimé Auteurs : Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur Article en page(s) : p.1348-1357 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD+ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD+ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12 years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD+ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p?< 0.001). There was no difference in the EQ-C between children with ASD+ID and ASD-noID (16.59+5.53 vs. 16.23+5.85, p = 0.973), and the difference in the SQ-C attenuated to null when adjusting for intelligence between children with ASD-noID and TD children (18.89+7.80 vs. 24.15+6.73, p = 0.089). Children with ASD+ID scored higher on empathizing-systemizing difference than TD children but lower than children with ASD-noID (all p?< 0.05). Negative associations between EQ-C and all autistic traits, null associations between SQ-C and all autistic traits, and positive associations between empathizing-systemizing difference and all autistic traits were found in all groups. We observed differences in empathizing, systemizing, and empathizing-systemizing difference and the consistency of their associations with autistic traits among the three groups. Our findings provide implication that behavioral interventions of ASD should consider the balance of empathizing and systemizing. LAY SUMMARY: We examined the profiles of empathizing, systemizing, and empathizing-systemizing difference in children with autism spectrum disorder, with and without intellectual disability (ASD+ID; ASD-noID), and typically developing (TD) children aged 6-12 years. We observed differences in these profiles and the consistency of their associations with autistic traits among the three groups. Empathizing and empathizing-systemizing difference, rather than systemizing, were associated with autistic traits within the three groups. Our findings provide implication that behavioral interventions of ASD should consider these imbalance profiles. En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability [texte imprimé] / Ning PAN, Auteur ; Bonnie AUYEUNG, Auteur ; Xin WANG, Auteur ; Li-Zi LIN, Auteur ; Hai-Lin LI, Auteur ; Xiao-Ling ZHAN, Auteur ; Cheng-Kai JIN, Auteur ; Jin JING, Auteur ; Xiu-Hong LI, Auteur . - p.1348-1357. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1348-1357 Mots-clés : autism spectrum disorder  empathy  intellectual disability  systemizing Index. décimale : PER Périodiques Résumé : Empathizing, systemizing, and empathizing-systemizing difference can be linked to autistic traits in the general adult population and those with autism spectrum disorder (ASD), but these profiles and associations remain unclear in children with ASD, with and without intellectual disability (ASD+ID; ASD-noID). We recruited three groups including 160 boys with ASD (73 ASD+ID; 87 ASD-noID) and 99 typically developing (TD) boys (6-12 years). We measured empathizing, systemizing, and empathizing-systemizing difference using the parent-reported child Empathy and Systemizing Quotient (EQ-C/SQ-C). We measured autistic traits using the Social Responsiveness Scale (SRS). Among the three groups, children with ASD+ID and ASD-noID scored lower on the EQ-C and SQ-C than TD children (all p?< 0.001). There was no difference in the EQ-C between children with ASD+ID and ASD-noID (16.59+5.53 vs. 16.23+5.85, p = 0.973), and the difference in the SQ-C attenuated to null when adjusting for intelligence between children with ASD-noID and TD children (18.89+7.80 vs. 24.15+6.73, p = 0.089). Children with ASD+ID scored higher on empathizing-systemizing difference than TD children but lower than children with ASD-noID (all p?< 0.05). Negative associations between EQ-C and all autistic traits, null associations between SQ-C and all autistic traits, and positive associations between empathizing-systemizing difference and all autistic traits were found in all groups. We observed differences in empathizing, systemizing, and empathizing-systemizing difference and the consistency of their associations with autistic traits among the three groups. Our findings provide implication that behavioral interventions of ASD should consider the balance of empathizing and systemizing. LAY SUMMARY: We examined the profiles of empathizing, systemizing, and empathizing-systemizing difference in children with autism spectrum disorder, with and without intellectual disability (ASD+ID; ASD-noID), and typically developing (TD) children aged 6-12 years. We observed differences in these profiles and the consistency of their associations with autistic traits among the three groups. Empathizing and empathizing-systemizing difference, rather than systemizing, were associated with autistic traits within the three groups. Our findings provide implication that behavioral interventions of ASD should consider these imbalance profiles. En ligne : http://dx.doi.org/10.1002/aur.2766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Executive function predicts the visuospatial working memory in autism spectrum disorder and attention-deficit/hyperactivity disorder / Ziqi WANG in Autism Research, 11-8 (August 2018)  

Public ISBD [article]  inAutism Research > 11-8 (August 2018) . - p.1148-1156 Titre : Executive function predicts the visuospatial working memory in autism spectrum disorder and attention-deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Ziqi WANG, Auteur ; Jin JING, Auteur ; Kazue IGARASHI, Auteur ; Lijun FAN, Auteur ; Siyuan YANG, Auteur ; Yongmei LI, Auteur ; Yu JIN, Auteur Année de publication : 2018 Article en page(s) : p.1148-1156 Langues : Anglais (eng) Mots-clés : attention-deficit/hyperactivity disorder  autism spectrum disorder  executive function  visuospatial working memory Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and those with attention deficit/hyperactivity disorder (ADHD) always show working memory deficits. However, research findings on the factors that affected the working memory in ASD and ADHD were inconsistent. Thus, we developed the present study to investigate the association of executive function (EF) with the visuospatial working memory (VSWM) in ASD and ADHD. Three groups of participants were examined: 21 children with ASD, 28 children with ADHD and 28 typically developing (TD) children as the controls. All participants completed two tests: the Wisconsin Card Sorting Test (WCST) and the Corsi Block Tapping Test for measuring EF and VSWM, respectively. The WCST included four domains: categories achieved (CA), perseverative errors (PE), failures to maintain set (FMS), and total errors (TE). The findings indicated that (1) the ASD group showed poorer performance in VSWM than the ADHD and TD groups; (2) for the ASD group, VSWM was positively correlated with CA, and was negatively correlated with PE and TE; (3) for the ADHD group, FMS showed a negative relationship with VSWM; and (4) TE predicted the performance of VSWM in ASD group, while FMS predicted VSWM in ADHD group. The study results suggested that VSWM was impaired in ASD but not in ADHD. Also, the EF domains were differently correlated with the VSWM performance in ASD and ADHD. Our study suggests that we should consider different intervention targets of working memory and EF contributions in improving the cognitive capacity of ASD and ADHD. Autism Res 2018, 11: 1148-1156. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The present study compared the visuospatial working memory (VSWM) in three groups of children: autism (ASD), attention deficit/hyperactivity disorder (ADHD), and typically developed children (TD). The ASD group showed poorer VSWM than the ADHD and TD groups. The total error of executive function predicted the performance of VSWM in ASD, while failures to maintain set predicted VSWM in ADHD . These findings suggested that we should consider the different working memory and executive function training targets to increase cognitive capacity of ASD and ADHD. En ligne : http://dx.doi.org/10.1002/aur.1967 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Executive function predicts the visuospatial working memory in autism spectrum disorder and attention-deficit/hyperactivity disorder [texte imprimé] / Ziqi WANG, Auteur ; Jin JING, Auteur ; Kazue IGARASHI, Auteur ; Lijun FAN, Auteur ; Siyuan YANG, Auteur ; Yongmei LI, Auteur ; Yu JIN, Auteur . - 2018 . - p.1148-1156. Langues : Anglais (eng) in Autism Research > 11-8 (August 2018) . - p.1148-1156 Mots-clés : attention-deficit/hyperactivity disorder  autism spectrum disorder  executive function  visuospatial working memory Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and those with attention deficit/hyperactivity disorder (ADHD) always show working memory deficits. However, research findings on the factors that affected the working memory in ASD and ADHD were inconsistent. Thus, we developed the present study to investigate the association of executive function (EF) with the visuospatial working memory (VSWM) in ASD and ADHD. Three groups of participants were examined: 21 children with ASD, 28 children with ADHD and 28 typically developing (TD) children as the controls. All participants completed two tests: the Wisconsin Card Sorting Test (WCST) and the Corsi Block Tapping Test for measuring EF and VSWM, respectively. The WCST included four domains: categories achieved (CA), perseverative errors (PE), failures to maintain set (FMS), and total errors (TE). The findings indicated that (1) the ASD group showed poorer performance in VSWM than the ADHD and TD groups; (2) for the ASD group, VSWM was positively correlated with CA, and was negatively correlated with PE and TE; (3) for the ADHD group, FMS showed a negative relationship with VSWM; and (4) TE predicted the performance of VSWM in ASD group, while FMS predicted VSWM in ADHD group. The study results suggested that VSWM was impaired in ASD but not in ADHD. Also, the EF domains were differently correlated with the VSWM performance in ASD and ADHD. Our study suggests that we should consider different intervention targets of working memory and EF contributions in improving the cognitive capacity of ASD and ADHD. Autism Res 2018, 11: 1148-1156. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The present study compared the visuospatial working memory (VSWM) in three groups of children: autism (ASD), attention deficit/hyperactivity disorder (ADHD), and typically developed children (TD). The ASD group showed poorer VSWM than the ADHD and TD groups. The total error of executive function predicted the performance of VSWM in ASD, while failures to maintain set predicted VSWM in ADHD . These findings suggested that we should consider the different working memory and executive function training targets to increase cognitive capacity of ASD and ADHD. En ligne : http://dx.doi.org/10.1002/aur.1967 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Gender Difference in the Association Between Executive Function and Autistic Traits in Typically Developing Children / Meixia DAI in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1182-1192 Titre : Gender Difference in the Association Between Executive Function and Autistic Traits in Typically Developing Children Type de document : texte imprimé Auteurs : Meixia DAI, Auteur ; Lizi LIN, Auteur ; Jingjing LIANG, Auteur ; Ziqi WANG, Auteur ; Jin JING, Auteur Article en page(s) : p.1182-1192 Langues : Anglais (eng) Mots-clés : Autistic trait  Children  Executive functions  Gender difference Index. décimale : PER Périodiques Résumé : Autistic traits and executive function (EF) were assessed in 413 typically developing children aged 6-9 years. The children were divided into the high- autistic-trait (HAT) and low-autistic-trait (LAT) groups based on their total autistic traits. Results suggested that there were gender differences in specific autistic traits in children with LAT. There were gender-specific associations between EF and autistic traits in children with HAT: the set shifting of EF predicted difficulties in social awareness in boys; whereas all the EF components predicted difficulties in social communication and social cognition in girls. These findings may have implications for developing customized interventions that are targeted at specific autistic deficits in males and females. En ligne : http://dx.doi.org/10.1007/s10803-018-3813-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Gender Difference in the Association Between Executive Function and Autistic Traits in Typically Developing Children [texte imprimé] / Meixia DAI, Auteur ; Lizi LIN, Auteur ; Jingjing LIANG, Auteur ; Ziqi WANG, Auteur ; Jin JING, Auteur . - p.1182-1192. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1182-1192 Mots-clés : Autistic trait  Children  Executive functions  Gender difference Index. décimale : PER Périodiques Résumé : Autistic traits and executive function (EF) were assessed in 413 typically developing children aged 6-9 years. The children were divided into the high- autistic-trait (HAT) and low-autistic-trait (LAT) groups based on their total autistic traits. Results suggested that there were gender differences in specific autistic traits in children with LAT. There were gender-specific associations between EF and autistic traits in children with HAT: the set shifting of EF predicted difficulties in social awareness in boys; whereas all the EF components predicted difficulties in social communication and social cognition in girls. These findings may have implications for developing customized interventions that are targeted at specific autistic deficits in males and females. En ligne : http://dx.doi.org/10.1007/s10803-018-3813-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis / Guifeng XU in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.766-775 Titre : Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Guifeng XU, Auteur ; Jin JING, Auteur ; Katherine BOWERS, Auteur ; Buyun LIU, Auteur ; Wei BAO, Auteur Année de publication : 2014 Article en page(s) : p.766-775 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Diabetes  Pregnancy Index. décimale : PER Périodiques Résumé : We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1928-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis [texte imprimé] / Guifeng XU, Auteur ; Jin JING, Auteur ; Katherine BOWERS, Auteur ; Buyun LIU, Auteur ; Wei BAO, Auteur . - 2014 . - p.766-775. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.766-775 Mots-clés : Autism spectrum disorders  Diabetes  Pregnancy Index. décimale : PER Périodiques Résumé : We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1928-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era / Xin WANG in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

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Psychometric properties of the chinese version of autism spectrum quotient-children's version: A sex-specific analysis / Fan SUN in Autism Research, 12-2 (February 2019)  

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Psychometric properties of the Chinese version of the children's empathy quotient and systemizing quotient: 4-12years / Xin WANG in Autism Research, 15-9 (September 2022)  

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Reliability and Validity of the Chinese Version of Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) / Cheng GUO in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

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Socioeconomic factors and autism among 16- to 30-month-old children: Evidence from a national survey of China / Muqing CAO in Autism, 27-5 (July 2023)  

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The association between motor coordination impairment and restricted/repetitive behaviors in autistic children: The partial mediating effect of executive function / Chengkai JIN in Research in Autism Spectrum Disorders, 99 (November)  

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The validity and reliability of the simplified Chinese version of the Social Communication Questionnaire / Si-Yu LIU in Autism Research, 15-9 (September 2022)  

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