Dépouillements

Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes / Christy D. YOON in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2140-2165 Titre : Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes Type de document : texte imprimé Auteurs : Christy D. YOON, Auteur ; Douglas C. DEAN III, Auteur Article en page(s) : p.2140-2165 Langues : Anglais (eng) Mots-clés : advanced quantitative MRI  autism  CSD  DKI  microstructure  MTI  NODDI  relaxometry Index. décimale : PER Périodiques Résumé : ABSTRACT Emerging evidence highlights widespread alterations in white matter microstructure in autism. Advances in magnetic resonance imaging (MRI) have enabled more precise examinations of these microstructural changes, leading to increased use of quantitative MRI techniques in autism research. This review summarizes the current landscape of these techniques, focusing on methodology, group differences, developmental associations, and regional variations. Following PRISMA guidelines, 34 studies published between 2006 and 2024 that employed advanced MRI techniques were reviewed. These included diffusion MRI signal representations (diffusion kurtosis imaging [DKI] and constrained spherical deconvolution [CSD]) and biophysical models (neurite orientation dispersion and density imaging [NODDI] and white matter tract integrity [WMTI]), as well as relaxometry and magnetization transfer imaging (MTI). CSD and NODDI were the most frequently used, while MTI was the least utilized, with notable variations in acquisition parameters and processing methods across the techniques. Findings suggest relatively consistent lower values of fixel-based analysis measures (CSD) and neurite density index (NODDI) across major white matter regions, while findings from DKI, WMTI, and relaxometry varied. Measures from these techniques were associated with various developmental outcomes, including cognitive, emotional, and social behaviors. Limitations and implications are also discussed. En ligne : https://doi.org/10.1002/aur.70122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes [texte imprimé] / Christy D. YOON, Auteur ; Douglas C. DEAN III, Auteur . - p.2140-2165. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2140-2165 Mots-clés : advanced quantitative MRI  autism  CSD  DKI  microstructure  MTI  NODDI  relaxometry Index. décimale : PER Périodiques Résumé : ABSTRACT Emerging evidence highlights widespread alterations in white matter microstructure in autism. Advances in magnetic resonance imaging (MRI) have enabled more precise examinations of these microstructural changes, leading to increased use of quantitative MRI techniques in autism research. This review summarizes the current landscape of these techniques, focusing on methodology, group differences, developmental associations, and regional variations. Following PRISMA guidelines, 34 studies published between 2006 and 2024 that employed advanced MRI techniques were reviewed. These included diffusion MRI signal representations (diffusion kurtosis imaging [DKI] and constrained spherical deconvolution [CSD]) and biophysical models (neurite orientation dispersion and density imaging [NODDI] and white matter tract integrity [WMTI]), as well as relaxometry and magnetization transfer imaging (MTI). CSD and NODDI were the most frequently used, while MTI was the least utilized, with notable variations in acquisition parameters and processing methods across the techniques. Findings suggest relatively consistent lower values of fixel-based analysis measures (CSD) and neurite density index (NODDI) across major white matter regions, while findings from DKI, WMTI, and relaxometry varied. Measures from these techniques were associated with various developmental outcomes, including cognitive, emotional, and social behaviors. Limitations and implications are also discussed. En ligne : https://doi.org/10.1002/aur.70122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Maximizing the Quality and Reporting Standards of Autism Intervention Science / Shannon LAPOINT in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2166-2173 Titre : Maximizing the Quality and Reporting Standards of Autism Intervention Science Type de document : texte imprimé Auteurs : Shannon LAPOINT, Auteur ; Claire Brito KLEIN, Auteur ; Micheal SANDBANK, Auteur ; Kristen BOTTEMA-BEUTEL, Auteur ; Sue FLETCHER-WATSON, Auteur ; Gauri DIVAN, Auteur ; Dagmara DIMITRIOU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Mette Elmose ANDERSEN, Auteur ; Amanda BINNS, Auteur ; Tony CHARMAN, Auteur ; Jasper A. ESTABILLO, Auteur ; Stephanie M. FECTEAU, Auteur ; Anna FERRARI, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Lauren H. HAMPTON, Auteur ; Sabri HERGUNER, Auteur ; Emily S. KUSCHNER, Auteur ; Jia Ying Sarah LEE, Auteur ; Julie SEGERS, Auteur ; Deanna SWAIN, Auteur ; Sarah VEJNOSKA, Auteur ; Giacomo VIVANTI, Auteur ; Chongying WANG, Auteur ; Jonathan GREEN, Auteur Article en page(s) : p.2166-2173 Langues : Anglais (eng) Mots-clés : autism  INSAR  intervention  reporting standards  special interest group  trial Index. décimale : PER Périodiques Résumé : ABSTRACT Although there are clear international standards for intervention science and reporting in healthcare, implementation and uptake have been limited within autism intervention research. To address this concern, a Special Interest Group (SIG) was convened at the International Society for Autism Research (INSAR) Annual Meetings in May 2023 and May 2024. This SIG comprised members of the autistic community, senior clinical scientists, clinicians, advanced researchers, and early career researchers, who discussed and debated quality standards for autism intervention trials. This commentary summarizes relevant literature highlighted by SIG panelists and recommendations generated from small breakout groups and larger group discussions with SIG attendees. We recommend that all journals publishing autism intervention findings, especially autism-focused journals, institute mandatory reporting practices (e.g., trial registration, protocol, analysis plan) to facilitate transparency and rigorous autism intervention science, as well as related education initiatives in support of this goal. Findings from the SIG offer practical, actionable recommendations that we advocate be systematically adopted across autism-focused journals. En ligne : https://doi.org/10.1002/aur.70126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Maximizing the Quality and Reporting Standards of Autism Intervention Science [texte imprimé] / Shannon LAPOINT, Auteur ; Claire Brito KLEIN, Auteur ; Micheal SANDBANK, Auteur ; Kristen BOTTEMA-BEUTEL, Auteur ; Sue FLETCHER-WATSON, Auteur ; Gauri DIVAN, Auteur ; Dagmara DIMITRIOU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Mette Elmose ANDERSEN, Auteur ; Amanda BINNS, Auteur ; Tony CHARMAN, Auteur ; Jasper A. ESTABILLO, Auteur ; Stephanie M. FECTEAU, Auteur ; Anna FERRARI, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Lauren H. HAMPTON, Auteur ; Sabri HERGUNER, Auteur ; Emily S. KUSCHNER, Auteur ; Jia Ying Sarah LEE, Auteur ; Julie SEGERS, Auteur ; Deanna SWAIN, Auteur ; Sarah VEJNOSKA, Auteur ; Giacomo VIVANTI, Auteur ; Chongying WANG, Auteur ; Jonathan GREEN, Auteur . - p.2166-2173. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2166-2173 Mots-clés : autism  INSAR  intervention  reporting standards  special interest group  trial Index. décimale : PER Périodiques Résumé : ABSTRACT Although there are clear international standards for intervention science and reporting in healthcare, implementation and uptake have been limited within autism intervention research. To address this concern, a Special Interest Group (SIG) was convened at the International Society for Autism Research (INSAR) Annual Meetings in May 2023 and May 2024. This SIG comprised members of the autistic community, senior clinical scientists, clinicians, advanced researchers, and early career researchers, who discussed and debated quality standards for autism intervention trials. This commentary summarizes relevant literature highlighted by SIG panelists and recommendations generated from small breakout groups and larger group discussions with SIG attendees. We recommend that all journals publishing autism intervention findings, especially autism-focused journals, institute mandatory reporting practices (e.g., trial registration, protocol, analysis plan) to facilitate transparency and rigorous autism intervention science, as well as related education initiatives in support of this goal. Findings from the SIG offer practical, actionable recommendations that we advocate be systematically adopted across autism-focused journals. En ligne : https://doi.org/10.1002/aur.70126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

ADNP Exhibits Methyltransferase Activity in Overexpression Systems and Modulates DNA and Histone Methylation / Claudio Peter D'INCAL in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2174-2191 Titre : ADNP Exhibits Methyltransferase Activity in Overexpression Systems and Modulates DNA and Histone Methylation Type de document : texte imprimé Auteurs : Claudio Peter D'INCAL, Auteur ; Kirsten Esther VAN ROSSEM, Auteur ; Elisa CAPPUYNS, Auteur ; Anke VAN DIJCK, Auteur ; Ellen ELINCK, Auteur ; Kevin DE MAN, Auteur ; Ayu SCOTT, Auteur ; Anthony KONINGS, Auteur ; Dale John ANNEAR, Auteur ; R. Frank KOOY, Auteur Article en page(s) : p.2174-2191 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Activity-Dependent Neuroprotective Protein (ADNP) is a putative transcription factor that differentially interacts with proteins involved in chromatin remodeling, thereby controlling neuronal differentiation. The protein contains nine zinc fingers, a bipartite nuclear localization signal (NLS), and a homeobox domain with a heterochromatin protein 1 interaction motif, ensuring nuclear association with DNA and chromatin. De novo variants in ADNP cause autism comorbid with intellectual disability in the Helsmoortel?Van der Aa syndrome. ADNP interacts with components of the SWI/SNF in HEK293T cells but has also been reported as part of the repressive ChAHP complex in mouse embryonic stem cells. Although converging evidence suggests a role in chromatin remodeling, Hi-C experiments failed to detect major alterations in 3D chromatin structure. We therefore investigated ADNP's role in epigenetic regulation and identified the chromatin scaffolding protein WDR5 and HDAC2 as interaction partners. Structural modeling revealed two N-terminal methyltransferase domains, suggesting catalytic activity via SAM to SAH conversion. Immunoprecipitated fractions containing wild-type ADNP exhibited methyltransferase activity, which was reduced by nonsense variants. ADNP was expressed in histone-enriched cerebellar fractions in mice and a Helsmoortel?Van der Aa autopsy case, with male-specific reduction of the H3K79me1 modification. At the DNA level, wild-type ADNP induced CpG hypermethylation. However, most variants caused CpG hypomethylation, supporting a loss-of-function mechanism, while NLS variants showed additional hypermethylation, suggesting a gain-of-function effect linked to apoptosis and microtubule transport. Taken together, we identified an ADNP-WDR5-HDAC2 protein complex involved in epigenetic regulation, with ADNP exhibiting methyltransferase activity in overexpression systems. En ligne : https://doi.org/10.1002/aur.70132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] ADNP Exhibits Methyltransferase Activity in Overexpression Systems and Modulates DNA and Histone Methylation [texte imprimé] / Claudio Peter D'INCAL, Auteur ; Kirsten Esther VAN ROSSEM, Auteur ; Elisa CAPPUYNS, Auteur ; Anke VAN DIJCK, Auteur ; Ellen ELINCK, Auteur ; Kevin DE MAN, Auteur ; Ayu SCOTT, Auteur ; Anthony KONINGS, Auteur ; Dale John ANNEAR, Auteur ; R. Frank KOOY, Auteur . - p.2174-2191. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2174-2191 Index. décimale : PER Périodiques Résumé : ABSTRACT Activity-Dependent Neuroprotective Protein (ADNP) is a putative transcription factor that differentially interacts with proteins involved in chromatin remodeling, thereby controlling neuronal differentiation. The protein contains nine zinc fingers, a bipartite nuclear localization signal (NLS), and a homeobox domain with a heterochromatin protein 1 interaction motif, ensuring nuclear association with DNA and chromatin. De novo variants in ADNP cause autism comorbid with intellectual disability in the Helsmoortel?Van der Aa syndrome. ADNP interacts with components of the SWI/SNF in HEK293T cells but has also been reported as part of the repressive ChAHP complex in mouse embryonic stem cells. Although converging evidence suggests a role in chromatin remodeling, Hi-C experiments failed to detect major alterations in 3D chromatin structure. We therefore investigated ADNP's role in epigenetic regulation and identified the chromatin scaffolding protein WDR5 and HDAC2 as interaction partners. Structural modeling revealed two N-terminal methyltransferase domains, suggesting catalytic activity via SAM to SAH conversion. Immunoprecipitated fractions containing wild-type ADNP exhibited methyltransferase activity, which was reduced by nonsense variants. ADNP was expressed in histone-enriched cerebellar fractions in mice and a Helsmoortel?Van der Aa autopsy case, with male-specific reduction of the H3K79me1 modification. At the DNA level, wild-type ADNP induced CpG hypermethylation. However, most variants caused CpG hypomethylation, supporting a loss-of-function mechanism, while NLS variants showed additional hypermethylation, suggesting a gain-of-function effect linked to apoptosis and microtubule transport. Taken together, we identified an ADNP-WDR5-HDAC2 protein complex involved in epigenetic regulation, with ADNP exhibiting methyltransferase activity in overexpression systems. En ligne : https://doi.org/10.1002/aur.70132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder / Alejandra FERNANDEZ in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2192-2209 Titre : Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alejandra FERNANDEZ, Auteur ; Nick SARN, Auteur ; Charis ENG, Auteur ; Kevin M. WRIGHT, Auteur Article en page(s) : p.2192-2209 Langues : Anglais (eng) Mots-clés : autism Spectrum disorder  DRG  neuronal differentiation  PTEN  somatosensory Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper- or hyposensitivity to sensory stimuli. The cellular mechanisms underlying the emergence of abnormal sensory sensitivity in ASD are not fully understood. Recent studies in rodent models of ASD identified differences in dorsal root ganglia (DRG) neurons that convey somatosensory information to the central nervous system. However, it is unknown how ASD-associated alterations in DRG neurons emerge during development and if these phenotypes are conserved across ASD models. We examined Pten (phosphatase and tensin homolog) heterozygous mice (Pten Het ) as a model for syndromic ASD and identified altered responses to sensory stimuli. Transcriptomic and in vivo analysis identified alterations in subtype-specific markers of DRG neurons in Pten Het mice, emerging during early DRG development and involving dysregulation of signaling pathways downstream of PTEN. Finally, we show that mice harboring an ASD-associated mutation (Pten Y69H ) show nearly identical alterations in the expression of somatosensory neuron subtype-specific markers. These results show that precise levels of PTEN are required for proper somatosensory development and provide insight into the molecular and cellular basis of sensory abnormalities in a model for syndromic ASD. En ligne : https://doi.org/10.1002/aur.70119 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder [texte imprimé] / Alejandra FERNANDEZ, Auteur ; Nick SARN, Auteur ; Charis ENG, Auteur ; Kevin M. WRIGHT, Auteur . - p.2192-2209. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2192-2209 Mots-clés : autism Spectrum disorder  DRG  neuronal differentiation  PTEN  somatosensory Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper- or hyposensitivity to sensory stimuli. The cellular mechanisms underlying the emergence of abnormal sensory sensitivity in ASD are not fully understood. Recent studies in rodent models of ASD identified differences in dorsal root ganglia (DRG) neurons that convey somatosensory information to the central nervous system. However, it is unknown how ASD-associated alterations in DRG neurons emerge during development and if these phenotypes are conserved across ASD models. We examined Pten (phosphatase and tensin homolog) heterozygous mice (Pten Het ) as a model for syndromic ASD and identified altered responses to sensory stimuli. Transcriptomic and in vivo analysis identified alterations in subtype-specific markers of DRG neurons in Pten Het mice, emerging during early DRG development and involving dysregulation of signaling pathways downstream of PTEN. Finally, we show that mice harboring an ASD-associated mutation (Pten Y69H ) show nearly identical alterations in the expression of somatosensory neuron subtype-specific markers. These results show that precise levels of PTEN are required for proper somatosensory development and provide insight into the molecular and cellular basis of sensory abnormalities in a model for syndromic ASD. En ligne : https://doi.org/10.1002/aur.70119 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder / Arash YAZDANBAKHSH in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2210-2230 Titre : Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Arash YAZDANBAKHSH, Auteur ; Kim T.M. DANG, Auteur ; Kelvin KUANG, Auteur ; Tingru LIAN, Auteur ; Xuefeng LIU, Auteur ; Songlin XIE, Auteur ; Basilis ZIKOPOULOS, Auteur Article en page(s) : p.2210-2230 Langues : Anglais (eng) Mots-clés : anterior cingulate cortex  convolutional neural network  deep neural network  long-range pathways  short-range pathways  white matter Index. décimale : PER Périodiques Résumé : ABSTRACT Axon features that underlie the structural and functional organization of cortical pathways have distinct patterns in the brains of neurotypical controls (CTR) compared to individuals with Autism Spectrum Disorder (ASD). However, detailed axon study demands labor-intensive surveys and time-consuming analysis of microscopic sections from postmortem human brain tissue, making it challenging to systematically examine large regions of the brain. To address these challenges, we developed an approach that uses machine learning to automatically classify microscopic sections from ASD and CTR brains, while also considering different white matter regions: superficial white matter (SWM), which contains a majority of axons that connect nearby cortical areas, and deep white matter (DWM), which is comprised exclusively of axons that participate in long-range pathways. The result was a deep neural network that can successfully classify the white matter below the anterior cingulate cortex (ACC) of ASD and CTR groups with 98% accuracy, while also distinguishing between DWM and SWM pathway composition with high average accuracy, up to 80%. Examination of image regions important for network classification and misclassification, through sensitivity maps, along with multidimensional scaling analysis, helped identify key pathological markers of ASD and highlighted the spectrum of ASD heterogeneity and overlaps with neurotypical characteristics. Large datasets that can be used to expand training, validation, and testing of this network have the potential to automate high-resolution microscopic analysis of postmortem brain tissue, so that it can be used to systematically study white matter across brain regions in health and disease. En ligne : https://doi.org/10.1002/aur.70135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder [texte imprimé] / Arash YAZDANBAKHSH, Auteur ; Kim T.M. DANG, Auteur ; Kelvin KUANG, Auteur ; Tingru LIAN, Auteur ; Xuefeng LIU, Auteur ; Songlin XIE, Auteur ; Basilis ZIKOPOULOS, Auteur . - p.2210-2230. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2210-2230 Mots-clés : anterior cingulate cortex  convolutional neural network  deep neural network  long-range pathways  short-range pathways  white matter Index. décimale : PER Périodiques Résumé : ABSTRACT Axon features that underlie the structural and functional organization of cortical pathways have distinct patterns in the brains of neurotypical controls (CTR) compared to individuals with Autism Spectrum Disorder (ASD). However, detailed axon study demands labor-intensive surveys and time-consuming analysis of microscopic sections from postmortem human brain tissue, making it challenging to systematically examine large regions of the brain. To address these challenges, we developed an approach that uses machine learning to automatically classify microscopic sections from ASD and CTR brains, while also considering different white matter regions: superficial white matter (SWM), which contains a majority of axons that connect nearby cortical areas, and deep white matter (DWM), which is comprised exclusively of axons that participate in long-range pathways. The result was a deep neural network that can successfully classify the white matter below the anterior cingulate cortex (ACC) of ASD and CTR groups with 98% accuracy, while also distinguishing between DWM and SWM pathway composition with high average accuracy, up to 80%. Examination of image regions important for network classification and misclassification, through sensitivity maps, along with multidimensional scaling analysis, helped identify key pathological markers of ASD and highlighted the spectrum of ASD heterogeneity and overlaps with neurotypical characteristics. Large datasets that can be used to expand training, validation, and testing of this network have the potential to automate high-resolution microscopic analysis of postmortem brain tissue, so that it can be used to systematically study white matter across brain regions in health and disease. En ligne : https://doi.org/10.1002/aur.70135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Hippocampal Subregion Function and Its Clinical Correlations in Childhood Autism Spectrum Disorders / Hui-Xian LI in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2231-2239 Titre : Hippocampal Subregion Function and Its Clinical Correlations in Childhood Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Hui-Xian LI, Auteur ; De-Sheng XUAN, Auteur ; Ronghao MU, Auteur ; Chi QIN, Auteur ; Xin ZHAO, Auteur Article en page(s) : p.2231-2239 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  child  clinical symptoms  functional connectivity  hippocampus Index. décimale : PER Périodiques Résumé : ABSTRACT The hippocampus plays a crucial role in memory and social processing, both of which are impaired in autism spectrum disorder (ASD). Investigating the functional activity of hippocampal subregions can provide valuable insights into their involvement in ASD-related social and behavioral symptoms. This study analyzed hippocampal resting-state functional connectivity (rsFC) in 507 male child participants from the ABIDE dataset (225 ASD, 282 typical controls) and its relation to clinical features. The hippocampus was subdivided into rostral and caudal subregions, and rsFC patterns were compared between groups. Significant group differences were observed in the left caudal, right rostral, and right caudal hippocampus, with enhanced connectivity to widespread cortical and subcortical regions, including visual, motor, parietal, and cerebellar networks. Machine learning using hippocampal rsFC achieved modest classification performance. Clinically, rsFC correlated with core ASD symptoms: social awareness was associated with right caudal connectivity to fusiform and temporal regions, while restricted and repetitive behaviors were linked to distinct rostral?caudal patterns involving frontal, motor, and cerebellar areas. Age of onset showed positive correlations with rsFC across all subregions, with rostral hippocampus engaging socioemotional and motor control networks and caudal hippocampus connecting more strongly to visual and sensorimotor integration regions. These findings demonstrate subregional specificity of hippocampal connectivity in ASD, suggesting distinct anterior?posterior contributions to symptom expression and developmental timing. En ligne : https://doi.org/10.1002/aur.70124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Hippocampal Subregion Function and Its Clinical Correlations in Childhood Autism Spectrum Disorders [texte imprimé] / Hui-Xian LI, Auteur ; De-Sheng XUAN, Auteur ; Ronghao MU, Auteur ; Chi QIN, Auteur ; Xin ZHAO, Auteur . - p.2231-2239. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2231-2239 Mots-clés : autism spectrum disorder  child  clinical symptoms  functional connectivity  hippocampus Index. décimale : PER Périodiques Résumé : ABSTRACT The hippocampus plays a crucial role in memory and social processing, both of which are impaired in autism spectrum disorder (ASD). Investigating the functional activity of hippocampal subregions can provide valuable insights into their involvement in ASD-related social and behavioral symptoms. This study analyzed hippocampal resting-state functional connectivity (rsFC) in 507 male child participants from the ABIDE dataset (225 ASD, 282 typical controls) and its relation to clinical features. The hippocampus was subdivided into rostral and caudal subregions, and rsFC patterns were compared between groups. Significant group differences were observed in the left caudal, right rostral, and right caudal hippocampus, with enhanced connectivity to widespread cortical and subcortical regions, including visual, motor, parietal, and cerebellar networks. Machine learning using hippocampal rsFC achieved modest classification performance. Clinically, rsFC correlated with core ASD symptoms: social awareness was associated with right caudal connectivity to fusiform and temporal regions, while restricted and repetitive behaviors were linked to distinct rostral?caudal patterns involving frontal, motor, and cerebellar areas. Age of onset showed positive correlations with rsFC across all subregions, with rostral hippocampus engaging socioemotional and motor control networks and caudal hippocampus connecting more strongly to visual and sensorimotor integration regions. These findings demonstrate subregional specificity of hippocampal connectivity in ASD, suggesting distinct anterior?posterior contributions to symptom expression and developmental timing. En ligne : https://doi.org/10.1002/aur.70124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD / Sergio OSORIO in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2240-2253 Titre : Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD Type de document : texte imprimé Auteurs : Sergio OSORIO, Auteur ; Jasmine TAN, Auteur ; Grace LEVINE, Auteur ; Seppo P. AHLFORS, Auteur ; Steven GRAHAM, Auteur ; Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Robert M. JOSEPH, Auteur ; Zein NAYAL, Auteur ; Ainsley LOSH, Auteur ; Stephanie PAWLYSZYN, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Hari BHARADWAJ, Auteur ; Tal KENET, Auteur Article en page(s) : p.2240-2253 Langues : Anglais (eng) Mots-clés : autism  functional connectivity  magnetoencephalography  sensory processing  sound localization Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a developmental condition characterized by difficulties in social interaction, communication, and sensory processing. The ability to orient towards sounds is a key component of social interactions, yet auditory spatial attention remains relatively understudied in ASD, despite prior research indicating differences in this domain. Here, we investigate the neural signatures associated with passive auditory spatial attention in children with ASD (n?=?21, ages 6?17) relative to age- and IQ-matched Typically Developing (TD) children (n?=?31), using source-localized magnetoencephalography (MEG). Participants listened passively, while watching a silenced movie, to non-social auditory stimuli designed to either remain lateralized to one hemifield (stay trials) or to change in location from one side to the contralateral hemifield (jump trials). Linear mixed effects modeling showed lower cortical activation in the auditory cortex in the ASD group in response to jump trials, relative to the TD group. Additionally, functional connectivity analyses showed higher alpha-band functional connectivity in the ASD group between left auditory cortex seeds and right prefrontal and left parietal regions known to be recruited during auditory spatial attention. Right prefrontal alpha-band connectivity estimates were associated with behaviorally assessed auditory processing scores, whereas left parietal connectivity estimates were associated with ASD symptomatology. Our results align with the hypothesis that auditory spatial attention generally, and specifically orientation to sounds even when experienced passively, differs in ASD versus TD children. En ligne : https://doi.org/10.1002/aur.70120 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD [texte imprimé] / Sergio OSORIO, Auteur ; Jasmine TAN, Auteur ; Grace LEVINE, Auteur ; Seppo P. AHLFORS, Auteur ; Steven GRAHAM, Auteur ; Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Robert M. JOSEPH, Auteur ; Zein NAYAL, Auteur ; Ainsley LOSH, Auteur ; Stephanie PAWLYSZYN, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Hari BHARADWAJ, Auteur ; Tal KENET, Auteur . - p.2240-2253. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2240-2253 Mots-clés : autism  functional connectivity  magnetoencephalography  sensory processing  sound localization Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a developmental condition characterized by difficulties in social interaction, communication, and sensory processing. The ability to orient towards sounds is a key component of social interactions, yet auditory spatial attention remains relatively understudied in ASD, despite prior research indicating differences in this domain. Here, we investigate the neural signatures associated with passive auditory spatial attention in children with ASD (n?=?21, ages 6?17) relative to age- and IQ-matched Typically Developing (TD) children (n?=?31), using source-localized magnetoencephalography (MEG). Participants listened passively, while watching a silenced movie, to non-social auditory stimuli designed to either remain lateralized to one hemifield (stay trials) or to change in location from one side to the contralateral hemifield (jump trials). Linear mixed effects modeling showed lower cortical activation in the auditory cortex in the ASD group in response to jump trials, relative to the TD group. Additionally, functional connectivity analyses showed higher alpha-band functional connectivity in the ASD group between left auditory cortex seeds and right prefrontal and left parietal regions known to be recruited during auditory spatial attention. Right prefrontal alpha-band connectivity estimates were associated with behaviorally assessed auditory processing scores, whereas left parietal connectivity estimates were associated with ASD symptomatology. Our results align with the hypothesis that auditory spatial attention generally, and specifically orientation to sounds even when experienced passively, differs in ASD versus TD children. En ligne : https://doi.org/10.1002/aur.70120 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Developmental Shift From Intrinsic Hyper- to Hypo-Connectivity Occurring at Pre-Adolescence in Autism Spectrum Disorder / Xiaolong SHAN in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2254-2264 Titre : Developmental Shift From Intrinsic Hyper- to Hypo-Connectivity Occurring at Pre-Adolescence in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Xiaolong SHAN, Auteur ; Ya LI, Auteur ; Jinming XIAO, Auteur ; Xiaotian WANG, Auteur ; Xinyue HUANG, Auteur ; Lei LI, Auteur ; Yu FENG, Auteur ; Weixin ZHAO, Auteur ; Huafu CHEN, Auteur ; Xujun DUAN, Auteur Article en page(s) : p.2254-2264 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental shift  functional connectivity  hyper-connectivity  hypo-connectivity Index. décimale : PER Périodiques Résumé : ABSTRACT Accumulating evidence suggests that hyper-connectivity is more characteristic of young children with autism spectrum disorder (ASD), while hypo-connectivity begins to emerge in adolescence and persists into adulthood. Despite increasing efforts being invested to explore the altered functional connectivity in ASD, the timing of the shift from intrinsic hyper-to hypo-connectivity of large-scale brain functional networks remains unclear. Here, we systematically depict the development of intrinsic functional connectivity in 800 participants from the Autism Brain Imaging Data Exchange. We first use independent component analyses to identify the large-scale brain functional networks. Then, we utilize the locally estimated scatterplot smoothing algorithm to fit the developmental trajectory of brain functional networks. Finally, we develop a ?sliding threshold? method to detect the age stage at which the shift from hyper- to hypo-connectivity occurs in ASD. We identify six large-scale brain functional networks, including the default mode network (DMN), fronto-parietal network (FPN), salience network (SAN), auditory network (AN), somatomotor network (SMN), and visual network (VN). We find that primary networks (AN, SMN, and VN) undergo the shift from hyper- to hypo-connectivity earlier than high-order networks (DMN, FPN, and SAN) in ASD. At pre-adolescence, the SMN, AN, VN, DMN, SAN, and FPN undergo the shift from hyper- to hypo-connectivity in sequence in ASD. Our findings shed light on the age-related changes of intrinsic functional connectivity in ASD, highlighting the need for conceptualizing functional connectivity in ASD from a developmental perspective. En ligne : https://doi.org/10.1002/aur.70117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Developmental Shift From Intrinsic Hyper- to Hypo-Connectivity Occurring at Pre-Adolescence in Autism Spectrum Disorder [texte imprimé] / Xiaolong SHAN, Auteur ; Ya LI, Auteur ; Jinming XIAO, Auteur ; Xiaotian WANG, Auteur ; Xinyue HUANG, Auteur ; Lei LI, Auteur ; Yu FENG, Auteur ; Weixin ZHAO, Auteur ; Huafu CHEN, Auteur ; Xujun DUAN, Auteur . - p.2254-2264. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2254-2264 Mots-clés : autism spectrum disorder  developmental shift  functional connectivity  hyper-connectivity  hypo-connectivity Index. décimale : PER Périodiques Résumé : ABSTRACT Accumulating evidence suggests that hyper-connectivity is more characteristic of young children with autism spectrum disorder (ASD), while hypo-connectivity begins to emerge in adolescence and persists into adulthood. Despite increasing efforts being invested to explore the altered functional connectivity in ASD, the timing of the shift from intrinsic hyper-to hypo-connectivity of large-scale brain functional networks remains unclear. Here, we systematically depict the development of intrinsic functional connectivity in 800 participants from the Autism Brain Imaging Data Exchange. We first use independent component analyses to identify the large-scale brain functional networks. Then, we utilize the locally estimated scatterplot smoothing algorithm to fit the developmental trajectory of brain functional networks. Finally, we develop a ?sliding threshold? method to detect the age stage at which the shift from hyper- to hypo-connectivity occurs in ASD. We identify six large-scale brain functional networks, including the default mode network (DMN), fronto-parietal network (FPN), salience network (SAN), auditory network (AN), somatomotor network (SMN), and visual network (VN). We find that primary networks (AN, SMN, and VN) undergo the shift from hyper- to hypo-connectivity earlier than high-order networks (DMN, FPN, and SAN) in ASD. At pre-adolescence, the SMN, AN, VN, DMN, SAN, and FPN undergo the shift from hyper- to hypo-connectivity in sequence in ASD. Our findings shed light on the age-related changes of intrinsic functional connectivity in ASD, highlighting the need for conceptualizing functional connectivity in ASD from a developmental perspective. En ligne : https://doi.org/10.1002/aur.70117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Assessing Anxiety in Autistic and Non-Autistic Youth: Validation of the German Parent Version of the Anxiety Scale for Children With Autism Spectrum Disorder / Magdalena GRUNER in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2265-2278 Titre : Assessing Anxiety in Autistic and Non-Autistic Youth: Validation of the German Parent Version of the Anxiety Scale for Children With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Magdalena GRUNER, Auteur ; Veit ROESSNER, Auteur ; Melanie RING, Auteur Article en page(s) : p.2265-2278 Langues : Anglais (eng) Mots-clés : anxiety  anxiety assessment  anxiety scale for children with autism  autism Index. décimale : PER Périodiques Résumé : ABSTRACT Anxiety is a prevalent co-occurring disorder in autistic youth, yet its accurate assessment remains challenging due to symptom overlap with autism. The Anxiety Scale for Children with Autism Spectrum Disorder?Parent Version (ASC-ASD-P) was designed to address this issue, but its utility in German clinical settings has not been established. This study validated the German translation of the ASC-ASD-P in a clinical sample of 317 participants presenting at a clinic for autism assessment, including 120 autistic youth. Internal consistency was excellent (Cronbach's α?=?0.92), and convergent validity was demonstrated through significant correlations with established psychopathology measures such as the Child Behavior Checklist (CBCL) and Strengths and Difficulties Questionnaire (SDQ). Factor analyses preferred a 4-factor structure in the autism group, but indicated difficulties replicating the Separation Anxiety Subscale. Autistic youth showed higher total anxiety and uncertainty scores compared to non-autistic youth, underlining the scale's sensitivity to autism-specific anxiety patterns. By including youth with intellectual disabilities, often underrepresented in research, this study provides a more comprehensive evaluation of the ASC-ASD-P's applicability across the autism spectrum. These findings support the ASC-ASD-P as a reliable tool for assessing anxiety in German-speaking autistic youth while highlighting areas where refinement could strengthen its utility. En ligne : https://doi.org/10.1002/aur.70107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Assessing Anxiety in Autistic and Non-Autistic Youth: Validation of the German Parent Version of the Anxiety Scale for Children With Autism Spectrum Disorder [texte imprimé] / Magdalena GRUNER, Auteur ; Veit ROESSNER, Auteur ; Melanie RING, Auteur . - p.2265-2278. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2265-2278 Mots-clés : anxiety  anxiety assessment  anxiety scale for children with autism  autism Index. décimale : PER Périodiques Résumé : ABSTRACT Anxiety is a prevalent co-occurring disorder in autistic youth, yet its accurate assessment remains challenging due to symptom overlap with autism. The Anxiety Scale for Children with Autism Spectrum Disorder?Parent Version (ASC-ASD-P) was designed to address this issue, but its utility in German clinical settings has not been established. This study validated the German translation of the ASC-ASD-P in a clinical sample of 317 participants presenting at a clinic for autism assessment, including 120 autistic youth. Internal consistency was excellent (Cronbach's α?=?0.92), and convergent validity was demonstrated through significant correlations with established psychopathology measures such as the Child Behavior Checklist (CBCL) and Strengths and Difficulties Questionnaire (SDQ). Factor analyses preferred a 4-factor structure in the autism group, but indicated difficulties replicating the Separation Anxiety Subscale. Autistic youth showed higher total anxiety and uncertainty scores compared to non-autistic youth, underlining the scale's sensitivity to autism-specific anxiety patterns. By including youth with intellectual disabilities, often underrepresented in research, this study provides a more comprehensive evaluation of the ASC-ASD-P's applicability across the autism spectrum. These findings support the ASC-ASD-P as a reliable tool for assessing anxiety in German-speaking autistic youth while highlighting areas where refinement could strengthen its utility. En ligne : https://doi.org/10.1002/aur.70107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Autistic Listeners Demonstrate Robust Lexically Guided Perceptual Learning / Shawn N. CUMMINGS in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2279-2291 Titre : Autistic Listeners Demonstrate Robust Lexically Guided Perceptual Learning Type de document : texte imprimé Auteurs : Shawn N. CUMMINGS, Auteur ; Brooke DUDA, Auteur ; Rachel M. THEODORE, Auteur Article en page(s) : p.2279-2291 Langues : Anglais (eng) Mots-clés : adaptation  autism spectrum disorder  perceptual learning  speech perception Index. décimale : PER Périodiques Résumé : ABSTRACT Listeners accommodate rampant variability in speech input, at least in part, by adapting to structured phonetic variation. However, most work demonstrating this type of perceptual learning has focused on group-level effects in modal populations. This approach masks potentially meaningful differences?present among all listeners but particularly associated with autism?in sensory perception, social functioning, and language processing. These differences may be expected to influence adaptation, but their roles remain unclear. The present investigation aimed to clarify the relationships between autism, perceptual acuity, and adaptation. Listeners (n?=?80, of which 40 were diagnosed with autism) were exposed to spectral energy ambiguous between /s/ and /?/ in lexical contexts designed to elicit adaptation. Learning was assessed by comparing categorization of an ashi?asi test continuum before and after the critical lexically guided exposure. Autistic traits and pitch pattern sensitivity were also assessed. Robust learning was observed by both the general population and autistic listeners, with no evidence to suggest that learning was associated with autistic traits or pitch pattern sensitivity. These results advance theories of speech adaptation by constraining determinants of lexically guided perceptual learning to suggest that the social language traits of autism may be orthogonal to adaptation in speech perception. En ligne : https://doi.org/10.1002/aur.70078 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Autistic Listeners Demonstrate Robust Lexically Guided Perceptual Learning [texte imprimé] / Shawn N. CUMMINGS, Auteur ; Brooke DUDA, Auteur ; Rachel M. THEODORE, Auteur . - p.2279-2291. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2279-2291 Mots-clés : adaptation  autism spectrum disorder  perceptual learning  speech perception Index. décimale : PER Périodiques Résumé : ABSTRACT Listeners accommodate rampant variability in speech input, at least in part, by adapting to structured phonetic variation. However, most work demonstrating this type of perceptual learning has focused on group-level effects in modal populations. This approach masks potentially meaningful differences?present among all listeners but particularly associated with autism?in sensory perception, social functioning, and language processing. These differences may be expected to influence adaptation, but their roles remain unclear. The present investigation aimed to clarify the relationships between autism, perceptual acuity, and adaptation. Listeners (n?=?80, of which 40 were diagnosed with autism) were exposed to spectral energy ambiguous between /s/ and /?/ in lexical contexts designed to elicit adaptation. Learning was assessed by comparing categorization of an ashi?asi test continuum before and after the critical lexically guided exposure. Autistic traits and pitch pattern sensitivity were also assessed. Robust learning was observed by both the general population and autistic listeners, with no evidence to suggest that learning was associated with autistic traits or pitch pattern sensitivity. These results advance theories of speech adaptation by constraining determinants of lexically guided perceptual learning to suggest that the social language traits of autism may be orthogonal to adaptation in speech perception. En ligne : https://doi.org/10.1002/aur.70078 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Development of Respiratory Sinus Arrhythmia in Young Infants With Autism Spectrum Disorder, Preterm Birth, and Typical Development / Jessica BRADSHAW in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2292-2306 Titre : Development of Respiratory Sinus Arrhythmia in Young Infants With Autism Spectrum Disorder, Preterm Birth, and Typical Development Type de document : texte imprimé Auteurs : Jessica BRADSHAW, Auteur ; John E. RICHARDS, Auteur ; Julia YURKOVIC-HARDING, Auteur ; Eilis MCLAUGHLIN, Auteur Article en page(s) : p.2292-2306 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  heart rate  infants  physiology  preterm  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : ABSTRACT Respiratory sinus arrhythmia (RSA) is a key index of parasympathetic function and environmental adaptability. Lower resting RSA has been linked to preterm (PT) birth in infancy and autism spectrum disorder (ASD) in childhood, yet RSA across the first 2?years in young infants born PT or later diagnosed with ASD remains unknown. This study examined resting RSA and mean interbeat interval (IBI) development from 1 to 24?months in infants at varying ASD likelihoods, including infant siblings of children with ASD and those born PT. A longitudinal design tracked resting RSA and mean IBI in 137 infants from 1 to 24?months. Infants were classified as elevated likelihood for ASD (EL), low likelihood for ASD (LL), or PT and later classified by developmental outcome as ASD, neurodivergent (ND), or typically developing (TD). Mixed-effects models examined developmental trajectories and group differences. Results indicated that both RSA and mean IBI increased across all groups from 1 to 24 months, with the most rapid growth observed in the first 6?months. PT infants exhibited lower RSA and mean IBI initially, but aligned with LL infants when age was corrected for prematurity. Infants later diagnosed with ASD showed no early RSA differences, but exhibited elevated RSA from 9 to 24?months, distinguishing them from TD and ND infants. Elevated resting RSA in ASD from 9 to 24?months may reflect reduced social monitoring, increased attentional regulation, or decreased stress during a resting period free of structured tasks. These findings contrast with lower RSA in older children with ASD, highlighting developmental shifts in autonomic function and the need for further research into RSA as an early biomarker for ASD. En ligne : https://doi.org/10.1002/aur.70114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Development of Respiratory Sinus Arrhythmia in Young Infants With Autism Spectrum Disorder, Preterm Birth, and Typical Development [texte imprimé] / Jessica BRADSHAW, Auteur ; John E. RICHARDS, Auteur ; Julia YURKOVIC-HARDING, Auteur ; Eilis MCLAUGHLIN, Auteur . - p.2292-2306. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2292-2306 Mots-clés : autism spectrum disorder  heart rate  infants  physiology  preterm  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : ABSTRACT Respiratory sinus arrhythmia (RSA) is a key index of parasympathetic function and environmental adaptability. Lower resting RSA has been linked to preterm (PT) birth in infancy and autism spectrum disorder (ASD) in childhood, yet RSA across the first 2?years in young infants born PT or later diagnosed with ASD remains unknown. This study examined resting RSA and mean interbeat interval (IBI) development from 1 to 24?months in infants at varying ASD likelihoods, including infant siblings of children with ASD and those born PT. A longitudinal design tracked resting RSA and mean IBI in 137 infants from 1 to 24?months. Infants were classified as elevated likelihood for ASD (EL), low likelihood for ASD (LL), or PT and later classified by developmental outcome as ASD, neurodivergent (ND), or typically developing (TD). Mixed-effects models examined developmental trajectories and group differences. Results indicated that both RSA and mean IBI increased across all groups from 1 to 24 months, with the most rapid growth observed in the first 6?months. PT infants exhibited lower RSA and mean IBI initially, but aligned with LL infants when age was corrected for prematurity. Infants later diagnosed with ASD showed no early RSA differences, but exhibited elevated RSA from 9 to 24?months, distinguishing them from TD and ND infants. Elevated resting RSA in ASD from 9 to 24?months may reflect reduced social monitoring, increased attentional regulation, or decreased stress during a resting period free of structured tasks. These findings contrast with lower RSA in older children with ASD, highlighting developmental shifts in autonomic function and the need for further research into RSA as an early biomarker for ASD. En ligne : https://doi.org/10.1002/aur.70114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Differences in the Social Experiences of Autistic and Non-Autistic Adolescents by Gender / Ellie ROBERTS in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2307-2322 Titre : Differences in the Social Experiences of Autistic and Non-Autistic Adolescents by Gender Type de document : texte imprimé Auteurs : Ellie ROBERTS, Auteur ; William MANDY, Auteur ; Eirini FLOURI, Auteur Article en page(s) : p.2307-2322 Langues : Anglais (eng) Mots-clés : adolescence  autism  friendship  gender  loneliness Index. décimale : PER Périodiques Résumé : ABSTRACT Adolescence is a time of complex social and emotional development when friendships become of particular importance. Previous research has highlighted differences in the social experience of autistic and non-autistic adolescents, as well as that of autistic girls and boys. However, no study has compared the social experiences of autistic and non-autistic adolescents, including gender differences, in a population-representative sample. Using data from the Millennium Cohort Study (MCS), Sweep 6, we investigated differences between autistic (girls n?=?111, boys n?=?387) and non-autistic (girls n?=?5847, boys?=?5697) adolescents (mean age?=?13.7?years, range?=?13?15) regarding self-reports of: (i) having close friends, (ii) time spent with friends, (iii) social support, (iv) social alienation, (v) happiness with friendships, and (vi) having a romantic partner. Autistic adolescents reported having fewer close friends and spending less time with their friends. Autistic boys felt less socially supported than non-autistic adolescents, while autistic girls felt more socially alienated than all other groups considered in the study. After accounting for hyperactivity and emotional problems, all girls felt more socially alienated than boys. Only autistic boys were unhappier with friendships than non-autistic children. No group differences were found regarding romantic relationships. Some social experiences of adolescents vary greatly by both gender and diagnostic status. Further research should seek to examine the impact of these differences on mental health and well-being. En ligne : https://doi.org/10.1002/aur.70118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Differences in the Social Experiences of Autistic and Non-Autistic Adolescents by Gender [texte imprimé] / Ellie ROBERTS, Auteur ; William MANDY, Auteur ; Eirini FLOURI, Auteur . - p.2307-2322. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2307-2322 Mots-clés : adolescence  autism  friendship  gender  loneliness Index. décimale : PER Périodiques Résumé : ABSTRACT Adolescence is a time of complex social and emotional development when friendships become of particular importance. Previous research has highlighted differences in the social experience of autistic and non-autistic adolescents, as well as that of autistic girls and boys. However, no study has compared the social experiences of autistic and non-autistic adolescents, including gender differences, in a population-representative sample. Using data from the Millennium Cohort Study (MCS), Sweep 6, we investigated differences between autistic (girls n?=?111, boys n?=?387) and non-autistic (girls n?=?5847, boys?=?5697) adolescents (mean age?=?13.7?years, range?=?13?15) regarding self-reports of: (i) having close friends, (ii) time spent with friends, (iii) social support, (iv) social alienation, (v) happiness with friendships, and (vi) having a romantic partner. Autistic adolescents reported having fewer close friends and spending less time with their friends. Autistic boys felt less socially supported than non-autistic adolescents, while autistic girls felt more socially alienated than all other groups considered in the study. After accounting for hyperactivity and emotional problems, all girls felt more socially alienated than boys. Only autistic boys were unhappier with friendships than non-autistic children. No group differences were found regarding romantic relationships. Some social experiences of adolescents vary greatly by both gender and diagnostic status. Further research should seek to examine the impact of these differences on mental health and well-being. En ligne : https://doi.org/10.1002/aur.70118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Examining Associations Between Social Experiences and Loneliness Among Autistic Youth / Natalie LIBSTER in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2323-2333 Titre : Examining Associations Between Social Experiences and Loneliness Among Autistic Youth Type de document : texte imprimé Auteurs : Natalie LIBSTER, Auteur ; Julie Lounds TAYLOR, Auteur ; Shuting ZHENG, Auteur ; Somer BISHOP, Auteur ; Ryan ADAMS, Auteur Article en page(s) : p.2323-2333 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  loneliness  peer experiences  social interactions  solitude Index. décimale : PER Périodiques Résumé : ABSTRACT To develop targeted interventions aimed at reducing loneliness among autistic youth, it is critical to understand which social experiences are associated with loneliness in this population. The current study examined associations between loneliness, social interaction/solitary experiences (i.e., time spent interacting and alone, feelings during time spent interacting and alone) and peer experiences (i.e., victimization, being ignored, and being included) among autistic youth. Autistic youth (N?=?241) between 15 and 26?years old (M?=?18.7) completed online surveys that measured their levels of loneliness and the degrees to which they were victimized, ignored, and included by peers. Furthermore, at 9?PM each day for 7 consecutive days, participants were prompted via a smartphone app to report events that occurred within five specific time frames throughout that day. Youth reported how long they participated in each event, whether they were interacting with others or alone, and for the longest lasting activity in each time frame, the degree to which they experienced positive and negative feelings. Results revealed that more negative feelings when interacting and when alone were associated with increased loneliness, whereas more positive feelings when alone were associated with reduced loneliness. Neither time spent interacting nor time spent alone was significantly associated with loneliness. Greater frequency of being ignored was also associated with increased loneliness. Therefore, rather than focusing on the amount of time autistic youth spend interacting and alone, it is equally important for future interventions to consider ways to increase youth's satisfaction with the quantity and quality of their social interactions. En ligne : https://doi.org/10.1002/aur.70115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Examining Associations Between Social Experiences and Loneliness Among Autistic Youth [texte imprimé] / Natalie LIBSTER, Auteur ; Julie Lounds TAYLOR, Auteur ; Shuting ZHENG, Auteur ; Somer BISHOP, Auteur ; Ryan ADAMS, Auteur . - p.2323-2333. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2323-2333 Mots-clés : autism spectrum disorder  loneliness  peer experiences  social interactions  solitude Index. décimale : PER Périodiques Résumé : ABSTRACT To develop targeted interventions aimed at reducing loneliness among autistic youth, it is critical to understand which social experiences are associated with loneliness in this population. The current study examined associations between loneliness, social interaction/solitary experiences (i.e., time spent interacting and alone, feelings during time spent interacting and alone) and peer experiences (i.e., victimization, being ignored, and being included) among autistic youth. Autistic youth (N?=?241) between 15 and 26?years old (M?=?18.7) completed online surveys that measured their levels of loneliness and the degrees to which they were victimized, ignored, and included by peers. Furthermore, at 9?PM each day for 7 consecutive days, participants were prompted via a smartphone app to report events that occurred within five specific time frames throughout that day. Youth reported how long they participated in each event, whether they were interacting with others or alone, and for the longest lasting activity in each time frame, the degree to which they experienced positive and negative feelings. Results revealed that more negative feelings when interacting and when alone were associated with increased loneliness, whereas more positive feelings when alone were associated with reduced loneliness. Neither time spent interacting nor time spent alone was significantly associated with loneliness. Greater frequency of being ignored was also associated with increased loneliness. Therefore, rather than focusing on the amount of time autistic youth spend interacting and alone, it is equally important for future interventions to consider ways to increase youth's satisfaction with the quantity and quality of their social interactions. En ligne : https://doi.org/10.1002/aur.70115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Comparison of Adulthood Outcomes in Autism Spectrum Disorder With and Without Regression: A Population-Based Birth Cohort Study / Satoru MINAMI in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2334-2344 Titre : Comparison of Adulthood Outcomes in Autism Spectrum Disorder With and Without Regression: A Population-Based Birth Cohort Study Type de document : texte imprimé Auteurs : Satoru MINAMI, Auteur ; Mitsuaki IWASA, Auteur ; Hiroko OHZONO, Auteur ; Daimei SASAYAMA, Auteur ; Hideo HONDA, Auteur Article en page(s) : p.2334-2344 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  birth cohort  epilepsy  mass screening  regression Index. décimale : PER Périodiques Résumé : ABSTRACT The long-term outcomes of regression in autism spectrum disorder (ASD) remain unclear. Previous evidence suggests that autistic individuals with regression have poorer adulthood outcomes across various indices than those without regression. We compared two groups?those with and without regression in ASD?among 168 participants from a population-based birth cohort study. These individuals were born in northern Yokohama, Japan, between 1988 and 1996 and were diagnosed with ASD by age seven. Participants were classified into groups based on real-time records from a community-oriented mass screening system. This study focused on four outcomes: IQ at age five, IQ in adulthood, incidence of epilepsy, and composite social ability score. None of the outcomes showed significant differences between the two groups. The standardized effect size (where a positive value favors the non-regression group) was 0.06 (95% CI: ?0.08 to 0.21) for the composite social ability score, ?0.16 (95% CI: ?0.55 to 0.22) for IQ at age five, and ?0.15 (95% CI: ?0.62 to 0.33) for IQ in adulthood. The risk ratio of epilepsy in the regression group compared to the non-regression group was 0.59 (95% CI: 0.22 to 1.5). No significant differences were observed in any of the four outcomes between autistic individuals with or without regression. The confidence intervals of the effect sizes indicate that the impact of regression on IQ and psychosocial adaptation in adulthood, if present, is likely to be small to intermediate. En ligne : https://doi.org/10.1002/aur.70121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Comparison of Adulthood Outcomes in Autism Spectrum Disorder With and Without Regression: A Population-Based Birth Cohort Study [texte imprimé] / Satoru MINAMI, Auteur ; Mitsuaki IWASA, Auteur ; Hiroko OHZONO, Auteur ; Daimei SASAYAMA, Auteur ; Hideo HONDA, Auteur . - p.2334-2344. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2334-2344 Mots-clés : autism spectrum disorder  birth cohort  epilepsy  mass screening  regression Index. décimale : PER Périodiques Résumé : ABSTRACT The long-term outcomes of regression in autism spectrum disorder (ASD) remain unclear. Previous evidence suggests that autistic individuals with regression have poorer adulthood outcomes across various indices than those without regression. We compared two groups?those with and without regression in ASD?among 168 participants from a population-based birth cohort study. These individuals were born in northern Yokohama, Japan, between 1988 and 1996 and were diagnosed with ASD by age seven. Participants were classified into groups based on real-time records from a community-oriented mass screening system. This study focused on four outcomes: IQ at age five, IQ in adulthood, incidence of epilepsy, and composite social ability score. None of the outcomes showed significant differences between the two groups. The standardized effect size (where a positive value favors the non-regression group) was 0.06 (95% CI: ?0.08 to 0.21) for the composite social ability score, ?0.16 (95% CI: ?0.55 to 0.22) for IQ at age five, and ?0.15 (95% CI: ?0.62 to 0.33) for IQ in adulthood. The risk ratio of epilepsy in the regression group compared to the non-regression group was 0.59 (95% CI: 0.22 to 1.5). No significant differences were observed in any of the four outcomes between autistic individuals with or without regression. The confidence intervals of the effect sizes indicate that the impact of regression on IQ and psychosocial adaptation in adulthood, if present, is likely to be small to intermediate. En ligne : https://doi.org/10.1002/aur.70121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India / Shoba S. MEERA in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2345-2355 Titre : Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India Type de document : texte imprimé Auteurs : Shoba S. MEERA, Auteur ; Prathyusha VASUKI, Auteur ; Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Shree VOLME, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Andrew WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur ; Ming Wai WAN, Auteur ; John Vijay SAGAR, Auteur ; Deepa Bhat NAIR, Auteur Article en page(s) : p.2345-2355 Langues : Anglais (eng) Mots-clés : autism  caregiver responsiveness  early intervention  India  infant siblings  LiL' STEPS  online intervention Index. décimale : PER Périodiques Résumé : ABSTRACT LiL' STEPS (Language development n?=?12) using fixed block randomization. While families in the former group received the LiL' STEPS early support program, those in the latter did not avail themselves of any early supports. Assessors were masked to group status. The primary outcome was caregiver sensitive responsiveness, assessed using the Manchester Assessment for Caregiver-Infant Interaction (MACI). Secondary outcomes included caregiver-reported measures of social communication and language. Outcomes were measured at three time points: baseline (T1), 12?weeks post-baseline (T2), and 12?weeks after program completion (T3). Intention-to-treat analyses were performed using linear mixed models. No significant treatment effects were found between baseline (T1) and endpoint (T3) on the primary or secondary outcomes. However, significant, large, positive treatment effects were observed for caregiver sensitive responsiveness (??=?1.48; 95% CI?=?0.51?2.34; d?=?1.15) and dyadic mutuality (??=?1.22; 95% CI?=?0.03?2.15; d?=?1.01) between baseline (T1) and T2, highlighting the need for ongoing support between T2 and T3?a key direction for future large scale efficacy trials. En ligne : https://doi.org/10.1002/aur.70116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India [texte imprimé] / Shoba S. MEERA, Auteur ; Prathyusha VASUKI, Auteur ; Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Shree VOLME, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Andrew WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur ; Ming Wai WAN, Auteur ; John Vijay SAGAR, Auteur ; Deepa Bhat NAIR, Auteur . - p.2345-2355. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2345-2355 Mots-clés : autism  caregiver responsiveness  early intervention  India  infant siblings  LiL' STEPS  online intervention Index. décimale : PER Périodiques Résumé : ABSTRACT LiL' STEPS (Language development n?=?12) using fixed block randomization. While families in the former group received the LiL' STEPS early support program, those in the latter did not avail themselves of any early supports. Assessors were masked to group status. The primary outcome was caregiver sensitive responsiveness, assessed using the Manchester Assessment for Caregiver-Infant Interaction (MACI). Secondary outcomes included caregiver-reported measures of social communication and language. Outcomes were measured at three time points: baseline (T1), 12?weeks post-baseline (T2), and 12?weeks after program completion (T3). Intention-to-treat analyses were performed using linear mixed models. No significant treatment effects were found between baseline (T1) and endpoint (T3) on the primary or secondary outcomes. However, significant, large, positive treatment effects were observed for caregiver sensitive responsiveness (??=?1.48; 95% CI?=?0.51?2.34; d?=?1.15) and dyadic mutuality (??=?1.22; 95% CI?=?0.03?2.15; d?=?1.01) between baseline (T1) and T2, highlighting the need for ongoing support between T2 and T3?a key direction for future large scale efficacy trials. En ligne : https://doi.org/10.1002/aur.70116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571