Brain hyperserotonemia causes autism-relevant social deficits in mice / Miho TANAKA in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 60p. Titre : Brain hyperserotonemia causes autism-relevant social deficits in mice Type de document : texte imprimé Auteurs : Miho TANAKA, Auteur ; Atsushi SATO, Auteur ; Shinya KASAI, Auteur ; Yoko HAGINO, Auteur ; Hiroko KOTAJIMA-MURAKAMI, Auteur ; Hirofumi KASHII, Auteur ; Yukio TAKAMATSU, Auteur ; Yasumasa NISHITO, Auteur ; Masumi INAGAKI, Auteur ; Masashi MIZUGUCHI, Auteur ; F. Scott HALL, Auteur ; George R. UHL, Auteur ; Dennis MURPHY, Auteur ; Ichiro SORA, Auteur ; Kazutaka IKEDA, Auteur Article en page(s) : 60p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Heterozygous mice  Serotonin transporter  Tryptophan depletion Index. décimale : PER Périodiques Résumé : Background: Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods: We analyzed behavior and gene expression to unveil the causal mechanism of ASD-relevant social deficits using serotonin transporter (Sert) knockout mice. Results: Social deficits were observed in both heterozygous knockout mice (HZ) and homozygous knockout mice (KO), but increases in general anxiety were only observed in KO mice. Two weeks of dietary restriction of the serotonin precursor tryptophan ameliorated both brain hyperserotonemia and ASD-relevant social deficits in Sert HZ and KO mice. The expression of rather distinct sets of genes was altered in Sert HZ and KO mice, and a substantial portion of these genes was also affected by tryptophan depletion. Tryptophan depletion in Sert HZ and KO mice was associated with alterations in the expression of genes involved in signal transduction pathways initiated by changes in extracellular serotonin or melatonin, a derivative of serotonin. Only expression of the AU015836 gene was altered in both Sert HZ and KO mice. AU015836 expression and ASD-relevant social deficits normalized after dietary tryptophan restriction. Conclusions: These findings reveal a Sert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits. En ligne : https://dx.doi.org/10.1186/s13229-018-0243-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Brain hyperserotonemia causes autism-relevant social deficits in mice [texte imprimé] / Miho TANAKA, Auteur ; Atsushi SATO, Auteur ; Shinya KASAI, Auteur ; Yoko HAGINO, Auteur ; Hiroko KOTAJIMA-MURAKAMI, Auteur ; Hirofumi KASHII, Auteur ; Yukio TAKAMATSU, Auteur ; Yasumasa NISHITO, Auteur ; Masumi INAGAKI, Auteur ; Masashi MIZUGUCHI, Auteur ; F. Scott HALL, Auteur ; George R. UHL, Auteur ; Dennis MURPHY, Auteur ; Ichiro SORA, Auteur ; Kazutaka IKEDA, Auteur . - 60p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 60p. Mots-clés : Autism spectrum disorder  Heterozygous mice  Serotonin transporter  Tryptophan depletion Index. décimale : PER Périodiques Résumé : Background: Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods: We analyzed behavior and gene expression to unveil the causal mechanism of ASD-relevant social deficits using serotonin transporter (Sert) knockout mice. Results: Social deficits were observed in both heterozygous knockout mice (HZ) and homozygous knockout mice (KO), but increases in general anxiety were only observed in KO mice. Two weeks of dietary restriction of the serotonin precursor tryptophan ameliorated both brain hyperserotonemia and ASD-relevant social deficits in Sert HZ and KO mice. The expression of rather distinct sets of genes was altered in Sert HZ and KO mice, and a substantial portion of these genes was also affected by tryptophan depletion. Tryptophan depletion in Sert HZ and KO mice was associated with alterations in the expression of genes involved in signal transduction pathways initiated by changes in extracellular serotonin or melatonin, a derivative of serotonin. Only expression of the AU015836 gene was altered in both Sert HZ and KO mice. AU015836 expression and ASD-relevant social deficits normalized after dietary tryptophan restriction. Conclusions: These findings reveal a Sert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits. En ligne : https://dx.doi.org/10.1186/s13229-018-0243-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Differential electrophysiological responses to biological motion in children and adults with and without autism spectrum disorders / Masahiro HIRAI in Research in Autism Spectrum Disorders, 8-12 (December 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1623-1634 Titre : Differential electrophysiological responses to biological motion in children and adults with and without autism spectrum disorders Type de document : texte imprimé Auteurs : Masahiro HIRAI, Auteur ; Atsuko GUNJI, Auteur ; Yuki INOUE, Auteur ; Yosuke KITA, Auteur ; Takashi HAYASHI, Auteur ; Kengo NISHIMAKI, Auteur ; Miho NAKAMURA, Auteur ; Ryusuke KAKIGI, Auteur ; Masumi INAGAKI, Auteur Article en page(s) : p.1623-1634 Langues : Anglais (eng) Mots-clés : Point-light walker  Biological motion  Event-related potential (ERP)  Autism spectrum disorder  Development  Children Index. décimale : PER Périodiques Résumé : Abstract Although atypical processing of biological motion (BM) in individuals with autism spectrum disorder (ASD) has been reported, the temporal profile of the neural response to BM is not well explored. In the current study, event-related potentials (ERPs) were measured in 12 individuals with ASD, aged 8–22 years, and 12 age- and gender-matched normal controls, to investigate the electrophysiological response to BM and a control visual stimulus. By introducing a novel experimental paradigm that can dissociate the electrophysiological responses to motion processing and the global shape processing of BM, we found that: (1) the timing of the response was preserved in ASD groups, whereas (2) the ERP response to BM was significantly enhanced compared with scrambled point-light motion (SM) in normal controls; the responses to both BM and SM were not significantly different in subjects with ASD. Because we did not find a significant group effect on the peak and mean amplitude induced by BM, it is presumed that this atypical response in individuals with ASD was due to over-sensitivity to the local motion signals. This experimental paradigm showed atypical local motion processing of BM in individuals with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Differential electrophysiological responses to biological motion in children and adults with and without autism spectrum disorders [texte imprimé] / Masahiro HIRAI, Auteur ; Atsuko GUNJI, Auteur ; Yuki INOUE, Auteur ; Yosuke KITA, Auteur ; Takashi HAYASHI, Auteur ; Kengo NISHIMAKI, Auteur ; Miho NAKAMURA, Auteur ; Ryusuke KAKIGI, Auteur ; Masumi INAGAKI, Auteur . - p.1623-1634. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1623-1634 Mots-clés : Point-light walker  Biological motion  Event-related potential (ERP)  Autism spectrum disorder  Development  Children Index. décimale : PER Périodiques Résumé : Abstract Although atypical processing of biological motion (BM) in individuals with autism spectrum disorder (ASD) has been reported, the temporal profile of the neural response to BM is not well explored. In the current study, event-related potentials (ERPs) were measured in 12 individuals with ASD, aged 8–22 years, and 12 age- and gender-matched normal controls, to investigate the electrophysiological response to BM and a control visual stimulus. By introducing a novel experimental paradigm that can dissociate the electrophysiological responses to motion processing and the global shape processing of BM, we found that: (1) the timing of the response was preserved in ASD groups, whereas (2) the ERP response to BM was significantly enhanced compared with scrambled point-light motion (SM) in normal controls; the responses to both BM and SM were not significantly different in subjects with ASD. Because we did not find a significant group effect on the peak and mean amplitude induced by BM, it is presumed that this atypical response in individuals with ASD was due to over-sensitivity to the local motion signals. This experimental paradigm showed atypical local motion processing of BM in individuals with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

The Relationships Among Autism Spectrum Disorder Traits, Loneliness, and Social Networking Service Use in College Students / Kota SUZUKI in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2047-2056 Titre : The Relationships Among Autism Spectrum Disorder Traits, Loneliness, and Social Networking Service Use in College Students Type de document : texte imprimé Auteurs : Kota SUZUKI, Auteur ; Yuhei OI, Auteur ; Masumi INAGAKI, Auteur Article en page(s) : p.2047-2056 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/psychology  Friends  Humans  Loneliness/psychology  Male  Phenotype  Social Networking  Social Skills  Students/psychology  Surveys and Questionnaires  Young Adult  Autism spectrum disorder (ASD)  College students  Friendship  Loneliness  Social networking services (SNS) Index. décimale : PER Périodiques Résumé : This study aimed to explore the relationships among autism spectrum disorder (ASD) traits, loneliness, and social networking services (SNS) use. We created a questionnaire to evaluate manners during LINE use, which included five factors: "low literacy," "inactive use," "low responsiveness," "lack of consideration," and "low group activity." Structural equation modeling revealed that difficulties in attention switching and low communication skills were associated with low literacy, low social skills were associated with inactive use, and low literacy and inactive use were associated with loneliness. We suggested that SNS use plays a role in maintaining and enhancing friendships, whereas college students with higher ASD traits tend to use inappropriate manners for SNS, which is associated with loneliness. En ligne : http://dx.doi.org/10.1007/s10803-020-04701-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] The Relationships Among Autism Spectrum Disorder Traits, Loneliness, and Social Networking Service Use in College Students [texte imprimé] / Kota SUZUKI, Auteur ; Yuhei OI, Auteur ; Masumi INAGAKI, Auteur . - p.2047-2056. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2047-2056 Mots-clés : Adolescent  Autism Spectrum Disorder/psychology  Friends  Humans  Loneliness/psychology  Male  Phenotype  Social Networking  Social Skills  Students/psychology  Surveys and Questionnaires  Young Adult  Autism spectrum disorder (ASD)  College students  Friendship  Loneliness  Social networking services (SNS) Index. décimale : PER Périodiques Résumé : This study aimed to explore the relationships among autism spectrum disorder (ASD) traits, loneliness, and social networking services (SNS) use. We created a questionnaire to evaluate manners during LINE use, which included five factors: "low literacy," "inactive use," "low responsiveness," "lack of consideration," and "low group activity." Structural equation modeling revealed that difficulties in attention switching and low communication skills were associated with low literacy, low social skills were associated with inactive use, and low literacy and inactive use were associated with loneliness. We suggested that SNS use plays a role in maintaining and enhancing friendships, whereas college students with higher ASD traits tend to use inappropriate manners for SNS, which is associated with loneliness. En ligne : http://dx.doi.org/10.1007/s10803-020-04701-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

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