Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents / Justine Nienke PANNEKOEK in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Titre : Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Justine Nienke PANNEKOEK, Auteur ; S. J. A. VAN DER WERFF, Auteur ; Paul H. F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D. J. VAN LANG, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur Article en page(s) : p.1317-1327 Langues : Anglais (eng) Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents [Texte imprimé et/ou numérique] / Justine Nienke PANNEKOEK, Auteur ; S. J. A. VAN DER WERFF, Auteur ; Paul H. F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D. J. VAN LANG, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur . - p.1317-1327. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits / Eduard T. KLAPWIJK in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.737-747 Titre : Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits Type de document : Texte imprimé et/ou numérique Auteurs : Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Olivier F. COLINS, Auteur ; Godfried M. MARIJNISSEN, Auteur ; Arne POPMA, Auteur ; Natasja D. J. VAN LANG, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur Article en page(s) : p.737-747 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  callous-unemotional  conduct disorder  emotions  empathy  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Deficits in empathy are reported in autism spectrum disorders (ASD) and also underlie antisocial behavior of individuals with conduct disorder and callous-unemotional traits (CD/CU+). Many studies suggest that individuals with ASD are typically impaired in cognitive aspects of empathy, and individuals with CD/CU+ typically in affective aspects. In the current study, we compared the neural correlates of cognitive and affective aspects of empathy between youth with ASD and youth with CD/CU+. Methods Functional magnetic resonance imaging (fMRI) was used to assess boys with ASD (N = 23), boys with CD/CU+ (N = 23), and typically developing (TD) boys (N = 33), aged 15–19 years. Angry and fearful faces were presented and participants were asked to either infer the emotional state from the face (other-task; emotion recognition) or to judge their own emotional response to the face (self-task; emotional resonance). Results During emotion recognition, boys with ASD showed reduced responses compared to the other groups in the ventromedial prefrontal cortex (vmPFC). During emotional resonance, the CD/CU+ and ASD groups showed reduced amygdala responses compared to the TD controls, boys with ASD showed reduced responses in bilateral hippocampus, and the CD/CU+ boys showed reduced responses in the inferior frontal gyrus (IFG) and anterior insula (AI). Conclusion Results suggest differential abnormal brain responses associated with specific aspects of empathic functioning in ASD and CD/CU+. Decreased amygdala responses in ASD and CD/CU+ might point to impaired emotion processing in both disorders, whereas reduced vmPFC responses suggest problems in processing cognitive aspects of empathy in ASD. Reduced IFG/AI responses, finally, suggest decreased emotional resonance in CD/CU+. En ligne : http://dx.doi.org/10.1111/jcpp.12498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits [Texte imprimé et/ou numérique] / Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Olivier F. COLINS, Auteur ; Godfried M. MARIJNISSEN, Auteur ; Arne POPMA, Auteur ; Natasja D. J. VAN LANG, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur . - p.737-747. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.737-747 Mots-clés : Autism spectrum disorders  callous-unemotional  conduct disorder  emotions  empathy  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Deficits in empathy are reported in autism spectrum disorders (ASD) and also underlie antisocial behavior of individuals with conduct disorder and callous-unemotional traits (CD/CU+). Many studies suggest that individuals with ASD are typically impaired in cognitive aspects of empathy, and individuals with CD/CU+ typically in affective aspects. In the current study, we compared the neural correlates of cognitive and affective aspects of empathy between youth with ASD and youth with CD/CU+. Methods Functional magnetic resonance imaging (fMRI) was used to assess boys with ASD (N = 23), boys with CD/CU+ (N = 23), and typically developing (TD) boys (N = 33), aged 15–19 years. Angry and fearful faces were presented and participants were asked to either infer the emotional state from the face (other-task; emotion recognition) or to judge their own emotional response to the face (self-task; emotional resonance). Results During emotion recognition, boys with ASD showed reduced responses compared to the other groups in the ventromedial prefrontal cortex (vmPFC). During emotional resonance, the CD/CU+ and ASD groups showed reduced amygdala responses compared to the TD controls, boys with ASD showed reduced responses in bilateral hippocampus, and the CD/CU+ boys showed reduced responses in the inferior frontal gyrus (IFG) and anterior insula (AI). Conclusion Results suggest differential abnormal brain responses associated with specific aspects of empathic functioning in ASD and CD/CU+. Decreased amygdala responses in ASD and CD/CU+ might point to impaired emotion processing in both disorders, whereas reduced vmPFC responses suggest problems in processing cognitive aspects of empathy in ASD. Reduced IFG/AI responses, finally, suggest decreased emotional resonance in CD/CU+. En ligne : http://dx.doi.org/10.1111/jcpp.12498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Differential Fairness Decisions and Brain Responses After Expressed Emotions of Others in Boys with Autism Spectrum Disorders / Eduard T. KLAPWIJK in Journal of Autism and Developmental Disorders, 47-8 (August 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-8 (August 2017) . - p.2390-2400 Titre : Differential Fairness Decisions and Brain Responses After Expressed Emotions of Others in Boys with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Gert-Jan LELIEVELD, Auteur ; Natasja D. J. VAN LANG, Auteur ; Arne POPMA, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Olivier F. COLINS, Auteur ; Robert R. J. M. VERMEIREN, Auteur Article en page(s) : p.2390-2400 Langues : Anglais (eng) Mots-clés : Social decision-making  Autism spectrum disorders  Interpersonal effects of emotions  Dictator game  fMRI Index. décimale : PER Périodiques Résumé : Little is known about how emotions expressed by others influence social decisions and associated brain responses in autism spectrum disorders (ASD). We investigated the neural mechanisms underlying fairness decisions in response to explicitly expressed emotions of others in boys with ASD and typically developing (TD) boys. Participants with ASD adjusted their allocation behavior in response to the emotions but reacted less unfair than TD controls in response to happiness. We also found reduced brain responses in the precental gyrus in the ASD versus TD group when receiving happy versus angry reactions and autistic traits were positively associated with activity in the postcentral gyrus. These results provide indications for a role of precentral and postcentral gyrus in social-affective difficulties in ASD. En ligne : https://doi.org/10.1007/s10803-017-3159-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314 [article] Differential Fairness Decisions and Brain Responses After Expressed Emotions of Others in Boys with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Gert-Jan LELIEVELD, Auteur ; Natasja D. J. VAN LANG, Auteur ; Arne POPMA, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Olivier F. COLINS, Auteur ; Robert R. J. M. VERMEIREN, Auteur . - p.2390-2400. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-8 (August 2017) . - p.2390-2400 Mots-clés : Social decision-making  Autism spectrum disorders  Interpersonal effects of emotions  Dictator game  fMRI Index. décimale : PER Périodiques Résumé : Little is known about how emotions expressed by others influence social decisions and associated brain responses in autism spectrum disorders (ASD). We investigated the neural mechanisms underlying fairness decisions in response to explicitly expressed emotions of others in boys with ASD and typically developing (TD) boys. Participants with ASD adjusted their allocation behavior in response to the emotions but reacted less unfair than TD controls in response to happiness. We also found reduced brain responses in the precental gyrus in the ASD versus TD group when receiving happy versus angry reactions and autistic traits were positively associated with activity in the postcentral gyrus. These results provide indications for a role of precentral and postcentral gyrus in social-affective difficulties in ASD. En ligne : https://doi.org/10.1007/s10803-017-3159-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314

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