Brief Report: Preliminary Feasibility of the TEDI: A Novel Parent-Administered Telehealth Assessment for Autism Spectrum Disorder Symptoms in the First Year of Life / Meagan R. TALBOTT in Journal of Autism and Developmental Disorders, 50-9 (September 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3432-3439 Titre : Brief Report: Preliminary Feasibility of the TEDI: A Novel Parent-Administered Telehealth Assessment for Autism Spectrum Disorder Symptoms in the First Year of Life Type de document : Texte imprimé et/ou numérique Auteurs : Meagan R. TALBOTT, Auteur ; Sarah DUFEK, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; Isabel M SMITH, Auteur ; Sally J ROGERS, Auteur Article en page(s) : p.3432-3439 Langues : Anglais (eng) Mots-clés : Aosi  Asd  Autism spectrum disorders  Eci  Igdi  Infancy  Parent–child interaction  Screening  Telehealth Index. décimale : PER Périodiques Résumé : Families with early concerns about infant symptoms of ASD have limited access to experienced professionals for screening and guidance. Telehealth has been used to reduce access disparities in other pediatric populations and has shown promise in parent-implemented interventions for ASD. We investigated the feasibility of a novel level-2 telehealth assessment of infants' early social communication and ASD symptoms, the Telehealth Evaluation of Development for Infants (TEDI). Parents of eleven infants aged 6-12 months were coached to administer specific semi-structured behavioral probes. Initial feasibility, reliability, and acceptability benchmarks were met. These findings suggest the feasibility of screening infants via telehealth, and are supportive of further large-scale efforts to validate this method for longitudinal monitoring of symptomatic infants in community settings. En ligne : http://dx.doi.org/10.1007/s10803-019-04314-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Brief Report: Preliminary Feasibility of the TEDI: A Novel Parent-Administered Telehealth Assessment for Autism Spectrum Disorder Symptoms in the First Year of Life [Texte imprimé et/ou numérique] / Meagan R. TALBOTT, Auteur ; Sarah DUFEK, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; Isabel M SMITH, Auteur ; Sally J ROGERS, Auteur . - p.3432-3439. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3432-3439 Mots-clés : Aosi  Asd  Autism spectrum disorders  Eci  Igdi  Infancy  Parent–child interaction  Screening  Telehealth Index. décimale : PER Périodiques Résumé : Families with early concerns about infant symptoms of ASD have limited access to experienced professionals for screening and guidance. Telehealth has been used to reduce access disparities in other pediatric populations and has shown promise in parent-implemented interventions for ASD. We investigated the feasibility of a novel level-2 telehealth assessment of infants' early social communication and ASD symptoms, the Telehealth Evaluation of Development for Infants (TEDI). Parents of eleven infants aged 6-12 months were coached to administer specific semi-structured behavioral probes. Initial feasibility, reliability, and acceptability benchmarks were met. These findings suggest the feasibility of screening infants via telehealth, and are supportive of further large-scale efforts to validate this method for longitudinal monitoring of symptomatic infants in community settings. En ligne : http://dx.doi.org/10.1007/s10803-019-04314-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Can combining existing behavioral tools improve identification of infants at elevated likelihood of autism in the first year of life? / Meagan R. TALBOTT ; Gregory S. YOUNG ; Sally OZONOFF in Autism, 29-2 (February 2025)  

Public ISBD [article]  inAutism > 29-2 (February 2025) . - p.462-475 Titre : Can combining existing behavioral tools improve identification of infants at elevated likelihood of autism in the first year of life? : Autism Type de document : Texte imprimé et/ou numérique Auteurs : Meagan R. TALBOTT, Auteur ; Gregory S. YOUNG, Auteur ; Sally OZONOFF, Auteur Article en page(s) : p.462-475 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  early detection  infant sibling  screening Index. décimale : PER Périodiques Résumé : Identifying infants at elevated likelihood for autism and other developmental differences in the first year of life remains a significant challenge. This study explored associations between behavioral differences in infancy and developmental outcomes in toddlerhood. We conducted a secondary data analysis of 256 infants with an older autistic sibling followed from 6 to 36?months of age. We defined conceptually driven cutoffs for three behavioral measures collected at 6, 9, and 12?months and examined the utility of these measures, individually and in combination, in predicting 36-month outcome classification (typical development or developmental concerns, including autism). Overall, relatively few infants met multiple measure definitions (range: 5 to 43 infants across ages). However, infants meeting multiple definitions had a higher likelihood of developmental concerns outcomes at all ages. Positive predictive values for meeting all three measure definitions combined ranged from 0.67 [0.22, 0.96] at 6?months to 0.95 [0.75, 1.0] at 12?months. These findings suggest that while majority of infants ultimately classified with developmental concerns do not show significant behavioral differences in the first year, when early differences are present, they have predictive value. Combining behavioral tools may help to improve identification of infants most in need of early supports. Lay abstract Many families have concerns about their infants' development in the first year of life. Current screeners cannot tell whether these differences might be related to autism, developmental delays, or likely to resolve on their own. As a result, many families are told to "wait and see." In this study, we looked at whether combining multiple behavior measures can improve prediction of outcomes in toddlerhood. This could help to provide families with more information about the significance of early behavioral differences. We assessed 256 infants with an older autistic sibling at 6, 9, and 12?months. We created three markers of behavioral differences at these ages. We looked at whether infants who had two or more markers were more likely to be on the autism spectrum or have other developmental differences than to have typically developing outcomes at 36?months. We found that very few infants had more than one marker at any age. However, infants who showed two or more markers were more likely to be on the spectrum or have other developmental differences at 36?months than infants who showed only one marker. These findings suggest that when behavioral differences are present on multiple measures, there is no need to wait and see before referring for services. En ligne : https://dx.doi.org/10.1177/13623613241275455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Can combining existing behavioral tools improve identification of infants at elevated likelihood of autism in the first year of life? : Autism [Texte imprimé et/ou numérique] / Meagan R. TALBOTT, Auteur ; Gregory S. YOUNG, Auteur ; Sally OZONOFF, Auteur . - p.462-475. Langues : Anglais (eng) in Autism > 29-2 (February 2025) . - p.462-475 Mots-clés : Autism spectrum disorders  early detection  infant sibling  screening Index. décimale : PER Périodiques Résumé : Identifying infants at elevated likelihood for autism and other developmental differences in the first year of life remains a significant challenge. This study explored associations between behavioral differences in infancy and developmental outcomes in toddlerhood. We conducted a secondary data analysis of 256 infants with an older autistic sibling followed from 6 to 36?months of age. We defined conceptually driven cutoffs for three behavioral measures collected at 6, 9, and 12?months and examined the utility of these measures, individually and in combination, in predicting 36-month outcome classification (typical development or developmental concerns, including autism). Overall, relatively few infants met multiple measure definitions (range: 5 to 43 infants across ages). However, infants meeting multiple definitions had a higher likelihood of developmental concerns outcomes at all ages. Positive predictive values for meeting all three measure definitions combined ranged from 0.67 [0.22, 0.96] at 6?months to 0.95 [0.75, 1.0] at 12?months. These findings suggest that while majority of infants ultimately classified with developmental concerns do not show significant behavioral differences in the first year, when early differences are present, they have predictive value. Combining behavioral tools may help to improve identification of infants most in need of early supports. Lay abstract Many families have concerns about their infants' development in the first year of life. Current screeners cannot tell whether these differences might be related to autism, developmental delays, or likely to resolve on their own. As a result, many families are told to "wait and see." In this study, we looked at whether combining multiple behavior measures can improve prediction of outcomes in toddlerhood. This could help to provide families with more information about the significance of early behavioral differences. We assessed 256 infants with an older autistic sibling at 6, 9, and 12?months. We created three markers of behavioral differences at these ages. We looked at whether infants who had two or more markers were more likely to be on the autism spectrum or have other developmental differences than to have typically developing outcomes at 36?months. We found that very few infants had more than one marker at any age. However, infants who showed two or more markers were more likely to be on the spectrum or have other developmental differences at 36?months than infants who showed only one marker. These findings suggest that when behavioral differences are present on multiple measures, there is no need to wait and see before referring for services. En ligne : https://dx.doi.org/10.1177/13623613241275455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Diary Reports of Concerns in Mothers of Infant Siblings of Children with Autism Across the First Year of Life / Meagan R. TALBOTT in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2187-2199 Titre : Diary Reports of Concerns in Mothers of Infant Siblings of Children with Autism Across the First Year of Life Type de document : Texte imprimé et/ou numérique Auteurs : Meagan R. TALBOTT, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur Année de publication : 2015 Article en page(s) : p.2187-2199 Langues : Anglais (eng) Mots-clés : High risk infant siblings  Parental concerns  Autism  Home-based measures Index. décimale : PER Périodiques Résumé : We examined the home-based concerns reported by mothers of infant siblings of children with autism across the first year of life. At all three ages measured, mothers of high-risk infants were significantly more likely than mothers of low-risk infants to report language, social communication, and restricted and repetitive behavior concerns but were not more likely to report general, medically based concerns. At 6 and 9 months of age, maternal concerns were poorly related to infant or family variables. At 12 months of age, there were moderate correlations between maternal concerns and infant behavior, and concerns were associated with the proband’s autism symptoms and mothers’ concurrent depressive symptoms. These findings highlight the need to examine high-risk infants’ development in the family context. En ligne : http://dx.doi.org/10.1007/s10803-015-2383-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Diary Reports of Concerns in Mothers of Infant Siblings of Children with Autism Across the First Year of Life [Texte imprimé et/ou numérique] / Meagan R. TALBOTT, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur . - 2015 . - p.2187-2199. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2187-2199 Mots-clés : High risk infant siblings  Parental concerns  Autism  Home-based measures Index. décimale : PER Périodiques Résumé : We examined the home-based concerns reported by mothers of infant siblings of children with autism across the first year of life. At all three ages measured, mothers of high-risk infants were significantly more likely than mothers of low-risk infants to report language, social communication, and restricted and repetitive behavior concerns but were not more likely to report general, medically based concerns. At 6 and 9 months of age, maternal concerns were poorly related to infant or family variables. At 12 months of age, there were moderate correlations between maternal concerns and infant behavior, and concerns were associated with the proband’s autism symptoms and mothers’ concurrent depressive symptoms. These findings highlight the need to examine high-risk infants’ development in the family context. En ligne : http://dx.doi.org/10.1007/s10803-015-2383-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Lateralization of ERPs to speech and handedness in the early development of Autism Spectrum Disorder / K. H. FINCH in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.4 Titre : Lateralization of ERPs to speech and handedness in the early development of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. H. FINCH, Auteur ; A. M. SEERY, Auteur ; Meagan R. TALBOTT, Auteur ; C. A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.4 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Event-related potentials  Handedness  Lateralization  Speech processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Language is a highly lateralized function, with typically developing individuals showing left hemispheric specialization. Individuals with autism spectrum disorder (ASD) often show reduced or reversed hemispheric lateralization in response to language. However, it is unclear when this difference emerges and whether or not it can serve as an early ASD biomarker. Additionally, atypical language lateralization is not specific to ASD as it is also seen more frequently in individuals with mixed- and left-handedness. Here, we examined early asymmetry patterns measured through neural responses to speech sounds at 12 months and behavioral observations of handedness at 36 months in children with and without ASD. METHODS: Three different groups of children participated in the study: low-risk controls (LRC), high risk for ASD (HRA; infants with older sibling with ASD) without ASD, and HRA infants who later receive a diagnosis of ASD (ASD). Event-related potentials (ERPs) to speech sounds were recorded at 12 months. Utilizing a novel observational approach, handedness was measured by hand preference on a variety of behaviors at 36 months. RESULTS: At 12 months, lateralization patterns of ERPs to speech stimuli differed across the groups with the ASD group showing reversed lateralization compared to the LRC group. At 36 months, factor analysis of behavioral observations of hand preferences indicated a one-factor model with medium to high factor loadings. A composite handedness score was derived; no group differences were observed. There was no association between lateralization to speech at 12 months and handedness at 36 months in the LRC and HRA groups. However, children with ASD did show an association such that infants with lateralization patterns more similar to the LRC group at 12 months were stronger right-handers at 36 months. CONCLUSIONS: These results highlight early developmental patterns that might be specific to ASD, including a potential early biomarker of reversed lateralization to speech stimuli at 12 months, and a relation between behavioral and neural asymmetries. Future investigations of early asymmetry patterns, especially atypical hemispheric specialization, may be informative in the early identification of ASD. En ligne : http://dx.doi.org/10.1186/s11689-017-9185-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] Lateralization of ERPs to speech and handedness in the early development of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. H. FINCH, Auteur ; A. M. SEERY, Auteur ; Meagan R. TALBOTT, Auteur ; C. A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.4. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.4 Mots-clés : Autism spectrum disorders  Event-related potentials  Handedness  Lateralization  Speech processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Language is a highly lateralized function, with typically developing individuals showing left hemispheric specialization. Individuals with autism spectrum disorder (ASD) often show reduced or reversed hemispheric lateralization in response to language. However, it is unclear when this difference emerges and whether or not it can serve as an early ASD biomarker. Additionally, atypical language lateralization is not specific to ASD as it is also seen more frequently in individuals with mixed- and left-handedness. Here, we examined early asymmetry patterns measured through neural responses to speech sounds at 12 months and behavioral observations of handedness at 36 months in children with and without ASD. METHODS: Three different groups of children participated in the study: low-risk controls (LRC), high risk for ASD (HRA; infants with older sibling with ASD) without ASD, and HRA infants who later receive a diagnosis of ASD (ASD). Event-related potentials (ERPs) to speech sounds were recorded at 12 months. Utilizing a novel observational approach, handedness was measured by hand preference on a variety of behaviors at 36 months. RESULTS: At 12 months, lateralization patterns of ERPs to speech stimuli differed across the groups with the ASD group showing reversed lateralization compared to the LRC group. At 36 months, factor analysis of behavioral observations of hand preferences indicated a one-factor model with medium to high factor loadings. A composite handedness score was derived; no group differences were observed. There was no association between lateralization to speech at 12 months and handedness at 36 months in the LRC and HRA groups. However, children with ASD did show an association such that infants with lateralization patterns more similar to the LRC group at 12 months were stronger right-handers at 36 months. CONCLUSIONS: These results highlight early developmental patterns that might be specific to ASD, including a potential early biomarker of reversed lateralization to speech stimuli at 12 months, and a relation between behavioral and neural asymmetries. Future investigations of early asymmetry patterns, especially atypical hemispheric specialization, may be informative in the early identification of ASD. En ligne : http://dx.doi.org/10.1186/s11689-017-9185-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

Maternal Gesture Use and Language Development in Infant Siblings of Children with Autism Spectrum Disorder / Meagan R. TALBOTT in Journal of Autism and Developmental Disorders, 45-1 (January 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-1 (January 2015) . - p.4-14 Titre : Maternal Gesture Use and Language Development in Infant Siblings of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Meagan R. TALBOTT, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.4-14 Langues : Anglais (eng) Mots-clés : Gesture  Language  Infant siblings  Autism Index. décimale : PER Périodiques Résumé : Impairments in language and communication are an early-appearing feature of autism spectrum disorders (ASD), with delays in language and gesture evident as early as the first year of life. Research with typically developing populations highlights the importance of both infant and maternal gesture use in infants’ early language development. The current study explores the gesture production of infants at risk for autism and their mothers at 12 months of age, and the association between these early maternal and infant gestures and between these early gestures and infants’ language at 18 months. Gestures were scored from both a caregiver-infant interaction (both infants and mothers) and from a semi-structured task (infants only). Mothers of non-diagnosed high risk infant siblings gestured more frequently than mothers of low risk infants. Infant and maternal gesture use at 12 months was associated with infants’ language scores at 18 months in both low risk and non-diagnosed high risk infants. These results demonstrate the impact of risk status on maternal behavior and the importance of considering the role of social and contextual factors on the language development of infants at risk for autism. Results from the subset of infants who meet preliminary criteria for ASD are also discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1820-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Maternal Gesture Use and Language Development in Infant Siblings of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Meagan R. TALBOTT, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.4-14. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-1 (January 2015) . - p.4-14 Mots-clés : Gesture  Language  Infant siblings  Autism Index. décimale : PER Périodiques Résumé : Impairments in language and communication are an early-appearing feature of autism spectrum disorders (ASD), with delays in language and gesture evident as early as the first year of life. Research with typically developing populations highlights the importance of both infant and maternal gesture use in infants’ early language development. The current study explores the gesture production of infants at risk for autism and their mothers at 12 months of age, and the association between these early maternal and infant gestures and between these early gestures and infants’ language at 18 months. Gestures were scored from both a caregiver-infant interaction (both infants and mothers) and from a semi-structured task (infants only). Mothers of non-diagnosed high risk infant siblings gestured more frequently than mothers of low risk infants. Infant and maternal gesture use at 12 months was associated with infants’ language scores at 18 months in both low risk and non-diagnosed high risk infants. These results demonstrate the impact of risk status on maternal behavior and the importance of considering the role of social and contextual factors on the language development of infants at risk for autism. Results from the subset of infants who meet preliminary criteria for ASD are also discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1820-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Maternal Vocal Feedback to 9-Month-Old Infant Siblings of Children with ASD / Meagan R. TALBOTT in Autism Research, 9-4 (April 2016)  

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Short report: Experiences of Caregivers Participating in a Telehealth Evaluation of Development for Infants (TEDI) / Meagan R. TALBOTT in Journal of Autism and Developmental Disorders, 52-12 (December 2022)  

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