Adaptive Profiles in Autism and Other Neurodevelopmental Disorders / Susana MOUGA in Journal of Autism and Developmental Disorders, 45-4 (April 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1001-1012 Titre : Adaptive Profiles in Autism and Other Neurodevelopmental Disorders Type de document : texte imprimé Auteurs : Susana MOUGA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur Article en page(s) : p.1001-1012 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Adaptive behaviour  Functional profile  Vineland Adaptive Behaviour Scale Index. décimale : PER Périodiques Résumé : We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale (VABS) in communication, daily living skills, socialization and adaptive behaviour composite. Pearson-correlation analysis was performed between each domain of VABS and Full-Scale, Verbal and Performance IQ, and chronological age (CA). Results indicated that impairment in adaptive behaviour within the domain of socialization skills remains a distinctive factor of ASD versus OND, independently of intellectual disability (ID). Co-occurring ID result in further debilitating effects on overall functioning, especially in ASD. CA is negatively associated with VABS scores. En ligne : http://dx.doi.org/10.1007/s10803-014-2256-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Adaptive Profiles in Autism and Other Neurodevelopmental Disorders [texte imprimé] / Susana MOUGA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur . - p.1001-1012. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1001-1012 Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Adaptive behaviour  Functional profile  Vineland Adaptive Behaviour Scale Index. décimale : PER Périodiques Résumé : We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale (VABS) in communication, daily living skills, socialization and adaptive behaviour composite. Pearson-correlation analysis was performed between each domain of VABS and Full-Scale, Verbal and Performance IQ, and chronological age (CA). Results indicated that impairment in adaptive behaviour within the domain of socialization skills remains a distinctive factor of ASD versus OND, independently of intellectual disability (ID). Co-occurring ID result in further debilitating effects on overall functioning, especially in ASD. CA is negatively associated with VABS scores. En ligne : http://dx.doi.org/10.1007/s10803-014-2256-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Autism Spectrum Disorder: FRAXE Mutation, a Rare Etiology / F. CORREIA in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.888-892 Titre : Autism Spectrum Disorder: FRAXE Mutation, a Rare Etiology Type de document : texte imprimé Auteurs : F. CORREIA, Auteur ; C. CAFE, Auteur ; J. ALMEIDA, Auteur ; Susana MOUGA, Auteur ; Guiomar OLIVEIRA, Auteur Article en page(s) : p.888-892 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Fragile X syndrome  FRAXE  FMR2  Intellectual disability  Compulsive behavior problems Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication, restricted interests and repetitive behaviors. Fragile X E is associated with X-linked non-specific mild intellectual disability (ID) and with behavioral problems. Most of the known genetic causes of ASD are also causes of ID, implying that these two identities share common genetic bases. We present a child with an ASD with a normal range of intelligence quotient, that later evolved to compulsive behavior. FRAXE locus analysis by polymerase chain reaction revealed a complete mutation of the FMR 2 gene. This report stresses the importance of clinicians being aware of the association between a full mutation of FMR2 and ASD associated with compulsive behavior despite normal intellectual level. En ligne : http://dx.doi.org/10.1007/s10803-014-2185-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Autism Spectrum Disorder: FRAXE Mutation, a Rare Etiology [texte imprimé] / F. CORREIA, Auteur ; C. CAFE, Auteur ; J. ALMEIDA, Auteur ; Susana MOUGA, Auteur ; Guiomar OLIVEIRA, Auteur . - p.888-892. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.888-892 Mots-clés : Autism spectrum disorder  Fragile X syndrome  FRAXE  FMR2  Intellectual disability  Compulsive behavior problems Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication, restricted interests and repetitive behaviors. Fragile X E is associated with X-linked non-specific mild intellectual disability (ID) and with behavioral problems. Most of the known genetic causes of ASD are also causes of ID, implying that these two identities share common genetic bases. We present a child with an ASD with a normal range of intelligence quotient, that later evolved to compulsive behavior. FRAXE locus analysis by polymerase chain reaction revealed a complete mutation of the FMR 2 gene. This report stresses the importance of clinicians being aware of the association between a full mutation of FMR2 and ASD associated with compulsive behavior despite normal intellectual level. En ligne : http://dx.doi.org/10.1007/s10803-014-2185-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders / Susana MOUGA in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2940-2955 Titre : Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders Type de document : texte imprimé Auteurs : Susana MOUGA, Auteur ; Cátia CAFÉ, Auteur ; Joana ALMEIDA, Auteur ; Carla MARQUES, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur Article en page(s) : p.2940-2955 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Intellectual profiles  Cognitive ability  Wechsler Intelligence Scale for Children-III Index. décimale : PER Périodiques Résumé : The influence of specific autism spectrum disorder (ASD) deficits in Intelligence Quotients (IQ), Indexes and subtests from the Wechsler Intelligence Scale for Children-III was investigated in 445 school-aged children: ASD (N = 224) and other neurodevelopmental disorders (N = 221), matched by Full-Scale IQ and chronological age. ASD have lower scores in the VIQ than PIQ. The core distinctive scores between groups are Processing Speed Index and “Comprehension” and “Coding” subtests with lower results in ASD. ASD group with normal/high IQ showed highest score on “Similarities” subtest whereas the lower IQ group performed better on “Object Assembly”. The results replicated our previous work on adaptive behaviour, showing that adaptive functioning is positively correlated with intellectual profile, especially with the Communication domain in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2838-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders [texte imprimé] / Susana MOUGA, Auteur ; Cátia CAFÉ, Auteur ; Joana ALMEIDA, Auteur ; Carla MARQUES, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur . - p.2940-2955. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2940-2955 Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Intellectual profiles  Cognitive ability  Wechsler Intelligence Scale for Children-III Index. décimale : PER Périodiques Résumé : The influence of specific autism spectrum disorder (ASD) deficits in Intelligence Quotients (IQ), Indexes and subtests from the Wechsler Intelligence Scale for Children-III was investigated in 445 school-aged children: ASD (N = 224) and other neurodevelopmental disorders (N = 221), matched by Full-Scale IQ and chronological age. ASD have lower scores in the VIQ than PIQ. The core distinctive scores between groups are Processing Speed Index and “Comprehension” and “Coding” subtests with lower results in ASD. ASD group with normal/high IQ showed highest score on “Similarities” subtest whereas the lower IQ group performed better on “Object Assembly”. The results replicated our previous work on adaptive behaviour, showing that adaptive functioning is positively correlated with intellectual profile, especially with the Communication domain in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2838-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels / Andreia CARVALHO PEREIRA in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1467-1482 Titre : Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels Type de document : texte imprimé Auteurs : Andreia CARVALHO PEREIRA, Auteur ; Inês R. VIOLANTE, Auteur ; Susana MOUGA, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Article en page(s) : p.1467-1482 Langues : Anglais (eng) Mots-clés : Autism diagnostic interview-revised  Autism spectrum disorder  Creatine  Gamma-aminobutyric acid  Glutamate + glutamine  N-acetylaspartate Index. décimale : PER Périodiques Résumé : The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased Glx/tNAA but unchanged glutamate + glutamine (Glx) and unchanged absolute or relative gamma-aminobutyric acid (GABA+) in the ASD group. Importantly, both smaller absolute and relative GABA+ levels were associated with worse communication skills and developmental delay scores assessed by the autism diagnostic interview-revised (ADI-R). We conclude that tNAA is reduced in the mPFC in ASD and that glutamatergic metabolism may be altered due to unbalanced Glx/tNAA. Moreover, GABA+ is related to autistic symptoms assessed by the ADI-R. En ligne : http://dx.doi.org/10.1007/s10803-017-3406-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 [article] Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels [texte imprimé] / Andreia CARVALHO PEREIRA, Auteur ; Inês R. VIOLANTE, Auteur ; Susana MOUGA, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur . - p.1467-1482. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1467-1482 Mots-clés : Autism diagnostic interview-revised  Autism spectrum disorder  Creatine  Gamma-aminobutyric acid  Glutamate + glutamine  N-acetylaspartate Index. décimale : PER Périodiques Résumé : The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased Glx/tNAA but unchanged glutamate + glutamine (Glx) and unchanged absolute or relative gamma-aminobutyric acid (GABA+) in the ASD group. Importantly, both smaller absolute and relative GABA+ levels were associated with worse communication skills and developmental delay scores assessed by the autism diagnostic interview-revised (ADI-R). We conclude that tNAA is reduced in the mPFC in ASD and that glutamatergic metabolism may be altered due to unbalanced Glx/tNAA. Moreover, GABA+ is related to autistic symptoms assessed by the ADI-R. En ligne : http://dx.doi.org/10.1007/s10803-017-3406-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355

Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder / Susana MOUGA in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder Type de document : texte imprimé Auteurs : Susana MOUGA, Auteur ; Isabel Catarina DUARTE, Auteur ; Cátia CAFÉ, Auteur ; Daniela SOUSA, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Cognition  Humans  Magnetic Resonance Imaging  Neuroimaging  Social Cognition  Autism spectrum disorder  Central executive network  Ecological task  Saliency network  Social cognition network  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The concomitant role of the Central Executive, the Saliency and the Social Cognition networks in autism spectrum disorder (ASD) in demanding ecological tasks remains unanswered. We addressed this question using a novel task-based fMRI virtual-reality task mimicking a challenging daily-life chore that may present some difficulties to individuals with ASD: the EcoSupermarketX. METHODS: Participants included 29 adolescents: 15 with ASD and 15 with typical neurodevelopment (TD). They performed the EcoSupermarketX (a shopping simulation with three goal-oriented sub-tasks including "no cue", "non-social" or "social" cues), during neuroimaging and eye-tracking. RESULTS: ASD differed from TD only in total time and distance to complete the "social cue" sub-task with matched eye-tracking measures. Neuroimaging revealed simultaneous hyperactivation across social, executive, and saliency circuits in ASD. In contrast, ASD showed reduced activation in the parahippocampal gyrus, involved in scene recognition. CONCLUSIONS: When performing a virtual shopping task matching the performance of controls, ASD adolescents hyperactivate three core networks: executive, saliency and social cognition. Parahippocampal hypoactivation is consistent with effortless eidetic scene processing, in line with the notion of peaks and valleys of neural recruitment in individuals with ASD. These hyperactivation/hypoactivation patterns in daily life tasks provide a circuit-level signature of neural diversity in ASD, a possible intervention target. En ligne : https://dx.doi.org/10.1186/s11689-022-09417-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder [texte imprimé] / Susana MOUGA, Auteur ; Isabel Catarina DUARTE, Auteur ; Cátia CAFÉ, Auteur ; Daniela SOUSA, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Cognition  Humans  Magnetic Resonance Imaging  Neuroimaging  Social Cognition  Autism spectrum disorder  Central executive network  Ecological task  Saliency network  Social cognition network  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The concomitant role of the Central Executive, the Saliency and the Social Cognition networks in autism spectrum disorder (ASD) in demanding ecological tasks remains unanswered. We addressed this question using a novel task-based fMRI virtual-reality task mimicking a challenging daily-life chore that may present some difficulties to individuals with ASD: the EcoSupermarketX. METHODS: Participants included 29 adolescents: 15 with ASD and 15 with typical neurodevelopment (TD). They performed the EcoSupermarketX (a shopping simulation with three goal-oriented sub-tasks including "no cue", "non-social" or "social" cues), during neuroimaging and eye-tracking. RESULTS: ASD differed from TD only in total time and distance to complete the "social cue" sub-task with matched eye-tracking measures. Neuroimaging revealed simultaneous hyperactivation across social, executive, and saliency circuits in ASD. In contrast, ASD showed reduced activation in the parahippocampal gyrus, involved in scene recognition. CONCLUSIONS: When performing a virtual shopping task matching the performance of controls, ASD adolescents hyperactivate three core networks: executive, saliency and social cognition. Parahippocampal hypoactivation is consistent with effortless eidetic scene processing, in line with the notion of peaks and valleys of neural recruitment in individuals with ASD. These hyperactivation/hypoactivation patterns in daily life tasks provide a circuit-level signature of neural diversity in ASD, a possible intervention target. En ligne : https://dx.doi.org/10.1186/s11689-022-09417-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders / Catarina T. CORREIA in Molecular Autism, (April 2014)  

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Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / Bruno DIREITO in Autism, 25-6 (August 2021)  

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Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / Bruno DIREITO in Autism, 26-6 (August 2022)  

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Virtual Reality Immersion Rescales Regulation of Interpersonal Distance in Controls but not in Autism Spectrum Disorder / Marco SIMÕES in Journal of Autism and Developmental Disorders, 50-12 (December 2020)  

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