Adaptive Profiles in Autism and Other Neurodevelopmental Disorders / Susana MOUGA in Journal of Autism and Developmental Disorders, 45-4 (April 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1001-1012 Titre : Adaptive Profiles in Autism and Other Neurodevelopmental Disorders Type de document : texte imprimé Auteurs : Susana MOUGA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur Article en page(s) : p.1001-1012 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Adaptive behaviour  Functional profile  Vineland Adaptive Behaviour Scale Index. décimale : PER Périodiques Résumé : We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale (VABS) in communication, daily living skills, socialization and adaptive behaviour composite. Pearson-correlation analysis was performed between each domain of VABS and Full-Scale, Verbal and Performance IQ, and chronological age (CA). Results indicated that impairment in adaptive behaviour within the domain of socialization skills remains a distinctive factor of ASD versus OND, independently of intellectual disability (ID). Co-occurring ID result in further debilitating effects on overall functioning, especially in ASD. CA is negatively associated with VABS scores. En ligne : http://dx.doi.org/10.1007/s10803-014-2256-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Adaptive Profiles in Autism and Other Neurodevelopmental Disorders [texte imprimé] / Susana MOUGA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur . - p.1001-1012. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1001-1012 Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Adaptive behaviour  Functional profile  Vineland Adaptive Behaviour Scale Index. décimale : PER Périodiques Résumé : We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale (VABS) in communication, daily living skills, socialization and adaptive behaviour composite. Pearson-correlation analysis was performed between each domain of VABS and Full-Scale, Verbal and Performance IQ, and chronological age (CA). Results indicated that impairment in adaptive behaviour within the domain of socialization skills remains a distinctive factor of ASD versus OND, independently of intellectual disability (ID). Co-occurring ID result in further debilitating effects on overall functioning, especially in ASD. CA is negatively associated with VABS scores. En ligne : http://dx.doi.org/10.1007/s10803-014-2256-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders / Susana MOUGA in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2940-2955 Titre : Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders Type de document : texte imprimé Auteurs : Susana MOUGA, Auteur ; Cátia CAFÉ, Auteur ; Joana ALMEIDA, Auteur ; Carla MARQUES, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur Article en page(s) : p.2940-2955 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Intellectual profiles  Cognitive ability  Wechsler Intelligence Scale for Children-III Index. décimale : PER Périodiques Résumé : The influence of specific autism spectrum disorder (ASD) deficits in Intelligence Quotients (IQ), Indexes and subtests from the Wechsler Intelligence Scale for Children-III was investigated in 445 school-aged children: ASD (N = 224) and other neurodevelopmental disorders (N = 221), matched by Full-Scale IQ and chronological age. ASD have lower scores in the VIQ than PIQ. The core distinctive scores between groups are Processing Speed Index and “Comprehension” and “Coding” subtests with lower results in ASD. ASD group with normal/high IQ showed highest score on “Similarities” subtest whereas the lower IQ group performed better on “Object Assembly”. The results replicated our previous work on adaptive behaviour, showing that adaptive functioning is positively correlated with intellectual profile, especially with the Communication domain in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2838-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders [texte imprimé] / Susana MOUGA, Auteur ; Cátia CAFÉ, Auteur ; Joana ALMEIDA, Auteur ; Carla MARQUES, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur . - p.2940-2955. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2940-2955 Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Intellectual profiles  Cognitive ability  Wechsler Intelligence Scale for Children-III Index. décimale : PER Périodiques Résumé : The influence of specific autism spectrum disorder (ASD) deficits in Intelligence Quotients (IQ), Indexes and subtests from the Wechsler Intelligence Scale for Children-III was investigated in 445 school-aged children: ASD (N = 224) and other neurodevelopmental disorders (N = 221), matched by Full-Scale IQ and chronological age. ASD have lower scores in the VIQ than PIQ. The core distinctive scores between groups are Processing Speed Index and “Comprehension” and “Coding” subtests with lower results in ASD. ASD group with normal/high IQ showed highest score on “Similarities” subtest whereas the lower IQ group performed better on “Object Assembly”. The results replicated our previous work on adaptive behaviour, showing that adaptive functioning is positively correlated with intellectual profile, especially with the Communication domain in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2838-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder / Susana MOUGA in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder Type de document : texte imprimé Auteurs : Susana MOUGA, Auteur ; Isabel Catarina DUARTE, Auteur ; Cátia CAFÉ, Auteur ; Daniela SOUSA, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Cognition  Humans  Magnetic Resonance Imaging  Neuroimaging  Social Cognition  Autism spectrum disorder  Central executive network  Ecological task  Saliency network  Social cognition network  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The concomitant role of the Central Executive, the Saliency and the Social Cognition networks in autism spectrum disorder (ASD) in demanding ecological tasks remains unanswered. We addressed this question using a novel task-based fMRI virtual-reality task mimicking a challenging daily-life chore that may present some difficulties to individuals with ASD: the EcoSupermarketX. METHODS: Participants included 29 adolescents: 15 with ASD and 15 with typical neurodevelopment (TD). They performed the EcoSupermarketX (a shopping simulation with three goal-oriented sub-tasks including "no cue", "non-social" or "social" cues), during neuroimaging and eye-tracking. RESULTS: ASD differed from TD only in total time and distance to complete the "social cue" sub-task with matched eye-tracking measures. Neuroimaging revealed simultaneous hyperactivation across social, executive, and saliency circuits in ASD. In contrast, ASD showed reduced activation in the parahippocampal gyrus, involved in scene recognition. CONCLUSIONS: When performing a virtual shopping task matching the performance of controls, ASD adolescents hyperactivate three core networks: executive, saliency and social cognition. Parahippocampal hypoactivation is consistent with effortless eidetic scene processing, in line with the notion of peaks and valleys of neural recruitment in individuals with ASD. These hyperactivation/hypoactivation patterns in daily life tasks provide a circuit-level signature of neural diversity in ASD, a possible intervention target. En ligne : https://dx.doi.org/10.1186/s11689-022-09417-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder [texte imprimé] / Susana MOUGA, Auteur ; Isabel Catarina DUARTE, Auteur ; Cátia CAFÉ, Auteur ; Daniela SOUSA, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Cognition  Humans  Magnetic Resonance Imaging  Neuroimaging  Social Cognition  Autism spectrum disorder  Central executive network  Ecological task  Saliency network  Social cognition network  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The concomitant role of the Central Executive, the Saliency and the Social Cognition networks in autism spectrum disorder (ASD) in demanding ecological tasks remains unanswered. We addressed this question using a novel task-based fMRI virtual-reality task mimicking a challenging daily-life chore that may present some difficulties to individuals with ASD: the EcoSupermarketX. METHODS: Participants included 29 adolescents: 15 with ASD and 15 with typical neurodevelopment (TD). They performed the EcoSupermarketX (a shopping simulation with three goal-oriented sub-tasks including "no cue", "non-social" or "social" cues), during neuroimaging and eye-tracking. RESULTS: ASD differed from TD only in total time and distance to complete the "social cue" sub-task with matched eye-tracking measures. Neuroimaging revealed simultaneous hyperactivation across social, executive, and saliency circuits in ASD. In contrast, ASD showed reduced activation in the parahippocampal gyrus, involved in scene recognition. CONCLUSIONS: When performing a virtual shopping task matching the performance of controls, ASD adolescents hyperactivate three core networks: executive, saliency and social cognition. Parahippocampal hypoactivation is consistent with effortless eidetic scene processing, in line with the notion of peaks and valleys of neural recruitment in individuals with ASD. These hyperactivation/hypoactivation patterns in daily life tasks provide a circuit-level signature of neural diversity in ASD, a possible intervention target. En ligne : https://dx.doi.org/10.1186/s11689-022-09417-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders / Catarina T. CORREIA in Molecular Autism, (April 2014)  

Public ISBD [article]  inMolecular Autism > (April 2014) . - p.1-14 Titre : Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders Type de document : texte imprimé Auteurs : Catarina T. CORREIA, Auteur ; Inês C. CONCEIÇÃO, Auteur ; Bárbara OLIVEIRA, Auteur ; Joana COELHO, Auteur ; Inês SOUSA, Auteur ; Ana F. SEQUEIRA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Susana MOUGA, Auteur ; Wendy ROBERTS, Auteur ; Kun GAO, Auteur ; Jennifer K. LOWE, Auteur ; Bhooma THIRUVAHINDRAPURAM, Auteur ; Susan WALKER, Auteur ; Christian R. MARSHALL, Auteur ; Dalila PINTO, Auteur ; John NURNBERGER, Auteur ; Stephen SCHERER, Auteur ; Daniel H. GESCHWIND, Auteur ; Guiomar OLIVEIRA, Auteur ; Astrid M. VICENTE, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Validating the potential pathogenicity of copy number variants (CNVs) identified in genome-wide studies of autism spectrum disorders (ASD) requires detailed assessment of case/control frequencies, inheritance patterns, clinical correlations, and functional impact. Here, we characterize a small recurrent duplication in the annexin A1 (ANXA1) gene, identified by the Autism Genome Project (AGP) study. En ligne : http://dx.doi.org/10.1186/2040-2392-5-28 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders [texte imprimé] / Catarina T. CORREIA, Auteur ; Inês C. CONCEIÇÃO, Auteur ; Bárbara OLIVEIRA, Auteur ; Joana COELHO, Auteur ; Inês SOUSA, Auteur ; Ana F. SEQUEIRA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Susana MOUGA, Auteur ; Wendy ROBERTS, Auteur ; Kun GAO, Auteur ; Jennifer K. LOWE, Auteur ; Bhooma THIRUVAHINDRAPURAM, Auteur ; Susan WALKER, Auteur ; Christian R. MARSHALL, Auteur ; Dalila PINTO, Auteur ; John NURNBERGER, Auteur ; Stephen SCHERER, Auteur ; Daniel H. GESCHWIND, Auteur ; Guiomar OLIVEIRA, Auteur ; Astrid M. VICENTE, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (April 2014) . - p.1-14 Index. décimale : PER Périodiques Résumé : Validating the potential pathogenicity of copy number variants (CNVs) identified in genome-wide studies of autism spectrum disorders (ASD) requires detailed assessment of case/control frequencies, inheritance patterns, clinical correlations, and functional impact. Here, we characterize a small recurrent duplication in the annexin A1 (ANXA1) gene, identified by the Autism Genome Project (AGP) study. En ligne : http://dx.doi.org/10.1186/2040-2392-5-28 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

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