Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) / Madeleine J. GROOM in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1496-1509 Titre : Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) Type de document : texte imprimé Auteurs : Madeleine J. GROOM, Auteur ; Puja KOCHHAR, Auteur ; Antonia HAMILTON, Auteur ; Elizabeth B. LIDDLE, Auteur ; Marina SIMEOU, Auteur ; Chris HOLLIS, Auteur Article en page(s) : p.1496-1509 Langues : Anglais (eng) Mots-clés : ASD  ADHD  ERPs  Comorbidity  Gaze cueing  Face processing Index. décimale : PER Périodiques Résumé : This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects of ASD, ADHD and their interaction on the EDAN, an ERP marker of orienting visual attention towards a spatially cued location and the N170, a right-hemisphere lateralised ERP linked to face processing. We identified atypical gaze cue and face processing in children with ASD and ADHD+ASD compared with the ADHD and CTRL groups. The findings indicate a neurobiological basis for the presence of comorbid ASD symptoms in ADHD. Further research using larger samples is needed. En ligne : http://dx.doi.org/10.1007/s10803-017-3078-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) [texte imprimé] / Madeleine J. GROOM, Auteur ; Puja KOCHHAR, Auteur ; Antonia HAMILTON, Auteur ; Elizabeth B. LIDDLE, Auteur ; Marina SIMEOU, Auteur ; Chris HOLLIS, Auteur . - p.1496-1509. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1496-1509 Mots-clés : ASD  ADHD  ERPs  Comorbidity  Gaze cueing  Face processing Index. décimale : PER Périodiques Résumé : This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects of ASD, ADHD and their interaction on the EDAN, an ERP marker of orienting visual attention towards a spatially cued location and the N170, a right-hemisphere lateralised ERP linked to face processing. We identified atypical gaze cue and face processing in children with ASD and ADHD+ASD compared with the ADHD and CTRL groups. The findings indicate a neurobiological basis for the presence of comorbid ASD symptoms in ADHD. Further research using larger samples is needed. En ligne : http://dx.doi.org/10.1007/s10803-017-3078-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions / Alessio BELLATO in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4679-4691 Titre : Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions Type de document : texte imprimé Auteurs : Alessio BELLATO, Auteur ; Iti ARORA, Auteur ; Puja KOCHHAR, Auteur ; Danielle ROPAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur Article en page(s) : p.4679-4691 Langues : Anglais (eng) Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Autonomic Nervous System  Child  Heart Rate/physiology  Humans  Adhd  Autism  Cognitive function  Comorbidity  Heart rate variability Index. décimale : PER Périodiques Résumé : Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents with autism, ADHD, co-occurring autism/ADHD, and neurotypical controls. Heart rate variability was recorded during resting-state, a 'passive' auditory oddball task and an 'active' response conflict task. Autistic children showed hyper-arousal during the active task, while those with ADHD showed hypo-arousal during resting-state and the passive task. Irrespective of diagnosis, children characterised by hyper-arousal showed more severe autistic symptomatology, increased anxiety and reduced global functioning than those displaying hypo-arousal, suggesting the importance of considering individual autonomic arousal profiles for differential diagnosis of autism/ADHD and when developing personalised interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05244-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions [texte imprimé] / Alessio BELLATO, Auteur ; Iti ARORA, Auteur ; Puja KOCHHAR, Auteur ; Danielle ROPAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur . - p.4679-4691. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4679-4691 Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Autonomic Nervous System  Child  Heart Rate/physiology  Humans  Adhd  Autism  Cognitive function  Comorbidity  Heart rate variability Index. décimale : PER Périodiques Résumé : Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents with autism, ADHD, co-occurring autism/ADHD, and neurotypical controls. Heart rate variability was recorded during resting-state, a 'passive' auditory oddball task and an 'active' response conflict task. Autistic children showed hyper-arousal during the active task, while those with ADHD showed hypo-arousal during resting-state and the passive task. Irrespective of diagnosis, children characterised by hyper-arousal showed more severe autistic symptomatology, increased anxiety and reduced global functioning than those displaying hypo-arousal, suggesting the importance of considering individual autonomic arousal profiles for differential diagnosis of autism/ADHD and when developing personalised interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05244-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Practitioner Review: Pathways to care for ADHD – a systematic review of barriers and facilitators / Nicola WRIGHT in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.598-617 Titre : Practitioner Review: Pathways to care for ADHD – a systematic review of barriers and facilitators Type de document : texte imprimé Auteurs : Nicola WRIGHT, Auteur ; Maria MOLDAVSKY, Auteur ; Justine SCHNEIDER, Auteur ; Ipsita CHAKRABARTI, Auteur ; Janine COATES, Auteur ; David DALEY, Auteur ; Puja KOCHHAR, Auteur ; Jon MILLS, Auteur ; Walid SOROUR, Auteur ; Kapil SAYAL, Auteur Article en page(s) : p.598-617 Langues : Anglais (eng) Mots-clés : Attention-deficit disorder with hyperactivity  child  continuity of patient care  health service needs and demands  developmental disability Index. décimale : PER Périodiques Résumé : Background Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder starting in childhood that may persist into adulthood. It can be managed through carefully monitored medication and nonpharmacological interventions. Access to care for children at risk of ADHD varies both within and between countries. A systematic literature review was conducted to investigate the research evidence related to factors which influence children accessing services for ADHD. Method Studies investigating access to care for children at risk of ADHD were identified through electronic searches of the international peer-reviewed and grey literature. Databases were searched from inception till 30th April 2012. This identified 23,156 articles which were subjected to three levels of screening (title, abstract and full text) by a minimum of two independent reviewers. Due to the heterogeneity in the study designs, a narrative approach was used to present the findings. Results Twenty-seven papers met the inclusion criteria; these were grouped into four main themes, with some papers being included in more than one. These were wider determinants (10 papers); identification of need (9 papers); entry and continuity of care (13 papers) and interventions to improve access (4 papers). Barriers and facilitators to access were found to operate at the individual, organisational and societal level. Limited evidence of effective interventions to improve access was identified. Conclusion This review explored the multilayered obstacles in the pathway to care for children at risk of ADHD and the lack of evidence-based interventions designed to address these issues, thereby indicating areas for service development and further evaluative research. En ligne : http://dx.doi.org/10.1111/jcpp.12398 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Practitioner Review: Pathways to care for ADHD – a systematic review of barriers and facilitators [texte imprimé] / Nicola WRIGHT, Auteur ; Maria MOLDAVSKY, Auteur ; Justine SCHNEIDER, Auteur ; Ipsita CHAKRABARTI, Auteur ; Janine COATES, Auteur ; David DALEY, Auteur ; Puja KOCHHAR, Auteur ; Jon MILLS, Auteur ; Walid SOROUR, Auteur ; Kapil SAYAL, Auteur . - p.598-617. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.598-617 Mots-clés : Attention-deficit disorder with hyperactivity  child  continuity of patient care  health service needs and demands  developmental disability Index. décimale : PER Périodiques Résumé : Background Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder starting in childhood that may persist into adulthood. It can be managed through carefully monitored medication and nonpharmacological interventions. Access to care for children at risk of ADHD varies both within and between countries. A systematic literature review was conducted to investigate the research evidence related to factors which influence children accessing services for ADHD. Method Studies investigating access to care for children at risk of ADHD were identified through electronic searches of the international peer-reviewed and grey literature. Databases were searched from inception till 30th April 2012. This identified 23,156 articles which were subjected to three levels of screening (title, abstract and full text) by a minimum of two independent reviewers. Due to the heterogeneity in the study designs, a narrative approach was used to present the findings. Results Twenty-seven papers met the inclusion criteria; these were grouped into four main themes, with some papers being included in more than one. These were wider determinants (10 papers); identification of need (9 papers); entry and continuity of care (13 papers) and interventions to improve access (4 papers). Barriers and facilitators to access were found to operate at the individual, organisational and societal level. Limited evidence of effective interventions to improve access was identified. Conclusion This review explored the multilayered obstacles in the pathway to care for children at risk of ADHD and the lack of evidence-based interventions designed to address these issues, thereby indicating areas for service development and further evaluative research. En ligne : http://dx.doi.org/10.1111/jcpp.12398 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

A Qualitative Study Exploring the Acceptability of Taking Part in a Large Multicentre RCT of Medication for Anxiety in Autistic Adults (the STRATA Trial) / Alba X. REALPE in Autism, 30-9 (September 2026)  

Public ISBD [article]  inAutism > 30-9 (September 2026) . - p.2318-2333 Titre : A Qualitative Study Exploring the Acceptability of Taking Part in a Large Multicentre RCT of Medication for Anxiety in Autistic Adults (the STRATA Trial) Type de document : texte imprimé Auteurs : Alba X. REALPE, Auteur ; Jade Eloise NORRIS, Auteur ; Ava LORENC, Auteur ; Leonora COTTON, Auteur ; Zoe MORGAN, Auteur ; Aws SADIK, Auteur ; Dheeraj RAI, Auteur ; Nicola MILLS, Auteur ; null NULL, Auteur ; David CARMICHAEL, Auteur ; Madeleine COCHRANE, Auteur ; Leonora COTTON, Auteur ; Abbie COTTRELL, Auteur ; Martin HOUSE, Auteur ; David KESSLER, Auteur ; Amanda LEWIS, Auteur ; Ava LORENC, Auteur ; Stephanie MACNEILL, Auteur ; Tim MEDLICOTT, Auteur ; Nicola MILLS, Auteur ; Maximiliano Vazquez MORALES, Auteur ; Jade Eloise NORRIS, Auteur ; Sunita PROCTER, Auteur ; Dheeraj RAI, Auteur ; Alba X REALPE, Auteur ; Jodi TAYLOR, Auteur ; Joanna THORN, Auteur ; Nicholas TURNER, Auteur ; Doug WEBB, Auteur ; Nicola WILES, Auteur ; Sarah DOUGLAS, Auteur ; Peter HALE, Auteur ; Sarah O’BRIEN, Auteur ; Amy WALKER, Auteur ; Jack WELCH, Auteur ; Claire CREE, Auteur ; Liz MCCULLAGH, Auteur ; Alex PARSONS, Auteur ; Jake ALBERTS, Auteur ; Monalisa BORA-WHITE, Auteur ; Alison CAPE, Auteur ; Victoria NIMMO-SMITH, Auteur ; Krist NOONAN, Auteur ; Dheeraj RAI, Auteur ; Aws SADIK, Auteur ; Holly SPRAY, Auteur ; Alexandra YOUNG, Auteur ; Gaurav BHATTARAI, Auteur ; Emma BUTLER, Auteur ; Suzee CHANG, Auteur ; Amy DAVIS, Auteur ; Laura JENKINS, Auteur ; Rose JONES, Auteur ; Laura LORD, Auteur ; Ariska BARBOSA, Auteur ; Didiana DOS SANTOS, Auteur ; Abhishek JHA, Auteur ; Sujata SONI, Auteur ; Kerry FLAHIVE, Auteur ; Emma HORNE, Auteur ; Liz LENAGHAN, Auteur ; Rani PATHANIA, Auteur ; Hafsa SHEIKH, Auteur ; Katie EWART, Auteur ; Anneka NEWMAN, Auteur ; Karen POON, Auteur ; Prasanna RAJBHANDARI, Auteur ; Amy GREEN, Auteur ; Brionne THOMAS, Auteur ; Regi ALEXANDER, Auteur ; Ayomipo Jeremiah AMIOLA, Auteur ; Peter LANGDON, Auteur ; Inder SAWHNEY, Auteur ; Lucy ALLENDER, Auteur ; Wendy ANDRUSJAK, Auteur ; Conor DAVIDSON, Auteur ; Sana FATIMA, Auteur ; Sharmistha GHOSH, Auteur ; Lisa HACKNEY, Auteur ; Alwyn KAM, Auteur ; Keri LODGE, Auteur ; Charlotte MACKNEY-HUDSON, Auteur ; Sarah PARKINSON, Auteur ; Holly LIVESEY, Auteur ; Eleni TSAPPIS, Auteur ; Sharon AUJLA, Auteur ; Sarah BAILLON, Auteur ; Meera BENTLEY, Auteur ; Asit BISWAS, Auteur ; Joy Fellows DAVIS, Auteur ; Ganesh KUNJITHAPATHAM, Auteur ; Rebekah POLE, Auteur ; Samuel TROMANS, Auteur ; Regi ALEXANDER, Auteur ; Catherine HAIG, Auteur ; Stephanie HOWARD, Auteur ; Ayomipo Jeremiah AMIOLA, Auteur ; Charlotte MAPLANKA, Auteur ; Gisela PEREZ-OLIVAS, Auteur ; Jack CHESHIRE, Auteur ; Jacqueline DZIEWANOWSKA, Auteur ; Angela HOLLAND, Auteur ; Puja KOCHHAR, Auteur ; Sowmy MURICKAL, Auteur ; Susan SMITH, Auteur ; Joshua CUDWORTH, Auteur ; Solveig HASELBACH, Auteur ; Jeremy MUDUNKOTUWE, Auteur ; Raja MUKHERJEE, Auteur ; Maria DEL PICCOLO, Auteur ; Ashkan SOWHANI, Auteur ; Emma GLASSON, Auteur ; Katherine HATCH, Auteur ; Helen LEONARD, Auteur ; Sergio STARKSTEIN, Auteur ; Bradleigh HAYHOW, Auteur ; Eleanor TEO, Auteur ; Don HULME, Auteur ; Katrina ORR, Auteur ; Ailsa RUSSELL, Auteur ; Traolach BRUGHA, Auteur ; Zoe MORGAN, Auteur ; David BALDWIN, Auteur ; Peter LANGDON, Auteur ; Jemma REGAN, Auteur ; Jonathan MARTIN, Auteur ; Alice MADDEN, Auteur ; Kathryn JANES, Auteur Article en page(s) : p.2318-2333 Langues : Anglais (eng) Mots-clés : autism  anxiety  randomisation  blinding  RCT  neurodevelopmental conditions  research participation  underserved populations  trial methodology  qualitative research Index. décimale : PER Périodiques Résumé : Autistic adults experience significant physical and mental health inequities yet remain underrepresented in clinical research, with few randomised controlled trials to guide care. Randomised controlled trials (RCTs) of selective serotonin reuptake inhibitors (SSRIs) are limited, underpowered, and rarely focused on anxiety. Anticipating recruitment challenges in a large RCT (“STRATA”) evaluating sertraline for anxiety in autistic adults, we embedded qualitative research to support recruitment, retention, and monitoring trial acceptability. We organised our findings into the theoretical framework of acceptability (TFA) constructs to assess the acceptability of trial design and delivery for autistic adults. We conducted 64 interviews with autistic adults at different trial stages. Data were analysed thematically and mapped to the seven TFA constructs. Participants considered involvement in a blinded medication RCT acceptable across the TFA domains, which they weighed differently when reflecting on anticipated versus experienced aspects of participation. STRATA was a low-burden, ethically sound, and methodologically coherent study for most participants, who reported minimal trade-offs, potential benefits, and self-efficacy in managing anxiety and research participation. Acceptability of trial participation is dynamic and multidimensional, which can be enhanced by meaningful involvement of autistic people throughout the research cycle, accessible participant information design, and responsive ongoing engagement.Lay Abstract Autistic adults often experience poorer physical and mental health than the general population. Yet they are rarely included in clinical research. There have been very few high-quality studies (RCTs) testing medications for anxiety in this group. Most existing studies are small and focus on other outcomes. They don’t provide clear guidance for care. To help address this gap, the STRATA trial tested whether the medication sertraline (an SSRI) can reduce anxiety in autistic adults. Recruiting participants for such trials can be challenging. We included a qualitative study to better understand what helps or hinders people from joining and staying in the trial. We aimed to explore what aspects of the STRATA trial made it easier or more appealing for autistic adults to take part. We used a framework called the theoretical framework of acceptability (TFA) to define acceptability in this context. We interviewed 64 autistic adults at different stages of the trial, including 2 who chose not to take part. Most participants found the trial acceptable when assessed against the seven aspects of the TFA (i.e., how someone feels about taking part, how much effort is needed, whether taking part fits with a person’s values, how well someone understands the study, what someone may have to give up, whether the study is likely to help, and how confident someone feels about taking part). In summary, they felt positive about taking part. They thought the study was ethical and easy to understand and believed it could benefit them. Many also felt more confident in managing their anxiety and contributing to research. STRATA is one of the largest studies of its kind; 318 autistic adults took part across the United Kingdom and Australia. The trial had a very high retention rate. Ninety-two per cent of participants stayed until the main outcome point, and 87% completed the full 52 weeks. How acceptable clinical trials like STRATA are may change during their course, and researchers need to be responsive. To do this well, researchers should involve autistic people meaningfully throughout the research process and from an early stage. Researchers also need to respect individual communication needs and provide clear and accessible information. These approaches were central to STRATA and supported by other studies. En ligne : https://dx.doi.org/10.1177/13623613261466306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] A Qualitative Study Exploring the Acceptability of Taking Part in a Large Multicentre RCT of Medication for Anxiety in Autistic Adults (the STRATA Trial) [texte imprimé] / Alba X. REALPE, Auteur ; Jade Eloise NORRIS, Auteur ; Ava LORENC, Auteur ; Leonora COTTON, Auteur ; Zoe MORGAN, Auteur ; Aws SADIK, Auteur ; Dheeraj RAI, Auteur ; Nicola MILLS, Auteur ; null NULL, Auteur ; David CARMICHAEL, Auteur ; Madeleine COCHRANE, Auteur ; Leonora COTTON, Auteur ; Abbie COTTRELL, Auteur ; Martin HOUSE, Auteur ; David KESSLER, Auteur ; Amanda LEWIS, Auteur ; Ava LORENC, Auteur ; Stephanie MACNEILL, Auteur ; Tim MEDLICOTT, Auteur ; Nicola MILLS, Auteur ; Maximiliano Vazquez MORALES, Auteur ; Jade Eloise NORRIS, Auteur ; Sunita PROCTER, Auteur ; Dheeraj RAI, Auteur ; Alba X REALPE, Auteur ; Jodi TAYLOR, Auteur ; Joanna THORN, Auteur ; Nicholas TURNER, Auteur ; Doug WEBB, Auteur ; Nicola WILES, Auteur ; Sarah DOUGLAS, Auteur ; Peter HALE, Auteur ; Sarah O’BRIEN, Auteur ; Amy WALKER, Auteur ; Jack WELCH, Auteur ; Claire CREE, Auteur ; Liz MCCULLAGH, Auteur ; Alex PARSONS, Auteur ; Jake ALBERTS, Auteur ; Monalisa BORA-WHITE, Auteur ; Alison CAPE, Auteur ; Victoria NIMMO-SMITH, Auteur ; Krist NOONAN, Auteur ; Dheeraj RAI, Auteur ; Aws SADIK, Auteur ; Holly SPRAY, Auteur ; Alexandra YOUNG, Auteur ; Gaurav BHATTARAI, Auteur ; Emma BUTLER, Auteur ; Suzee CHANG, Auteur ; Amy DAVIS, Auteur ; Laura JENKINS, Auteur ; Rose JONES, Auteur ; Laura LORD, Auteur ; Ariska BARBOSA, Auteur ; Didiana DOS SANTOS, Auteur ; Abhishek JHA, Auteur ; Sujata SONI, Auteur ; Kerry FLAHIVE, Auteur ; Emma HORNE, Auteur ; Liz LENAGHAN, Auteur ; Rani PATHANIA, Auteur ; Hafsa SHEIKH, Auteur ; Katie EWART, Auteur ; Anneka NEWMAN, Auteur ; Karen POON, Auteur ; Prasanna RAJBHANDARI, Auteur ; Amy GREEN, Auteur ; Brionne THOMAS, Auteur ; Regi ALEXANDER, Auteur ; Ayomipo Jeremiah AMIOLA, Auteur ; Peter LANGDON, Auteur ; Inder SAWHNEY, Auteur ; Lucy ALLENDER, Auteur ; Wendy ANDRUSJAK, Auteur ; Conor DAVIDSON, Auteur ; Sana FATIMA, Auteur ; Sharmistha GHOSH, Auteur ; Lisa HACKNEY, Auteur ; Alwyn KAM, Auteur ; Keri LODGE, Auteur ; Charlotte MACKNEY-HUDSON, Auteur ; Sarah PARKINSON, Auteur ; Holly LIVESEY, Auteur ; Eleni TSAPPIS, Auteur ; Sharon AUJLA, Auteur ; Sarah BAILLON, Auteur ; Meera BENTLEY, Auteur ; Asit BISWAS, Auteur ; Joy Fellows DAVIS, Auteur ; Ganesh KUNJITHAPATHAM, Auteur ; Rebekah POLE, Auteur ; Samuel TROMANS, Auteur ; Regi ALEXANDER, Auteur ; Catherine HAIG, Auteur ; Stephanie HOWARD, Auteur ; Ayomipo Jeremiah AMIOLA, Auteur ; Charlotte MAPLANKA, Auteur ; Gisela PEREZ-OLIVAS, Auteur ; Jack CHESHIRE, Auteur ; Jacqueline DZIEWANOWSKA, Auteur ; Angela HOLLAND, Auteur ; Puja KOCHHAR, Auteur ; Sowmy MURICKAL, Auteur ; Susan SMITH, Auteur ; Joshua CUDWORTH, Auteur ; Solveig HASELBACH, Auteur ; Jeremy MUDUNKOTUWE, Auteur ; Raja MUKHERJEE, Auteur ; Maria DEL PICCOLO, Auteur ; Ashkan SOWHANI, Auteur ; Emma GLASSON, Auteur ; Katherine HATCH, Auteur ; Helen LEONARD, Auteur ; Sergio STARKSTEIN, Auteur ; Bradleigh HAYHOW, Auteur ; Eleanor TEO, Auteur ; Don HULME, Auteur ; Katrina ORR, Auteur ; Ailsa RUSSELL, Auteur ; Traolach BRUGHA, Auteur ; Zoe MORGAN, Auteur ; David BALDWIN, Auteur ; Peter LANGDON, Auteur ; Jemma REGAN, Auteur ; Jonathan MARTIN, Auteur ; Alice MADDEN, Auteur ; Kathryn JANES, Auteur . - p.2318-2333. Langues : Anglais (eng) in Autism > 30-9 (September 2026) . - p.2318-2333 Mots-clés : autism  anxiety  randomisation  blinding  RCT  neurodevelopmental conditions  research participation  underserved populations  trial methodology  qualitative research Index. décimale : PER Périodiques Résumé : Autistic adults experience significant physical and mental health inequities yet remain underrepresented in clinical research, with few randomised controlled trials to guide care. Randomised controlled trials (RCTs) of selective serotonin reuptake inhibitors (SSRIs) are limited, underpowered, and rarely focused on anxiety. Anticipating recruitment challenges in a large RCT (“STRATA”) evaluating sertraline for anxiety in autistic adults, we embedded qualitative research to support recruitment, retention, and monitoring trial acceptability. We organised our findings into the theoretical framework of acceptability (TFA) constructs to assess the acceptability of trial design and delivery for autistic adults. We conducted 64 interviews with autistic adults at different trial stages. Data were analysed thematically and mapped to the seven TFA constructs. Participants considered involvement in a blinded medication RCT acceptable across the TFA domains, which they weighed differently when reflecting on anticipated versus experienced aspects of participation. STRATA was a low-burden, ethically sound, and methodologically coherent study for most participants, who reported minimal trade-offs, potential benefits, and self-efficacy in managing anxiety and research participation. Acceptability of trial participation is dynamic and multidimensional, which can be enhanced by meaningful involvement of autistic people throughout the research cycle, accessible participant information design, and responsive ongoing engagement.Lay Abstract Autistic adults often experience poorer physical and mental health than the general population. Yet they are rarely included in clinical research. There have been very few high-quality studies (RCTs) testing medications for anxiety in this group. Most existing studies are small and focus on other outcomes. They don’t provide clear guidance for care. To help address this gap, the STRATA trial tested whether the medication sertraline (an SSRI) can reduce anxiety in autistic adults. Recruiting participants for such trials can be challenging. We included a qualitative study to better understand what helps or hinders people from joining and staying in the trial. We aimed to explore what aspects of the STRATA trial made it easier or more appealing for autistic adults to take part. We used a framework called the theoretical framework of acceptability (TFA) to define acceptability in this context. We interviewed 64 autistic adults at different stages of the trial, including 2 who chose not to take part. Most participants found the trial acceptable when assessed against the seven aspects of the TFA (i.e., how someone feels about taking part, how much effort is needed, whether taking part fits with a person’s values, how well someone understands the study, what someone may have to give up, whether the study is likely to help, and how confident someone feels about taking part). In summary, they felt positive about taking part. They thought the study was ethical and easy to understand and believed it could benefit them. Many also felt more confident in managing their anxiety and contributing to research. STRATA is one of the largest studies of its kind; 318 autistic adults took part across the United Kingdom and Australia. The trial had a very high retention rate. Ninety-two per cent of participants stayed until the main outcome point, and 87% completed the full 52 weeks. How acceptable clinical trials like STRATA are may change during their course, and researchers need to be responsive. To do this well, researchers should involve autistic people meaningfully throughout the research process and from an early stage. Researchers also need to respect individual communication needs and provide clear and accessible information. These approaches were central to STRATA and supported by other studies. En ligne : https://dx.doi.org/10.1177/13623613261466306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? / Iti ARORA in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.600-616 Titre : What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? Type de document : texte imprimé Auteurs : Iti ARORA, Auteur ; Alessio BELLATO, Auteur ; Teodora GLIGA, Auteur ; Danielle ROPAR, Auteur ; Puja KOCHHAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur Article en page(s) : p.600-616 Langues : Anglais (eng) Mots-clés : Adolescent  Attentional Bias  Autism Spectrum Disorder  Autistic Disorder  Child  Humans  Autism  Autistic traits  Eye-tracking  Habituation  Information foraging Index. décimale : PER Périodiques Résumé : Slower habituation to repeating stimuli characterises Autism, but it is not known whether this is driven by difficulties with information processing or an attentional bias towards sameness. We conducted eye-tracking and presented looming geometrical shapes, clocks with moving arms and smiling faces, as two separate streams of stimuli (one repeating and one changing), to 7-15 years old children and adolescents (n = 103) with Autism, ADHD or co-occurring Autism+ADHD, and neurotypical children (Study-1); and to neurotypical children (n = 64) with varying levels of autistic traits (Study-2). Across both studies, autistic features were associated with longer looks to the repeating stimulus, and shorter looks to the changing stimulus, but only for more complex stimuli, indicating greater difficulty in processing complex or unpredictable information. En ligne : http://dx.doi.org/10.1007/s10803-021-04961-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? [texte imprimé] / Iti ARORA, Auteur ; Alessio BELLATO, Auteur ; Teodora GLIGA, Auteur ; Danielle ROPAR, Auteur ; Puja KOCHHAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur . - p.600-616. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.600-616 Mots-clés : Adolescent  Attentional Bias  Autism Spectrum Disorder  Autistic Disorder  Child  Humans  Autism  Autistic traits  Eye-tracking  Habituation  Information foraging Index. décimale : PER Périodiques Résumé : Slower habituation to repeating stimuli characterises Autism, but it is not known whether this is driven by difficulties with information processing or an attentional bias towards sameness. We conducted eye-tracking and presented looming geometrical shapes, clocks with moving arms and smiling faces, as two separate streams of stimuli (one repeating and one changing), to 7-15 years old children and adolescents (n = 103) with Autism, ADHD or co-occurring Autism+ADHD, and neurotypical children (Study-1); and to neurotypical children (n = 64) with varying levels of autistic traits (Study-2). Across both studies, autistic features were associated with longer looks to the repeating stimulus, and shorter looks to the changing stimulus, but only for more complex stimuli, indicating greater difficulty in processing complex or unpredictable information. En ligne : http://dx.doi.org/10.1007/s10803-021-04961-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

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