Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts / Lucy THOMPSON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290 Titre : Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts Type de document : texte imprimé Auteurs : Lucy THOMPSON, Auteur ; Christopher GILLBERG, Auteur ; Sara LANDBERG, Auteur ; Anne-Katrin KANTZER, Auteur ; Carmela MINISCALCO, Auteur ; Martina BARNEVIK OLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Elisabeth FERNELL, Auteur Article en page(s) : p.2281-2290 Langues : Anglais (eng) Mots-clés : Asd  Autism  Developmental language disorder  Intellectual developmental disorder  Non-regressive autism  Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts [texte imprimé] / Lucy THOMPSON, Auteur ; Christopher GILLBERG, Auteur ; Sara LANDBERG, Auteur ; Anne-Katrin KANTZER, Auteur ; Carmela MINISCALCO, Auteur ; Martina BARNEVIK OLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Elisabeth FERNELL, Auteur . - p.2281-2290. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290 Mots-clés : Asd  Autism  Developmental language disorder  Intellectual developmental disorder  Non-regressive autism  Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Children with autism spectrum disorders who do not develop phrase speech in the preschool years / Fritjof NORRELGEN in Autism, 19-8 (November 2015)  

Public ISBD [article]  inAutism > 19-8 (November 2015) . - p.934-943 Titre : Children with autism spectrum disorders who do not develop phrase speech in the preschool years Type de document : texte imprimé Auteurs : Fritjof NORRELGEN, Auteur ; Elisabeth FERNELL, Auteur ; Mats ERIKSSON, Auteur ; Asa HEDVALL, Auteur ; Clara PERSSON, Auteur ; Maria SJÖLIN, Auteur ; Christopher GILLBERG, Auteur ; Liselotte KJELLMER, Auteur Article en page(s) : p.934-943 Langues : Anglais (eng) Mots-clés : autism  intellectual disability  minimally verbal  nonverbal  preschool  Vineland Index. décimale : PER Périodiques Résumé : There is uncertainty about the proportion of children with autism spectrum disorders who do not develop phrase speech during the preschool years. The main purpose of this study was to examine this ratio in a population-based community sample of children. The cohort consisted of 165 children (141 boys, 24 girls) with autism spectrum disorders aged 4–6 years followed longitudinally over 2 years during which time they had received intervention at a specialized autism center. In this study, data collected at the 2-year follow-up were used. Three categories of expressive language were defined: nonverbal, minimally verbal, and phrase speech. Data from the Vineland Adaptive Behavior Scales-II were used to classify expressive language. A secondary objective of the study was to analyze factors that might be linked to verbal ability, namely, child age, cognitive level, autism subtype and severity of core autism symptoms, developmental regression, epilepsy or other medical conditions, and intensity of intervention. The proportion of children who met the criteria for nonverbal, minimally verbal, and phrase speech were 15%, 10%, and 75%, respectively. The single most important factor linked to expressive language was the child’s cognitive level, and all children classified as being nonverbal or minimally verbal had intellectual disability. En ligne : http://dx.doi.org/10.1177/1362361314556782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269 [article] Children with autism spectrum disorders who do not develop phrase speech in the preschool years [texte imprimé] / Fritjof NORRELGEN, Auteur ; Elisabeth FERNELL, Auteur ; Mats ERIKSSON, Auteur ; Asa HEDVALL, Auteur ; Clara PERSSON, Auteur ; Maria SJÖLIN, Auteur ; Christopher GILLBERG, Auteur ; Liselotte KJELLMER, Auteur . - p.934-943. Langues : Anglais (eng) in Autism > 19-8 (November 2015) . - p.934-943 Mots-clés : autism  intellectual disability  minimally verbal  nonverbal  preschool  Vineland Index. décimale : PER Périodiques Résumé : There is uncertainty about the proportion of children with autism spectrum disorders who do not develop phrase speech during the preschool years. The main purpose of this study was to examine this ratio in a population-based community sample of children. The cohort consisted of 165 children (141 boys, 24 girls) with autism spectrum disorders aged 4–6 years followed longitudinally over 2 years during which time they had received intervention at a specialized autism center. In this study, data collected at the 2-year follow-up were used. Three categories of expressive language were defined: nonverbal, minimally verbal, and phrase speech. Data from the Vineland Adaptive Behavior Scales-II were used to classify expressive language. A secondary objective of the study was to analyze factors that might be linked to verbal ability, namely, child age, cognitive level, autism subtype and severity of core autism symptoms, developmental regression, epilepsy or other medical conditions, and intensity of intervention. The proportion of children who met the criteria for nonverbal, minimally verbal, and phrase speech were 15%, 10%, and 75%, respectively. The single most important factor linked to expressive language was the child’s cognitive level, and all children classified as being nonverbal or minimally verbal had intellectual disability. En ligne : http://dx.doi.org/10.1177/1362361314556782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269

HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study / Ryad TAMOUZA in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.182-186 Titre : HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study Type de document : texte imprimé Auteurs : Ryad TAMOUZA, Auteur ; Elisabeth FERNELL, Auteur ; Mats Anders ERIKSSON, Auteur ; Britt-Marie ANDERLID, Auteur ; Celine MANIER, Auteur ; Christina Mary MARIASELVAM, Auteur ; Wahid BOUKOUACI, Auteur ; Marion LEBOYER, Auteur ; Christopher GILLBERG, Auteur Article en page(s) : p.182-186 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  autoimmunity  haplotypes  human leucocyte antigens  inflammation  regression Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) comprises heterogeneous neurodevelopmental conditions with symptom onset usually during infancy. However, about 10%-30% of affected cases experience a loss of language and social skills around 18-30 months, so-called regressive autism. In this subset with regression, immune dysfunctions including inflammation and autoimmunity have been proposed to be at risk factors. Given the implication of the human histocompatibility antigens (HLA) system in various aspects of immune responses, including autoimmunity, and in ASD, we investigate here the distribution of the HLA Class I and Class II haplotypes in 131 children with ASD meeting DSM-IV TR criteria, with and without regression. We found that 62 of the 98 non-regressive ASD patients carry the HLA-DPA1*01-DPB1*04 sub-haplotype as compared to 14 of the 33 patients with regression (63% vs. 43% respectively, Pc = 0.02), suggesting that this HLA haplotype may exert a protective effect against regression. Similarly, the HLA-DPA1*01-DPB1*04 has also been found to be more represented in healthy controls as compared to patients affected with common nonpsychiatric autoimmune disorders. Overall our findings suggest a possible involvement of HLA polymorphism in the context of regressive ASD. Autism Res 2020, 13: 182-186. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Immune dysfunctions including inflammatory and autoimmune processes have been reported in autism, particularly in regressive forms. In this study, we analyzed the distribution of HLA haplotypes among children with autism spectrum disorder (ASD), with and without regression from Sweden and observed that HLA-DPA1*01-DPB1*04 sub-haplotype was less represented in patients with regressive autism as compared with those without regression. Such possible protective effect, also observed in other common autoimmune disorders, may constitute a link between HLA-mediated immune processes and regressive ASD. En ligne : http://dx.doi.org/10.1002/aur.2217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study [texte imprimé] / Ryad TAMOUZA, Auteur ; Elisabeth FERNELL, Auteur ; Mats Anders ERIKSSON, Auteur ; Britt-Marie ANDERLID, Auteur ; Celine MANIER, Auteur ; Christina Mary MARIASELVAM, Auteur ; Wahid BOUKOUACI, Auteur ; Marion LEBOYER, Auteur ; Christopher GILLBERG, Auteur . - p.182-186. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.182-186 Mots-clés : autism spectrum disorders  autoimmunity  haplotypes  human leucocyte antigens  inflammation  regression Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) comprises heterogeneous neurodevelopmental conditions with symptom onset usually during infancy. However, about 10%-30% of affected cases experience a loss of language and social skills around 18-30 months, so-called regressive autism. In this subset with regression, immune dysfunctions including inflammation and autoimmunity have been proposed to be at risk factors. Given the implication of the human histocompatibility antigens (HLA) system in various aspects of immune responses, including autoimmunity, and in ASD, we investigate here the distribution of the HLA Class I and Class II haplotypes in 131 children with ASD meeting DSM-IV TR criteria, with and without regression. We found that 62 of the 98 non-regressive ASD patients carry the HLA-DPA1*01-DPB1*04 sub-haplotype as compared to 14 of the 33 patients with regression (63% vs. 43% respectively, Pc = 0.02), suggesting that this HLA haplotype may exert a protective effect against regression. Similarly, the HLA-DPA1*01-DPB1*04 has also been found to be more represented in healthy controls as compared to patients affected with common nonpsychiatric autoimmune disorders. Overall our findings suggest a possible involvement of HLA polymorphism in the context of regressive ASD. Autism Res 2020, 13: 182-186. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Immune dysfunctions including inflammatory and autoimmune processes have been reported in autism, particularly in regressive forms. In this study, we analyzed the distribution of HLA haplotypes among children with autism spectrum disorder (ASD), with and without regression from Sweden and observed that HLA-DPA1*01-DPB1*04 sub-haplotype was less represented in patients with regressive autism as compared with those without regression. Such possible protective effect, also observed in other common autoimmune disorders, may constitute a link between HLA-mediated immune processes and regressive ASD. En ligne : http://dx.doi.org/10.1002/aur.2217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Preschoolers with Autism Spectrum Disorder Followed for 2 Years: Those Who Gained and Those Who Lost the Most in Terms of Adaptive Functioning Outcome / Asa HEDVALL in Journal of Autism and Developmental Disorders, 45-11 (November 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3624-3633 Titre : Preschoolers with Autism Spectrum Disorder Followed for 2 Years: Those Who Gained and Those Who Lost the Most in Terms of Adaptive Functioning Outcome Type de document : texte imprimé Auteurs : Asa HEDVALL, Auteur ; Joakim WESTERLUND, Auteur ; Elisabeth FERNELL, Auteur ; Fritjof NORRELGEN, Auteur ; Liselotte KJELLMER, Auteur ; Martina BARNEVIKOLSSON, Auteur ; Lotta HÖGLUND CARLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Eva BILLSTEDT, Auteur ; Christopher GILLBERG, Auteur Article en page(s) : p.3624-3633 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Outcome  Preschool children  Clinical characteristics  Predictors Index. décimale : PER Périodiques Résumé : Clinical predictors of 2-year outcome in preschoolers with ASD were studied in a population-based group of very young children with ASD (n = 208). Children who gained the most (n = 30) and lost the most (n = 23), i.e., increased or decreased their adaptive functioning outcome according to the Vineland Composite Score between study entry (T1) and follow-up (T2), 2 years later were compared. Individual factors that differed significantly between the two outcome groups were cognitive level, age at referral, not passing expected milestones at 18 months, autistic type behavior problems and regression. However, logistic regression analysis showed that only cognitive level at T1 (dichotomized into IQ < 70 and IQ ≥ 70) made a unique statistically significant contribution to outcome prediction (p = <.001) with an odds ratio of 18.01. The findings have significant clinical implications in terms of information at diagnosis regarding clinical prognosis in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2509-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Preschoolers with Autism Spectrum Disorder Followed for 2 Years: Those Who Gained and Those Who Lost the Most in Terms of Adaptive Functioning Outcome [texte imprimé] / Asa HEDVALL, Auteur ; Joakim WESTERLUND, Auteur ; Elisabeth FERNELL, Auteur ; Fritjof NORRELGEN, Auteur ; Liselotte KJELLMER, Auteur ; Martina BARNEVIKOLSSON, Auteur ; Lotta HÖGLUND CARLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Eva BILLSTEDT, Auteur ; Christopher GILLBERG, Auteur . - p.3624-3633. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3624-3633 Mots-clés : Autism spectrum disorder  Outcome  Preschool children  Clinical characteristics  Predictors Index. décimale : PER Périodiques Résumé : Clinical predictors of 2-year outcome in preschoolers with ASD were studied in a population-based group of very young children with ASD (n = 208). Children who gained the most (n = 30) and lost the most (n = 23), i.e., increased or decreased their adaptive functioning outcome according to the Vineland Composite Score between study entry (T1) and follow-up (T2), 2 years later were compared. Individual factors that differed significantly between the two outcome groups were cognitive level, age at referral, not passing expected milestones at 18 months, autistic type behavior problems and regression. However, logistic regression analysis showed that only cognitive level at T1 (dichotomized into IQ < 70 and IQ ≥ 70) made a unique statistically significant contribution to outcome prediction (p = <.001) with an odds ratio of 18.01. The findings have significant clinical implications in terms of information at diagnosis regarding clinical prognosis in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2509-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

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