Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm / Simona SPINELLI in Development and Psychopathology, 19-4 (Fall 2007)  

Public ISBD [article]  inDevelopment and Psychopathology > 19-4 (Fall 2007) . - p.977-987 Titre : Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm Type de document : Texte imprimé et/ou numérique Auteurs : Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Timothy K. NEWMAN, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur Année de publication : 2007 Article en page(s) : p.977-987 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression. Relative to the long (l) allele, the short (s) allele increases the risk of developing depression in individuals exposed to stressful life events. An orthologue of the human variant is present in rhesus macaques and allows for studies in animals exposed to stress. Here, we used an established model of early life stress exposure, in which rhesus macaques are raised without adults in a group of peers (peer-only reared [PR]), or with their mothers. At 6 months of age, animals were subjected to 4-day long social separations for 4 consecutive weeks, with 3 days of reunion in between. Data were collected during both the acute (Day 1) and chronic phases (Days 2–4) of separation. Behavioral factors were separately extracted for each phase of separation. For acute separation, the behavioral factors generated were despair and behavioral pathology and, for the chronic phase despair, agitation, and behavioral pathology. During both phases of social separation, PR l/s animals were more likely to exhibit pathological behaviors, whereas PR l/l monkeys show higher levels of despair compared to the other three groups. These findings indicate that early stress affects the behavioral response to separation differently as a function of recombinant human serotonin transporter linked polymorphic repeat genotype and suggest that carriers of the s allele are not only more anxious but may also be more vulnerable to developing behavioral pathology in the face of chronic adversity. En ligne : http://dx.doi.org/10.1017/s095457940700048x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181 [article] Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm [Texte imprimé et/ou numérique] / Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Timothy K. NEWMAN, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur . - 2007 . - p.977-987. Langues : Anglais (eng) in Development and Psychopathology > 19-4 (Fall 2007) . - p.977-987 Index. décimale : PER Périodiques Résumé : Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression. Relative to the long (l) allele, the short (s) allele increases the risk of developing depression in individuals exposed to stressful life events. An orthologue of the human variant is present in rhesus macaques and allows for studies in animals exposed to stress. Here, we used an established model of early life stress exposure, in which rhesus macaques are raised without adults in a group of peers (peer-only reared [PR]), or with their mothers. At 6 months of age, animals were subjected to 4-day long social separations for 4 consecutive weeks, with 3 days of reunion in between. Data were collected during both the acute (Day 1) and chronic phases (Days 2–4) of separation. Behavioral factors were separately extracted for each phase of separation. For acute separation, the behavioral factors generated were despair and behavioral pathology and, for the chronic phase despair, agitation, and behavioral pathology. During both phases of social separation, PR l/s animals were more likely to exhibit pathological behaviors, whereas PR l/l monkeys show higher levels of despair compared to the other three groups. These findings indicate that early stress affects the behavioral response to separation differently as a function of recombinant human serotonin transporter linked polymorphic repeat genotype and suggest that carriers of the s allele are not only more anxious but may also be more vulnerable to developing behavioral pathology in the face of chronic adversity. En ligne : http://dx.doi.org/10.1017/s095457940700048x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181

Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation / Renaud MASSART in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1259-1272 Titre : Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation Type de document : Texte imprimé et/ou numérique Auteurs : Renaud MASSART, Auteur ; Zsofia NEMODA, Auteur ; Matthew J. SUDERMAN, Auteur ; Sheila SUTTI, Auteur ; Angela M. RUGGIERO, Auteur ; Amanda M. DETTMER, Auteur ; Stephen J. SUOMI, Auteur ; Moshe SZYF, Auteur Article en page(s) : p.1259-1272 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through 2 years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Maternal separation at birth alters the normal evolution of DNA methylation profiles and targets genes that are also affected by a later stage maternal separation, that is, weaning. Our results suggest that early life events dynamically interfere with the normal developmental evolution of the DNA methylation profile and that these changes are highly effected by sex. En ligne : http://dx.doi.org/10.1017/s0954579416000833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation [Texte imprimé et/ou numérique] / Renaud MASSART, Auteur ; Zsofia NEMODA, Auteur ; Matthew J. SUDERMAN, Auteur ; Sheila SUTTI, Auteur ; Angela M. RUGGIERO, Auteur ; Amanda M. DETTMER, Auteur ; Stephen J. SUOMI, Auteur ; Moshe SZYF, Auteur . - p.1259-1272. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1259-1272 Index. décimale : PER Périodiques Résumé : Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through 2 years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Maternal separation at birth alters the normal evolution of DNA methylation profiles and targets genes that are also affected by a later stage maternal separation, that is, weaning. Our results suggest that early life events dynamically interfere with the normal developmental evolution of the DNA methylation profile and that these changes are highly effected by sex. En ligne : http://dx.doi.org/10.1017/s0954579416000833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys / Alexander BAXTER in Development and Psychopathology, 32-1 (February 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-1 (February 2020) . - p.1-10 Titre : Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys Type de document : Texte imprimé et/ou numérique Auteurs : Alexander BAXTER, Auteur ; Elizabeth K. WOOD, Auteur ; Christina S. BARR, Auteur ; Daniel B. KAY, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Mots-clés : 5-hydroxyindoleacetic acid  development  infant sleep  maternal neglect  serotonin transporter gene Index. décimale : PER Périodiques Résumé : Environmental and biological factors contribute to sleep development during infancy. Parenting plays a particularly important role in modulating infant sleep, potentially via the serotonin system, which is itself involved in regulating infant sleep. We hypothesized that maternal neglect and serotonin system dysregulation would be associated with daytime sleep in infant rhesus monkeys. Subjects were nursery-reared infant rhesus macaques (n = 287). During the first month of life, daytime sleep-wake states were rated bihourly (0800-2100). Infants were considered neglected (n = 16) if before nursery-rearing, their mother repeatedly failed to retrieve them. Serotonin transporter genotype and concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) were used as markers of central serotonin system functioning. t tests showed that neglected infants were observed sleeping less frequently, weighed less, and had higher 5-HIAA than non-neglected nursery-reared infants. Regression revealed that serotonin transporter genotype moderated the relationship between 5-HIAA and daytime sleep: in subjects possessing the Ls genotype, there was a positive correlation between 5-HIAA and daytime sleep, whereas in subjects possessing the LL genotype there was no association. These results highlight the pivotal roles that parents and the serotonin system play in sleep development. Daytime sleep alterations observed in neglected infants may partially derive from serotonin system dysregulation. En ligne : http://dx.doi.org/10.1017/s0954579418001359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys [Texte imprimé et/ou numérique] / Alexander BAXTER, Auteur ; Elizabeth K. WOOD, Auteur ; Christina S. BARR, Auteur ; Daniel B. KAY, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur . - p.1-10. Langues : Anglais (eng) in Development and Psychopathology > 32-1 (February 2020) . - p.1-10 Mots-clés : 5-hydroxyindoleacetic acid  development  infant sleep  maternal neglect  serotonin transporter gene Index. décimale : PER Périodiques Résumé : Environmental and biological factors contribute to sleep development during infancy. Parenting plays a particularly important role in modulating infant sleep, potentially via the serotonin system, which is itself involved in regulating infant sleep. We hypothesized that maternal neglect and serotonin system dysregulation would be associated with daytime sleep in infant rhesus monkeys. Subjects were nursery-reared infant rhesus macaques (n = 287). During the first month of life, daytime sleep-wake states were rated bihourly (0800-2100). Infants were considered neglected (n = 16) if before nursery-rearing, their mother repeatedly failed to retrieve them. Serotonin transporter genotype and concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) were used as markers of central serotonin system functioning. t tests showed that neglected infants were observed sleeping less frequently, weighed less, and had higher 5-HIAA than non-neglected nursery-reared infants. Regression revealed that serotonin transporter genotype moderated the relationship between 5-HIAA and daytime sleep: in subjects possessing the Ls genotype, there was a positive correlation between 5-HIAA and daytime sleep, whereas in subjects possessing the LL genotype there was no association. These results highlight the pivotal roles that parents and the serotonin system play in sleep development. Daytime sleep alterations observed in neglected infants may partially derive from serotonin system dysregulation. En ligne : http://dx.doi.org/10.1017/s0954579418001359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Measuring early life adversity: A dimensional approach / Ilana S. BERMAN in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 499-511 Titre : Measuring early life adversity: A dimensional approach Type de document : Texte imprimé et/ou numérique Auteurs : Ilana S. BERMAN, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Nim TOTTENHAM, Auteur ; Keith GODFREY, Auteur ; Teresa E. SEEMAN, Auteur ; Eric LOUCKS, Auteur ; Stephen J. SUOMI, Auteur ; Andrea DANESE, Auteur ; Margaret A. SHERIDAN, Auteur Article en page(s) : 499-511 Langues : Anglais (eng) Mots-clés : dimensional models  adversity  measurement  deprivation and threat  adverse early experiences  ACEs Index. décimale : PER Périodiques Résumé : Exposure to adversity in childhood is associated with elevations in numerous physical and mental health outcomes across the life course. The biological embedding of early experience during periods of developmental plasticity is one pathway that contributes to these associations. Dimensional models specify mechanistic pathways linking different dimensions of adversity to health and well-being outcomes later in life. While findings from existing studies testing these dimensions have provided promising preliminary support for these models, less agreement exists about how to measure the experiences that comprise each dimension. Here, we review existing approaches to measuring two dimensions of adversity: threat and deprivation. We recommend specific measures for measuring these constructs and, when possible, document when the same measure can be used by different reporters and across the lifespan to maximize the utility with which these recommendations can be applied. Through this approach, we hope to stimulate progress in understanding how particular dimensions of early environmental experience contribute to lifelong health. En ligne : http://dx.doi.org/10.1017/s0954579421001826 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Measuring early life adversity: A dimensional approach [Texte imprimé et/ou numérique] / Ilana S. BERMAN, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Nim TOTTENHAM, Auteur ; Keith GODFREY, Auteur ; Teresa E. SEEMAN, Auteur ; Eric LOUCKS, Auteur ; Stephen J. SUOMI, Auteur ; Andrea DANESE, Auteur ; Margaret A. SHERIDAN, Auteur . - 499-511. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 499-511 Mots-clés : dimensional models  adversity  measurement  deprivation and threat  adverse early experiences  ACEs Index. décimale : PER Périodiques Résumé : Exposure to adversity in childhood is associated with elevations in numerous physical and mental health outcomes across the life course. The biological embedding of early experience during periods of developmental plasticity is one pathway that contributes to these associations. Dimensional models specify mechanistic pathways linking different dimensions of adversity to health and well-being outcomes later in life. While findings from existing studies testing these dimensions have provided promising preliminary support for these models, less agreement exists about how to measure the experiences that comprise each dimension. Here, we review existing approaches to measuring two dimensions of adversity: threat and deprivation. We recommend specific measures for measuring these constructs and, when possible, document when the same measure can be used by different reporters and across the lifespan to maximize the utility with which these recommendations can be applied. Through this approach, we hope to stimulate progress in understanding how particular dimensions of early environmental experience contribute to lifelong health. En ligne : http://dx.doi.org/10.1017/s0954579421001826 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction / Stephen G. LINDELL in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1391-1400 Titre : The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction Type de document : Texte imprimé et/ou numérique Auteurs : Stephen G. LINDELL, Auteur ; Qiaoping YUAN, Auteur ; Zhifeng ZHOU, Auteur ; David GOLDMAN, Auteur ; Robert C. THOMPSON, Auteur ; Juan F. LOPEZ, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; Christina S. BARR, Auteur Année de publication : 2012 Article en page(s) : p.1391-1400 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In humans, it has been demonstrated that the serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates risk in the face of adversity. One mechanism by which stress could interact with genotype is via epigenetic modifications. We wanted to examine whether stress interacted with genotype to predict binding of a histone 3 protein trimethylated at lysine 3 (H3K4me3) that marks active promoters. The brains (N = 61) of male rhesus macaques that had been reared in the presence or absence of stress were archived and the hippocampusi dissected. Chromatin immunoprecipitation was performed with an antibody against H3K4me3 followed by sequencing on a SolexaG2A. The effects of age, genotype (5-HTTLPR long/long vs. short), and stress exposure (peer-reared vs. mother-reared) on levels of H3K4me3 binding were determined. We found effects of age and stress exposure. There was a decline in H3K4me3 from preadolescence to postadolescence and lower levels in peer-reared monkeys and no effects of genotype. When we controlled for age, however, we found that there were effects of 5-HTTLPR genotype and rearing condition on H3K4me3 binding. In a larger sample, we observed that cerebrospinal fluid 5-hydroxyindoleacetic acid levels were subject to interactive effects among age, rearing history, and genotype. Genes containing both genetic selection and epigenetic regulation may be particularly important in stress adaptation and development. We find evidence for selection at the solute carrier family C6 member 4 gene and observe epigenetic reorganization according to genotype, stress, and age. These data suggest that developmental stage may moderate effects of stress and serotonin transporter genotype in the emergence of alternative adaptation strategies and in the vulnerability to developmental or psychiatric disorders. En ligne : http://dx.doi.org/10.1017/S0954579412000788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction [Texte imprimé et/ou numérique] / Stephen G. LINDELL, Auteur ; Qiaoping YUAN, Auteur ; Zhifeng ZHOU, Auteur ; David GOLDMAN, Auteur ; Robert C. THOMPSON, Auteur ; Juan F. LOPEZ, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; Christina S. BARR, Auteur . - 2012 . - p.1391-1400. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1391-1400 Index. décimale : PER Périodiques Résumé : In humans, it has been demonstrated that the serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates risk in the face of adversity. One mechanism by which stress could interact with genotype is via epigenetic modifications. We wanted to examine whether stress interacted with genotype to predict binding of a histone 3 protein trimethylated at lysine 3 (H3K4me3) that marks active promoters. The brains (N = 61) of male rhesus macaques that had been reared in the presence or absence of stress were archived and the hippocampusi dissected. Chromatin immunoprecipitation was performed with an antibody against H3K4me3 followed by sequencing on a SolexaG2A. The effects of age, genotype (5-HTTLPR long/long vs. short), and stress exposure (peer-reared vs. mother-reared) on levels of H3K4me3 binding were determined. We found effects of age and stress exposure. There was a decline in H3K4me3 from preadolescence to postadolescence and lower levels in peer-reared monkeys and no effects of genotype. When we controlled for age, however, we found that there were effects of 5-HTTLPR genotype and rearing condition on H3K4me3 binding. In a larger sample, we observed that cerebrospinal fluid 5-hydroxyindoleacetic acid levels were subject to interactive effects among age, rearing history, and genotype. Genes containing both genetic selection and epigenetic regulation may be particularly important in stress adaptation and development. We find evidence for selection at the solute carrier family C6 member 4 gene and observe epigenetic reorganization according to genotype, stress, and age. These data suggest that developmental stage may moderate effects of stress and serotonin transporter genotype in the emergence of alternative adaptation strategies and in the vulnerability to developmental or psychiatric disorders. En ligne : http://dx.doi.org/10.1017/S0954579412000788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interactions—CORRIGENDUM / Stephen G. LINDELL in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

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The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques / Simona SPINELLI in Development and Psychopathology, 24-1 (January 2012)  

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