Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples / Sara MASCHERETTI in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.75-82 Titre : Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples Type de document : Texte imprimé et/ou numérique Auteurs : Sara MASCHERETTI, Auteur ; Vittoria TREZZI, Auteur ; Roberto GIORDA, Auteur ; Michel BOIVIN, Auteur ; Vickie PLOURDE, Auteur ; Frank VITARO, Auteur ; Mara BRENDGEN, Auteur ; Ginette DIONNE, Auteur ; Cecilia MARINO, Auteur Article en page(s) : p.75-82 Langues : Anglais (eng) Mots-clés : Developmental dyslexia  attention deficit/hyperactivity disorder  association study  gene-by-environment interaction  gene-by-gene interaction  pleiotropy Index. décimale : PER Périodiques Résumé : Background Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD and ADHD co-occur in the same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, and specific genes associated with either DD or ADHD have been investigated for association in the other disorder. Moreover, there are likely to be gene-by-gene and gene-by-environment interaction effects (G × G and G × E, respectively) underlying the comorbidity between DD and ADHD. We investigated the pleiotropic effects of 19 SNPs spanning five DD genes (DYX1C1, DCDC2, KIAA0319, ROBO1, and GRIN2B) and seven DD environmental factors (smoke, miscarriage, birth weight, breastfeeding, parental age, socioeconomic status, and parental education) for main, either (a) genetic or (b) environmental, (c) G × G, and (d) G × E upon inattention and hyperactivity/impulsivity. We then attempted replication of these findings in an independent twin cohort. Methods Marker-trait association was analyzed by implementing the Quantitative Transmission Disequilibrium Test (QTDT). Environmental associations were tested by partial correlations. G × G were investigated by a general linear model equation and a family-based association test. G × E were analyzed through a general test for G × E in sib pair-based association analysis of quantitative traits. Results DCDC2-rs793862 was associated with hyperactivity/impulsivity via G × G (KIAA0319) and G × E (miscarriage). Smoke was significantly correlated with hyperactivity/impulsivity. We replicated the DCDC2 × KIAA0319 interaction upon hyperactivity/impulsivity in the twin cohort. Conclusions En ligne : http://dx.doi.org/10.1111/jcpp.12612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples [Texte imprimé et/ou numérique] / Sara MASCHERETTI, Auteur ; Vittoria TREZZI, Auteur ; Roberto GIORDA, Auteur ; Michel BOIVIN, Auteur ; Vickie PLOURDE, Auteur ; Frank VITARO, Auteur ; Mara BRENDGEN, Auteur ; Ginette DIONNE, Auteur ; Cecilia MARINO, Auteur . - p.75-82. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.75-82 Mots-clés : Developmental dyslexia  attention deficit/hyperactivity disorder  association study  gene-by-environment interaction  gene-by-gene interaction  pleiotropy Index. décimale : PER Périodiques Résumé : Background Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD and ADHD co-occur in the same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, and specific genes associated with either DD or ADHD have been investigated for association in the other disorder. Moreover, there are likely to be gene-by-gene and gene-by-environment interaction effects (G × G and G × E, respectively) underlying the comorbidity between DD and ADHD. We investigated the pleiotropic effects of 19 SNPs spanning five DD genes (DYX1C1, DCDC2, KIAA0319, ROBO1, and GRIN2B) and seven DD environmental factors (smoke, miscarriage, birth weight, breastfeeding, parental age, socioeconomic status, and parental education) for main, either (a) genetic or (b) environmental, (c) G × G, and (d) G × E upon inattention and hyperactivity/impulsivity. We then attempted replication of these findings in an independent twin cohort. Methods Marker-trait association was analyzed by implementing the Quantitative Transmission Disequilibrium Test (QTDT). Environmental associations were tested by partial correlations. G × G were investigated by a general linear model equation and a family-based association test. G × E were analyzed through a general test for G × E in sib pair-based association analysis of quantitative traits. Results DCDC2-rs793862 was associated with hyperactivity/impulsivity via G × G (KIAA0319) and G × E (miscarriage). Smoke was significantly correlated with hyperactivity/impulsivity. We replicated the DCDC2 × KIAA0319 interaction upon hyperactivity/impulsivity in the twin cohort. Conclusions En ligne : http://dx.doi.org/10.1111/jcpp.12612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Phenotypic and genetic associations between reading comprehension, decoding skills, and ADHD dimensions: evidence from two population-based studies / Vickie PLOURDE in Journal of Child Psychology and Psychiatry, 56-10 (October 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-10 (October 2015) . - p.1074-1082 Titre : Phenotypic and genetic associations between reading comprehension, decoding skills, and ADHD dimensions: evidence from two population-based studies Type de document : Texte imprimé et/ou numérique Auteurs : Vickie PLOURDE, Auteur ; Michel BOIVIN, Auteur ; Nadine FORGET-DUBOIS, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Cecilia MARINO, Auteur ; Richard T. TREMBLAY, Auteur ; Ginette DIONNE, Auteur Article en page(s) : p.1074-1082 Langues : Anglais (eng) Mots-clés : Reading  decoding  comprehension  inattention  hyperactivity/impulsivity  population-based studies Index. décimale : PER Périodiques Résumé : Background The phenotypic and genetic associations between decoding skills and ADHD dimensions have been documented but less is known about the association with reading comprehension. The aim of the study is to document the phenotypic and genetic associations between reading comprehension and ADHD dimensions of inattention and hyperactivity/impulsivity in early schooling and compare them to those with decoding skills. Methods Data were collected in two population-based samples of twins (Quebec Newborn Twin Study – QNTS) and singletons (Quebec Longitudinal Study of Child Development – QLSCD) totaling ? 2300 children. Reading was assessed with normed measures in second or third grade. Teachers assessed ADHD dimensions in kindergarten and first grade. Results Both decoding and reading comprehension were correlated with ADHD dimensions in a similar way: associations with inattention remained after controlling for the other ADHD dimension, behavior disorder symptoms and nonverbal abilities, whereas associations with hyperactivity/impulsivity did not. Genetic modeling showed that decoding and comprehension largely shared the same genetic etiology at this age and that their associations with inattention were mostly explained by shared genetic influences. Conclusion Both reading comprehension and decoding are uniquely associated with inattention through a shared genetic etiology. En ligne : http://dx.doi.org/10.1111/jcpp.12394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269 [article] Phenotypic and genetic associations between reading comprehension, decoding skills, and ADHD dimensions: evidence from two population-based studies [Texte imprimé et/ou numérique] / Vickie PLOURDE, Auteur ; Michel BOIVIN, Auteur ; Nadine FORGET-DUBOIS, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Cecilia MARINO, Auteur ; Richard T. TREMBLAY, Auteur ; Ginette DIONNE, Auteur . - p.1074-1082. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-10 (October 2015) . - p.1074-1082 Mots-clés : Reading  decoding  comprehension  inattention  hyperactivity/impulsivity  population-based studies Index. décimale : PER Périodiques Résumé : Background The phenotypic and genetic associations between decoding skills and ADHD dimensions have been documented but less is known about the association with reading comprehension. The aim of the study is to document the phenotypic and genetic associations between reading comprehension and ADHD dimensions of inattention and hyperactivity/impulsivity in early schooling and compare them to those with decoding skills. Methods Data were collected in two population-based samples of twins (Quebec Newborn Twin Study – QNTS) and singletons (Quebec Longitudinal Study of Child Development – QLSCD) totaling ? 2300 children. Reading was assessed with normed measures in second or third grade. Teachers assessed ADHD dimensions in kindergarten and first grade. Results Both decoding and reading comprehension were correlated with ADHD dimensions in a similar way: associations with inattention remained after controlling for the other ADHD dimension, behavior disorder symptoms and nonverbal abilities, whereas associations with hyperactivity/impulsivity did not. Genetic modeling showed that decoding and comprehension largely shared the same genetic etiology at this age and that their associations with inattention were mostly explained by shared genetic influences. Conclusion Both reading comprehension and decoding are uniquely associated with inattention through a shared genetic etiology. En ligne : http://dx.doi.org/10.1111/jcpp.12394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269

Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence / Maria NOBILE in Development and Psychopathology, 19-4 (Fall 2007)  

Public ISBD [article]  inDevelopment and Psychopathology > 19-4 (Fall 2007) . - p.1147-1160 Titre : Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Valentina PASTORE, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur Année de publication : 2007 Article en page(s) : p.1147-1160 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The impact of socioeconomic status (SES) and genetic polymorphisms on individual differences for externalized behaviors have often been investigated separately in studies of children and adults. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 (DRD4) and serotonin transporter linked promoter region (5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6–18. We found evidence, which was based on both one locus and two-loci genotype analyses, that low SES and DRD4 long and 5-HTTLPR long alleles, both alone and in interaction, are associated with higher aggressive behavior scores. The effects were similar but more modest and limited to one locus genotype analyses for rule-breaking behavior. Consistent with studies that showed the effects of societal moderators on the heritability of externalized behaviors across different segments of the population, we suggest that diminished social constraints associated with low parental SES may act as enhancers of the genetic influence of specific DRD4 and 5-HTTLPR alleles over aggressive behaviors in preadolescence. En ligne : http://dx.doi.org/10.1017/s0954579407000594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Valentina PASTORE, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur . - 2007 . - p.1147-1160. Langues : Anglais (eng) in Development and Psychopathology > 19-4 (Fall 2007) . - p.1147-1160 Index. décimale : PER Périodiques Résumé : The impact of socioeconomic status (SES) and genetic polymorphisms on individual differences for externalized behaviors have often been investigated separately in studies of children and adults. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 (DRD4) and serotonin transporter linked promoter region (5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6–18. We found evidence, which was based on both one locus and two-loci genotype analyses, that low SES and DRD4 long and 5-HTTLPR long alleles, both alone and in interaction, are associated with higher aggressive behavior scores. The effects were similar but more modest and limited to one locus genotype analyses for rule-breaking behavior. Consistent with studies that showed the effects of societal moderators on the heritability of externalized behaviors across different segments of the population, we suggest that diminished social constraints associated with low parental SES may act as enhancers of the genetic influence of specific DRD4 and 5-HTTLPR alleles over aggressive behaviors in preadolescence. En ligne : http://dx.doi.org/10.1017/s0954579407000594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years / Maria NOBILE in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325 Titre : The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur Année de publication : 2009 Article en page(s) : p.317-325 Langues : Anglais (eng) Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective. Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years. Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size. Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719 [article] The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur . - 2009 . - p.317-325. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325 Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective. Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years. Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size. Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719

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