Alexithymia and autism diagnostic assessments: Evidence from twins at genetic risk of autism and adults with anorexia nervosa / Hannah HOBSON in Research in Autism Spectrum Disorders, 73 (May 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 73 (May 2019) . - 101531 Titre : Alexithymia and autism diagnostic assessments: Evidence from twins at genetic risk of autism and adults with anorexia nervosa Type de document : texte imprimé Auteurs : Hannah HOBSON, Auteur ; Heather WESTWOOD, Auteur ; Jane CONWAY, Auteur ; Fiona S. MCEWEN, Auteur ; Emma COLVERT, Auteur ; Caroline CATMUR, Auteur ; Geoffrey BIRD, Auteur ; Francesca HAPPE, Auteur Article en page(s) : 101531 Langues : Anglais (eng) Mots-clés : ADOS  Alexithymia  Diagnosis  Autism  Anorexia nervosa Index. décimale : PER Périodiques Résumé : Background Alexithymia, a difficulty identifying and communicating one’s own emotions, affects socio-emotional processes, such as emotion recognition and empathy. Co-occurring alexithymia is prevalent in Autism Spectrum Disorder (ASD) and underlies some socio-emotional difficulties usually attributed to autism. Socio-emotional abilities are examined during behavioural diagnostic assessments of autism, yet the effect of alexithymia on these assessments is not known. This study aimed to examine the associations between alexithymia and Autism Diagnostic Observation Schedule (ADOS) assessment scores. Method Two previously collected samples of ADOS assessments were used to examine the relationship between alexithymia and ADOS scores. Participants included 96 women with anorexia, and 147 adolescents who were either high in autistic symptoms, or whose twin had high autistic symptoms. We examined 1) the impact of alexithymia on meeting the criteria for autism/ASD, 2) correlations between alexithymia and ADOS subscales, and 3) whether alexithymia predicted scores on specific ADOS items, selected a priori based on existing literature. Results In the adolescent group, parent-reported (but not self-reported) alexithymia correlated with both ADOS sub-scales, predicted scores on ADOS items, and predicted meeting clinical cut-offs for an ASD/autism diagnosis. Few associations were observed in the anorexic sample between self-reported alexithymia and ADOS subscale and item scores, but the presence of alexithymia predicted the likelihood of meeting diagnostic criteria for autism/ASD in this sample. Conclusions Alexithymia does show relationships with ADOS assessment scores. We discuss potential clinical and research implications, particularly in studies of autism where the ADOS is often the only diagnostic measure used. En ligne : https://doi.org/10.1016/j.rasd.2020.101531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Alexithymia and autism diagnostic assessments: Evidence from twins at genetic risk of autism and adults with anorexia nervosa [texte imprimé] / Hannah HOBSON, Auteur ; Heather WESTWOOD, Auteur ; Jane CONWAY, Auteur ; Fiona S. MCEWEN, Auteur ; Emma COLVERT, Auteur ; Caroline CATMUR, Auteur ; Geoffrey BIRD, Auteur ; Francesca HAPPE, Auteur . - 101531. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 73 (May 2019) . - 101531 Mots-clés : ADOS  Alexithymia  Diagnosis  Autism  Anorexia nervosa Index. décimale : PER Périodiques Résumé : Background Alexithymia, a difficulty identifying and communicating one’s own emotions, affects socio-emotional processes, such as emotion recognition and empathy. Co-occurring alexithymia is prevalent in Autism Spectrum Disorder (ASD) and underlies some socio-emotional difficulties usually attributed to autism. Socio-emotional abilities are examined during behavioural diagnostic assessments of autism, yet the effect of alexithymia on these assessments is not known. This study aimed to examine the associations between alexithymia and Autism Diagnostic Observation Schedule (ADOS) assessment scores. Method Two previously collected samples of ADOS assessments were used to examine the relationship between alexithymia and ADOS scores. Participants included 96 women with anorexia, and 147 adolescents who were either high in autistic symptoms, or whose twin had high autistic symptoms. We examined 1) the impact of alexithymia on meeting the criteria for autism/ASD, 2) correlations between alexithymia and ADOS subscales, and 3) whether alexithymia predicted scores on specific ADOS items, selected a priori based on existing literature. Results In the adolescent group, parent-reported (but not self-reported) alexithymia correlated with both ADOS sub-scales, predicted scores on ADOS items, and predicted meeting clinical cut-offs for an ASD/autism diagnosis. Few associations were observed in the anorexic sample between self-reported alexithymia and ADOS subscale and item scores, but the presence of alexithymia predicted the likelihood of meeting diagnostic criteria for autism/ASD in this sample. Conclusions Alexithymia does show relationships with ADOS assessment scores. We discuss potential clinical and research implications, particularly in studies of autism where the ADOS is often the only diagnostic measure used. En ligne : https://doi.org/10.1016/j.rasd.2020.101531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample / Fiona S. MCEWEN in Journal of Child Psychology and Psychiatry, 57-2 (February 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.161-170 Titre : Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample Type de document : texte imprimé Auteurs : Fiona S. MCEWEN, Auteur ; Catherine S. STEWART, Auteur ; Emma COLVERT, Auteur ; Emma WOODHOUSE, Auteur ; Sarah CURRAN, Auteur ; Nicola GILLAN, Auteur ; Victoria HALLETT, Auteur ; Stephanie LIETZ, Auteur ; Tracy GARNETT, Auteur ; Angelica RONALD, Auteur ; Declan G.M. MURPHY, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur Article en page(s) : p.161-170 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  adolescence  assessment  diagnosis Index. décimale : PER Périodiques Résumé : Background Increasing numbers of people are being referred for the assessment of autism spectrum disorder (ASD). The NICE (UK) and the American Academy of Pediatrics recommend gathering a developmental history using a tool that operationalises ICD/DSM criteria. However, the best-established diagnostic interview instruments are time consuming, costly and rarely used outside national specialist centres. What is needed is a brief, cost-effective measure validated in community settings. We tested the Development and Well-Being Assessment (DAWBA) for diagnosing ASD in a sample of children/adolescents representative of those presenting in community mental health settings. Methods A general population sample of twins (TEDS) was screened and 276 adolescents were selected as at low (CAST score < 12; n = 164) or high risk for ASD (CAST score ≥ 15 and/or parent reported that ASD suspected/previously diagnosed; n = 112). Parents completed the ASD module of the DAWBA interview by telephone or online. Families were visited at home: the ADI-R and autism diagnostic observation schedule (ADOS) were completed to allow a best-estimate research diagnosis of ASD to be made. Results Development and Well-Being Assessment ASD symptom scores correlated highly with ADI-R algorithm scores (ρ = .82, p < .001). Good sensitivity (0.88) and specificity (0.85) were achieved using DAWBA computerised algorithms. Clinician review of responses to DAWBA questions minimally changed sensitivity (0.86) and specificity (0.87). Positive (0.82–0.95) and negative (0.90) predictive values were high. Eighty-six per cent of children were correctly classified. Performance was improved by using it in conjunction with the ADOS. Conclusions The DAWBA is a brief structured interview that showed good sensitivity and specificity in this general population sample. It requires little training, is easy to administer (online or by interview) and diagnosis is aided by an algorithm. It holds promise as a tool for assisting with assessment in community settings and may help services implement the recommendations made by NICE and the American Academy of Pediatrics regarding diagnosis of young people on the autism spectrum. En ligne : http://dx.doi.org/10.1111/jcpp.12447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 [article] Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample [texte imprimé] / Fiona S. MCEWEN, Auteur ; Catherine S. STEWART, Auteur ; Emma COLVERT, Auteur ; Emma WOODHOUSE, Auteur ; Sarah CURRAN, Auteur ; Nicola GILLAN, Auteur ; Victoria HALLETT, Auteur ; Stephanie LIETZ, Auteur ; Tracy GARNETT, Auteur ; Angelica RONALD, Auteur ; Declan G.M. MURPHY, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur . - p.161-170. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.161-170 Mots-clés : Autism spectrum disorder  adolescence  assessment  diagnosis Index. décimale : PER Périodiques Résumé : Background Increasing numbers of people are being referred for the assessment of autism spectrum disorder (ASD). The NICE (UK) and the American Academy of Pediatrics recommend gathering a developmental history using a tool that operationalises ICD/DSM criteria. However, the best-established diagnostic interview instruments are time consuming, costly and rarely used outside national specialist centres. What is needed is a brief, cost-effective measure validated in community settings. We tested the Development and Well-Being Assessment (DAWBA) for diagnosing ASD in a sample of children/adolescents representative of those presenting in community mental health settings. Methods A general population sample of twins (TEDS) was screened and 276 adolescents were selected as at low (CAST score < 12; n = 164) or high risk for ASD (CAST score ≥ 15 and/or parent reported that ASD suspected/previously diagnosed; n = 112). Parents completed the ASD module of the DAWBA interview by telephone or online. Families were visited at home: the ADI-R and autism diagnostic observation schedule (ADOS) were completed to allow a best-estimate research diagnosis of ASD to be made. Results Development and Well-Being Assessment ASD symptom scores correlated highly with ADI-R algorithm scores (ρ = .82, p < .001). Good sensitivity (0.88) and specificity (0.85) were achieved using DAWBA computerised algorithms. Clinician review of responses to DAWBA questions minimally changed sensitivity (0.86) and specificity (0.87). Positive (0.82–0.95) and negative (0.90) predictive values were high. Eighty-six per cent of children were correctly classified. Performance was improved by using it in conjunction with the ADOS. Conclusions The DAWBA is a brief structured interview that showed good sensitivity and specificity in this general population sample. It requires little training, is easy to administer (online or by interview) and diagnosis is aided by an algorithm. It holds promise as a tool for assisting with assessment in community settings and may help services implement the recommendations made by NICE and the American Academy of Pediatrics regarding diagnosis of young people on the autism spectrum. En ligne : http://dx.doi.org/10.1111/jcpp.12447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280

Predictors of Environmental Sensitivity in Syrian refugee children / Andrew K. MAY in Journal of Child Psychology and Psychiatry, 66-11 (November 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1688-1702 Titre : Predictors of Environmental Sensitivity in Syrian refugee children Type de document : texte imprimé Auteurs : Andrew K. MAY, Auteur ; Demelza SMEETH, Auteur ; Fiona S. MCEWEN, Auteur ; Elie G. KARAM, Auteur ; Michael PLUESS, Auteur Article en page(s) : p.1688-1702 Langues : Anglais (eng) Mots-clés : Environmental Sensitivity  predictors  refugees  children  Syria Index. décimale : PER Périodiques Résumé : Background Although more prone to psychopathology on average, refugee children differ in their response to adversity. Growing evidence attributes some of these individual differences to varying levels of Environmental Sensitivity ? the extent to which children perceive and process contextual influences. However, there is limited knowledge of how Environmental Sensitivity is developmentally influenced, particularly in the refugee setting. Methods Here, we investigated whether individual-, family- and community-level predictors (psychosocial and genetic) were associated with self-reported Environmental Sensitivity and its subscales (measured using the 12-item Highly Sensitive Child Scale). Participants were a subsample (n?=?1,409) from a cohort of Syrian refugee children and their biological mothers, recruited from informal tented settlements in Lebanon. Multivariate adaptive regression spline models were fitted to identify the best selection from over 40 available predictors. Results Twelve predictors of Environmental Sensitivity emerged, with the five most commonly selected being maternal behavioural control, human insecurity, positive home experiences, maternal anxiety and child-reported child abuse, the latter three of which were also suggested to predict changes in sensitivity over a 12-month period. Some predictors such as maternal PTSD, war exposure and bullying showed a non-linear, V-shape relationship with sensitivity. All effect sizes, however, were small. Conclusions Our findings suggest that both highly supportive and highly adverse contextual factors associate with greater childhood Environmental Sensitivity, in line with current theorising. Despite previous suggestive evidence, we did not find that polygenic scores for autism and attention deficit hyperactivity disorder predicted sensitivity. Further research into predictors of Environmental Sensitivity is encouraged, as this may help with improved assessment of the trait in children. En ligne : https://doi.org/10.1111/jcpp.14178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Predictors of Environmental Sensitivity in Syrian refugee children [texte imprimé] / Andrew K. MAY, Auteur ; Demelza SMEETH, Auteur ; Fiona S. MCEWEN, Auteur ; Elie G. KARAM, Auteur ; Michael PLUESS, Auteur . - p.1688-1702. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1688-1702 Mots-clés : Environmental Sensitivity  predictors  refugees  children  Syria Index. décimale : PER Périodiques Résumé : Background Although more prone to psychopathology on average, refugee children differ in their response to adversity. Growing evidence attributes some of these individual differences to varying levels of Environmental Sensitivity ? the extent to which children perceive and process contextual influences. However, there is limited knowledge of how Environmental Sensitivity is developmentally influenced, particularly in the refugee setting. Methods Here, we investigated whether individual-, family- and community-level predictors (psychosocial and genetic) were associated with self-reported Environmental Sensitivity and its subscales (measured using the 12-item Highly Sensitive Child Scale). Participants were a subsample (n?=?1,409) from a cohort of Syrian refugee children and their biological mothers, recruited from informal tented settlements in Lebanon. Multivariate adaptive regression spline models were fitted to identify the best selection from over 40 available predictors. Results Twelve predictors of Environmental Sensitivity emerged, with the five most commonly selected being maternal behavioural control, human insecurity, positive home experiences, maternal anxiety and child-reported child abuse, the latter three of which were also suggested to predict changes in sensitivity over a 12-month period. Some predictors such as maternal PTSD, war exposure and bullying showed a non-linear, V-shape relationship with sensitivity. All effect sizes, however, were small. Conclusions Our findings suggest that both highly supportive and highly adverse contextual factors associate with greater childhood Environmental Sensitivity, in line with current theorising. Despite previous suggestive evidence, we did not find that polygenic scores for autism and attention deficit hyperactivity disorder predicted sensitivity. Further research into predictors of Environmental Sensitivity is encouraged, as this may help with improved assessment of the trait in children. En ligne : https://doi.org/10.1111/jcpp.14178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Predictors of psychological risk and resilience among Syrian refugee children / Cassandra M. POPHAM in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.91-99 Titre : Predictors of psychological risk and resilience among Syrian refugee children Type de document : texte imprimé Auteurs : Cassandra M. POPHAM, Auteur ; Fiona S. MCEWEN, Auteur ; Elie G. KARAM, Auteur ; John FAYYAD, Auteur ; Georges KARAM, Auteur ; Dahlia SAAB, Auteur ; Patricia MOGHAMES, Auteur ; Michael PLUESS, Auteur Article en page(s) : p.91-99 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Objectives War-exposed refugee children are at elevated risk for mental health problems, but a notable proportion appear resilient. We aimed to investigate the proportion of Syrian refugee children who can be considered resilient, and applied a novel approach to identify factors predicting individual differences in mental health outcomes following war exposure. Methods The sample included 1,528 war-exposed Syrian refugee children and their primary caregiver living in refugee settlements in Lebanon. Children were classed as having low symptoms (LS) if they scored below clinically validated cut-offs for post-traumatic stress disorder (PTSD), depression and externalising behaviour problems. Children scoring above any cut-off were classified as having high symptoms (HS). Each LS child was matched with one HS who reported similar war exposure, to test what differentiates children with similar exposures but different outcomes. Results 19.3% of the children met our resilience criteria and were considered LS. At the individual level, protective traits (e.g. self-esteem; OR=1.51, 95% CI [1.25, 1.81]) predicted LS classification, while environmental sensitivity (OR=0.69, 95% CI [0.59, 0.82]), poorer general health (OR=0.71, 95% CI [0.58, 0.87]) and specific coping strategies (e.g. avoidance; OR=0.90, 95% CI [0.85, 0.96]) predicted HS classification. Social/environmental predictors included perceived social support (OR=1.23, 95% CI [1.02, 1.49]), loneliness and social isolation (OR=0.85, 95% CI [0.80, 0.90]), child maltreatment (OR=0.96, 95% CI [0.94, 0.97]), and caregiver mental and general health (e.g. caregiver depression; OR=0.94, 95% CI [0.92, 0.97]). Conclusions Future research should take multiple dimensions of functioning into account when defining risk for mental health problems and consider the identified predictors as potential targets for interventions. En ligne : https://doi.org/10.1111/jcpp.13670 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Predictors of psychological risk and resilience among Syrian refugee children [texte imprimé] / Cassandra M. POPHAM, Auteur ; Fiona S. MCEWEN, Auteur ; Elie G. KARAM, Auteur ; John FAYYAD, Auteur ; Georges KARAM, Auteur ; Dahlia SAAB, Auteur ; Patricia MOGHAMES, Auteur ; Michael PLUESS, Auteur . - p.91-99. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.91-99 Index. décimale : PER Périodiques Résumé : Objectives War-exposed refugee children are at elevated risk for mental health problems, but a notable proportion appear resilient. We aimed to investigate the proportion of Syrian refugee children who can be considered resilient, and applied a novel approach to identify factors predicting individual differences in mental health outcomes following war exposure. Methods The sample included 1,528 war-exposed Syrian refugee children and their primary caregiver living in refugee settlements in Lebanon. Children were classed as having low symptoms (LS) if they scored below clinically validated cut-offs for post-traumatic stress disorder (PTSD), depression and externalising behaviour problems. Children scoring above any cut-off were classified as having high symptoms (HS). Each LS child was matched with one HS who reported similar war exposure, to test what differentiates children with similar exposures but different outcomes. Results 19.3% of the children met our resilience criteria and were considered LS. At the individual level, protective traits (e.g. self-esteem; OR=1.51, 95% CI [1.25, 1.81]) predicted LS classification, while environmental sensitivity (OR=0.69, 95% CI [0.59, 0.82]), poorer general health (OR=0.71, 95% CI [0.58, 0.87]) and specific coping strategies (e.g. avoidance; OR=0.90, 95% CI [0.85, 0.96]) predicted HS classification. Social/environmental predictors included perceived social support (OR=1.23, 95% CI [1.02, 1.49]), loneliness and social isolation (OR=0.85, 95% CI [0.80, 0.90]), child maltreatment (OR=0.96, 95% CI [0.94, 0.97]), and caregiver mental and general health (e.g. caregiver depression; OR=0.94, 95% CI [0.92, 0.97]). Conclusions Future research should take multiple dimensions of functioning into account when defining risk for mental health problems and consider the identified predictors as potential targets for interventions. En ligne : https://doi.org/10.1111/jcpp.13670 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research / Niamh PEARSON in Autism Research, 11-12 (December 2018)  

Public ISBD [article]  inAutism Research > 11-12 (December 2018) . - p.1602-1620 Titre : Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research Type de document : texte imprimé Auteurs : Niamh PEARSON, Auteur ; Tony CHARMAN, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur ; Fiona S. MCEWEN, Auteur Article en page(s) : p.1602-1620 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental trajectories  high-risk siblings  infant  regression Index. décimale : PER Périodiques Résumé : The way in which the behavioral manifestations of autism spectrum disorder (ASD) emerge in infancy is variable. Regression-loss of previously acquired skills-occurs in a subset of children. However, the etiology and significance of regression remains unclear. Until recently, investigation of regression relied on retrospective report by parents or examination of home videos from early in life. However, home videos and retrospective report of the nature and timing of regression, and association with factors such as illness or immunization, is potentially subject to bias. The advent of prospective studies of infant siblings at familial high-risk of ASD has the potential to document regression as it occurs. Recent research has suggested that subtle loss of skills occurs in a larger proportion of children with ASD than previously assumed; however, there are few reports of clear-cut regressions, such as that involving dramatic loss of language and other established skills, in the prospective literature. This could be because of the following: clear-cut regression occurs less commonly than parent report suggests, study design limits the potential to detect regression, or there are differences between multiplex and simplex families in the rate of de novo genetic mutations and therefore regression risk. This review will bring together literature from retrospective and prospective research and attempt to reconcile diverging findings, with a specific focus on methodological issues. Changing conceptualizations of regression will be discussed, as well as etiological factors that may be associated with regression. The main challenges that need to be addressed to measure regression in prospective studies will be set out. Autism Research 2018, 11: 1602-1620. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Regression-a loss of previously established skills-occurs in a subset of children with ASD. Parental recall is not always accurate but studying younger siblings of children with ASD, 10-20% of whom will develop ASD, should make it possible to measure regression as it occurs. Clear-cut regression, like loss of language, has not often been reported in infant sibling studies, but recent research suggests that gradual loss of social engagement might be more common. This review looks at the evidence for regression from infant sibling studies and asks how study design affects the likelihood of capturing regression. En ligne : http://dx.doi.org/10.1002/aur.2035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372 [article] Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research [texte imprimé] / Niamh PEARSON, Auteur ; Tony CHARMAN, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur ; Fiona S. MCEWEN, Auteur . - p.1602-1620. Langues : Anglais (eng) in Autism Research > 11-12 (December 2018) . - p.1602-1620 Mots-clés : autism spectrum disorder  developmental trajectories  high-risk siblings  infant  regression Index. décimale : PER Périodiques Résumé : The way in which the behavioral manifestations of autism spectrum disorder (ASD) emerge in infancy is variable. Regression-loss of previously acquired skills-occurs in a subset of children. However, the etiology and significance of regression remains unclear. Until recently, investigation of regression relied on retrospective report by parents or examination of home videos from early in life. However, home videos and retrospective report of the nature and timing of regression, and association with factors such as illness or immunization, is potentially subject to bias. The advent of prospective studies of infant siblings at familial high-risk of ASD has the potential to document regression as it occurs. Recent research has suggested that subtle loss of skills occurs in a larger proportion of children with ASD than previously assumed; however, there are few reports of clear-cut regressions, such as that involving dramatic loss of language and other established skills, in the prospective literature. This could be because of the following: clear-cut regression occurs less commonly than parent report suggests, study design limits the potential to detect regression, or there are differences between multiplex and simplex families in the rate of de novo genetic mutations and therefore regression risk. This review will bring together literature from retrospective and prospective research and attempt to reconcile diverging findings, with a specific focus on methodological issues. Changing conceptualizations of regression will be discussed, as well as etiological factors that may be associated with regression. The main challenges that need to be addressed to measure regression in prospective studies will be set out. Autism Research 2018, 11: 1602-1620. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Regression-a loss of previously established skills-occurs in a subset of children with ASD. Parental recall is not always accurate but studying younger siblings of children with ASD, 10-20% of whom will develop ASD, should make it possible to measure regression as it occurs. Clear-cut regression, like loss of language, has not often been reported in infant sibling studies, but recent research suggests that gradual loss of social engagement might be more common. This review looks at the evidence for regression from infant sibling studies and asks how study design affects the likelihood of capturing regression. En ligne : http://dx.doi.org/10.1002/aur.2035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372

Screening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study / James L. FINDON in Autism Research, 9-12 (December 2016)  

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