Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study / Jolien RIJLAARSDAM in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.854-863 Titre : Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study Type de document : Texte imprimé et/ou numérique Auteurs : Jolien RIJLAARSDAM, Auteur ; Charlotte A. M. CECIL, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.854-863 Langues : Anglais (eng) Mots-clés : ALSPAC  autistic traits  DNA methylation  longitudinal  methylome-wide Index. décimale : PER Périodiques Résumé : While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm: nbirth = 804, nage 7 = 877) and trajectories of social communication deficits at age 8 “17 years. Methylomic variation at three loci across the genome (false discovery rate = 0.048) differentiated children following high (n = 80) versus low (n = 724) trajectories of social communication deficits. This differential DNAm was specific to the neonatal period and not observed at 7 years of age. Associations between DNAm and trajectory membership remained robust after controlling for co-occurring mental health problems (i.e., hyperactivity/inattention, conduct problems). The three loci identified at birth were not replicated in the Generation R Study. However, to the best of our knowledge, ALSPAC is the only study to date that is prospective enough to examine DNAm in relation to longitudinal trajectories of social communication deficits from childhood to adolescence. Although the present findings might point to potentially novel sites that differentiate between a high versus low trajectory of social communication deficits, the results should be considered tentative until further replicated. En ligne : http://dx.doi.org/10.1017/S0954579420001662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study [Texte imprimé et/ou numérique] / Jolien RIJLAARSDAM, Auteur ; Charlotte A. M. CECIL, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur . - p.854-863. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.854-863 Mots-clés : ALSPAC  autistic traits  DNA methylation  longitudinal  methylome-wide Index. décimale : PER Périodiques Résumé : While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm: nbirth = 804, nage 7 = 877) and trajectories of social communication deficits at age 8 “17 years. Methylomic variation at three loci across the genome (false discovery rate = 0.048) differentiated children following high (n = 80) versus low (n = 724) trajectories of social communication deficits. This differential DNAm was specific to the neonatal period and not observed at 7 years of age. Associations between DNAm and trajectory membership remained robust after controlling for co-occurring mental health problems (i.e., hyperactivity/inattention, conduct problems). The three loci identified at birth were not replicated in the Generation R Study. However, to the best of our knowledge, ALSPAC is the only study to date that is prospective enough to examine DNAm in relation to longitudinal trajectories of social communication deficits from childhood to adolescence. Although the present findings might point to potentially novel sites that differentiate between a high versus low trajectory of social communication deficits, the results should be considered tentative until further replicated. En ligne : http://dx.doi.org/10.1017/S0954579420001662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio / Esther WALTON in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350 Titre : Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio Type de document : Texte imprimé et/ou numérique Auteurs : Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A TURNER, Auteur ; Vince D. CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.1341-1350 Langues : Anglais (eng) Mots-clés : DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children Index. décimale : PER Périodiques Résumé : Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio [Texte imprimé et/ou numérique] / Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A TURNER, Auteur ; Vince D. CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur . - p.1341-1350. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350 Mots-clés : DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children Index. décimale : PER Périodiques Résumé : Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study / Charlotte A. M. CECIL in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.383-397 Titre : Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Sara R. JAFFEE, Auteur ; Tom O'CONNOR, Auteur ; Barbara MAUGHAN, Auteur ; Caroline L. RELTON, Auteur ; Rebecca G. SMITH, Auteur ; Wendy MCARDLE, Auteur ; Tom R. GAUNT, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.383-397 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early-onset conduct problems (CP) are a key predictor of adult criminality and poor mental health. While previous studies suggest that both genetic and environmental risks play an important role in the development of early-onset CP, little is known about potential biological processes underlying these associations. In this study, we examined prospective associations between DNA methylation (cord blood at birth) and trajectories of CP (4–13 years), using data drawn from the Avon Longitudinal Study of Parents and Children. Methylomic variation at seven loci across the genome (false discovery rate < 0.05) differentiated children who go on to develop early-onset (n = 174) versus low (n = 86) CP, including sites in the vicinity of the monoglyceride lipase (MGLL) gene (involved in endocannabinoid signaling and pain perception). Subthreshold associations in the vicinity of three candidate genes for CP (monoamine oxidase A [MAOA], brain-derived neurotrophic factor [BDNF], and FK506 binding protein 5 [FKBP5]) were also identified. Within the early-onset CP group, methylation levels of the identified sites did not distinguish children who will go on to persist versus desist in CP behavior over time. Overall, we found that several of the identified sites correlated with prenatal exposures, and none were linked to known genetic methylation quantitative trait loci. Findings contribute to a better understanding of epigenetic patterns associated with early-onset CP. En ligne : http://dx.doi.org/10.1017/S095457941700092X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study [Texte imprimé et/ou numérique] / Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Sara R. JAFFEE, Auteur ; Tom O'CONNOR, Auteur ; Barbara MAUGHAN, Auteur ; Caroline L. RELTON, Auteur ; Rebecca G. SMITH, Auteur ; Wendy MCARDLE, Auteur ; Tom R. GAUNT, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Edward D. BARKER, Auteur . - p.383-397. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.383-397 Index. décimale : PER Périodiques Résumé : Early-onset conduct problems (CP) are a key predictor of adult criminality and poor mental health. While previous studies suggest that both genetic and environmental risks play an important role in the development of early-onset CP, little is known about potential biological processes underlying these associations. In this study, we examined prospective associations between DNA methylation (cord blood at birth) and trajectories of CP (4–13 years), using data drawn from the Avon Longitudinal Study of Parents and Children. Methylomic variation at seven loci across the genome (false discovery rate < 0.05) differentiated children who go on to develop early-onset (n = 174) versus low (n = 86) CP, including sites in the vicinity of the monoglyceride lipase (MGLL) gene (involved in endocannabinoid signaling and pain perception). Subthreshold associations in the vicinity of three candidate genes for CP (monoamine oxidase A [MAOA], brain-derived neurotrophic factor [BDNF], and FK506 binding protein 5 [FKBP5]) were also identified. Within the early-onset CP group, methylation levels of the identified sites did not distinguish children who will go on to persist versus desist in CP behavior over time. Overall, we found that several of the identified sites correlated with prenatal exposures, and none were linked to known genetic methylation quantitative trait loci. Findings contribute to a better understanding of epigenetic patterns associated with early-onset CP. En ligne : http://dx.doi.org/10.1017/S095457941700092X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems / Jolien RIJLAARSDAM in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.19-27 Titre : Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems Type de document : Texte imprimé et/ou numérique Auteurs : Jolien RIJLAARSDAM, Auteur ; Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Maurissa S. C. MESIROW, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.19-27 Langues : Anglais (eng) Mots-clés : DNA methylation  Avon Longitudinal Study of Parents and Children  diet  conduct problems  attention deficit hyperactivity disorder  IGF2 Index. décimale : PER Périodiques Résumé : Background Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to ‘unhealthy diet’. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth. Methods Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7–13) differed for EOP versus low CP youth. Results Prenatal ‘unhealthy diet’ was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal ‘unhealthy diet’ was associated with higher ADHD symptoms indirectly via higher IGF2 methylation. Conclusions Preventing ‘unhealthy diet’ in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation. En ligne : http://dx.doi.org/10.1111/jcpp.12589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems [Texte imprimé et/ou numérique] / Jolien RIJLAARSDAM, Auteur ; Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Maurissa S. C. MESIROW, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Edward D. BARKER, Auteur . - p.19-27. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.19-27 Mots-clés : DNA methylation  Avon Longitudinal Study of Parents and Children  diet  conduct problems  attention deficit hyperactivity disorder  IGF2 Index. décimale : PER Périodiques Résumé : Background Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to ‘unhealthy diet’. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth. Methods Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7–13) differed for EOP versus low CP youth. Results Prenatal ‘unhealthy diet’ was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal ‘unhealthy diet’ was associated with higher ADHD symptoms indirectly via higher IGF2 methylation. Conclusions Preventing ‘unhealthy diet’ in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation. En ligne : http://dx.doi.org/10.1111/jcpp.12589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress / Izabela MILANIAK in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1663-1674 Titre : Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress Type de document : Texte imprimé et/ou numérique Auteurs : Izabela MILANIAK, Auteur ; Charlotte A. M. CECIL, Auteur ; Edward D. BARKER, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Sara R. JAFFEE, Auteur Article en page(s) : p.1663-1674 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Emerging research in epigenetics has shown that there is variability in how environmental exposures “get under the skin” through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social–cognitive processes that may underlie a wide range of childhood psychopathology. Participants were 91 youth exposed to pre- and postnatal adversity with established conduct problem trajectories drawn from the Avon Longitudinal Study of Parents and Children. Consistent with our hypothesis, OXTR DNA methylation was predictive of resilience in the conduct problems domain in middle childhood. DNA methylation profiles did not predict resilience in domains of emotional, hyperactivity, and global symptomatology, suggesting a potential role for OXTR in the development of conduct problems in particular. However, individuals who were resilient to conduct problems were also broadly resilient across multiple domains. Therefore, future research should elucidate the biological pathways between OXTR DNA methylation and gene expression and its relation to impairments in social behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress [Texte imprimé et/ou numérique] / Izabela MILANIAK, Auteur ; Charlotte A. M. CECIL, Auteur ; Edward D. BARKER, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Sara R. JAFFEE, Auteur . - p.1663-1674. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1663-1674 Index. décimale : PER Périodiques Résumé : Emerging research in epigenetics has shown that there is variability in how environmental exposures “get under the skin” through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social–cognitive processes that may underlie a wide range of childhood psychopathology. Participants were 91 youth exposed to pre- and postnatal adversity with established conduct problem trajectories drawn from the Avon Longitudinal Study of Parents and Children. Consistent with our hypothesis, OXTR DNA methylation was predictive of resilience in the conduct problems domain in middle childhood. DNA methylation profiles did not predict resilience in domains of emotional, hyperactivity, and global symptomatology, suggesting a potential role for OXTR in the development of conduct problems in particular. However, individuals who were resilient to conduct problems were also broadly resilient across multiple domains. Therefore, future research should elucidate the biological pathways between OXTR DNA methylation and gene expression and its relation to impairments in social behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

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