Brief Report: Major Depressive Disorder with Psychotic Features in Williams Syndrome: A Case Series / F. VALDES in Journal of Autism and Developmental Disorders, 48-3 (March 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.947-952 Titre : Brief Report: Major Depressive Disorder with Psychotic Features in Williams Syndrome: A Case Series Type de document : Texte imprimé et/ou numérique Auteurs : F. VALDES, Auteur ; Christopher J. KEARY, Auteur ; J. E. MULLETT, Auteur ; M. L. PALUMBO, Auteur ; Jessica L. WAXLER, Auteur ; B. R. POBER, Auteur ; C. J. MCDOUGLE, Auteur Année de publication : 2018 Article en page(s) : p.947-952 Langues : Anglais (eng) Mots-clés : Co-morbidity  Major depressive disorder  Psychopharmacology  Psychosis  Williams syndrome Index. décimale : PER Périodiques Résumé : Descriptions of individuals with Williams syndrome (WS) and co-morbid major depressive disorder (MDD) with psychotic features have not appeared in the literature. In addition to reviewing previous reports of psychotic symptoms in persons with WS, this paper introduces clinical histories and therapeutic management strategies for three previously unreported adults with WS diagnosed with co-morbid MDD with psychotic features. Co-morbid medical disorders common in WS are highlighted with regard to safe and appropriate pharmacological treatment. The importance of assessment for co-morbid MDD with psychotic features in individuals with WS is emphasized. En ligne : https://doi.org/10.1007/s10803-017-3384-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Brief Report: Major Depressive Disorder with Psychotic Features in Williams Syndrome: A Case Series [Texte imprimé et/ou numérique] / F. VALDES, Auteur ; Christopher J. KEARY, Auteur ; J. E. MULLETT, Auteur ; M. L. PALUMBO, Auteur ; Jessica L. WAXLER, Auteur ; B. R. POBER, Auteur ; C. J. MCDOUGLE, Auteur . - 2018 . - p.947-952. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.947-952 Mots-clés : Co-morbidity  Major depressive disorder  Psychopharmacology  Psychosis  Williams syndrome Index. décimale : PER Périodiques Résumé : Descriptions of individuals with Williams syndrome (WS) and co-morbid major depressive disorder (MDD) with psychotic features have not appeared in the literature. In addition to reviewing previous reports of psychotic symptoms in persons with WS, this paper introduces clinical histories and therapeutic management strategies for three previously unreported adults with WS diagnosed with co-morbid MDD with psychotic features. Co-morbid medical disorders common in WS are highlighted with regard to safe and appropriate pharmacological treatment. The importance of assessment for co-morbid MDD with psychotic features in individuals with WS is emphasized. En ligne : https://doi.org/10.1007/s10803-017-3384-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD) / M. MODY in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.155-162 Titre : Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : M. MODY, Auteur ; A. M. SHUI, Auteur ; L. A. NOWINSKI, Auteur ; S. B. GOLAS, Auteur ; C. FERRONE, Auteur ; J. A. O’ROURKE, Auteur ; C. J. MCDOUGLE, Auteur Article en page(s) : p.155-162 Langues : Anglais (eng) Mots-clés : Autism  Motor deficits  Language  Social interactions Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and speech-language deficits in ASD. To this end, we examined data from children with ASD (n?=?1781), 2–17 years of age, enrolled in the Autism Speaks—Autism Treatment Network (AS-ATN) registry who completed a multidisciplinary evaluation that included diagnostic, physical, cognitive and behavioral assessments as part of a routine standard of care protocol. After adjusting for age, non-verbal IQ, Attention Deficit Hyperactivity Disorder (ADHD) medication use, and muscle tone, separate multiple linear regression analyses revealed significant positive associations of fine motor skills (FM) with both expressive language (EL) and receptive language (RL) skills in an impaired FM subgroup; in contrast, the impaired gross motor (GM) subgroup showed no association with EL but a significant negative association with RL. Similar analyses between motor skills and interpersonal relationships across the sample found both GM skills and FM skills to be associated with social interactions. These results suggest potential differences in the contributions of fine versus gross motor skills to autistic profiles and may provide another lens with which to view communication differences across the autism spectrum for use in treatment interventions. En ligne : http://dx.doi.org/10.1007/s10803-016-2934-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / M. MODY, Auteur ; A. M. SHUI, Auteur ; L. A. NOWINSKI, Auteur ; S. B. GOLAS, Auteur ; C. FERRONE, Auteur ; J. A. O’ROURKE, Auteur ; C. J. MCDOUGLE, Auteur . - p.155-162. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.155-162 Mots-clés : Autism  Motor deficits  Language  Social interactions Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and speech-language deficits in ASD. To this end, we examined data from children with ASD (n?=?1781), 2–17 years of age, enrolled in the Autism Speaks—Autism Treatment Network (AS-ATN) registry who completed a multidisciplinary evaluation that included diagnostic, physical, cognitive and behavioral assessments as part of a routine standard of care protocol. After adjusting for age, non-verbal IQ, Attention Deficit Hyperactivity Disorder (ADHD) medication use, and muscle tone, separate multiple linear regression analyses revealed significant positive associations of fine motor skills (FM) with both expressive language (EL) and receptive language (RL) skills in an impaired FM subgroup; in contrast, the impaired gross motor (GM) subgroup showed no association with EL but a significant negative association with RL. Similar analyses between motor skills and interpersonal relationships across the sample found both GM skills and FM skills to be associated with social interactions. These results suggest potential differences in the contributions of fine versus gross motor skills to autistic profiles and may provide another lens with which to view communication differences across the autism spectrum for use in treatment interventions. En ligne : http://dx.doi.org/10.1007/s10803-016-2934-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

d-Cycloserine enhances durability of social skills training in autism spectrum disorder / L. K. WINK in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 2p. Titre : d-Cycloserine enhances durability of social skills training in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. K. WINK, Auteur ; N. F. MINSHAWI, Auteur ; R. C. SHAFFER, Auteur ; M. H. PLAWECKI, Auteur ; D. J. POSEY, Auteur ; P. S. HORN, Auteur ; R. ADAMS, Auteur ; Ernest V. PEDAPATI, Auteur ; T. L. SCHAEFER, Auteur ; C. J. MCDOUGLE, Auteur ; N. B. SWIEZY, Auteur ; C. A. ERICKSON, Auteur Article en page(s) : 2p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/*drug therapy/psychology  Child  Child, Preschool  Cycloserine/*administration & dosage/pharmacology  Double-Blind Method  Drug Administration Schedule  Female  Humans  Learning/*drug effects  Male  Severity of Illness Index  Social Behavior  Treatment Outcome  *Autism  *Autism spectrum disorder  *Social skills training  *d-Cycloserine Index. décimale : PER Périodiques Résumé : BACKGROUND: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. METHODS: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. RESULTS: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. CONCLUSIONS: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01086475. En ligne : http://dx.doi.org/10.1186/s13229-017-0116-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] d-Cycloserine enhances durability of social skills training in autism spectrum disorder [Texte imprimé et/ou numérique] / L. K. WINK, Auteur ; N. F. MINSHAWI, Auteur ; R. C. SHAFFER, Auteur ; M. H. PLAWECKI, Auteur ; D. J. POSEY, Auteur ; P. S. HORN, Auteur ; R. ADAMS, Auteur ; Ernest V. PEDAPATI, Auteur ; T. L. SCHAEFER, Auteur ; C. J. MCDOUGLE, Auteur ; N. B. SWIEZY, Auteur ; C. A. ERICKSON, Auteur . - 2p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 2p. Mots-clés : Autism Spectrum Disorder/*drug therapy/psychology  Child  Child, Preschool  Cycloserine/*administration & dosage/pharmacology  Double-Blind Method  Drug Administration Schedule  Female  Humans  Learning/*drug effects  Male  Severity of Illness Index  Social Behavior  Treatment Outcome  *Autism  *Autism spectrum disorder  *Social skills training  *d-Cycloserine Index. décimale : PER Périodiques Résumé : BACKGROUND: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. METHODS: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. RESULTS: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. CONCLUSIONS: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01086475. En ligne : http://dx.doi.org/10.1186/s13229-017-0116-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Overweight and obese status in children with autism spectrum disorder and disruptive behavior / K. K. CRIADO in Autism, 22-4 (May 2018)  

Public ISBD [article]  inAutism > 22-4 (May 2018) . - p.450-459 Titre : Overweight and obese status in children with autism spectrum disorder and disruptive behavior Type de document : Texte imprimé et/ou numérique Auteurs : K. K. CRIADO, Auteur ; W. G. SHARP, Auteur ; C. E. MCCRACKEN, Auteur ; O. DE VINCK-BAROODY, Auteur ; L. DONG, Auteur ; Michael G. AMAN, Auteur ; C. J. MCDOUGLE, Auteur ; J. T. MCCRACKEN, Auteur ; L. EUGENE ARNOLD, Auteur ; C. WEITZMAN, Auteur ; J. M. LEVENTHAL, Auteur ; B. VITIELLO, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.450-459 Langues : Anglais (eng) Mots-clés : National Health and Nutrition Examination Surveys  prevalence  risperidone Index. décimale : PER Périodiques Résumé : Overweight and obesity are common in pediatric populations. Children with autism spectrum disorder and disruptive behavior may be at higher risk. This study examined whether children with autism spectrum disorder and disruptive behavior are more likely to be overweight or obese than matched controls. Baseline data from medication-free children with autism spectrum disorder who participated in trials conducted by the Research Units on Pediatric Psychopharmacology Autism Network (N = 276) were compared to 544 control children from the National Health and Nutrition Examination Survey database matched on age, sex, race, parent education, and era of data collection. The mean age of the children with autism spectrum disorder was 7.9 +/- 2.6 years; 84.4% were males. In the autism spectrum disorder group, the prevalence was 42.4% for overweight and 21.4% for obesity compared to 26.1% for overweight and 12.0% for obesity among controls (p < 0.001 for each contrast). Within the autism spectrum disorder sample, obesity was associated with minority status and lower daily living skills. These findings suggest that children with autism spectrum disorder and disruptive behavior are at increased risk for obesity and underscore the need for weight management interventions in this population. En ligne : http://dx.doi.org/10.1177/1362361316683888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361 [article] Overweight and obese status in children with autism spectrum disorder and disruptive behavior [Texte imprimé et/ou numérique] / K. K. CRIADO, Auteur ; W. G. SHARP, Auteur ; C. E. MCCRACKEN, Auteur ; O. DE VINCK-BAROODY, Auteur ; L. DONG, Auteur ; Michael G. AMAN, Auteur ; C. J. MCDOUGLE, Auteur ; J. T. MCCRACKEN, Auteur ; L. EUGENE ARNOLD, Auteur ; C. WEITZMAN, Auteur ; J. M. LEVENTHAL, Auteur ; B. VITIELLO, Auteur ; Lawrence SCAHILL, Auteur . - p.450-459. Langues : Anglais (eng) in Autism > 22-4 (May 2018) . - p.450-459 Mots-clés : National Health and Nutrition Examination Surveys  prevalence  risperidone Index. décimale : PER Périodiques Résumé : Overweight and obesity are common in pediatric populations. Children with autism spectrum disorder and disruptive behavior may be at higher risk. This study examined whether children with autism spectrum disorder and disruptive behavior are more likely to be overweight or obese than matched controls. Baseline data from medication-free children with autism spectrum disorder who participated in trials conducted by the Research Units on Pediatric Psychopharmacology Autism Network (N = 276) were compared to 544 control children from the National Health and Nutrition Examination Survey database matched on age, sex, race, parent education, and era of data collection. The mean age of the children with autism spectrum disorder was 7.9 +/- 2.6 years; 84.4% were males. In the autism spectrum disorder group, the prevalence was 42.4% for overweight and 21.4% for obesity compared to 26.1% for overweight and 12.0% for obesity among controls (p < 0.001 for each contrast). Within the autism spectrum disorder sample, obesity was associated with minority status and lower daily living skills. These findings suggest that children with autism spectrum disorder and disruptive behavior are at increased risk for obesity and underscore the need for weight management interventions in this population. En ligne : http://dx.doi.org/10.1177/1362361316683888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361

Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder / Jessica BRADSHAW in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3039-3049 Titre : Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRADSHAW, Auteur ; S. GILLESPIE, Auteur ; C. MCCRACKEN, Auteur ; B. H. KING, Auteur ; J. T. MCCRACKEN, Auteur ; C. R. JOHNSON, Auteur ; L. LECAVALIER, Auteur ; T. SMITH, Auteur ; N. SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; L. SIKICH, Auteur ; C. DONNELLY, Auteur ; E. HOLLANDER, Auteur ; C. J. MCDOUGLE, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.3039-3049 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Caregivers  Child  Family  Humans  Parents  Surveys and Questionnaires  Autism spectrum disorder  Caregiver strain  Disruptive behavior  Stress  Wellbeing Index. décimale : PER Périodiques Résumé : Parents of children with autism spectrum disorder (ASD) face higher levels of caregiver strain compared to parents of children with other disabilities. This study examined child clinical features that predict high levels of caregiver strain for 374 parents of children with ASD. Caregiver strain was measured using the Caregiver Strain Questionnaire (CGSQ) objective, subjective internalized, and subjective externalized subscales. Confirmatory factor analysis indicated an acceptable fit for the original CGSQ three-factor solution. The strongest child predictors across CGSQ subscales were: disruptive behavior for objective strain, autism severity and disruptive behavior for subjective internalized strain, and oppositional behavior and hyperactivity for subjective externalized strain. Individualized interventions that attend to specific elements of parental strain may reduce strain and improve family wellbeing. En ligne : http://dx.doi.org/10.1007/s10803-020-04625-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jessica BRADSHAW, Auteur ; S. GILLESPIE, Auteur ; C. MCCRACKEN, Auteur ; B. H. KING, Auteur ; J. T. MCCRACKEN, Auteur ; C. R. JOHNSON, Auteur ; L. LECAVALIER, Auteur ; T. SMITH, Auteur ; N. SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; L. SIKICH, Auteur ; C. DONNELLY, Auteur ; E. HOLLANDER, Auteur ; C. J. MCDOUGLE, Auteur ; Lawrence SCAHILL, Auteur . - p.3039-3049. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3039-3049 Mots-clés : Autism Spectrum Disorder  Caregivers  Child  Family  Humans  Parents  Surveys and Questionnaires  Autism spectrum disorder  Caregiver strain  Disruptive behavior  Stress  Wellbeing Index. décimale : PER Périodiques Résumé : Parents of children with autism spectrum disorder (ASD) face higher levels of caregiver strain compared to parents of children with other disabilities. This study examined child clinical features that predict high levels of caregiver strain for 374 parents of children with ASD. Caregiver strain was measured using the Caregiver Strain Questionnaire (CGSQ) objective, subjective internalized, and subjective externalized subscales. Confirmatory factor analysis indicated an acceptable fit for the original CGSQ three-factor solution. The strongest child predictors across CGSQ subscales were: disruptive behavior for objective strain, autism severity and disruptive behavior for subjective internalized strain, and oppositional behavior and hyperactivity for subjective externalized strain. Individualized interventions that attend to specific elements of parental strain may reduce strain and improve family wellbeing. En ligne : http://dx.doi.org/10.1007/s10803-020-04625-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder / C. J. SMITH in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Permalink

A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder / L. K. WINK in Molecular Autism, 7 (2016)  

Permalink

A randomized, placebo-controlled trial of D-cycloserine for the enhancement of social skills training in autism spectrum disorders / N. F. MINSHAWI in Molecular Autism, 7 (2016)  

Permalink

Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome / J. C. HUSTON in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Permalink

---

1 (1 - 9 / 9)