Autism screening at 18 months of age: a comparison of the Q-CHAT-10 and M-CHAT screeners / Raymond STURNER in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 2p. Titre : Autism screening at 18 months of age: a comparison of the Q-CHAT-10 and M-CHAT screeners Type de document : texte imprimé Auteurs : Raymond STURNER, Auteur ; Barbara HOWARD, Auteur ; Paul BERGMANN, Auteur ; Shana M. ATTAR, Auteur ; Lydia STEWART, Auteur ; Kerry BET, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 2p. Langues : Anglais (eng) Mots-clés : Autism screening  Developmental screening  M-chat  Q-CHAT  Primary Care and its for-profit subsidiary,  CHADIS, Inc. CHADIS, the web-tool used  in the study was developed by Dr. Sturner and his spouse, Dr. Howard. Dr. Sturner is  Director of the Center and Dr. Howard is President of CHADIS, Inc. Both are members  of the Board of Directors of Center and are paid employees or consultants to both  entities. The other authors have indicated they have no financial relationships  relevant to this article to disclose. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism screening is recommended at 18- and 24-month pediatric well visits. The Modified Checklist for Autism in Toddlers-Revised (M-CHAT-R) authors recommend a follow-up interview (M-CHAT-R/F) when positive. M-CHAT-R/F may be less accurate for 18-month-olds than 24-month-olds and accuracy for identification prior to two years is not known in samples that include children screening negative. Since autism symptoms may emerge gradually, ordinally scoring items based on the full range of response options, such as in the 10-item version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10), might better capture autism signs than the dichotomous (i.e., yes/no) items in M-CHAT-R or the pass/fail scoring of Q-CHAT-10 items. The aims of this study were to determine and compare the accuracy of the M-CHAT-R/F and the Q-CHAT-10 and to describe the accuracy of the ordinally scored Q-CHAT-10 (Q-CHAT-10-O) for predicting autism in a sample of children who were screened at 18 months. METHODS: This is a community pediatrics validation study with screen positive (n = 167) and age- and practice-matched screen negative children (n = 241) recruited for diagnostic evaluations completed prior to 2 years old. Clinical diagnosis of autism was based on results of in-person diagnostic autism evaluations by research reliable testers blind to screening results and using the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) Toddler Module and Mullen Scales of Early Learning (MSEL) per standard guidelines. RESULTS: While the M-CHAT-R/F had higher specificity and PPV compared to M-CHAT-R, Q-CHAT-10-O showed higher sensitivity than M-CHAT-R/F and Q-CHAT-10. LIMITATIONS: Many parents declined participation and the sample is over-represented by higher educated parents. Results cannot be extended to older ages. CONCLUSIONS: Limitations of the currently recommended two-stage M-CHAT-R/F at the 18-month visit include low sensitivity with minimal balancing benefit of improved PPV from the follow-up interview. Ordinal, rather than dichotomous, scoring of autism screening items appears to be beneficial at this age. The Q-CHAT-10-O with ordinal scoring shows advantages to M-CHAT-R/F with half the number of items, no requirement for a follow-up interview, and improved sensitivity. Yet, Q-CHAT-10-O sensitivity is less than M-CHAT-R (without follow-up) and specificity is less than the two-stage procedure. Such limitations are consistent with recognition that screening needs to recur beyond this age. En ligne : http://dx.doi.org/10.1186/s13229-021-00480-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Autism screening at 18 months of age: a comparison of the Q-CHAT-10 and M-CHAT screeners [texte imprimé] / Raymond STURNER, Auteur ; Barbara HOWARD, Auteur ; Paul BERGMANN, Auteur ; Shana M. ATTAR, Auteur ; Lydia STEWART, Auteur ; Kerry BET, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur . - 2p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 2p. Mots-clés : Autism screening  Developmental screening  M-chat  Q-CHAT  Primary Care and its for-profit subsidiary,  CHADIS, Inc. CHADIS, the web-tool used  in the study was developed by Dr. Sturner and his spouse, Dr. Howard. Dr. Sturner is  Director of the Center and Dr. Howard is President of CHADIS, Inc. Both are members  of the Board of Directors of Center and are paid employees or consultants to both  entities. The other authors have indicated they have no financial relationships  relevant to this article to disclose. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism screening is recommended at 18- and 24-month pediatric well visits. The Modified Checklist for Autism in Toddlers-Revised (M-CHAT-R) authors recommend a follow-up interview (M-CHAT-R/F) when positive. M-CHAT-R/F may be less accurate for 18-month-olds than 24-month-olds and accuracy for identification prior to two years is not known in samples that include children screening negative. Since autism symptoms may emerge gradually, ordinally scoring items based on the full range of response options, such as in the 10-item version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10), might better capture autism signs than the dichotomous (i.e., yes/no) items in M-CHAT-R or the pass/fail scoring of Q-CHAT-10 items. The aims of this study were to determine and compare the accuracy of the M-CHAT-R/F and the Q-CHAT-10 and to describe the accuracy of the ordinally scored Q-CHAT-10 (Q-CHAT-10-O) for predicting autism in a sample of children who were screened at 18 months. METHODS: This is a community pediatrics validation study with screen positive (n = 167) and age- and practice-matched screen negative children (n = 241) recruited for diagnostic evaluations completed prior to 2 years old. Clinical diagnosis of autism was based on results of in-person diagnostic autism evaluations by research reliable testers blind to screening results and using the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) Toddler Module and Mullen Scales of Early Learning (MSEL) per standard guidelines. RESULTS: While the M-CHAT-R/F had higher specificity and PPV compared to M-CHAT-R, Q-CHAT-10-O showed higher sensitivity than M-CHAT-R/F and Q-CHAT-10. LIMITATIONS: Many parents declined participation and the sample is over-represented by higher educated parents. Results cannot be extended to older ages. CONCLUSIONS: Limitations of the currently recommended two-stage M-CHAT-R/F at the 18-month visit include low sensitivity with minimal balancing benefit of improved PPV from the follow-up interview. Ordinal, rather than dichotomous, scoring of autism screening items appears to be beneficial at this age. The Q-CHAT-10-O with ordinal scoring shows advantages to M-CHAT-R/F with half the number of items, no requirement for a follow-up interview, and improved sensitivity. Yet, Q-CHAT-10-O sensitivity is less than M-CHAT-R (without follow-up) and specificity is less than the two-stage procedure. Such limitations are consistent with recognition that screening needs to recur beyond this age. En ligne : http://dx.doi.org/10.1186/s13229-021-00480-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Comparison of Autism Screening in Younger and Older Toddlers / Raymond STURNER in Journal of Autism and Developmental Disorders, 47-10 (October 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.3180-3188 Titre : Comparison of Autism Screening in Younger and Older Toddlers Type de document : texte imprimé Auteurs : Raymond STURNER, Auteur ; Barbara HOWARD, Auteur ; Paul BERGMANN, Auteur ; Lydia STEWART, Auteur ; Talin E. AFARIAN, Auteur Article en page(s) : p.3180-3188 Langues : Anglais (eng) Mots-clés : Autism screening  M-CHAT  Developmental screening  Test development Index. décimale : PER Périodiques Résumé : This study examined the effect of age at completion of an autism screening test on item failure rates contrasting older (>20 months) with younger (<20 months) toddlers in a community primary care sample of 73,564 children. Items related to social development were categorized into one of three age sets per criteria from Inada et al. (Research in Autism Spectrum Disorders 4(4):605–611, 2010). Younger toddlers produced higher rates of item failure than older toddlers and items in both of the later acquired item sets had higher probability rates for failure than the earliest acquired item set (prior to 8 months). Use of the same items and the same scoring throughout the target age range for autism screening may not be the best strategy for identifying the youngest toddlers at risk for autism. En ligne : https://doi.org/10.1007/s10803-017-3230-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319 [article] Comparison of Autism Screening in Younger and Older Toddlers [texte imprimé] / Raymond STURNER, Auteur ; Barbara HOWARD, Auteur ; Paul BERGMANN, Auteur ; Lydia STEWART, Auteur ; Talin E. AFARIAN, Auteur . - p.3180-3188. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.3180-3188 Mots-clés : Autism screening  M-CHAT  Developmental screening  Test development Index. décimale : PER Périodiques Résumé : This study examined the effect of age at completion of an autism screening test on item failure rates contrasting older (>20 months) with younger (<20 months) toddlers in a community primary care sample of 73,564 children. Items related to social development were categorized into one of three age sets per criteria from Inada et al. (Research in Autism Spectrum Disorders 4(4):605–611, 2010). Younger toddlers produced higher rates of item failure than older toddlers and items in both of the later acquired item sets had higher probability rates for failure than the earliest acquired item set (prior to 8 months). Use of the same items and the same scoring throughout the target age range for autism screening may not be the best strategy for identifying the youngest toddlers at risk for autism. En ligne : https://doi.org/10.1007/s10803-017-3230-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319

Remembering Dr Li-Ching Lee, a pioneer of global autism research / Eric RUBENSTEIN in Autism, 26-2 (February 2022)  

Public ISBD [article]  inAutism > 26-2 (February 2022) . - p.562-563 Titre : Remembering Dr Li-Ching Lee, a pioneer of global autism research Type de document : texte imprimé Auteurs : Eric RUBENSTEIN, Auteur ; Catherine E. RICE, Auteur ; C. HOLLINGUE, Auteur ; Peng-Chou TSAI, Auteur ; Lydia STEWART, Auteur ; M. Daniele FALLIN, Auteur Article en page(s) : p.562-563 Langues : Anglais (eng) Mots-clés : epidemiology  global health Index. décimale : PER Périodiques Résumé : The field of global autism research lost a pioneer, champion, and innovator with the passing of Dr Li-Ching Lee in May 2021. Dr Lee served as the editor for a special issue in Autism on global autism research (2017, Volume 21, Issue 5) and her substantial impact on autism research and autistic individuals and their families in low- and middle-income countries warrants a place in this special issue. While a giant in the professional arena, her large impact on science is minor compared to the compassion, kindness, and love she brought to her family, friends, and her professional communities at Johns Hopkins, across institutions, her native Taiwan, and the areas in which she conducted her research. Dr Lee was immensely humble and intensely focused on harnessing epidemiology to positively impact the lives of people with autism and developmental disabilities. Her humility and professional dedication was coupled with a desire to keep her own challenges and triumphs private including her courageous efforts to stave off cancer while accomplishing so much in support of others. En ligne : http://dx.doi.org/10.1177/13623613211059641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Remembering Dr Li-Ching Lee, a pioneer of global autism research [texte imprimé] / Eric RUBENSTEIN, Auteur ; Catherine E. RICE, Auteur ; C. HOLLINGUE, Auteur ; Peng-Chou TSAI, Auteur ; Lydia STEWART, Auteur ; M. Daniele FALLIN, Auteur . - p.562-563. Langues : Anglais (eng) in Autism > 26-2 (February 2022) . - p.562-563 Mots-clés : epidemiology  global health Index. décimale : PER Périodiques Résumé : The field of global autism research lost a pioneer, champion, and innovator with the passing of Dr Li-Ching Lee in May 2021. Dr Lee served as the editor for a special issue in Autism on global autism research (2017, Volume 21, Issue 5) and her substantial impact on autism research and autistic individuals and their families in low- and middle-income countries warrants a place in this special issue. While a giant in the professional arena, her large impact on science is minor compared to the compassion, kindness, and love she brought to her family, friends, and her professional communities at Johns Hopkins, across institutions, her native Taiwan, and the areas in which she conducted her research. Dr Lee was immensely humble and intensely focused on harnessing epidemiology to positively impact the lives of people with autism and developmental disabilities. Her humility and professional dedication was coupled with a desire to keep her own challenges and triumphs private including her courageous efforts to stave off cancer while accomplishing so much in support of others. En ligne : http://dx.doi.org/10.1177/13623613211059641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Screening for autism spectrum disorder in low- and middle-income countries: A systematic review / Lydia A. STEWART in Autism, 21-5 (July 2017)  

Public ISBD [article]  inAutism > 21-5 (July 2017) . - p.527-539 Titre : Screening for autism spectrum disorder in low- and middle-income countries: A systematic review Type de document : texte imprimé Auteurs : Lydia A. STEWART, Auteur ; Li-Ching LEE, Auteur Article en page(s) : p.527-539 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This review contributes to the growing body of global autism spectrum disorder literature by examining the use of screening instruments in low- and middle-income countries with respect to study design and methodology, instrument adaptation and performance, and collaboration with community stakeholders in research. A systematic review was conducted to understand the use of autism spectrum disorder screening instruments in low- and middle-income countries from studies published between 1992 and 2015. This review found that 18 different autism spectrum disorder screeners have been used in low- and middle-income settings with wide ranges of sensitivities and specificities. The significant variation in study design, screening methodology, and population characteristics limits the ability of this review to make robust recommendations about optimal screening tool selection. Clinical-based screening for autism spectrum disorder was the most widely reported method. However, community-based screening was shown to be an effective method for identifying autism spectrum disorder in communities with limited clinical resources. Only a few studies included in this review reported cultural adaptation of screening tools and collaboration with local stakeholders. Establishing guidelines for the reporting of cultural adaptation and community collaboration procedures as well as screening instrument psychometrics and screening methodology will enable the field to develop best practices for autism spectrum disorder screening in low-resource settings. En ligne : http://dx.doi.org/10.1177/1362361316677025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Screening for autism spectrum disorder in low- and middle-income countries: A systematic review [texte imprimé] / Lydia A. STEWART, Auteur ; Li-Ching LEE, Auteur . - p.527-539. Langues : Anglais (eng) in Autism > 21-5 (July 2017) . - p.527-539 Index. décimale : PER Périodiques Résumé : This review contributes to the growing body of global autism spectrum disorder literature by examining the use of screening instruments in low- and middle-income countries with respect to study design and methodology, instrument adaptation and performance, and collaboration with community stakeholders in research. A systematic review was conducted to understand the use of autism spectrum disorder screening instruments in low- and middle-income countries from studies published between 1992 and 2015. This review found that 18 different autism spectrum disorder screeners have been used in low- and middle-income settings with wide ranges of sensitivities and specificities. The significant variation in study design, screening methodology, and population characteristics limits the ability of this review to make robust recommendations about optimal screening tool selection. Clinical-based screening for autism spectrum disorder was the most widely reported method. However, community-based screening was shown to be an effective method for identifying autism spectrum disorder in communities with limited clinical resources. Only a few studies included in this review reported cultural adaptation of screening tools and collaboration with local stakeholders. Establishing guidelines for the reporting of cultural adaptation and community collaboration procedures as well as screening instrument psychometrics and screening methodology will enable the field to develop best practices for autism spectrum disorder screening in low-resource settings. En ligne : http://dx.doi.org/10.1177/1362361316677025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

The Utility of the Screening Tool for Autism in 2-Year-Olds in Detecting Autism in Taiwanese Toddlers Who are Less than 24 Months of Age: A Longitudinal Study / Chin-Chin WU in Journal of Autism and Developmental Disorders, 50-4 (April 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-4 (April 2020) . - p.1172-1181 Titre : The Utility of the Screening Tool for Autism in 2-Year-Olds in Detecting Autism in Taiwanese Toddlers Who are Less than 24 Months of Age: A Longitudinal Study Type de document : texte imprimé Auteurs : Chin-Chin WU, Auteur ; Ching-Lin CHU, Auteur ; Lydia STEWART, Auteur ; Chung-Hsin CHIANG, Auteur ; Yuh-Ming HOU, Auteur ; Jiun-Horng LIU, Auteur Article en page(s) : p.1172-1181 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Screening  Sensitivity  Specificity  Toddler Index. décimale : PER Périodiques Résumé : The present longitudinal study examined the utility of the screening tool for autism in 2-year-olds (STAT) in detecting autism spectrum disorder (ASD) in toddlers who are less than 24 months of age. The study sample, which consisted of 119 toddlers with developmental problems, were assessed when they were between 16 and 24 months of age (Time 1) and after a period of 18 months to finalize the diagnosis (Time 2); 57 children had ASD and 62 children had developmental delays. A cutoff score of 2.5 on the STAT yielded an optimal combination of high sensitivity and specificity. The STAT demonstrated adequate predictive validity in detecting ASD in Taiwanese toddlers who are less than 24 months of age. En ligne : http://dx.doi.org/10.1007/s10803-019-04350-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] The Utility of the Screening Tool for Autism in 2-Year-Olds in Detecting Autism in Taiwanese Toddlers Who are Less than 24 Months of Age: A Longitudinal Study [texte imprimé] / Chin-Chin WU, Auteur ; Ching-Lin CHU, Auteur ; Lydia STEWART, Auteur ; Chung-Hsin CHIANG, Auteur ; Yuh-Ming HOU, Auteur ; Jiun-Horng LIU, Auteur . - p.1172-1181. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-4 (April 2020) . - p.1172-1181 Mots-clés : Autism spectrum disorder  Screening  Sensitivity  Specificity  Toddler Index. décimale : PER Périodiques Résumé : The present longitudinal study examined the utility of the screening tool for autism in 2-year-olds (STAT) in detecting autism spectrum disorder (ASD) in toddlers who are less than 24 months of age. The study sample, which consisted of 119 toddlers with developmental problems, were assessed when they were between 16 and 24 months of age (Time 1) and after a period of 18 months to finalize the diagnosis (Time 2); 57 children had ASD and 62 children had developmental delays. A cutoff score of 2.5 on the STAT yielded an optimal combination of high sensitivity and specificity. The STAT demonstrated adequate predictive validity in detecting ASD in Taiwanese toddlers who are less than 24 months of age. En ligne : http://dx.doi.org/10.1007/s10803-019-04350-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Use of the Chinese version modified checklist for autism in toddlers in a high-risk sample in Taiwan / Yi Shan WONG in Research in Autism Spectrum Disorders, 49 (May 2018)  

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