Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study / A. RAUSCH in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 13p. Titre : Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study Type de document : Texte imprimé et/ou numérique Auteurs : A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur Article en page(s) : 13p. Langues : Anglais (eng) Mots-clés : Adolescent  Afferent Pathways/pathology/physiopathology  Amygdala/pathology/physiopathology  Autism Spectrum Disorder/pathology/physiopathology  Basolateral Nuclear Complex/pathology/physiopathology  Central Amygdaloid Nucleus/pathology/physiopathology  Connectome  Efferent Pathways/pathology/physiopathology  Emotions  Female  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Models, Neurological  Models, Psychological  Neocortex/pathology/physiopathology  Nerve Net/pathology/physiopathology  Signal-To-Noise Ratio  Social Perception  Surveys and Questionnaires  Temporal Lobe/pathology/physiopathology  Young Adult  Amygdala  Autism spectrum disorder  Centromedial  Connectivity  Input-output  Laterobasal  Nuclei  Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study [Texte imprimé et/ou numérique] / A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur . - 13p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 13p. Mots-clés : Adolescent  Afferent Pathways/pathology/physiopathology  Amygdala/pathology/physiopathology  Autism Spectrum Disorder/pathology/physiopathology  Basolateral Nuclear Complex/pathology/physiopathology  Central Amygdaloid Nucleus/pathology/physiopathology  Connectome  Efferent Pathways/pathology/physiopathology  Emotions  Female  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Models, Neurological  Models, Psychological  Neocortex/pathology/physiopathology  Nerve Net/pathology/physiopathology  Signal-To-Noise Ratio  Social Perception  Surveys and Questionnaires  Temporal Lobe/pathology/physiopathology  Young Adult  Amygdala  Autism spectrum disorder  Centromedial  Connectivity  Input-output  Laterobasal  Nuclei  Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Brief Report: Factors Associated with Emergency Department Visits for Epilepsy Among Children with Autism Spectrum Disorder / W. ZHANG in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1854-1860 Titre : Brief Report: Factors Associated with Emergency Department Visits for Epilepsy Among Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : W. ZHANG, Auteur ; Grace T. BARANEK, Auteur ; B. BOYD, Auteur Article en page(s) : p.1854-1860 Langues : Anglais (eng) Mots-clés : Autism  Children with ASD  Emergency department (ED)  Epilepsy Index. décimale : PER Périodiques Résumé : We examined how demographic and clinical characteristics differ between emergency department (ED) visits for epilepsy (EP cohort) and ED visits for other reasons (non-EP cohort) in children with ASD. The data were drawn from the 2009 and 2010 Nationwide Emergency Department Sample. We performed both univariate and multivariate analyses to compare and contrast similarities and differences between EP cohort and non-EP cohort among children with ASD. The results showed ED visits in EP cohort were more likely to occur among adolescents aged 13-17 years, less likely to occur among children with co-occurring psychiatric conditions, and were more likely to co-occur with injury. We discussed some unique challenges for managing children with both ASD and epilepsy. En ligne : http://dx.doi.org/10.1007/s10803-017-3433-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 [article] Brief Report: Factors Associated with Emergency Department Visits for Epilepsy Among Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / W. ZHANG, Auteur ; Grace T. BARANEK, Auteur ; B. BOYD, Auteur . - p.1854-1860. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1854-1860 Mots-clés : Autism  Children with ASD  Emergency department (ED)  Epilepsy Index. décimale : PER Périodiques Résumé : We examined how demographic and clinical characteristics differ between emergency department (ED) visits for epilepsy (EP cohort) and ED visits for other reasons (non-EP cohort) in children with ASD. The data were drawn from the 2009 and 2010 Nationwide Emergency Department Sample. We performed both univariate and multivariate analyses to compare and contrast similarities and differences between EP cohort and non-EP cohort among children with ASD. The results showed ED visits in EP cohort were more likely to occur among adolescents aged 13-17 years, less likely to occur among children with co-occurring psychiatric conditions, and were more likely to co-occur with injury. We discussed some unique challenges for managing children with both ASD and epilepsy. En ligne : http://dx.doi.org/10.1007/s10803-017-3433-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355

Brief Report: Regional Variations in Characteristics of ASD Hospitalizations in the U.S / W. ZHANG in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1289-1297 Titre : Brief Report: Regional Variations in Characteristics of ASD Hospitalizations in the U.S Type de document : Texte imprimé et/ou numérique Auteurs : W. ZHANG, Auteur ; M. ESHGHI, Auteur Article en page(s) : p.1289-1297 Langues : Anglais (eng) Mots-clés : ASD inpatient care  Autism  Hospitalizations  U.S. Census Bureau-defined regions Index. décimale : PER Périodiques Résumé : Regional differences in ASD inpatient care remain understudied. We used the Nationwide Inpatient Sample to examine contributory causes and potential determinants associated with regional variations in ASD hospitalizations. We performed univariate and multivariate analyses to identify differences in ASD hospitalizations across four U.S. Census Bureau-defined regions. Our results revealed considerable variations in ASD hospitalizations across U.S. regions. Compared with patients in the Northeast, those in the Midwest, South, and West were less likely to be hospitalized for ASD. Significant differences were observed among regions with regard to the effect of health insurance type, hospital length of stay, hospital bed size, hospital location and teaching status on ASD hospitalizations. The region-specific analysis provides direction for further investigation. En ligne : http://dx.doi.org/10.1007/s10803-018-3826-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Brief Report: Regional Variations in Characteristics of ASD Hospitalizations in the U.S [Texte imprimé et/ou numérique] / W. ZHANG, Auteur ; M. ESHGHI, Auteur . - p.1289-1297. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1289-1297 Mots-clés : ASD inpatient care  Autism  Hospitalizations  U.S. Census Bureau-defined regions Index. décimale : PER Périodiques Résumé : Regional differences in ASD inpatient care remain understudied. We used the Nationwide Inpatient Sample to examine contributory causes and potential determinants associated with regional variations in ASD hospitalizations. We performed univariate and multivariate analyses to identify differences in ASD hospitalizations across four U.S. Census Bureau-defined regions. Our results revealed considerable variations in ASD hospitalizations across U.S. regions. Compared with patients in the Northeast, those in the Midwest, South, and West were less likely to be hospitalized for ASD. Significant differences were observed among regions with regard to the effect of health insurance type, hospital length of stay, hospital bed size, hospital location and teaching status on ASD hospitalizations. The region-specific analysis provides direction for further investigation. En ligne : http://dx.doi.org/10.1007/s10803-018-3826-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder / A. RAUSCH in Journal of Autism and Developmental Disorders, 48-2 (February 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.572-582 Titre : Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. RAUSCH, Auteur ; W. ZHANG, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur ; K. V. HAAK, Auteur Article en page(s) : p.572-582 Langues : Anglais (eng) Mots-clés : Amygdala  Autism spectrum disorder  Functional connectivity  Parcellation  Prefrontal Index. décimale : PER Périodiques Résumé : Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway. En ligne : https://doi.org/10.1007/s10803-017-3370-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338 [article] Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. RAUSCH, Auteur ; W. ZHANG, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur ; K. V. HAAK, Auteur . - p.572-582. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.572-582 Mots-clés : Amygdala  Autism spectrum disorder  Functional connectivity  Parcellation  Prefrontal Index. décimale : PER Périodiques Résumé : Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway. En ligne : https://doi.org/10.1007/s10803-017-3370-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338

Developmental changes in longitudinal associations between academic achievement and psychopathological symptoms from late childhood to middle adolescence / W. ZHANG in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.178-188 Titre : Developmental changes in longitudinal associations between academic achievement and psychopathological symptoms from late childhood to middle adolescence Type de document : Texte imprimé et/ou numérique Auteurs : W. ZHANG, Auteur ; L. ZHANG, Auteur ; L. CHEN, Auteur ; L. JI, Auteur ; K. DEATER-DECKARD, Auteur Article en page(s) : p.178-188 Langues : Anglais (eng) Mots-clés : Academic achievement  depression  developmental change  externalizing problems Index. décimale : PER Périodiques Résumé : BACKGROUND: Research reveals longitudinal bidirectional associations between changes in academic achievement and psychopathological symptoms. However, little is known about developmental changes in the magnitude of these associations, from childhood to adolescence. METHODS: Participants were 648 Chinese children (347 males) who were followed from Grade 5 (mean age: 11.18 years) to Grade 9. Academic achievement and two types of symptoms (externalizing, depressive) were assessed annually. Structural equation modeling was used to examine longitudinal bidirectional associations between achievement and psychopathological symptoms, and developmental changes in effect sizes. Models were estimated using cross-lagged panel modeling (CLPM), as well as random intercepts cross-lagged panel modeling (RI-CLPM). RESULTS: The data supported the hypothesized academic incompetence and adjustment erosion effects, as well as the hypothesized developmental change in the academic incompetence effect whereby prior achievement's effects on subsequent externalizing increased with age. Results were similar for both genders and unaffected by inclusion of common risk factors as covariates. CONCLUSIONS: There are bidirectional associations between symptoms and achievement that change markedly across the transition into adolescence. Interpreting the effects using a developmental perspective, changes in reciprocal effects may be dynamic. The findings suggest that targeting both psychopathology and low academic achievement is worthwhile, but that distinct treatment effects will be found in childhood versus adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.12927 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Developmental changes in longitudinal associations between academic achievement and psychopathological symptoms from late childhood to middle adolescence [Texte imprimé et/ou numérique] / W. ZHANG, Auteur ; L. ZHANG, Auteur ; L. CHEN, Auteur ; L. JI, Auteur ; K. DEATER-DECKARD, Auteur . - p.178-188. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.178-188 Mots-clés : Academic achievement  depression  developmental change  externalizing problems Index. décimale : PER Périodiques Résumé : BACKGROUND: Research reveals longitudinal bidirectional associations between changes in academic achievement and psychopathological symptoms. However, little is known about developmental changes in the magnitude of these associations, from childhood to adolescence. METHODS: Participants were 648 Chinese children (347 males) who were followed from Grade 5 (mean age: 11.18 years) to Grade 9. Academic achievement and two types of symptoms (externalizing, depressive) were assessed annually. Structural equation modeling was used to examine longitudinal bidirectional associations between achievement and psychopathological symptoms, and developmental changes in effect sizes. Models were estimated using cross-lagged panel modeling (CLPM), as well as random intercepts cross-lagged panel modeling (RI-CLPM). RESULTS: The data supported the hypothesized academic incompetence and adjustment erosion effects, as well as the hypothesized developmental change in the academic incompetence effect whereby prior achievement's effects on subsequent externalizing increased with age. Results were similar for both genders and unaffected by inclusion of common risk factors as covariates. CONCLUSIONS: There are bidirectional associations between symptoms and achievement that change markedly across the transition into adolescence. Interpreting the effects using a developmental perspective, changes in reciprocal effects may be dynamic. The findings suggest that targeting both psychopathology and low academic achievement is worthwhile, but that distinct treatment effects will be found in childhood versus adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.12927 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

In Search of Culturally Appropriate Autism Interventions: Perspectives of Latino Caregivers / M. DUBAY in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

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Parent and professional perspectives on behavioral inflexibility in autism spectrum disorders: A qualitative study / C. SETHI in Autism, 23-5 (July 2019)  

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