Globally weaker and topologically different: resting-state connectivity in youth with autism / B. E. YERYS in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 39p. Titre : Globally weaker and topologically different: resting-state connectivity in youth with autism Type de document : Texte imprimé et/ou numérique Auteurs : B. E. YERYS, Auteur ; J. D. HERRINGTON, Auteur ; Theodore D. SATTERTHWAITE, Auteur ; L. GUY, Auteur ; Robert T. SCHULTZ, Auteur ; D. S. BASSETT, Auteur Article en page(s) : 39p. Langues : Anglais (eng) Mots-clés : Attention  Autism spectrum disorder  Children  Intrinsic networks  Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND: There is a lack of agreement about functional connectivity differences in individuals with autism spectrum disorder (ASD). Studies using absolute strength have found reduced connectivity, while those using relative strength--a measure of system topology--reveal mostly enhanced connectivity. We hypothesized that mixed findings may be driven by the metric of functional connectivity. METHODS: Resting-state echo planar 3 T functional magnetic resonance imaging scans were acquired on a Siemens Verio Scanner from 6 to 17-year-old youth with ASD (n = 81) and a matched typically developing control group (n = 82). All functional time series data were preprocessed using a confound regression procedure that has been previously validated in large-scale developmental datasets. It has also been shown to be highly effective at reducing the influence of motion artifact on connectivity data. We extracted time series data from a 333-node parcellation scheme, which was previously mapped to 13 functional systems. A Pearson's correlation was calculated and transformed to Fisher's z between every pair of nodes to create a weighted 333 x 333 adjacency matrix. Mean absolute functional connectivity strength was the mean Fisher's z of the matrix. Relative functional connectivity was corrected for individual differences in mean absolute functional connectivity (i.e., each connection in the matrix was divided by their mean z), and functional connectivity was evaluated within and across each of the functional networks in the parcellation scheme. RESULTS: Absolute functional connectivity strength was lower in ASD, and lower functional connectivity was correlated with greater ASD symptom severity. Relative functional connectivity was higher for the ASD group in the ventral attention and retrosplenial-temporal systems, with lower cross-system functional connectivity between the ventral attention and somatomotor-mouth systems. Functional connectivity within the ventral attention and retro-splenial systems correlated significantly with ASD symptom severity. CONCLUSIONS: Within a context of globally weaker functional connectivity, youth with ASD have an atypical topology of brain systems that support social perception and communication. This study clarifies the mixed results reported previously and demonstrates that the functional connectivity metric influences the observed direction of functional connectivity differences for individuals with ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0156-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] Globally weaker and topologically different: resting-state connectivity in youth with autism [Texte imprimé et/ou numérique] / B. E. YERYS, Auteur ; J. D. HERRINGTON, Auteur ; Theodore D. SATTERTHWAITE, Auteur ; L. GUY, Auteur ; Robert T. SCHULTZ, Auteur ; D. S. BASSETT, Auteur . - 39p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 39p. Mots-clés : Attention  Autism spectrum disorder  Children  Intrinsic networks  Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND: There is a lack of agreement about functional connectivity differences in individuals with autism spectrum disorder (ASD). Studies using absolute strength have found reduced connectivity, while those using relative strength--a measure of system topology--reveal mostly enhanced connectivity. We hypothesized that mixed findings may be driven by the metric of functional connectivity. METHODS: Resting-state echo planar 3 T functional magnetic resonance imaging scans were acquired on a Siemens Verio Scanner from 6 to 17-year-old youth with ASD (n = 81) and a matched typically developing control group (n = 82). All functional time series data were preprocessed using a confound regression procedure that has been previously validated in large-scale developmental datasets. It has also been shown to be highly effective at reducing the influence of motion artifact on connectivity data. We extracted time series data from a 333-node parcellation scheme, which was previously mapped to 13 functional systems. A Pearson's correlation was calculated and transformed to Fisher's z between every pair of nodes to create a weighted 333 x 333 adjacency matrix. Mean absolute functional connectivity strength was the mean Fisher's z of the matrix. Relative functional connectivity was corrected for individual differences in mean absolute functional connectivity (i.e., each connection in the matrix was divided by their mean z), and functional connectivity was evaluated within and across each of the functional networks in the parcellation scheme. RESULTS: Absolute functional connectivity strength was lower in ASD, and lower functional connectivity was correlated with greater ASD symptom severity. Relative functional connectivity was higher for the ASD group in the ventral attention and retrosplenial-temporal systems, with lower cross-system functional connectivity between the ventral attention and somatomotor-mouth systems. Functional connectivity within the ventral attention and retro-splenial systems correlated significantly with ASD symptom severity. CONCLUSIONS: Within a context of globally weaker functional connectivity, youth with ASD have an atypical topology of brain systems that support social perception and communication. This study clarifies the mixed results reported previously and demonstrates that the functional connectivity metric influences the observed direction of functional connectivity differences for individuals with ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0156-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability / B. B. MADDOX in Autism, 22-8 (November 2018)  

Public ISBD [article]  inAutism > 22-8 (November 2018) . - p.898-906 Titre : Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : B. B. MADDOX, Auteur ; P. CLEARY, Auteur ; E. S. KUSCHNER, Auteur ; J. S. MILLER, Auteur ; Anna Chelsea ARMOUR, Auteur ; L. GUY, Auteur ; L. KENWORTHY, Auteur ; Robert T. SCHULTZ, Auteur ; B. E. YERYS, Auteur Article en page(s) : p.898-906 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  challenging behaviors  cognitive-behavioral treatment  emotion regulation  executive function Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder display challenging behaviors. These behaviors are not limited to those with cognitive and/or language impairments. The Collaborative and Proactive Solutions framework proposes that challenging behaviors result from an incompatibility between environmental demands and a child's "lagging skills." The primary Collaborative and Proactive Solutions lagging skills-executive function, emotion regulation, language, and social skills-are often areas of weakness for individuals with autism spectrum disorder. The purpose of this study was to evaluate whether these lagging skills are associated with challenging behaviors in youth with autism spectrum disorder without intellectual disability. Parents of 182 youth with autism spectrum disorder (6-15 years) completed measures of their children's challenging behaviors, executive function, language, emotion regulation, and social skills. We tested whether the Collaborative and Proactive Solutions lagging skills predicted challenging behaviors using multiple linear regression. The Collaborative and Proactive Solutions lagging skills explained significant variance in participants' challenging behaviors. The Depression (emotion regulation), Inhibit (executive function), and Sameness (executive function) scales emerged as significant predictors. Impairments in emotion regulation and executive function may contribute substantially to aggressive and oppositional behaviors in school-age youth with autism spectrum disorder without intellectual disability. Treatment for challenging behaviors in this group may consider targeting the incompatibility between environmental demands and a child's lagging skills. En ligne : http://dx.doi.org/10.1177/1362361317712651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability [Texte imprimé et/ou numérique] / B. B. MADDOX, Auteur ; P. CLEARY, Auteur ; E. S. KUSCHNER, Auteur ; J. S. MILLER, Auteur ; Anna Chelsea ARMOUR, Auteur ; L. GUY, Auteur ; L. KENWORTHY, Auteur ; Robert T. SCHULTZ, Auteur ; B. E. YERYS, Auteur . - p.898-906. Langues : Anglais (eng) in Autism > 22-8 (November 2018) . - p.898-906 Mots-clés : autism spectrum disorder  challenging behaviors  cognitive-behavioral treatment  emotion regulation  executive function Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder display challenging behaviors. These behaviors are not limited to those with cognitive and/or language impairments. The Collaborative and Proactive Solutions framework proposes that challenging behaviors result from an incompatibility between environmental demands and a child's "lagging skills." The primary Collaborative and Proactive Solutions lagging skills-executive function, emotion regulation, language, and social skills-are often areas of weakness for individuals with autism spectrum disorder. The purpose of this study was to evaluate whether these lagging skills are associated with challenging behaviors in youth with autism spectrum disorder without intellectual disability. Parents of 182 youth with autism spectrum disorder (6-15 years) completed measures of their children's challenging behaviors, executive function, language, emotion regulation, and social skills. We tested whether the Collaborative and Proactive Solutions lagging skills predicted challenging behaviors using multiple linear regression. The Collaborative and Proactive Solutions lagging skills explained significant variance in participants' challenging behaviors. The Depression (emotion regulation), Inhibit (executive function), and Sameness (executive function) scales emerged as significant predictors. Impairments in emotion regulation and executive function may contribute substantially to aggressive and oppositional behaviors in school-age youth with autism spectrum disorder without intellectual disability. Treatment for challenging behaviors in this group may consider targeting the incompatibility between environmental demands and a child's lagging skills. En ligne : http://dx.doi.org/10.1177/1362361317712651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety / V. PARMA in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4459-4470 Titre : Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety Type de document : Texte imprimé et/ou numérique Auteurs : V. PARMA, Auteur ; N. CELLINI, Auteur ; L. GUY, Auteur ; A. J. MCVEY, Auteur ; K. RUMP, Auteur ; J. WORLEY, Auteur ; B. B. MADDOX, Auteur ; J. BUSH, Auteur ; Amanda E. BENNETT, Auteur ; M. FRANKLIN, Auteur ; J. S. MILLER, Auteur ; J. HERRINGTON, Auteur Article en page(s) : p.4459-4470 Langues : Anglais (eng) Mots-clés : Adolescent  Anxiety  Anxiety Disorders/epidemiology  Autism Spectrum Disorder  Autonomic Nervous System  Child  Humans  Anxiety disorder  Autism spectrum disorder  Autonomic profile  Electrodermal activity  Heart rate variability Index. décimale : PER Périodiques Résumé : Both anxiety and autism spectrum disorder (ASD) are associated with atypical physiological activity. Few studies have systematically assessed the resting physiological activity in ASD with co-occurring anxiety disorders. We tested 75 participants divided in four groups: youth with ASD, with (ASD?+?Anxiety?=?22, 6F, 12.29 ± 2.83 years old) and without co-occurring anxiety (ASD Alone?=?15, 6F, 11.59 ± 2.85 years old) and compared their physiological profile with that of matched typically developing controls (TDC) with (Anxiety Alone?=?16, 6F, 11.24 ± 3.36 years old) and without co-occurring anxiety disorders (TDC?=?22, 8F, 11.88 ± 2.88 years old). Results indicated reduced sympathetic and parasympathetic activity at rest in ASD as compared to TDC youth. ASD?+?Anxiety and Anxiety Alone groups showed different sympathetic, but similar parasympathetic activity. These findings suggest that autonomic profile-based approaches may advance research, diagnosis, and treatment of ASD and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-020-04862-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety [Texte imprimé et/ou numérique] / V. PARMA, Auteur ; N. CELLINI, Auteur ; L. GUY, Auteur ; A. J. MCVEY, Auteur ; K. RUMP, Auteur ; J. WORLEY, Auteur ; B. B. MADDOX, Auteur ; J. BUSH, Auteur ; Amanda E. BENNETT, Auteur ; M. FRANKLIN, Auteur ; J. S. MILLER, Auteur ; J. HERRINGTON, Auteur . - p.4459-4470. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4459-4470 Mots-clés : Adolescent  Anxiety  Anxiety Disorders/epidemiology  Autism Spectrum Disorder  Autonomic Nervous System  Child  Humans  Anxiety disorder  Autism spectrum disorder  Autonomic profile  Electrodermal activity  Heart rate variability Index. décimale : PER Périodiques Résumé : Both anxiety and autism spectrum disorder (ASD) are associated with atypical physiological activity. Few studies have systematically assessed the resting physiological activity in ASD with co-occurring anxiety disorders. We tested 75 participants divided in four groups: youth with ASD, with (ASD?+?Anxiety?=?22, 6F, 12.29 ± 2.83 years old) and without co-occurring anxiety (ASD Alone?=?15, 6F, 11.59 ± 2.85 years old) and compared their physiological profile with that of matched typically developing controls (TDC) with (Anxiety Alone?=?16, 6F, 11.24 ± 3.36 years old) and without co-occurring anxiety disorders (TDC?=?22, 8F, 11.88 ± 2.88 years old). Results indicated reduced sympathetic and parasympathetic activity at rest in ASD as compared to TDC youth. ASD?+?Anxiety and Anxiety Alone groups showed different sympathetic, but similar parasympathetic activity. These findings suggest that autonomic profile-based approaches may advance research, diagnosis, and treatment of ASD and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-020-04862-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

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