Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins / Jeanne E. SAVAGE in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.79-92 Titre : Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins Type de document : Texte imprimé et/ou numérique Auteurs : Jeanne E. SAVAGE, Auteur ; Richard J. ROSE, Auteur ; Lea PULKKINEN, Auteur ; Karri SILVENTOINEN, Auteur ; Tellervo KORHONEN, Auteur ; Jaakko KAPRIO, Auteur ; Nathan GILLESPIE, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.79-92 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early maturation, indexed by pubertal development (PD), has been associated with earlier initiation and greater frequency of adolescent substance use, but this relationship may be biased by confounding factors and effects that change across development. Using a population-based Finnish twin sample (N = 3,632 individuals), we conducted twin modeling and multilevel structural equation modeling of the relationship between PD and substance use at ages 12–22. Shared environmental factors contributed to early PD and heavier substance use for females. Biological father absence was associated with early PD for boys but not girls, and did not account for the relationship between PD and substance use. The association between early PD and heavier substance use was partially due to between-family confounds, although early PD appeared to qualitatively alter long-term trajectories for some substances (nicotine), but not others (alcohol). Mediation by peer and parental factors did not explain this relationship within families. However, higher peer substance use and lower parental monitoring were themselves associated with heavier substance use, strengthening the existing evidence for these factors as targets for prevention/intervention efforts. Early maturation was not supported as a robust determinant of alcohol use trajectories in adolescence and young adulthood, but may require longer term follow-up. Subtle effects of early PD on nicotine and illicit drug use trajectories throughout adolescence and adulthood merit further investigation. En ligne : https://doi.org/10.1017/S0954579417000487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335 [article] Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins [Texte imprimé et/ou numérique] / Jeanne E. SAVAGE, Auteur ; Richard J. ROSE, Auteur ; Lea PULKKINEN, Auteur ; Karri SILVENTOINEN, Auteur ; Tellervo KORHONEN, Auteur ; Jaakko KAPRIO, Auteur ; Nathan GILLESPIE, Auteur ; Danielle M. DICK, Auteur . - p.79-92. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.79-92 Index. décimale : PER Périodiques Résumé : Early maturation, indexed by pubertal development (PD), has been associated with earlier initiation and greater frequency of adolescent substance use, but this relationship may be biased by confounding factors and effects that change across development. Using a population-based Finnish twin sample (N = 3,632 individuals), we conducted twin modeling and multilevel structural equation modeling of the relationship between PD and substance use at ages 12–22. Shared environmental factors contributed to early PD and heavier substance use for females. Biological father absence was associated with early PD for boys but not girls, and did not account for the relationship between PD and substance use. The association between early PD and heavier substance use was partially due to between-family confounds, although early PD appeared to qualitatively alter long-term trajectories for some substances (nicotine), but not others (alcohol). Mediation by peer and parental factors did not explain this relationship within families. However, higher peer substance use and lower parental monitoring were themselves associated with heavier substance use, strengthening the existing evidence for these factors as targets for prevention/intervention efforts. Early maturation was not supported as a robust determinant of alcohol use trajectories in adolescence and young adulthood, but may require longer term follow-up. Subtle effects of early PD on nicotine and illicit drug use trajectories throughout adolescence and adulthood merit further investigation. En ligne : https://doi.org/10.1017/S0954579417000487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335

Evaluation of the Psychometric Properties of the Social Communication Questionnaire in Rural Kenya / Jeanne E. SAVAGE ; Joseph GONA ; Kenneth RIMBA ; Martha KOMBE ; Paul MWANGI ; Collins KIPKOECH ; Daniëlle POSTHUMA ; Charles R. J. C. NEWTON ; Amina ABUBAKAR in Journal of Autism and Developmental Disorders, 55-8 (August 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-8 (August 2025) . - p.2919-2937 Titre : Evaluation of the Psychometric Properties of the Social Communication Questionnaire in Rural Kenya Type de document : Texte imprimé et/ou numérique Auteurs : Jeanne E. SAVAGE, Auteur ; Joseph GONA, Auteur ; Kenneth RIMBA, Auteur ; Martha KOMBE, Auteur ; Paul MWANGI, Auteur ; Collins KIPKOECH, Auteur ; Daniëlle POSTHUMA, Auteur ; Charles R. J. C. NEWTON, Auteur ; Amina ABUBAKAR, Auteur Article en page(s) : p.2919-2937 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children can be reliably diagnosed with autism as early as 3 years of age, and early interventions are initiated. There is often a significant gap between the age of onset of symptoms (2-3 years) and diagnosis (8-10 years) in Africa. We conducted a study to validate the Social Communication Questionnaire (SCQ) as a screening instrument in a rural setting in Kenya. The study was conducted along the Kenyan Coast. Study participants included 172 children with a neurodevelopmental disorder (NDD) diagnosis (84 of which were autism) and 112 controls. Internal consistency was evaluated through the use of Cronbach?s alpha, confirmatory factor analysis (CFA) with maximum likelihood procedure to assess the conceptual model for the SCQ. Additionally, the sensitivity and specificity of cut-off scores using ROC analysis and item difficulties and discrimination quality using an IRT framework were also assessed. Factor analysis revealed an adequate fitting model for the three-factor DSM-IV-TR (root mean squared error of approximation (RMSEA) = 0.050; Comparative Fit Index (CFI) = 0.974; Tucker-Lewis Index (TLI) = 0.973) and two-factor DSM-5 factor structure (RMSEA = 0.050; CFI = 0.972; TLI = 0.974). The reliability coefficient alphas for the whole group for all items (Cronbach?s ? = 0.90) and all three domains (Cronbach?s ? = 0.68-0.84) were acceptable to excellent. The recommended cut-off score of 15 yielded 72% sensitivity and 100% specificity in the ASD group compared to the typically developing group. We provide early evidence of the adequate factor structure and good internal consistency of the SCQ. We also note that the recommended cut-off yielded sufficient predictive validity. En ligne : https://doi.org/10.1007/s10803-024-06380-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Evaluation of the Psychometric Properties of the Social Communication Questionnaire in Rural Kenya [Texte imprimé et/ou numérique] / Jeanne E. SAVAGE, Auteur ; Joseph GONA, Auteur ; Kenneth RIMBA, Auteur ; Martha KOMBE, Auteur ; Paul MWANGI, Auteur ; Collins KIPKOECH, Auteur ; Daniëlle POSTHUMA, Auteur ; Charles R. J. C. NEWTON, Auteur ; Amina ABUBAKAR, Auteur . - p.2919-2937. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-8 (August 2025) . - p.2919-2937 Index. décimale : PER Périodiques Résumé : Children can be reliably diagnosed with autism as early as 3 years of age, and early interventions are initiated. There is often a significant gap between the age of onset of symptoms (2-3 years) and diagnosis (8-10 years) in Africa. We conducted a study to validate the Social Communication Questionnaire (SCQ) as a screening instrument in a rural setting in Kenya. The study was conducted along the Kenyan Coast. Study participants included 172 children with a neurodevelopmental disorder (NDD) diagnosis (84 of which were autism) and 112 controls. Internal consistency was evaluated through the use of Cronbach?s alpha, confirmatory factor analysis (CFA) with maximum likelihood procedure to assess the conceptual model for the SCQ. Additionally, the sensitivity and specificity of cut-off scores using ROC analysis and item difficulties and discrimination quality using an IRT framework were also assessed. Factor analysis revealed an adequate fitting model for the three-factor DSM-IV-TR (root mean squared error of approximation (RMSEA) = 0.050; Comparative Fit Index (CFI) = 0.974; Tucker-Lewis Index (TLI) = 0.973) and two-factor DSM-5 factor structure (RMSEA = 0.050; CFI = 0.972; TLI = 0.974). The reliability coefficient alphas for the whole group for all items (Cronbach?s ? = 0.90) and all three domains (Cronbach?s ? = 0.68-0.84) were acceptable to excellent. The recommended cut-off score of 15 yielded 72% sensitivity and 100% specificity in the ASD group compared to the typically developing group. We provide early evidence of the adequate factor structure and good internal consistency of the SCQ. We also note that the recommended cut-off yielded sufficient predictive validity. En ligne : https://doi.org/10.1007/s10803-024-06380-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls / A. G. JANSEN in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1079-1089 Titre : The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls Type de document : Texte imprimé et/ou numérique Auteurs : A. G. JANSEN, Auteur ; P. R. JANSEN, Auteur ; Jeanne E. SAVAGE, Auteur ; J. KRAFT, Auteur ; N. SKARABIS, Auteur ; Tinca J. C. POLDERMAN, Auteur ; G. C. DIELEMAN, Auteur Article en page(s) : p.1079-1089 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Aged  Aged, 80 and over  Anxiety Disorders/epidemiology/genetics  Attention Deficit Disorder with Hyperactivity  Child  Child, Preschool  Depressive Disorder, Major  Humans  Infant  Middle Aged  Multifactorial Inheritance/genetics  Risk Factors  Young Adult  Genetics  comorbidity  general P factor  neurodevelopmental disorders  psychiatry Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychiatric traits are heritable, highly comorbid and genetically correlated, suggesting that genetic effects that are shared across disorders are at play. The aim of the present study is to quantify the predictive capacity of common genetic variation of a variety of traits, as captured by their PRS, to predict case-control status in a child and adolescent psychiatric sample including controls to reveal which traits contribute to the shared genetic risk across disorders. METHOD: Polygenic risk scores (PRS) of 14 traits were used as predictor phenotypes to predict case-control status in a clinical sample. Clinical cases (N = 1,402), age 1-21, diagnostic categories: Autism spectrum disorders (N = 492), Attention-deficit/ hyperactivity disorders (N = 471), Anxiety (N = 293), disruptive behaviors (N = 101), eating disorders (N = 97), OCD (N = 43), Tic disorder (N = 50), Disorder of infancy, childhood or adolescence NOS (N = 65), depression (N = 64), motor, learning and communication disorders (N = 59), Anorexia Nervosa (N = 48), somatoform disorders (N = 47), Trauma/stress (N = 39) and controls (N = 1,448, age 17-84) of European ancestry. First, these 14 PRS were tested in univariate regression analyses. The traits that significantly predicted case-control status were included in a multivariable regression model to investigate the gain in explained variance when leveraging the genetic effects of multiple traits simultaneously. RESULTS: In the univariate analyses, we observed significant associations between clinical status and the PRS of educational attainment (EA), smoking initiation (SI), intelligence, neuroticism, alcohol dependence, ADHD, major depression and anti-social behavior. EA (p-value: 3.53E-20, explained variance: 3.99%, OR: 0.66), and SI (p-value: 4.77E-10, explained variance: 1.91%, OR: 1.33) were the most predictive traits. In the multivariable analysis with these eight significant traits, EA and SI, remained significant predictors. The explained variance of the PRS in the model with these eight traits combined was 5.9%. CONCLUSION: Our study provides more insights into the genetic signal that is shared between childhood and adolescent psychiatric disorders. As such, our findings might guide future studies on psychiatric comorbidity and offer insights into shared etiology between psychiatric disorders. The increase in explained variance when leveraging the genetic signal of different predictor traits supports a multivariable approach to optimize precision accuracy for general psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13370 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls [Texte imprimé et/ou numérique] / A. G. JANSEN, Auteur ; P. R. JANSEN, Auteur ; Jeanne E. SAVAGE, Auteur ; J. KRAFT, Auteur ; N. SKARABIS, Auteur ; Tinca J. C. POLDERMAN, Auteur ; G. C. DIELEMAN, Auteur . - p.1079-1089. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1079-1089 Mots-clés : Adolescent  Adult  Aged  Aged, 80 and over  Anxiety Disorders/epidemiology/genetics  Attention Deficit Disorder with Hyperactivity  Child  Child, Preschool  Depressive Disorder, Major  Humans  Infant  Middle Aged  Multifactorial Inheritance/genetics  Risk Factors  Young Adult  Genetics  comorbidity  general P factor  neurodevelopmental disorders  psychiatry Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychiatric traits are heritable, highly comorbid and genetically correlated, suggesting that genetic effects that are shared across disorders are at play. The aim of the present study is to quantify the predictive capacity of common genetic variation of a variety of traits, as captured by their PRS, to predict case-control status in a child and adolescent psychiatric sample including controls to reveal which traits contribute to the shared genetic risk across disorders. METHOD: Polygenic risk scores (PRS) of 14 traits were used as predictor phenotypes to predict case-control status in a clinical sample. Clinical cases (N = 1,402), age 1-21, diagnostic categories: Autism spectrum disorders (N = 492), Attention-deficit/ hyperactivity disorders (N = 471), Anxiety (N = 293), disruptive behaviors (N = 101), eating disorders (N = 97), OCD (N = 43), Tic disorder (N = 50), Disorder of infancy, childhood or adolescence NOS (N = 65), depression (N = 64), motor, learning and communication disorders (N = 59), Anorexia Nervosa (N = 48), somatoform disorders (N = 47), Trauma/stress (N = 39) and controls (N = 1,448, age 17-84) of European ancestry. First, these 14 PRS were tested in univariate regression analyses. The traits that significantly predicted case-control status were included in a multivariable regression model to investigate the gain in explained variance when leveraging the genetic effects of multiple traits simultaneously. RESULTS: In the univariate analyses, we observed significant associations between clinical status and the PRS of educational attainment (EA), smoking initiation (SI), intelligence, neuroticism, alcohol dependence, ADHD, major depression and anti-social behavior. EA (p-value: 3.53E-20, explained variance: 3.99%, OR: 0.66), and SI (p-value: 4.77E-10, explained variance: 1.91%, OR: 1.33) were the most predictive traits. In the multivariable analysis with these eight significant traits, EA and SI, remained significant predictors. The explained variance of the PRS in the model with these eight traits combined was 5.9%. CONCLUSION: Our study provides more insights into the genetic signal that is shared between childhood and adolescent psychiatric disorders. As such, our findings might guide future studies on psychiatric comorbidity and offer insights into shared etiology between psychiatric disorders. The increase in explained variance when leveraging the genetic signal of different predictor traits supports a multivariable approach to optimize precision accuracy for general psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13370 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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