31 recherche sur le mot-clé 'Aged'

Adaptation, Content Validity and Reliability of the Autism Classification System of Functioning for Social Communication: From Toddlerhood to Adolescent-Aged Children with Autism / Briano DI REZZE in Journal of Autism and Developmental Disorders, 52-12 (December 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5150-5161 Titre : Adaptation, Content Validity and Reliability of the Autism Classification System of Functioning for Social Communication: From Toddlerhood to Adolescent-Aged Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Briano DI REZZE, Auteur ; Stephen James GENTLES, Auteur ; Mary Jo Cooley HIDECKER, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter ROSENBAUM, Auteur ; Eric DUKU, Auteur ; Stelios GEORGIADES, Auteur ; Caroline RONCADIN, Auteur ; Hanna FANG, Auteur ; Diana J. TAJIK-PARVINCHI, Auteur ; Helena VIVEIROS, Auteur Année de publication : 2022 Article en page(s) : p.5150-5161 Langues : Anglais (eng) Mots-clés : Child  Adolescent  Humans  Aged  Child, Preschool  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Reproducibility of Results  Communication  Parents  Autism spectrum disorder  Childhood  Classification  International classification of functioning  Social communication Index. décimale : PER Périodiques Résumé : The Autism Classification System of Functioning: Social Communication (ACSF) describes social communication functioning levels. First developed for preschoolers with ASD, this study tests an expanded age range (2-to-18 years). The ACFS rates the child's typical and best (i.e., capacity) performance. Qualitative methods tested parent and clinician perspectives of the ACSF age expansion using content analysis. The ACSF was used twice by parents and professionals for the same child/youth. Reliabilities were assessed using weighted kappa. Content validity supported the ACSF's applicability, clarity, and usability. The ACSF adaptations did not change its original construct. Reliability were calculated from 90 parent and professional Time-1 and Time-2 ratings for children/youth (2.1-15.6 years). Results showed good-to-very good intra-rater agreement (typical) and good inter-rater agreement (capacity). En ligne : http://dx.doi.org/10.1007/s10803-022-05621-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Adaptation, Content Validity and Reliability of the Autism Classification System of Functioning for Social Communication: From Toddlerhood to Adolescent-Aged Children with Autism [Texte imprimé et/ou numérique] / Briano DI REZZE, Auteur ; Stephen James GENTLES, Auteur ; Mary Jo Cooley HIDECKER, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter ROSENBAUM, Auteur ; Eric DUKU, Auteur ; Stelios GEORGIADES, Auteur ; Caroline RONCADIN, Auteur ; Hanna FANG, Auteur ; Diana J. TAJIK-PARVINCHI, Auteur ; Helena VIVEIROS, Auteur . - 2022 . - p.5150-5161. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5150-5161 Mots-clés : Child  Adolescent  Humans  Aged  Child, Preschool  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Reproducibility of Results  Communication  Parents  Autism spectrum disorder  Childhood  Classification  International classification of functioning  Social communication Index. décimale : PER Périodiques Résumé : The Autism Classification System of Functioning: Social Communication (ACSF) describes social communication functioning levels. First developed for preschoolers with ASD, this study tests an expanded age range (2-to-18 years). The ACFS rates the child's typical and best (i.e., capacity) performance. Qualitative methods tested parent and clinician perspectives of the ACSF age expansion using content analysis. The ACSF was used twice by parents and professionals for the same child/youth. Reliabilities were assessed using weighted kappa. Content validity supported the ACSF's applicability, clarity, and usability. The ACSF adaptations did not change its original construct. Reliability were calculated from 90 parent and professional Time-1 and Time-2 ratings for children/youth (2.1-15.6 years). Results showed good-to-very good intra-rater agreement (typical) and good inter-rater agreement (capacity). En ligne : http://dx.doi.org/10.1007/s10803-022-05621-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Current and lifetime somatic symptom burden among transition-aged autistic young adults / Zachary J. WILLIAMS in Autism Research, 15-4 (April 2022)  

Public ISBD [article]  inAutism Research > 15-4 (April 2022) . - p.761-770 Titre : Current and lifetime somatic symptom burden among transition-aged autistic young adults Type de document : Texte imprimé et/ou numérique Auteurs : Zachary J. WILLIAMS, Auteur ; Katherine O. GOTHAM, Auteur Article en page(s) : p.761-770 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Aged  Anxiety/epidemiology  Autism Spectrum Disorder/psychology  Autistic Disorder/complications/epidemiology/psychology  Female  Humans  Male  Medically Unexplained Symptoms  Quality of Life  Young Adult  autism  bodily distress syndrome  physical symptoms  prevalence  sex differences  somatic symptoms  somatization Index. décimale : PER Périodiques Résumé : Somatic symptoms are the most common cause of outpatient medical visits in the general population, yet their presence and severity in individuals on the autism spectrum has rarely been studied. We sought to assess the prevalence, impact, and clinical correlates of 14 commonly reported somatic symptoms in a sample of 290 transition-aged autistic young adults (mean [SD] age: 23.10 [2.38] years, range 18-26; 76.7% diagnosed with autism before age 18) recruited from the Simons Foundation SPARK participant pool. A modified version of the Patient Health Questionnaire-15 was used to assess somatic symptom prevalence/impact, along with measures of depression, anxiety, autistic traits, and quality of life. Somatic symptom burden was much higher in autistic young adults than previously reported in the general population. The most commonly reported current symptoms were fatigue (72.8%), sleep problems (69.0%), and menstrual problems (61.4% of females). Moderate or severe symptom levels were reported by 53.9% of females and 18.75% of males in our cohort, with the odds of females endorsing any given symptom being 2-4 times greater than males. Both individual symptoms and total symptom burden were related to higher levels of depression, anxiety, and autistic traits, along with lower quality of life. Despite little research on this topic previously, somatic symptoms are highly prevalent in autistic young adults, particularly women. Future research is needed to investigate links between somatic symptoms, medical and psychiatric morbidity, and health care utilization in the autistic population. LAY SUMMARY: Somatic symptoms (i.e., physical symptoms such as such as pain, weakness, stomachache, or shortness of breath) are highly prevalent in the general population and account for a large proportion of health care costs. However, few studies have investigated how often these symptoms are reported by autistic adults or their associations with other clinical and demographic variables. Based on self-report data from 290 young autistic adults, we found very high rates of bothersome somatic symptoms in this population, with females endorsing all symptoms at substantially higher rates than males. Somatic symptoms were also associated with worse mental health and quality of life, suggesting that they represent an overlooked contributor to poor health outcomes in the autistic adult population. En ligne : https://dx.doi.org/10.1002/aur.2671 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Current and lifetime somatic symptom burden among transition-aged autistic young adults [Texte imprimé et/ou numérique] / Zachary J. WILLIAMS, Auteur ; Katherine O. GOTHAM, Auteur . - p.761-770. Langues : Anglais (eng) in Autism Research > 15-4 (April 2022) . - p.761-770 Mots-clés : Adolescent  Adult  Aged  Anxiety/epidemiology  Autism Spectrum Disorder/psychology  Autistic Disorder/complications/epidemiology/psychology  Female  Humans  Male  Medically Unexplained Symptoms  Quality of Life  Young Adult  autism  bodily distress syndrome  physical symptoms  prevalence  sex differences  somatic symptoms  somatization Index. décimale : PER Périodiques Résumé : Somatic symptoms are the most common cause of outpatient medical visits in the general population, yet their presence and severity in individuals on the autism spectrum has rarely been studied. We sought to assess the prevalence, impact, and clinical correlates of 14 commonly reported somatic symptoms in a sample of 290 transition-aged autistic young adults (mean [SD] age: 23.10 [2.38] years, range 18-26; 76.7% diagnosed with autism before age 18) recruited from the Simons Foundation SPARK participant pool. A modified version of the Patient Health Questionnaire-15 was used to assess somatic symptom prevalence/impact, along with measures of depression, anxiety, autistic traits, and quality of life. Somatic symptom burden was much higher in autistic young adults than previously reported in the general population. The most commonly reported current symptoms were fatigue (72.8%), sleep problems (69.0%), and menstrual problems (61.4% of females). Moderate or severe symptom levels were reported by 53.9% of females and 18.75% of males in our cohort, with the odds of females endorsing any given symptom being 2-4 times greater than males. Both individual symptoms and total symptom burden were related to higher levels of depression, anxiety, and autistic traits, along with lower quality of life. Despite little research on this topic previously, somatic symptoms are highly prevalent in autistic young adults, particularly women. Future research is needed to investigate links between somatic symptoms, medical and psychiatric morbidity, and health care utilization in the autistic population. LAY SUMMARY: Somatic symptoms (i.e., physical symptoms such as such as pain, weakness, stomachache, or shortness of breath) are highly prevalent in the general population and account for a large proportion of health care costs. However, few studies have investigated how often these symptoms are reported by autistic adults or their associations with other clinical and demographic variables. Based on self-report data from 290 young autistic adults, we found very high rates of bothersome somatic symptoms in this population, with females endorsing all symptoms at substantially higher rates than males. Somatic symptoms were also associated with worse mental health and quality of life, suggesting that they represent an overlooked contributor to poor health outcomes in the autistic adult population. En ligne : https://dx.doi.org/10.1002/aur.2671 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Self-Determination in Autistic Transition-Aged Youth without Intellectual Disability / Brianne TOMASZEWSKI in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.4067-4078 Titre : Self-Determination in Autistic Transition-Aged Youth without Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Brianne TOMASZEWSKI, Auteur ; Laura G. KLINGER, Auteur ; Cara E. PUGLIESE, Auteur Article en page(s) : p.4067-4078 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Aged  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Communication  Humans  Intellectual Disability/diagnosis  Personal Autonomy  Adolescence  Autism  Executive function  Self-determination  Transition  Young adult Index. décimale : PER Périodiques Résumé : Self-determination refers to an individual's capacity and opportunities to act as a causal agent in their own lives to make choices, decisions, and set goals. The current study examined self- and parent-reports of the AIR Self-Determination Scale in transition-aged autistic youth (Based on stakeholder preferences, we use identity-first(autistic) or neutral language (on the autism spectrum) (Bottema-Beutel in JAMA 3:18-29, 2020)). Autistic youth completed depression and executive function measures, and parents rated their child's social-communication and executive function difficulties. Despite differences between youth and parent reports, both youth and their parents reported lower self-determination skills (capacity) than opportunities to practice self-determined behaviors. Both depression and executive function skills were related to self-determination capacity, highlighting potential intervention targets for transition-aged youth to facilitate increased self-determination and potentially improved adult outcomes. En ligne : http://dx.doi.org/10.1007/s10803-021-05280-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Self-Determination in Autistic Transition-Aged Youth without Intellectual Disability [Texte imprimé et/ou numérique] / Brianne TOMASZEWSKI, Auteur ; Laura G. KLINGER, Auteur ; Cara E. PUGLIESE, Auteur . - p.4067-4078. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.4067-4078 Mots-clés : Adolescent  Adult  Aged  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Communication  Humans  Intellectual Disability/diagnosis  Personal Autonomy  Adolescence  Autism  Executive function  Self-determination  Transition  Young adult Index. décimale : PER Périodiques Résumé : Self-determination refers to an individual's capacity and opportunities to act as a causal agent in their own lives to make choices, decisions, and set goals. The current study examined self- and parent-reports of the AIR Self-Determination Scale in transition-aged autistic youth (Based on stakeholder preferences, we use identity-first(autistic) or neutral language (on the autism spectrum) (Bottema-Beutel in JAMA 3:18-29, 2020)). Autistic youth completed depression and executive function measures, and parents rated their child's social-communication and executive function difficulties. Despite differences between youth and parent reports, both youth and their parents reported lower self-determination skills (capacity) than opportunities to practice self-determined behaviors. Both depression and executive function skills were related to self-determination capacity, highlighting potential intervention targets for transition-aged youth to facilitate increased self-determination and potentially improved adult outcomes. En ligne : http://dx.doi.org/10.1007/s10803-021-05280-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

The role of parental advocacy in addressing service disparities for transition-aged youth on the autism spectrum / Chung Eun LEE in Autism, 26-4 (May 2022)  

Public ISBD [article]  inAutism > 26-4 (May 2022) . - p.1001-1006 Titre : The role of parental advocacy in addressing service disparities for transition-aged youth on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Chung Eun LEE, Auteur ; Meghan M. BURKE, Auteur ; Leann S. DAWALT, Auteur ; Chak LI, Auteur ; Julie LOUNDS TAYLOR, Auteur Article en page(s) : p.1001-1006 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Aged  Autism Spectrum Disorder/therapy  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Intellectual Disability  Parents  autism spectrum disorder  parental advocacy  service access  transition-aged youth Index. décimale : PER Périodiques Résumé : It can be difficult for youth on the autism spectrum to get the services they need after they leave high school. Because of this, many studies have examined the different factors that are related to service access. These studies have shown that youth on the autism spectrum who belong to an underrepresented racial or ethnic group or whose families have lower incomes are less likely to receive the services that they need. However, it is difficult or impossible to change things like race/ethnicity or family income. It is important to also identify factors that might improve service access that we can change. One potential factor that fits into this category is parental advocacy activities. Using data collected from 185 parents of youth on the autism spectrum, we found that more parental advocacy activities were related to youth receiving more services, even after accounting for variables related to the functioning of the youth (e.g. whether they have an intellectual disability, their autism symptom severity) and demographic information about the family (e.g. state in which they live, parental race/ethnicity, and family income). Our findings suggest that building parental advocacy skills may be one important way to increase the number of services that youth on the autism spectrum receive as they transition to adulthood. En ligne : https://dx.doi.org/10.1177/13623613211057660 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] The role of parental advocacy in addressing service disparities for transition-aged youth on the autism spectrum [Texte imprimé et/ou numérique] / Chung Eun LEE, Auteur ; Meghan M. BURKE, Auteur ; Leann S. DAWALT, Auteur ; Chak LI, Auteur ; Julie LOUNDS TAYLOR, Auteur . - p.1001-1006. Langues : Anglais (eng) in Autism > 26-4 (May 2022) . - p.1001-1006 Mots-clés : Adolescent  Adult  Aged  Autism Spectrum Disorder/therapy  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Intellectual Disability  Parents  autism spectrum disorder  parental advocacy  service access  transition-aged youth Index. décimale : PER Périodiques Résumé : It can be difficult for youth on the autism spectrum to get the services they need after they leave high school. Because of this, many studies have examined the different factors that are related to service access. These studies have shown that youth on the autism spectrum who belong to an underrepresented racial or ethnic group or whose families have lower incomes are less likely to receive the services that they need. However, it is difficult or impossible to change things like race/ethnicity or family income. It is important to also identify factors that might improve service access that we can change. One potential factor that fits into this category is parental advocacy activities. Using data collected from 185 parents of youth on the autism spectrum, we found that more parental advocacy activities were related to youth receiving more services, even after accounting for variables related to the functioning of the youth (e.g. whether they have an intellectual disability, their autism symptom severity) and demographic information about the family (e.g. state in which they live, parental race/ethnicity, and family income). Our findings suggest that building parental advocacy skills may be one important way to increase the number of services that youth on the autism spectrum receive as they transition to adulthood. En ligne : https://dx.doi.org/10.1177/13623613211057660 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years / Danielle CHRISTENSEN ; Jingying WANG ; Desirae J SHIRLEY ; Ann-Marie ORLANDO ; Regilda A ROMERO ; David E VAILLANCOURT ; Bradley J WILKES ; Stephen A COOMBES ; Zheng WANG in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 16 Titre : Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years Type de document : Texte imprimé et/ou numérique Auteurs : Danielle CHRISTENSEN, Auteur ; Jingying WANG, Auteur ; Desirae J SHIRLEY, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A ROMERO, Auteur ; David E VAILLANCOURT, Auteur ; Bradley J WILKES, Auteur ; Stephen A COOMBES, Auteur ; Zheng WANG, Auteur Article en page(s) : 16 Langues : Anglais (eng) Mots-clés : Humans  Male  Gray Matter/diagnostic imaging/pathology  White Matter/diagnostic imaging/pathology  Female  Adult  Middle Aged  Aged  Case-Control Studies  Autistic Disorder/diagnostic imaging/pathology  Corpus Callosum/diagnostic imaging/pathology  Autism Spectrum Disorder/diagnostic imaging/pathology  Anisotropy  Diffusion Magnetic Resonance Imaging  Aging  Autism spectrum disorder  Autistic adults  Diffusion MRI  Free water  Free water corrected fractional anisotropy  Free water corrected mean diffusivity  Gray matter  Transcallosal tracts  White matter  in this study were approved by the Institutional Review Board (IRB) at the  University of Florida following the Declaration of Helsinki. The IRB number is  202100659, with an approval date of July 26, 2022. Consent for publication: All  authors have read and approved the submission. Competing interests: The authors  declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a lifelong condition that profoundly impacts health, independence, and quality of life. However, research on brain aging in autistic adults is limited, and microstructural variations in white and gray matter remain poorly understood. To address this critical gap, we assessed novel diffusion MRI (dMRI) biomarkers, free water, and free water corrected fractional anisotropy (fwcFA), and mean diffusivity (fwcMD) across 32 transcallosal tracts and their corresponding homotopic grey matter origin/endpoint regions of interest (ROIs) in middle and old aged autistic adults. METHODS: Forty-three autistic adults aged 30-73 and 43 age-, sex-, and IQ-matched neurotypical controls underwent dMRI scans. We examined free water, fwcFA, fwcMD differences between the two groups and age-related pattern of each dMRI metric across the whole brain for each group. The relationships between clinical measures of ASD and free water in regions that significantly differentiated autistic adults from neurotypical controls were also explored. In supplementary analyses, we also assessed free water uncorrected FA and MD using conventional single tensor modeling. RESULTS: Autistic adults exhibited significantly elevated free water in seven frontal transcallosal tracts compared to controls. In controls, age-related increases in free water and decreases in fwcFA were observed across most transcallosal tracts. However, these age-associated patterns were entirely absent in autistic adults. In gray matter, autistic adults showed elevated free water in the calcarine cortices and lower fwcMD in the dorsal premotor cortices compared to controls. Lastly, age-related increases in free water were found across all white matter and gray matter ROIs in neurotypical controls, whereas no age-related associations were detected in any dMRI metrics for autistic adults. LIMITATIONS: We only recruited cognitively capable autistic adults, which limits the generalizability of our findings across the full autism spectrum. The cross-sectional design precludes inferences about microstructural changes over time in middle and old aged autistic adults. CONCLUSIONS: Our findings revealed increased free water load in frontal white matter in autistic adults and identified distinct age-associated microstructural variations between the two groups. These findings highlight more heterogeneous brain aging profiles in autistic adults. Our study also demonstrated the importance of quantifying free water in dMRI studies of ASD. En ligne : https://dx.doi.org/10.1186/s13229-025-00652-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years [Texte imprimé et/ou numérique] / Danielle CHRISTENSEN, Auteur ; Jingying WANG, Auteur ; Desirae J SHIRLEY, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A ROMERO, Auteur ; David E VAILLANCOURT, Auteur ; Bradley J WILKES, Auteur ; Stephen A COOMBES, Auteur ; Zheng WANG, Auteur . - 16. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 16 Mots-clés : Humans  Male  Gray Matter/diagnostic imaging/pathology  White Matter/diagnostic imaging/pathology  Female  Adult  Middle Aged  Aged  Case-Control Studies  Autistic Disorder/diagnostic imaging/pathology  Corpus Callosum/diagnostic imaging/pathology  Autism Spectrum Disorder/diagnostic imaging/pathology  Anisotropy  Diffusion Magnetic Resonance Imaging  Aging  Autism spectrum disorder  Autistic adults  Diffusion MRI  Free water  Free water corrected fractional anisotropy  Free water corrected mean diffusivity  Gray matter  Transcallosal tracts  White matter  in this study were approved by the Institutional Review Board (IRB) at the  University of Florida following the Declaration of Helsinki. The IRB number is  202100659, with an approval date of July 26, 2022. Consent for publication: All  authors have read and approved the submission. Competing interests: The authors  declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a lifelong condition that profoundly impacts health, independence, and quality of life. However, research on brain aging in autistic adults is limited, and microstructural variations in white and gray matter remain poorly understood. To address this critical gap, we assessed novel diffusion MRI (dMRI) biomarkers, free water, and free water corrected fractional anisotropy (fwcFA), and mean diffusivity (fwcMD) across 32 transcallosal tracts and their corresponding homotopic grey matter origin/endpoint regions of interest (ROIs) in middle and old aged autistic adults. METHODS: Forty-three autistic adults aged 30-73 and 43 age-, sex-, and IQ-matched neurotypical controls underwent dMRI scans. We examined free water, fwcFA, fwcMD differences between the two groups and age-related pattern of each dMRI metric across the whole brain for each group. The relationships between clinical measures of ASD and free water in regions that significantly differentiated autistic adults from neurotypical controls were also explored. In supplementary analyses, we also assessed free water uncorrected FA and MD using conventional single tensor modeling. RESULTS: Autistic adults exhibited significantly elevated free water in seven frontal transcallosal tracts compared to controls. In controls, age-related increases in free water and decreases in fwcFA were observed across most transcallosal tracts. However, these age-associated patterns were entirely absent in autistic adults. In gray matter, autistic adults showed elevated free water in the calcarine cortices and lower fwcMD in the dorsal premotor cortices compared to controls. Lastly, age-related increases in free water were found across all white matter and gray matter ROIs in neurotypical controls, whereas no age-related associations were detected in any dMRI metrics for autistic adults. LIMITATIONS: We only recruited cognitively capable autistic adults, which limits the generalizability of our findings across the full autism spectrum. The cross-sectional design precludes inferences about microstructural changes over time in middle and old aged autistic adults. CONCLUSIONS: Our findings revealed increased free water load in frontal white matter in autistic adults and identified distinct age-associated microstructural variations between the two groups. These findings highlight more heterogeneous brain aging profiles in autistic adults. Our study also demonstrated the importance of quantifying free water in dMRI studies of ASD. En ligne : https://dx.doi.org/10.1186/s13229-025-00652-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants / D. A. GHEORGHE in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

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Age differences in broader autism phenotype traits from young adulthood to older adulthood / W. J. CHOPIK in Autism Research, 14-7 (July 2021)  

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Assessing subtypes of restricted and repetitive behaviour using the Adult Repetitive Behaviour Questionnaire-2 in autistic adults / Sarah L. BARRETT in Molecular Autism, 9 (2018)  

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Brief Report: Sources of Sexuality and Relationship Education for Autistic and Neurotypical Adults in the U.S. and a Call to Action / E. T. CREHAN in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

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Commentary: Splitting and lumping brain and childhood adversity measures - a commentary on Gheorghe, Li, Gallacher, and Bauermeister (2020) / H. TIEMEIER in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

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