Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder / S. CASEY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Titre : Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur Article en page(s) : p.3919-3932 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur . - p.3919-3932. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse / J. VEENSTRA-VANDERWEELE in Journal of Neurodevelopmental Disorders, 1-2 (June 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.158-71 Titre : Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse Type de document : Texte imprimé et/ou numérique Auteurs : J. VEENSTRA-VANDERWEELE, Auteur ; T. N. JESSEN, Auteur ; B. J. THOMPSON, Auteur ; M. CARTER, Auteur ; H. C. PRASAD, Auteur ; J. A. STEINER, Auteur ; J. S. SUTCLIFFE, Auteur ; R. D. BLAKELY, Auteur Article en page(s) : p.158-71 Langues : Anglais (eng) Mots-clés : Autism  Polymorphism  Protein kinase G  Serotonin  Transgenic mouse  Transporter  p38 mitogen activated protein kinase Index. décimale : PER Périodiques Résumé : Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attention as a potential risk locus for autism-spectrum disorders, as well as disorders with overlapping symptoms, including obsessive-compulsive disorder (OCD). Here, we review our efforts to characterize rare, nonsynonymous polymorphisms in SERT derived from multiplex pedigrees carrying diagnoses of autism and OCD and present the initial stages of our effort to model one of these variants, Gly56Ala, in vivo. We generated a targeting vector to produce the Gly56Ala substitution in the Slc6a4 locus by homologous recombination. Following removal of a neomycin resistance selection cassette, animals exhibiting germline transmission of the Ala56 variant were bred to establish a breeding colony on a 129S6 background, suitable for initial evaluation of biochemical, physiological and behavioral alterations relative to SERT Gly56 (wild-type) animals. SERT Ala56 mice were achieved and exhibit a normal pattern of transmission. The initial growth and gross morphology of these animals is comparable to wildtype littermate controls. The SERT Ala56 variant can be propagated in 129S6 mice without apparent disruption of fertility and growth. We discuss both the opportunities and challenges that await the physiological/behavioral analysis of Gly56Ala transgenic mice, with particular reference to modeling autism-associated traits. En ligne : http://dx.doi.org/10.1007/s11689-009-9020-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse [Texte imprimé et/ou numérique] / J. VEENSTRA-VANDERWEELE, Auteur ; T. N. JESSEN, Auteur ; B. J. THOMPSON, Auteur ; M. CARTER, Auteur ; H. C. PRASAD, Auteur ; J. A. STEINER, Auteur ; J. S. SUTCLIFFE, Auteur ; R. D. BLAKELY, Auteur . - p.158-71. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.158-71 Mots-clés : Autism  Polymorphism  Protein kinase G  Serotonin  Transgenic mouse  Transporter  p38 mitogen activated protein kinase Index. décimale : PER Périodiques Résumé : Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attention as a potential risk locus for autism-spectrum disorders, as well as disorders with overlapping symptoms, including obsessive-compulsive disorder (OCD). Here, we review our efforts to characterize rare, nonsynonymous polymorphisms in SERT derived from multiplex pedigrees carrying diagnoses of autism and OCD and present the initial stages of our effort to model one of these variants, Gly56Ala, in vivo. We generated a targeting vector to produce the Gly56Ala substitution in the Slc6a4 locus by homologous recombination. Following removal of a neomycin resistance selection cassette, animals exhibiting germline transmission of the Ala56 variant were bred to establish a breeding colony on a 129S6 background, suitable for initial evaluation of biochemical, physiological and behavioral alterations relative to SERT Gly56 (wild-type) animals. SERT Ala56 mice were achieved and exhibit a normal pattern of transmission. The initial growth and gross morphology of these animals is comparable to wildtype littermate controls. The SERT Ala56 variant can be propagated in 129S6 mice without apparent disruption of fertility and growth. We discuss both the opportunities and challenges that await the physiological/behavioral analysis of Gly56Ala transgenic mice, with particular reference to modeling autism-associated traits. En ligne : http://dx.doi.org/10.1007/s11689-009-9020-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

Perspectives of University Students with Autism Spectrum Disorder / A. H. ANDERSON in Journal of Autism and Developmental Disorders, 48-3 (March 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.651-665 Titre : Perspectives of University Students with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. H. ANDERSON, Auteur ; M. CARTER, Auteur ; J. STEPHENSON, Auteur Année de publication : 2018 Article en page(s) : p.651-665 Langues : Anglais (eng) Mots-clés : Autistic spectrum disorder  Educational supports  Experiences  Higher education  On-line survey  University Index. décimale : PER Périodiques Résumé : Students with autism spectrum disorder (ASD) are at heightened risk of post-secondary educational failure and account for approximately 1% of students in post-secondary education. Findings from an on-line survey of students with ASD attending university in Australian are reported in this study. Respondents indicated high rates of academic and non-academic difficulties but low usage of supports. Ratings for supports were idiosyncratic, and some students indicated discomfort from using supports or disclosing their disability. Those students who delayed their disclosure accessed fewer supports and reported a poorer overall university experience. Recommendations were made including the need for better transition support and alternative strengths based approaches that use more flexible and individualised curriculum designs. En ligne : https://doi.org/10.1007/s10803-017-3257-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338 [article] Perspectives of University Students with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. H. ANDERSON, Auteur ; M. CARTER, Auteur ; J. STEPHENSON, Auteur . - 2018 . - p.651-665. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.651-665 Mots-clés : Autistic spectrum disorder  Educational supports  Experiences  Higher education  On-line survey  University Index. décimale : PER Périodiques Résumé : Students with autism spectrum disorder (ASD) are at heightened risk of post-secondary educational failure and account for approximately 1% of students in post-secondary education. Findings from an on-line survey of students with ASD attending university in Australian are reported in this study. Respondents indicated high rates of academic and non-academic difficulties but low usage of supports. Ratings for supports were idiosyncratic, and some students indicated discomfort from using supports or disclosing their disability. Those students who delayed their disclosure accessed fewer supports and reported a poorer overall university experience. Recommendations were made including the need for better transition support and alternative strengths based approaches that use more flexible and individualised curriculum designs. En ligne : https://doi.org/10.1007/s10803-017-3257-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338

A Systematic Literature Review of Empirical Research on Postsecondary Students with Autism Spectrum Disorder / A. H. ANDERSON in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1531-1558 Titre : A Systematic Literature Review of Empirical Research on Postsecondary Students with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. H. ANDERSON, Auteur ; J. STEPHENSON, Auteur ; M. CARTER, Auteur ; Sarah CARLON, Auteur Article en page(s) : p.1531-1558 Langues : Anglais (eng) Mots-clés : Asd  Autism spectrum disorder  College  Post-secondary  Students  University Index. décimale : PER Périodiques Résumé : The findings from a systematic literature review of 24 empirical studies of interventions for post-secondary students with autism spectrum disorder (ASD) are reported in this study. A diverse range of interventions were examined, many of which appeared feasible and high rates of participant satisfaction were also reported. Differing responses within and among interventions may point to the possible need for individualized supports. Few studies analyzed a specific academic support despite many students with ASD indicating they prefer these supports and that they find them useful. This may highlight the need for participant preferences to be given more consideration when designing supports. Most studies were of poor quality, however, so any conclusions are tentative. Directions for future research were discussed. En ligne : https://dx.doi.org/10.1007/s10803-018-3840-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] A Systematic Literature Review of Empirical Research on Postsecondary Students with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. H. ANDERSON, Auteur ; J. STEPHENSON, Auteur ; M. CARTER, Auteur ; Sarah CARLON, Auteur . - p.1531-1558. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1531-1558 Mots-clés : Asd  Autism spectrum disorder  College  Post-secondary  Students  University Index. décimale : PER Périodiques Résumé : The findings from a systematic literature review of 24 empirical studies of interventions for post-secondary students with autism spectrum disorder (ASD) are reported in this study. A diverse range of interventions were examined, many of which appeared feasible and high rates of participant satisfaction were also reported. Differing responses within and among interventions may point to the possible need for individualized supports. Few studies analyzed a specific academic support despite many students with ASD indicating they prefer these supports and that they find them useful. This may highlight the need for participant preferences to be given more consideration when designing supports. Most studies were of poor quality, however, so any conclusions are tentative. Directions for future research were discussed. En ligne : https://dx.doi.org/10.1007/s10803-018-3840-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

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