Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence / Nathalie MICHELS ; George M. SLAVICH ; Matteo GILETTA in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Titre : Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur Article en page(s) : p.311-321 Langues : Anglais (eng) Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage?=?12.69?years; SD?=?0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6?months over 1.5?years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves (?12?=?.13; ?23?=?.12; ?34?=?.08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence [Texte imprimé et/ou numérique] / Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur . - p.311-321. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage?=?12.69?years; SD?=?0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6?months over 1.5?years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves (?12?=?.13; ?23?=?.12; ?34?=?.08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents / Matteo GILETTA in Journal of Child Psychology and Psychiatry, 59-2 (February 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.129-139 Titre : Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Matteo GILETTA, Auteur ; George M. SLAVICH, Auteur ; Karen D. RUDOLPH, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Mitchell J. PRINSTEIN, Auteur Article en page(s) : p.129-139 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background During adolescence, peer victimization is a potent type of social stressor that can confer enduring risk for poor mental and physical health. Given recent research implicating inflammation in promoting a variety of serious mental and physical health problems, this study examined the role that peer victimization and cognitive vulnerability (i.e. negative cognitive styles and hopelessness) play in shaping adolescents’ pro?inflammatory cytokine responses to an acute social stressor. Methods Adolescent girls at risk for psychopathology (n = 157; Mage = 14.73 years; SD = 1.38) were exposed to a laboratory?based social stressor before and after which we assessed salivary levels of three key pro?inflammatory cytokines – interleukin?6 (IL?6), interleukin?1? (IL?1?), and tumor necrosis factor?? (TNF??). Results As hypothesized, adolescents with greater peer victimization exposure exhibited greater increases in IL?6 and IL1?? in response to the laboratory?based social stressor. Moreover, for all three cytokines individually, as well as for a combined latent factor of inflammation, peer victimization predicted enhanced inflammatory responding most strongly for adolescents with high levels of hopelessness. Conclusions The findings reveal a biological pathway by which peer victimization may interact with cognitive vulnerability to influence health in adolescence. En ligne : https://doi.org/10.1111/jcpp.12804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents [Texte imprimé et/ou numérique] / Matteo GILETTA, Auteur ; George M. SLAVICH, Auteur ; Karen D. RUDOLPH, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Mitchell J. PRINSTEIN, Auteur . - p.129-139. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.129-139 Index. décimale : PER Périodiques Résumé : Background During adolescence, peer victimization is a potent type of social stressor that can confer enduring risk for poor mental and physical health. Given recent research implicating inflammation in promoting a variety of serious mental and physical health problems, this study examined the role that peer victimization and cognitive vulnerability (i.e. negative cognitive styles and hopelessness) play in shaping adolescents’ pro?inflammatory cytokine responses to an acute social stressor. Methods Adolescent girls at risk for psychopathology (n = 157; Mage = 14.73 years; SD = 1.38) were exposed to a laboratory?based social stressor before and after which we assessed salivary levels of three key pro?inflammatory cytokines – interleukin?6 (IL?6), interleukin?1? (IL?1?), and tumor necrosis factor?? (TNF??). Results As hypothesized, adolescents with greater peer victimization exposure exhibited greater increases in IL?6 and IL1?? in response to the laboratory?based social stressor. Moreover, for all three cytokines individually, as well as for a combined latent factor of inflammation, peer victimization predicted enhanced inflammatory responding most strongly for adolescents with high levels of hopelessness. Conclusions The findings reveal a biological pathway by which peer victimization may interact with cognitive vulnerability to influence health in adolescence. En ligne : https://doi.org/10.1111/jcpp.12804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

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