Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence / Nathalie MICHELS ; George M. SLAVICH ; Matteo GILETTA in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Titre : Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence Type de document : texte imprimé Auteurs : Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur Article en page(s) : p.311-321 Langues : Anglais (eng) Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage 12.69 years; SD 0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6 months over 1.5 years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves ( 12 .13; 23 .12; 34 .08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence [texte imprimé] / Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur . - p.311-321. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage 12.69 years; SD 0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6 months over 1.5 years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves ( 12 .13; 23 .12; 34 .08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study / Rachel L. MOSELEY in Autism, 29-5 (May 2025)  

Public ISBD [article]  inAutism > 29-5 (May 2025) . - p.1184-1208 Titre : Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study Type de document : texte imprimé Auteurs : Rachel L. MOSELEY, Auteur ; Darren HEDLEY, Auteur ; Julie M. GAMBLE-TURNER, Auteur ; Mirko ULJAREVIĆ, Auteur ; Simon M. BURY, Auteur ; Grant S. SHIELDS, Auteur ; Julian N. TROLLOR, Auteur ; Mark A. STOKES, Auteur ; George M. SLAVICH, Auteur Article en page(s) : p.1184-1208 Langues : Anglais (eng) Mots-clés : gender  life stress  psychopathology  STRAIN  suicide Index. décimale : PER Périodiques Résumé : Despite very high rates of suicidal thoughts and behaviors (STB) in autistic adults, the key psychosocial drivers of this phenomenon remain unknown. To investigate, we examined how lifetime stressor exposure and severity, which have been found to predict STB in non-autistic populations, related to STB in a multinational dataset of 226 autistic adults from the United Kingdom and Australia (67% female; Mage = 41.8, SD = 13.6, range = 19-73 years old). Results revealed that autistic men and women differ with respect to the count, severity, and type of stressors they experienced over the life course. Whereas autistic men were exposed to more numerous legal/crime-related stressors, autistic women experienced more stressors related to social relationships and chronic humiliation and typically experienced stressors as more severe. In addition, whereas chronic interpersonal loss was related to STB for men, acute stressors involving physical danger and lower exposure to chronic entrapment were related to STB in autistic women. These findings indicate that certain lifetime stressors may be differentially experienced, and relevant to STB, in autistic men versus women. They also suggest that screening for lifetime stressor exposure may help identify autistic individuals at greatest risk of suicide.Lay abstract When we encounter life events that we experience as stressful ("stressors"), it sets off a biological stress response that can impact mental health and contribute to suicidal thoughts and behaviors (STB). Although we know about specific stressors that are associated with STB in the general population, little is known about the kinds of stressors that increase the risk of STB in autistic people and whether these associations differ by gender. To examine this issue, we cataloged the life stressors that autistic men and women experienced over the entire life course and investigated how these stressors were related to STB. Data were derived from a multinational sample of 226 autistic adults from the United Kingdom and Australia who completed the Stress and Adversity Inventory for Adults. We found that autistic men and women differed in terms of both the lifetime stressors they experienced as well as their perceived severity. Whereas men experienced more legal/crime-related stressors, women experienced more stressors related to relationships with other people and more long-lasting stressors associated with humiliation. Autistic women often perceived life stressors as more severe than men, which is important given that it is the perceived severity of stressors that most strongly affects our health. We also found that different stressors may predict STB in autistic men versus women. Whereas loss of loved ones was most strongly associated with STB for men, for women, physically dangerous stressors were most relevant. In addition, women with fewer lifetime stressors involving entrapment had higher lifetime STB. These results suggest that lifetime stressor exposure may be important to assess to understand suicide risk in autistic people. Additional research is needed to confirm these associations and to examine possible mechanisms linking stress and STB. En ligne : https://dx.doi.org/10.1177/13623613241299872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study [texte imprimé] / Rachel L. MOSELEY, Auteur ; Darren HEDLEY, Auteur ; Julie M. GAMBLE-TURNER, Auteur ; Mirko ULJAREVIĆ, Auteur ; Simon M. BURY, Auteur ; Grant S. SHIELDS, Auteur ; Julian N. TROLLOR, Auteur ; Mark A. STOKES, Auteur ; George M. SLAVICH, Auteur . - p.1184-1208. Langues : Anglais (eng) in Autism > 29-5 (May 2025) . - p.1184-1208 Mots-clés : gender  life stress  psychopathology  STRAIN  suicide Index. décimale : PER Périodiques Résumé : Despite very high rates of suicidal thoughts and behaviors (STB) in autistic adults, the key psychosocial drivers of this phenomenon remain unknown. To investigate, we examined how lifetime stressor exposure and severity, which have been found to predict STB in non-autistic populations, related to STB in a multinational dataset of 226 autistic adults from the United Kingdom and Australia (67% female; Mage = 41.8, SD = 13.6, range = 19-73 years old). Results revealed that autistic men and women differ with respect to the count, severity, and type of stressors they experienced over the life course. Whereas autistic men were exposed to more numerous legal/crime-related stressors, autistic women experienced more stressors related to social relationships and chronic humiliation and typically experienced stressors as more severe. In addition, whereas chronic interpersonal loss was related to STB for men, acute stressors involving physical danger and lower exposure to chronic entrapment were related to STB in autistic women. These findings indicate that certain lifetime stressors may be differentially experienced, and relevant to STB, in autistic men versus women. They also suggest that screening for lifetime stressor exposure may help identify autistic individuals at greatest risk of suicide.Lay abstract When we encounter life events that we experience as stressful ("stressors"), it sets off a biological stress response that can impact mental health and contribute to suicidal thoughts and behaviors (STB). Although we know about specific stressors that are associated with STB in the general population, little is known about the kinds of stressors that increase the risk of STB in autistic people and whether these associations differ by gender. To examine this issue, we cataloged the life stressors that autistic men and women experienced over the entire life course and investigated how these stressors were related to STB. Data were derived from a multinational sample of 226 autistic adults from the United Kingdom and Australia who completed the Stress and Adversity Inventory for Adults. We found that autistic men and women differed in terms of both the lifetime stressors they experienced as well as their perceived severity. Whereas men experienced more legal/crime-related stressors, women experienced more stressors related to relationships with other people and more long-lasting stressors associated with humiliation. Autistic women often perceived life stressors as more severe than men, which is important given that it is the perceived severity of stressors that most strongly affects our health. We also found that different stressors may predict STB in autistic men versus women. Whereas loss of loved ones was most strongly associated with STB for men, for women, physically dangerous stressors were most relevant. In addition, women with fewer lifetime stressors involving entrapment had higher lifetime STB. These results suggest that lifetime stressor exposure may be important to assess to understand suicide risk in autistic people. Additional research is needed to confirm these associations and to examine possible mechanisms linking stress and STB. En ligne : https://dx.doi.org/10.1177/13623613241299872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Parental overprotection moderates the association between recent stressor exposure and anxiety during the transition to university / Lidia Y. X. PANIER in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.357-367 Titre : Parental overprotection moderates the association between recent stressor exposure and anxiety during the transition to university Type de document : texte imprimé Auteurs : Lidia Y. X. PANIER, Auteur ; Grace O. ALLISON, Auteur ; Corinne SEJOURNE, Auteur ; George M. SLAVICH, Auteur ; Anna WEINBERG, Auteur Article en page(s) : p.357-367 Langues : Anglais (eng) Mots-clés : Anxiety life stress parental care parental overprotection transition to university Index. décimale : PER Périodiques Résumé : The first year of university is a developmentally significant transition that involves substantial stressor exposure and, for some, heightened anxiety. Parenting may influence the association between stressor exposure and anxiety symptoms, with some research showing that parental care and overprotection throughout childhood and adolescence are associated with the experience of anxiety. However, how these factors interact and relate to anxiety symptoms in early adulthood is not clear. To address this issue, we examined interactions between parenting characteristics (care and overprotection) and stressors experienced during the transition to university, and how they relate to anxiety symptoms in 240 first-year undergraduates (Mage = 18.2, SD = 1.18, 75% female, 51.7% White). Results revealed a significant interaction between parental overprotection and stressor exposure, such that higher parental overprotection and higher levels of recent stressor exposure were associated with more anxiety symptoms (β = 0.52, p = .008). These findings demonstrate continued evidence for associations between experiences of parenting and psychopathology in emerging adulthood and suggest that overprotective parenting behaviors may exacerbate effects of stress exposure. En ligne : https://dx.doi.org/10.1017/S095457942510028X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Parental overprotection moderates the association between recent stressor exposure and anxiety during the transition to university [texte imprimé] / Lidia Y. X. PANIER, Auteur ; Grace O. ALLISON, Auteur ; Corinne SEJOURNE, Auteur ; George M. SLAVICH, Auteur ; Anna WEINBERG, Auteur . - p.357-367. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.357-367 Mots-clés : Anxiety life stress parental care parental overprotection transition to university Index. décimale : PER Périodiques Résumé : The first year of university is a developmentally significant transition that involves substantial stressor exposure and, for some, heightened anxiety. Parenting may influence the association between stressor exposure and anxiety symptoms, with some research showing that parental care and overprotection throughout childhood and adolescence are associated with the experience of anxiety. However, how these factors interact and relate to anxiety symptoms in early adulthood is not clear. To address this issue, we examined interactions between parenting characteristics (care and overprotection) and stressors experienced during the transition to university, and how they relate to anxiety symptoms in 240 first-year undergraduates (Mage = 18.2, SD = 1.18, 75% female, 51.7% White). Results revealed a significant interaction between parental overprotection and stressor exposure, such that higher parental overprotection and higher levels of recent stressor exposure were associated with more anxiety symptoms (β = 0.52, p = .008). These findings demonstrate continued evidence for associations between experiences of parenting and psychopathology in emerging adulthood and suggest that overprotective parenting behaviors may exacerbate effects of stress exposure. En ligne : https://dx.doi.org/10.1017/S095457942510028X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents / Matteo GILETTA in Journal of Child Psychology and Psychiatry, 59-2 (February 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.129-139 Titre : Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents Type de document : texte imprimé Auteurs : Matteo GILETTA, Auteur ; George M. SLAVICH, Auteur ; Karen D. RUDOLPH, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Mitchell J. PRINSTEIN, Auteur Article en page(s) : p.129-139 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background During adolescence, peer victimization is a potent type of social stressor that can confer enduring risk for poor mental and physical health. Given recent research implicating inflammation in promoting a variety of serious mental and physical health problems, this study examined the role that peer victimization and cognitive vulnerability (i.e. negative cognitive styles and hopelessness) play in shaping adolescents’ pro‐inflammatory cytokine responses to an acute social stressor. Methods Adolescent girls at risk for psychopathology (n = 157; Mage = 14.73 years; SD = 1.38) were exposed to a laboratory‐based social stressor before and after which we assessed salivary levels of three key pro‐inflammatory cytokines – interleukin‐6 (IL‐6), interleukin‐1β (IL‐1β), and tumor necrosis factor‐α (TNF‐α). Results As hypothesized, adolescents with greater peer victimization exposure exhibited greater increases in IL‐6 and IL1‐β in response to the laboratory‐based social stressor. Moreover, for all three cytokines individually, as well as for a combined latent factor of inflammation, peer victimization predicted enhanced inflammatory responding most strongly for adolescents with high levels of hopelessness. Conclusions The findings reveal a biological pathway by which peer victimization may interact with cognitive vulnerability to influence health in adolescence. En ligne : https://doi.org/10.1111/jcpp.12804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents [texte imprimé] / Matteo GILETTA, Auteur ; George M. SLAVICH, Auteur ; Karen D. RUDOLPH, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Mitchell J. PRINSTEIN, Auteur . - p.129-139. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.129-139 Index. décimale : PER Périodiques Résumé : Background During adolescence, peer victimization is a potent type of social stressor that can confer enduring risk for poor mental and physical health. Given recent research implicating inflammation in promoting a variety of serious mental and physical health problems, this study examined the role that peer victimization and cognitive vulnerability (i.e. negative cognitive styles and hopelessness) play in shaping adolescents’ pro‐inflammatory cytokine responses to an acute social stressor. Methods Adolescent girls at risk for psychopathology (n = 157; Mage = 14.73 years; SD = 1.38) were exposed to a laboratory‐based social stressor before and after which we assessed salivary levels of three key pro‐inflammatory cytokines – interleukin‐6 (IL‐6), interleukin‐1β (IL‐1β), and tumor necrosis factor‐α (TNF‐α). Results As hypothesized, adolescents with greater peer victimization exposure exhibited greater increases in IL‐6 and IL1‐β in response to the laboratory‐based social stressor. Moreover, for all three cytokines individually, as well as for a combined latent factor of inflammation, peer victimization predicted enhanced inflammatory responding most strongly for adolescents with high levels of hopelessness. Conclusions The findings reveal a biological pathway by which peer victimization may interact with cognitive vulnerability to influence health in adolescence. En ligne : https://doi.org/10.1111/jcpp.12804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months / Matthew G. CLAYTON in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1676-1684 Titre : Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months Type de document : texte imprimé Auteurs : Matthew G. CLAYTON, Auteur ; Steven W. COLE, Auteur ; Matteo GILETTA, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Karen D. RUDOLPH, Auteur ; George M. SLAVICH, Auteur ; Mitchell J. PRINSTEIN, Auteur Article en page(s) : p.1676-1684 Langues : Anglais (eng) Mots-clés : adolescence  biomarkers  childhood trauma  inflammation  suicide Index. décimale : PER Périodiques Résumé : Objective:Recent theories have implicated inflammatory biology in the development of psychopathology and maladaptive behaviors in adolescence, including suicidal thoughts and behaviors (STB). Examining specific biological markers related to inflammation is thus warranted to better understand risk for STB in adolescents, for whom suicide is a leading cause of death.Method:Participants were 211 adolescent females (ages 9-14 years; Mage = 11.8 years, SD = 1.8 years) at increased risk for STB. This study examined the prospective association between basal levels of inflammatory gene expression (average of 15 proinflammatory mRNA transcripts) and subsequent risk for suicidal ideation and suicidal behavior over a 12-month follow-up period.Results:Controlling for past levels of STB, greater proinflammatory gene expression was associated with prospective risk for STB in these youth. Similar effects were observed for CD14 mRNA level, a marker of monocyte abundance within the blood sample. Sensitivity analyses controlling for other relevant covariates, including history of trauma, depressive symptoms, and STB prior to data collection, yielded similar patterns of results.Conclusions:Upregulated inflammatory signaling in the immune system is prospectively associated with STB among at-risk adolescent females, even after controlling for history of trauma, depressive symptoms, and STB prior to data collection. Additional research is needed to identify the sources of inflammatory up-regulation in adolescents (e.g., stress psychobiology, physiological development, microbial exposures) and strategies for mitigating such effects to reduce STB. En ligne : https://www.cambridge.org/core/product/25AD4CF3A7BD16D263771246B7E45F56 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months [texte imprimé] / Matthew G. CLAYTON, Auteur ; Steven W. COLE, Auteur ; Matteo GILETTA, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Karen D. RUDOLPH, Auteur ; George M. SLAVICH, Auteur ; Mitchell J. PRINSTEIN, Auteur . - p.1676-1684. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1676-1684 Mots-clés : adolescence  biomarkers  childhood trauma  inflammation  suicide Index. décimale : PER Périodiques Résumé : Objective:Recent theories have implicated inflammatory biology in the development of psychopathology and maladaptive behaviors in adolescence, including suicidal thoughts and behaviors (STB). Examining specific biological markers related to inflammation is thus warranted to better understand risk for STB in adolescents, for whom suicide is a leading cause of death.Method:Participants were 211 adolescent females (ages 9-14 years; Mage = 11.8 years, SD = 1.8 years) at increased risk for STB. This study examined the prospective association between basal levels of inflammatory gene expression (average of 15 proinflammatory mRNA transcripts) and subsequent risk for suicidal ideation and suicidal behavior over a 12-month follow-up period.Results:Controlling for past levels of STB, greater proinflammatory gene expression was associated with prospective risk for STB in these youth. Similar effects were observed for CD14 mRNA level, a marker of monocyte abundance within the blood sample. Sensitivity analyses controlling for other relevant covariates, including history of trauma, depressive symptoms, and STB prior to data collection, yielded similar patterns of results.Conclusions:Upregulated inflammatory signaling in the immune system is prospectively associated with STB among at-risk adolescent females, even after controlling for history of trauma, depressive symptoms, and STB prior to data collection. Additional research is needed to identify the sources of inflammatory up-regulation in adolescents (e.g., stress psychobiology, physiological development, microbial exposures) and strategies for mitigating such effects to reduce STB. En ligne : https://www.cambridge.org/core/product/25AD4CF3A7BD16D263771246B7E45F56 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

The Stress and Adversity Inventory for Adolescents (Adolescent STRAIN): associations with mental and physical health, risky behaviors, and psychiatric diagnoses in youth seeking treatment / George M. SLAVICH in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Permalink

---

1 (1 - 6 / 6) Par page : 25 50 100 200