Atypical sound discrimination in children with ASD as indicated by cortical ERPs / Aurélie BIDET-CAULET in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.13 Titre : Atypical sound discrimination in children with ASD as indicated by cortical ERPs Type de document : Texte imprimé et/ou numérique Auteurs : Aurélie BIDET-CAULET, Auteur ; Marianne LATINUS, Auteur ; S. ROUX, Auteur ; J. MALVY, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; N. BRUNEAU, Auteur Article en page(s) : p.13 Langues : Anglais (eng) Mots-clés : Auditory  Autism  Development  Ftpv  Speech  Voice Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) show a relative indifference to the human voice. Accordingly, and contrarily to their typically developed peers, adults with autism do not show a preferential response to voices in the superior temporal sulcus; this lack of voice-specific response was previously linked to atypical processing of voices. In electroencephalography, a slow event-related potential (ERP) called the fronto-temporal positivity to voice (FTPV) is larger for vocal than for non-vocal sounds, resulting in a voice-sensitive response over right fronto-temporal sites. Here, we investigated the neurophysiological correlates of voice perception in children with and without ASD. METHODS: Sixteen children with autism and 16 age-matched typically developing children heard vocal (speech and non-speech) and non-vocal sounds while their electroencephalographic activity was recorded; overall IQ was smaller in the group of children with ASD. ERP amplitudes were compared using non-parametric statistical tests at each electrode and in successive 20-ms time windows. Within each group, differences between conditions were assessed using a non-parametric Quade test between 0 and 400 ms post-stimulus. Inter-group comparisons of ERP amplitudes were performed using non-paired Kruskal-Wallis tests between 140 and 180 ms post-stimulus. RESULTS: Typically developing children showed the classical voice-sensitive response over right fronto-temporal electrodes, for both speech and non-speech vocal sounds. Children with ASD did not show a preferential response to vocal sounds. Inter-group analysis showed no difference in the processing of vocal sounds, both speech and non-speech, but significant differences in the processing of non-vocal sounds over right fronto-temporal sites. CONCLUSIONS: Our results demonstrate a lack of voice-preferential response in children with autism spectrum disorders. In contrast to observations in adults with ASD, the lack of voice-preferential response was attributed to an atypical response to non-vocal sounds, which was overall more similar to the event-related potentials evoked by vocal sounds in both groups. This result suggests atypical maturation processes in ASD impeding the specialization of temporal regions in voice processing. En ligne : http://dx.doi.org/10.1186/s11689-017-9194-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Atypical sound discrimination in children with ASD as indicated by cortical ERPs [Texte imprimé et/ou numérique] / Aurélie BIDET-CAULET, Auteur ; Marianne LATINUS, Auteur ; S. ROUX, Auteur ; J. MALVY, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; N. BRUNEAU, Auteur . - p.13. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.13 Mots-clés : Auditory  Autism  Development  Ftpv  Speech  Voice Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) show a relative indifference to the human voice. Accordingly, and contrarily to their typically developed peers, adults with autism do not show a preferential response to voices in the superior temporal sulcus; this lack of voice-specific response was previously linked to atypical processing of voices. In electroencephalography, a slow event-related potential (ERP) called the fronto-temporal positivity to voice (FTPV) is larger for vocal than for non-vocal sounds, resulting in a voice-sensitive response over right fronto-temporal sites. Here, we investigated the neurophysiological correlates of voice perception in children with and without ASD. METHODS: Sixteen children with autism and 16 age-matched typically developing children heard vocal (speech and non-speech) and non-vocal sounds while their electroencephalographic activity was recorded; overall IQ was smaller in the group of children with ASD. ERP amplitudes were compared using non-parametric statistical tests at each electrode and in successive 20-ms time windows. Within each group, differences between conditions were assessed using a non-parametric Quade test between 0 and 400 ms post-stimulus. Inter-group comparisons of ERP amplitudes were performed using non-paired Kruskal-Wallis tests between 140 and 180 ms post-stimulus. RESULTS: Typically developing children showed the classical voice-sensitive response over right fronto-temporal electrodes, for both speech and non-speech vocal sounds. Children with ASD did not show a preferential response to vocal sounds. Inter-group analysis showed no difference in the processing of vocal sounds, both speech and non-speech, but significant differences in the processing of non-vocal sounds over right fronto-temporal sites. CONCLUSIONS: Our results demonstrate a lack of voice-preferential response in children with autism spectrum disorders. In contrast to observations in adults with ASD, the lack of voice-preferential response was attributed to an atypical response to non-vocal sounds, which was overall more similar to the event-related potentials evoked by vocal sounds in both groups. This result suggests atypical maturation processes in ASD impeding the specialization of temporal regions in voice processing. En ligne : http://dx.doi.org/10.1186/s11689-017-9194-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Autism is a prenatal disorder: Evidence from late gestation brain overgrowth / Frédérique BONNET-BRILHAULT in Autism Research, 11-12 (December 2018)  

Public ISBD [article]  inAutism Research > 11-12 (December 2018) . - p.1635-1642 Titre : Autism is a prenatal disorder: Evidence from late gestation brain overgrowth Type de document : Texte imprimé et/ou numérique Auteurs : Frédérique BONNET-BRILHAULT, Auteur ; T. A. RAJERISON, Auteur ; C. PAILLET, Auteur ; M. GUIMARD-BRUNAULT, Auteur ; A. SABY, Auteur ; L. PONSON, Auteur ; G. TRIPI, Auteur ; J. MALVY, Auteur ; S. ROUX, Auteur Article en page(s) : p.1635-1642 Langues : Anglais (eng) Mots-clés : brain growth  head circumference  neurodevelopmental disorder  ultrasound Index. décimale : PER Périodiques Résumé : This retrospective study aimed to specify the critical period for atypical brain development in individuals with autism spectrum disorder (ASD) using prenatal and postnatal head growth parameters. The sample consisted of 80 Caucasian, unrelated, idiopathic patients with ASD born after 1995. Fetal ultrasound parameters (head circumference [HC], abdominal circumference, and femur length) were obtained during the second and third trimesters of gestation. HC at birth and postnatal parameters at 12 and 24 months of age were also collected. Head overgrowth, assessed by HC, was highlighted during the second (20-26 weeks of amenorrhea) and third (28-36 weeks of amenorrhea) trimesters. Normal growth of body fetal parameters indicated that head overgrowth was not because of overall body overgrowth. Moreover, postnatal results replicated previously and reported head overgrowth. A critical time window for atypical brain development in autism is hypothesized to begin from the 22nd week of amenorrhea. This period is critical for cortical lamination and glial activation. A pathophysiological cascade is suggested with interactions between candidate genes and environmental factors. Autism Research 2018, 11: 1635-1642. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is now widely acknowledged in the scientific community, that autism is a neurodevelopmental disorder. Recent evidence from animal and pathological studies has implicated the in utero period. However, the precise time of onset of abnormal brain development remains unknown. This retrospective study reports novel findings, identifying an atypical head growth trajectory in children with autism, during the in utero period (after the 22nd week of amenorrhea). In the same children, postnatal head overgrowth was also observed. Late gestation is identified as a critical period for atypical brain development underlying autism symptoms. En ligne : http://dx.doi.org/10.1002/aur.2036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372 [article] Autism is a prenatal disorder: Evidence from late gestation brain overgrowth [Texte imprimé et/ou numérique] / Frédérique BONNET-BRILHAULT, Auteur ; T. A. RAJERISON, Auteur ; C. PAILLET, Auteur ; M. GUIMARD-BRUNAULT, Auteur ; A. SABY, Auteur ; L. PONSON, Auteur ; G. TRIPI, Auteur ; J. MALVY, Auteur ; S. ROUX, Auteur . - p.1635-1642. Langues : Anglais (eng) in Autism Research > 11-12 (December 2018) . - p.1635-1642 Mots-clés : brain growth  head circumference  neurodevelopmental disorder  ultrasound Index. décimale : PER Périodiques Résumé : This retrospective study aimed to specify the critical period for atypical brain development in individuals with autism spectrum disorder (ASD) using prenatal and postnatal head growth parameters. The sample consisted of 80 Caucasian, unrelated, idiopathic patients with ASD born after 1995. Fetal ultrasound parameters (head circumference [HC], abdominal circumference, and femur length) were obtained during the second and third trimesters of gestation. HC at birth and postnatal parameters at 12 and 24 months of age were also collected. Head overgrowth, assessed by HC, was highlighted during the second (20-26 weeks of amenorrhea) and third (28-36 weeks of amenorrhea) trimesters. Normal growth of body fetal parameters indicated that head overgrowth was not because of overall body overgrowth. Moreover, postnatal results replicated previously and reported head overgrowth. A critical time window for atypical brain development in autism is hypothesized to begin from the 22nd week of amenorrhea. This period is critical for cortical lamination and glial activation. A pathophysiological cascade is suggested with interactions between candidate genes and environmental factors. Autism Research 2018, 11: 1635-1642. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is now widely acknowledged in the scientific community, that autism is a neurodevelopmental disorder. Recent evidence from animal and pathological studies has implicated the in utero period. However, the precise time of onset of abnormal brain development remains unknown. This retrospective study reports novel findings, identifying an atypical head growth trajectory in children with autism, during the in utero period (after the 22nd week of amenorrhea). In the same children, postnatal head overgrowth was also observed. Late gestation is identified as a critical period for atypical brain development underlying autism symptoms. En ligne : http://dx.doi.org/10.1002/aur.2036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372

Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults / J. CHARPENTIER in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 28 p. Titre : Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults Type de document : Texte imprimé et/ou numérique Auteurs : J. CHARPENTIER, Auteur ; K. KOVARSKI, Auteur ; Emmanuelle HOUY-DURAND, Auteur ; J. MALVY, Auteur ; A. SABY, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marianne LATINUS, Auteur ; Marie GOMOT, Auteur Année de publication : 2018 Article en page(s) : 28 p. Langues : Anglais (eng) Mots-clés : Adults  Autism spectrum disorder  Change detection  Children  Eeg  Emotion  Mismatch negativity (MMN)  Prosody Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical behaviors in social environments and in reaction to changing events. While this dyad of symptoms is at the core of the pathology along with atypical sensory behaviors, most studies have investigated only one dimension. A focus on the sameness dimension has shown that intolerance to change is related to an atypical pre-attentional detection of irregularity. In the present study, we addressed the same process in response to emotional change in order to evaluate the interplay between alterations of change detection and socio-emotional processing in children and adults with autism. METHODS: Brain responses to neutral and emotional prosodic deviancies (mismatch negativity (MMN) and P3a, reflecting change detection and orientation of attention toward change, respectively) were recorded in children and adults with autism and in controls. Comparison of neutral and emotional conditions allowed distinguishing between general deviancy and emotional deviancy effects. Moreover, brain responses to the same neutral and emotional stimuli were recorded when they were not deviants to evaluate the sensory processing of these vocal stimuli. RESULTS: In controls, change detection was modulated by prosody: in children, this was characterized by a lateralization of emotional MMN to the right hemisphere, and in adults, by an earlier MMN for emotional deviancy than for neutral deviancy. In ASD, an overall atypical change detection was observed with an earlier MMN and a larger P3a compared to controls suggesting an unusual pre-attentional orientation toward any changes in the auditory environment. Moreover, in children with autism, deviancy detection depicted reduced MMN amplitude. In addition in children with autism, contrary to adults with autism, no modulation of the MMN by prosody was present and sensory processing of both neutral and emotional vocal stimuli appeared atypical. CONCLUSIONS: Overall, change detection remains altered in people with autism. However, differences between children and adults with ASD evidence a trend toward normalization of vocal processing and of the automatic detection of emotion deviancy with age. En ligne : http://dx.doi.org/10.1186/s11689-018-9246-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults [Texte imprimé et/ou numérique] / J. CHARPENTIER, Auteur ; K. KOVARSKI, Auteur ; Emmanuelle HOUY-DURAND, Auteur ; J. MALVY, Auteur ; A. SABY, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marianne LATINUS, Auteur ; Marie GOMOT, Auteur . - 2018 . - 28 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 28 p. Mots-clés : Adults  Autism spectrum disorder  Change detection  Children  Eeg  Emotion  Mismatch negativity (MMN)  Prosody Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical behaviors in social environments and in reaction to changing events. While this dyad of symptoms is at the core of the pathology along with atypical sensory behaviors, most studies have investigated only one dimension. A focus on the sameness dimension has shown that intolerance to change is related to an atypical pre-attentional detection of irregularity. In the present study, we addressed the same process in response to emotional change in order to evaluate the interplay between alterations of change detection and socio-emotional processing in children and adults with autism. METHODS: Brain responses to neutral and emotional prosodic deviancies (mismatch negativity (MMN) and P3a, reflecting change detection and orientation of attention toward change, respectively) were recorded in children and adults with autism and in controls. Comparison of neutral and emotional conditions allowed distinguishing between general deviancy and emotional deviancy effects. Moreover, brain responses to the same neutral and emotional stimuli were recorded when they were not deviants to evaluate the sensory processing of these vocal stimuli. RESULTS: In controls, change detection was modulated by prosody: in children, this was characterized by a lateralization of emotional MMN to the right hemisphere, and in adults, by an earlier MMN for emotional deviancy than for neutral deviancy. In ASD, an overall atypical change detection was observed with an earlier MMN and a larger P3a compared to controls suggesting an unusual pre-attentional orientation toward any changes in the auditory environment. Moreover, in children with autism, deviancy detection depicted reduced MMN amplitude. In addition in children with autism, contrary to adults with autism, no modulation of the MMN by prosody was present and sensory processing of both neutral and emotional vocal stimuli appeared atypical. CONCLUSIONS: Overall, change detection remains altered in people with autism. However, differences between children and adults with ASD evidence a trend toward normalization of vocal processing and of the automatic detection of emotion deviancy with age. En ligne : http://dx.doi.org/10.1186/s11689-018-9246-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Faster eye movements in children with autism spectrum disorder / K. KOVARSKI in Autism Research, 12-2 (February 2019)  

Public ISBD [article]  inAutism Research > 12-2 (February 2019) . - p.212-224 Titre : Faster eye movements in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. KOVARSKI, Auteur ; M. SIWIASZCZYK, Auteur ; J. MALVY, Auteur ; Magali BATTY, Auteur ; Marianne LATINUS, Auteur Article en page(s) : p.212-224 Langues : Anglais (eng) Mots-clés : autism  children  oculomotor functioning  saccadic eye movements  visual perception Index. décimale : PER Périodiques Résumé : Atypical visual exploration of both social and nonsocial scenes is often reported in Autism Spectrum Disorder (ASD) with less precise and longer saccades, potentially reflecting difficulties in oculomotor control. To assess a subset of oculomotor functions in ASD, 20 children with ASD and 21 age-matched typically developing (TD) children (2.6-11.5 years) partook in three tasks of increasing complexity, while no explicit instruction was provided: a prosaccade gap task, a color and a "categorical" visual search tasks (a face among butterflies and vice-versa). In addition to classical saccade metrics, we measured Distance error, (the distance between the target and the closest gaze position) and Time-to-target (the time taken to reach the target). In the prosaccade task, children with ASD were as accurate as TD children, yet faster to reach the stimulus. In the color visual search task, children with ASD were faster but less precise than TD children. In the categorical visual search, while TD children were more precise in orienting their gaze towards the face, children with ASD performed similarly in the two conditions; Time-to-target did not differ. Our results provide contradictory evidence regarding enhanced visual search ability in ASD: when considering response times, enhanced visual search performance was found in one task only, while when considering gaze precision no advantage was found. These three experiments demonstrate that the automatic saccadic system may function more rapidly in children with ASD. Nonetheless, a diminished sensitivity to bottom-up saliency and top-down influence might suppress this advantage in more complex visual environments. Autism Res 2019, 12: 212-224 (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Three experiments with no instructions were designed to assess oculomotor functions in children with Autism Spectrum Disorder (ASD). In a saccade task, children with ASD were faster than but as accurate as control children. In visual search tasks, accuracy and speed decreased with increasing complexity of visual environment. Children with ASD showed faster automatic visual orientation, but this might hinder exploratory behaviors, leading to difficulties in complex and social situations. En ligne : http://dx.doi.org/10.1002/aur.2054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Faster eye movements in children with autism spectrum disorder [Texte imprimé et/ou numérique] / K. KOVARSKI, Auteur ; M. SIWIASZCZYK, Auteur ; J. MALVY, Auteur ; Magali BATTY, Auteur ; Marianne LATINUS, Auteur . - p.212-224. Langues : Anglais (eng) in Autism Research > 12-2 (February 2019) . - p.212-224 Mots-clés : autism  children  oculomotor functioning  saccadic eye movements  visual perception Index. décimale : PER Périodiques Résumé : Atypical visual exploration of both social and nonsocial scenes is often reported in Autism Spectrum Disorder (ASD) with less precise and longer saccades, potentially reflecting difficulties in oculomotor control. To assess a subset of oculomotor functions in ASD, 20 children with ASD and 21 age-matched typically developing (TD) children (2.6-11.5 years) partook in three tasks of increasing complexity, while no explicit instruction was provided: a prosaccade gap task, a color and a "categorical" visual search tasks (a face among butterflies and vice-versa). In addition to classical saccade metrics, we measured Distance error, (the distance between the target and the closest gaze position) and Time-to-target (the time taken to reach the target). In the prosaccade task, children with ASD were as accurate as TD children, yet faster to reach the stimulus. In the color visual search task, children with ASD were faster but less precise than TD children. In the categorical visual search, while TD children were more precise in orienting their gaze towards the face, children with ASD performed similarly in the two conditions; Time-to-target did not differ. Our results provide contradictory evidence regarding enhanced visual search ability in ASD: when considering response times, enhanced visual search performance was found in one task only, while when considering gaze precision no advantage was found. These three experiments demonstrate that the automatic saccadic system may function more rapidly in children with ASD. Nonetheless, a diminished sensitivity to bottom-up saliency and top-down influence might suppress this advantage in more complex visual environments. Autism Res 2019, 12: 212-224 (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Three experiments with no instructions were designed to assess oculomotor functions in children with Autism Spectrum Disorder (ASD). In a saccade task, children with ASD were faster than but as accurate as control children. In visual search tasks, accuracy and speed decreased with increasing complexity of visual environment. Children with ASD showed faster automatic visual orientation, but this might hinder exploratory behaviors, leading to difficulties in complex and social situations. En ligne : http://dx.doi.org/10.1002/aur.2054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

Incomplete Gestation has an Impact on Cognitive Abilities in Autism Spectrum Disorder / M. BRAYETTE in Journal of Autism and Developmental Disorders, 49-10 (October 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-10 (October 2019) . - p.4339-4345 Titre : Incomplete Gestation has an Impact on Cognitive Abilities in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. BRAYETTE, Auteur ; E. SALIBA, Auteur ; J. MALVY, Auteur ; R. BLANC, Auteur ; L. PONSON, Auteur ; G. TRIPI, Auteur ; S. ROUX, Auteur ; Frédérique BONNET-BRILHAULT, Auteur Article en page(s) : p.4339-4345 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Cognitive abilities  Early term  Moderately and late preterm Index. décimale : PER Périodiques Résumé : Extreme prematurity is known as a risk factor for autism spectrum disorder (ASD). However, the association between prematurity and ASD, for children born moderately and late preterm (MLPT) and those born early term (ET), is less established. This retrospective study aimed to characterize the phenotypic characteristics (i.e. behavioral profile and cognitive abilities) of 254 children with ASD, between 3 and 15 years of age, born MLPT (19 children), ET (60 children) and full term (175 children). MLPT and ET births do not modify ASD symptomatology, but modify cognitive development. The results highlight that incomplete gestation, i.e., MLPT or ET, has a negative impact on both verbal and nonverbal cognitive abilities, in children with neurodevelopmental vulnerability. En ligne : http://dx.doi.org/10.1007/s10803-019-04105-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407 [article] Incomplete Gestation has an Impact on Cognitive Abilities in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / M. BRAYETTE, Auteur ; E. SALIBA, Auteur ; J. MALVY, Auteur ; R. BLANC, Auteur ; L. PONSON, Auteur ; G. TRIPI, Auteur ; S. ROUX, Auteur ; Frédérique BONNET-BRILHAULT, Auteur . - p.4339-4345. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-10 (October 2019) . - p.4339-4345 Mots-clés : Autism spectrum disorder  Cognitive abilities  Early term  Moderately and late preterm Index. décimale : PER Périodiques Résumé : Extreme prematurity is known as a risk factor for autism spectrum disorder (ASD). However, the association between prematurity and ASD, for children born moderately and late preterm (MLPT) and those born early term (ET), is less established. This retrospective study aimed to characterize the phenotypic characteristics (i.e. behavioral profile and cognitive abilities) of 254 children with ASD, between 3 and 15 years of age, born MLPT (19 children), ET (60 children) and full term (175 children). MLPT and ET births do not modify ASD symptomatology, but modify cognitive development. The results highlight that incomplete gestation, i.e., MLPT or ET, has a negative impact on both verbal and nonverbal cognitive abilities, in children with neurodevelopmental vulnerability. En ligne : http://dx.doi.org/10.1007/s10803-019-04105-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407

What do parents of children with autism expect from participation in research? A community survey about early autism studies / Sue FLETCHER-WATSON in Autism, 23-1 (January 2019)  

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