Child and family characteristics moderate agreement between caregiver and clinician report of autism symptoms / E. NEUHAUS in Autism Research, 11-3 (March 2018)  

Public ISBD [article]  inAutism Research > 11-3 (March 2018) . - p.476-487 Titre : Child and family characteristics moderate agreement between caregiver and clinician report of autism symptoms Type de document : Texte imprimé et/ou numérique Auteurs : E. NEUHAUS, Auteur ; Theodore P. BEAUCHAINE, Auteur ; Raphael BERNIER, Auteur ; S. J. WEBB, Auteur Article en page(s) : p.476-487 Langues : Anglais (eng) Mots-clés : autism diagnostic observation schedule  autism spectrum disorder  diagnosis Index. décimale : PER Périodiques Résumé : Rates of autism spectrum disorder (ASD) and age at first diagnosis vary considerably across the United States and are moderated by children's sex, race, ethnicity, and availability of services. We additionally suggest that degree of caregiver-clinician agreement on ASD symptoms may play a role in ASD assessment. Since gold standard ASD assessment integrates caregiver-reported developmental history with clinician observations, differential agreement between reporters across demographic groups may contribute to a host of detrimental outcomes. Here, we investigate whether caregiver-clinician agreement on ASD symptoms varies according to child and family characteristics. Comprehensive data from 2,759 families in the Simons Simplex Collection were analyzed. Linear models were created with caregiver reports predicting clinician reports, and moderating effects of child characteristics and family factors were examined. Poorer reporter correspondence was observed when children had higher IQ scores, stronger adaptive behavior, and more behavioral difficulties. Greater disagreement was also associated with African American racial status (for younger children), lower household income, and paternal social difficulties (for older children). Children's biological sex did not moderate caregiver-clinician agreement. Marked disagreement between caregivers and clinicians could lead to suboptimal or insufficient intervention services and negative experiences for families throughout development. Such families may also be less likely to qualify for research studies, and therefore be underrepresented in the ASD literature. Modified assessment procedures may be required to improve assessment accuracy and family experiences. Autism Res 2018, 11: 476-487. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Evaluation of autism spectrum disorder (ASD) incorporates both caregiver and clinician perspectives of symptoms, and disagreement between these perspectives could lead to poorer outcomes for families. Using data from 2,759 families, we show that caregiver-clinician agreement on ASD symptoms is poorer for children with higher cognitive and adaptive skills, more behavioral difficulties, lower household income, and African American racial status. These children may be at higher risk for misdiagnosis, poorer family experiences during evaluations, and poorer representation in ASD research. En ligne : http://dx.doi.org/10.1002/aur.1907 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Child and family characteristics moderate agreement between caregiver and clinician report of autism symptoms [Texte imprimé et/ou numérique] / E. NEUHAUS, Auteur ; Theodore P. BEAUCHAINE, Auteur ; Raphael BERNIER, Auteur ; S. J. WEBB, Auteur . - p.476-487. Langues : Anglais (eng) in Autism Research > 11-3 (March 2018) . - p.476-487 Mots-clés : autism diagnostic observation schedule  autism spectrum disorder  diagnosis Index. décimale : PER Périodiques Résumé : Rates of autism spectrum disorder (ASD) and age at first diagnosis vary considerably across the United States and are moderated by children's sex, race, ethnicity, and availability of services. We additionally suggest that degree of caregiver-clinician agreement on ASD symptoms may play a role in ASD assessment. Since gold standard ASD assessment integrates caregiver-reported developmental history with clinician observations, differential agreement between reporters across demographic groups may contribute to a host of detrimental outcomes. Here, we investigate whether caregiver-clinician agreement on ASD symptoms varies according to child and family characteristics. Comprehensive data from 2,759 families in the Simons Simplex Collection were analyzed. Linear models were created with caregiver reports predicting clinician reports, and moderating effects of child characteristics and family factors were examined. Poorer reporter correspondence was observed when children had higher IQ scores, stronger adaptive behavior, and more behavioral difficulties. Greater disagreement was also associated with African American racial status (for younger children), lower household income, and paternal social difficulties (for older children). Children's biological sex did not moderate caregiver-clinician agreement. Marked disagreement between caregivers and clinicians could lead to suboptimal or insufficient intervention services and negative experiences for families throughout development. Such families may also be less likely to qualify for research studies, and therefore be underrepresented in the ASD literature. Modified assessment procedures may be required to improve assessment accuracy and family experiences. Autism Res 2018, 11: 476-487. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Evaluation of autism spectrum disorder (ASD) incorporates both caregiver and clinician perspectives of symptoms, and disagreement between these perspectives could lead to poorer outcomes for families. Using data from 2,759 families, we show that caregiver-clinician agreement on ASD symptoms is poorer for children with higher cognitive and adaptive skills, more behavioral difficulties, lower household income, and African American racial status. These children may be at higher risk for misdiagnosis, poorer family experiences during evaluations, and poorer representation in ASD research. En ligne : http://dx.doi.org/10.1002/aur.1907 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

Exploring the heterogeneity of neural social indices for genetically distinct etiologies of autism / C. M. HUDAC in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.24 Titre : Exploring the heterogeneity of neural social indices for genetically distinct etiologies of autism Type de document : Texte imprimé et/ou numérique Auteurs : C. M. HUDAC, Auteur ; H. A. F. STESSMAN, Auteur ; Trent D. DESCHAMPS, Auteur ; A. KRESSE, Auteur ; S. FAJA, Auteur ; E. NEUHAUS, Auteur ; S. J. WEBB, Auteur ; E. E. EICHLER, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.24 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD)  Electroencephalography (EEG)  Likely gene-disrupting mutations  Molecular subtyping  Mu rhythm attenuation  Social cognition  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a genetically and phenotypically heterogeneous disorder. Promising initiatives utilizing interdisciplinary characterization of ASD suggest phenotypic subtypes related to specific likely gene-disrupting mutations (LGDMs). However, the role of functionally associated LGDMs in the neural social phenotype is unknown. METHODS: In this study of 26 children with ASD (n = 13 with an LGDM) and 13 control children, we characterized patterns of mu attenuation and habituation as children watched videos containing social and nonsocial motions during electroencephalography acquisition. RESULTS: Diagnostic comparisons were consistent with prior work suggesting aberrant mu attenuation in ASD within the upper mu band (10-12 Hz), but typical patterns within the lower mu band (8-10 Hz). Preliminary exploration indicated distinct social sensitization patterns (i.e., increasing mu attenuation for social motion) for children with an LGDM that is primarily expressed during embryonic development. In contrast, children with an LGDM primarily expressed post-embryonic development exhibited stable typical patterns of lower mu attenuation. Neural social indices were associated with social responsiveness, but not cognition. CONCLUSIONS: These findings suggest unique neurophysiological profiles for certain genetic etiologies of ASD, further clarifying possible genetic functional subtypes of ASD and providing insight into mechanisms for targeted treatment approaches. En ligne : http://dx.doi.org/10.1186/s11689-017-9199-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Exploring the heterogeneity of neural social indices for genetically distinct etiologies of autism [Texte imprimé et/ou numérique] / C. M. HUDAC, Auteur ; H. A. F. STESSMAN, Auteur ; Trent D. DESCHAMPS, Auteur ; A. KRESSE, Auteur ; S. FAJA, Auteur ; E. NEUHAUS, Auteur ; S. J. WEBB, Auteur ; E. E. EICHLER, Auteur ; Raphael BERNIER, Auteur . - p.24. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.24 Mots-clés : Autism spectrum disorders (ASD)  Electroencephalography (EEG)  Likely gene-disrupting mutations  Molecular subtyping  Mu rhythm attenuation  Social cognition  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a genetically and phenotypically heterogeneous disorder. Promising initiatives utilizing interdisciplinary characterization of ASD suggest phenotypic subtypes related to specific likely gene-disrupting mutations (LGDMs). However, the role of functionally associated LGDMs in the neural social phenotype is unknown. METHODS: In this study of 26 children with ASD (n = 13 with an LGDM) and 13 control children, we characterized patterns of mu attenuation and habituation as children watched videos containing social and nonsocial motions during electroencephalography acquisition. RESULTS: Diagnostic comparisons were consistent with prior work suggesting aberrant mu attenuation in ASD within the upper mu band (10-12 Hz), but typical patterns within the lower mu band (8-10 Hz). Preliminary exploration indicated distinct social sensitization patterns (i.e., increasing mu attenuation for social motion) for children with an LGDM that is primarily expressed during embryonic development. In contrast, children with an LGDM primarily expressed post-embryonic development exhibited stable typical patterns of lower mu attenuation. Neural social indices were associated with social responsiveness, but not cognition. CONCLUSIONS: These findings suggest unique neurophysiological profiles for certain genetic etiologies of ASD, further clarifying possible genetic functional subtypes of ASD and providing insight into mechanisms for targeted treatment approaches. En ligne : http://dx.doi.org/10.1186/s11689-017-9199-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Language and Aggressive Behaviors in Male and Female Youth with Autism Spectrum Disorder / E. NEUHAUS in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.454-462 Titre : Language and Aggressive Behaviors in Male and Female Youth with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. NEUHAUS, Auteur ; V. Y. KANG, Auteur ; A. KRESSE, Auteur ; S. CORRIGAN, Auteur ; Elizabeth H. AYLWARD, Auteur ; Raphael BERNIER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; A. JACK, Auteur ; S. JESTE, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Kevin A. PELPHREY, Auteur ; S. J. WEBB, Auteur Article en page(s) : p.454-462 Langues : Anglais (eng) Mots-clés : Adolescent  Aggression  Autism Spectrum Disorder  Child  Communication  Female  Humans  Language  Male  Asd  Autism  Externalizing behaviors  Gender  Sex differences Index. décimale : PER Périodiques Résumé : Aggressive behaviors are common among youth with autism spectrum disorder (ASD) and correlate with pervasive social-emotional difficulties. Communication skill is an important correlate of disruptive behavior in typical development, and clarification of links between communication and aggression in ASD may inform intervention methods. We investigate child/family factors and communication in relation to aggression among 145 individuals with ASD (65 female; ages 8-17 years). Overall, more severe aggression was associated with younger age, lower family income, and difficulties with communication skills. However, this pattern of results was driven by males, and aggression was unrelated to child or family characteristics for females. Future work should incorporate these predictors in conjunction with broader contextual factors to understand aggressive behavior in females with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04773-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Language and Aggressive Behaviors in Male and Female Youth with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / E. NEUHAUS, Auteur ; V. Y. KANG, Auteur ; A. KRESSE, Auteur ; S. CORRIGAN, Auteur ; Elizabeth H. AYLWARD, Auteur ; Raphael BERNIER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; A. JACK, Auteur ; S. JESTE, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Kevin A. PELPHREY, Auteur ; S. J. WEBB, Auteur . - p.454-462. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.454-462 Mots-clés : Adolescent  Aggression  Autism Spectrum Disorder  Child  Communication  Female  Humans  Language  Male  Asd  Autism  Externalizing behaviors  Gender  Sex differences Index. décimale : PER Périodiques Résumé : Aggressive behaviors are common among youth with autism spectrum disorder (ASD) and correlate with pervasive social-emotional difficulties. Communication skill is an important correlate of disruptive behavior in typical development, and clarification of links between communication and aggression in ASD may inform intervention methods. We investigate child/family factors and communication in relation to aggression among 145 individuals with ASD (65 female; ages 8-17 years). Overall, more severe aggression was associated with younger age, lower family income, and difficulties with communication skills. However, this pattern of results was driven by males, and aggression was unrelated to child or family characteristics for females. Future work should incorporate these predictors in conjunction with broader contextual factors to understand aggressive behavior in females with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04773-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

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