Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children / M. H. RAHBAR in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.1953-1965 Titre : Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children Type de document : texte imprimé Auteurs : M. H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Sepideh SAROUKHANI, Auteur ; M. LEE, Auteur ; J. ZHANG, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; M. L. GROVE, Auteur ; K. A. LOVELAND, Auteur Article en page(s) : p.1953-1965 Langues : Anglais (eng) Mots-clés : African Americans  Autism Spectrum Disorder/blood/genetics  Case-Control Studies  Child  Child, Preschool  Genetic Predisposition to Disease  Genotype  Glutathione S-Transferase pi  Glutathione Transferase/genetics  Humans  Male  Manganese/blood  Polymorphism, Genetic  Autism spectrum disorder (ASD)  Blood manganese concentrations (BMC)  Conditional logistic regression (CLR)  Glutathione S-transferase (GST) genes  Interaction  Jamaica  interest. Maureen Samms-Vaughan declares that she has no conflict of interest.  Sepideh Saroukhani declares that she has no conflict of interest. MinJae Lee  declares that she has no conflict of interest. Jing Zhang declares that she has no  conflict of interest. Jan Bressler declares that she has no conflict of interest.  Manouchehr Hessabi declares that he has no conflict of interest. Sydonnie  Shakespeare-Pellington declares that she has no conflict of interest. Megan L. Grove  declares that she has no conflict of interest. Katherine A. Loveland declares that  she has no conflict of interest. Index. décimale : PER Périodiques Résumé : Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2-8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1007/s10803-020-04677-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children [texte imprimé] / M. H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Sepideh SAROUKHANI, Auteur ; M. LEE, Auteur ; J. ZHANG, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; M. L. GROVE, Auteur ; K. A. LOVELAND, Auteur . - p.1953-1965. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.1953-1965 Mots-clés : African Americans  Autism Spectrum Disorder/blood/genetics  Case-Control Studies  Child  Child, Preschool  Genetic Predisposition to Disease  Genotype  Glutathione S-Transferase pi  Glutathione Transferase/genetics  Humans  Male  Manganese/blood  Polymorphism, Genetic  Autism spectrum disorder (ASD)  Blood manganese concentrations (BMC)  Conditional logistic regression (CLR)  Glutathione S-transferase (GST) genes  Interaction  Jamaica  interest. Maureen Samms-Vaughan declares that she has no conflict of interest.  Sepideh Saroukhani declares that she has no conflict of interest. MinJae Lee  declares that she has no conflict of interest. Jing Zhang declares that she has no  conflict of interest. Jan Bressler declares that she has no conflict of interest.  Manouchehr Hessabi declares that he has no conflict of interest. Sydonnie  Shakespeare-Pellington declares that she has no conflict of interest. Megan L. Grove  declares that she has no conflict of interest. Katherine A. Loveland declares that  she has no conflict of interest. Index. décimale : PER Périodiques Résumé : Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2-8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1007/s10803-020-04677-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children / MacKinsey A. CHRISTIAN in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2766-2778 Titre : Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children Type de document : texte imprimé Auteurs : MacKinsey A. CHRISTIAN, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; M. LEE, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; M. L. GROVE, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; C. COORE DESAI, Auteur ; J. A. REECE, Auteur ; K. A. LOVELAND, Auteur ; Eric BOERWINKLE, Auteur ; M. H. RAHBAR, Auteur Article en page(s) : p.2766-2778 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Fever  Jamaica  Pesticides  Physical trauma  Volatile organic compounds Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children [texte imprimé] / MacKinsey A. CHRISTIAN, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; M. LEE, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; M. L. GROVE, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; C. COORE DESAI, Auteur ; J. A. REECE, Auteur ; K. A. LOVELAND, Auteur ; Eric BOERWINKLE, Auteur ; M. H. RAHBAR, Auteur . - p.2766-2778. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2766-2778 Mots-clés : Autism spectrum disorder  Fever  Jamaica  Pesticides  Physical trauma  Volatile organic compounds Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

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