Decreased anterior cingulate activation in a motor task in youths with bipolar disorder / J. B. KING in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.900-907 Titre : Decreased anterior cingulate activation in a motor task in youths with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. B. KING, Auteur ; Jeffrey S. ANDERSON, Auteur ; D. A. YURGELUN-TODD, Auteur ; P. SUBRAMANIAM, Auteur ; M. R. EHRLER, Auteur ; M. P. LOPEZ-LARSON, Auteur Article en page(s) : p.900-907 Langues : Anglais (eng) Mots-clés : Bipolar disorder  adolescents  anterior cingulate  fMRI  finger tapping Index. décimale : PER Périodiques Résumé : BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between-group whole-brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole-brain false discovery rate (FDR) correction (qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention-deficit/hyperactivity disorder (ADHD) in the BP group were also conducted. RESULTS: Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP. CONCLUSIONS: These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP. En ligne : http://dx.doi.org/10.1111/jcpp.12875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Decreased anterior cingulate activation in a motor task in youths with bipolar disorder [Texte imprimé et/ou numérique] / J. B. KING, Auteur ; Jeffrey S. ANDERSON, Auteur ; D. A. YURGELUN-TODD, Auteur ; P. SUBRAMANIAM, Auteur ; M. R. EHRLER, Auteur ; M. P. LOPEZ-LARSON, Auteur . - p.900-907. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.900-907 Mots-clés : Bipolar disorder  adolescents  anterior cingulate  fMRI  finger tapping Index. décimale : PER Périodiques Résumé : BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between-group whole-brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole-brain false discovery rate (FDR) correction (qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention-deficit/hyperactivity disorder (ADHD) in the BP group were also conducted. RESULTS: Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP. CONCLUSIONS: These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP. En ligne : http://dx.doi.org/10.1111/jcpp.12875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Functional MRI connectivity of children with autism and low verbal and cognitive performance / T. P. GABRIELSEN in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 67 p. Titre : Functional MRI connectivity of children with autism and low verbal and cognitive performance Type de document : Texte imprimé et/ou numérique Auteurs : T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Functional MRI connectivity of children with autism and low verbal and cognitive performance [Texte imprimé et/ou numérique] / T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 67 p. Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Generalizability and reproducibility of functional connectivity in autism / J. B. KING in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 27 p. Titre : Generalizability and reproducibility of functional connectivity in autism Type de document : Texte imprimé et/ou numérique Auteurs : J. B. KING, Auteur ; M. B. D. PRIGGE, Auteur ; C. K. KING, Auteur ; J. MORGAN, Auteur ; F. WEATHERSBY, Auteur ; J. C. FOX, Auteur ; D. C. DEAN, Auteur ; A. FREEMAN, Auteur ; J. A. M. VILLARUZ, Auteur ; Karen L. KANE, Auteur ; Erin D. BIGLER, Auteur ; A. L. ALEXANDER, Auteur ; N. LANGE, Auteur ; B. ZIELINSKI, Auteur ; J. E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur Article en page(s) : 27 p. Langues : Anglais (eng) Mots-clés : Autism spectrum conditions  Functional connectivity MRI  Replicability  Reproducibility  Resting-state  fMRI Index. décimale : PER Périodiques Résumé : Background: Autism is hypothesized to represent a disorder of brain connectivity, yet patterns of atypical functional connectivity show marked heterogeneity across individuals. Methods: We used a large multi-site dataset comprised of a heterogeneous population of individuals with autism and typically developing individuals to compare a number of resting-state functional connectivity features of autism. These features were also tested in a single site sample that utilized a high-temporal resolution, long-duration resting-state acquisition technique. Results: No one method of analysis provided reproducible results across research sites, combined samples, and the high-resolution dataset. Distinct categories of functional connectivity features that differed in autism such as homotopic, default network, salience network, long-range connections, and corticostriatal connectivity, did not align with differences in clinical and behavioral traits in individuals with autism. One method, lag-based functional connectivity, was not correlated to other methods in describing patterns of resting-state functional connectivity and their relationship to autism traits. Conclusion: Overall, functional connectivity features predictive of autism demonstrated limited generalizability across sites, with consistent results only for large samples. Different types of functional connectivity features do not consistently predict different symptoms of autism. Rather, specific features that predict autism symptoms are distributed across feature types. En ligne : https://dx.doi.org/10.1186/s13229-019-0273-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Generalizability and reproducibility of functional connectivity in autism [Texte imprimé et/ou numérique] / J. B. KING, Auteur ; M. B. D. PRIGGE, Auteur ; C. K. KING, Auteur ; J. MORGAN, Auteur ; F. WEATHERSBY, Auteur ; J. C. FOX, Auteur ; D. C. DEAN, Auteur ; A. FREEMAN, Auteur ; J. A. M. VILLARUZ, Auteur ; Karen L. KANE, Auteur ; Erin D. BIGLER, Auteur ; A. L. ALEXANDER, Auteur ; N. LANGE, Auteur ; B. ZIELINSKI, Auteur ; J. E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur . - 27 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 27 p. Mots-clés : Autism spectrum conditions  Functional connectivity MRI  Replicability  Reproducibility  Resting-state  fMRI Index. décimale : PER Périodiques Résumé : Background: Autism is hypothesized to represent a disorder of brain connectivity, yet patterns of atypical functional connectivity show marked heterogeneity across individuals. Methods: We used a large multi-site dataset comprised of a heterogeneous population of individuals with autism and typically developing individuals to compare a number of resting-state functional connectivity features of autism. These features were also tested in a single site sample that utilized a high-temporal resolution, long-duration resting-state acquisition technique. Results: No one method of analysis provided reproducible results across research sites, combined samples, and the high-resolution dataset. Distinct categories of functional connectivity features that differed in autism such as homotopic, default network, salience network, long-range connections, and corticostriatal connectivity, did not align with differences in clinical and behavioral traits in individuals with autism. One method, lag-based functional connectivity, was not correlated to other methods in describing patterns of resting-state functional connectivity and their relationship to autism traits. Conclusion: Overall, functional connectivity features predictive of autism demonstrated limited generalizability across sites, with consistent results only for large samples. Different types of functional connectivity features do not consistently predict different symptoms of autism. Rather, specific features that predict autism symptoms are distributed across feature types. En ligne : https://dx.doi.org/10.1186/s13229-019-0273-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

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