Physical and neurophysiological maturation associated with ADHD among previously institutionalized children: a randomized controlled trial / Anne B. ARNETT in Journal of Child Psychology and Psychiatry, 66-7 (July 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.967-979 Titre : Physical and neurophysiological maturation associated with ADHD among previously institutionalized children: a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Anne B. ARNETT, Auteur ; Martín ANTÚNEZ, Auteur ; Charles ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur Article en page(s) : p.967-979 Langues : Anglais (eng) Mots-clés : Neurodevelopment  EEG  Bucharest Early Intervention Project  growth trajectory  peak alpha frequency  theta-beta ratio Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental outcome among children with a history of early institutional care. Prior research on institutionalized children suggested that accelerated physical growth in childhood is a risk factor for ADHD outcomes. Methods The current study examined physical and neurophysiological growth trajectories among institutionalized children randomized to foster care treatment (n?=?59) or care as usual (n?=?54), and never institutionalized children (n?=?64) enrolled in the Bucharest Early Intervention Project (NCT00747396, clinicaltrials.gov). Participants completed physical and electroencephalography (EEG) assessments at six time points from infancy through adolescence, as well as structured diagnostic interviews at the 54-month and 12-year time points. A series of multilevel growth models and cross-lagged path models were estimated to examine associations among physical and neurophysiological maturation, treatment group, age of foster care placement, and ADHD diagnostic outcomes. Results Twenty-seven percent of the institutionalized children met research criteria for ADHD at one or both time points. Slowed, prolonged growth of height and head circumference were associated with both ADHD and delayed foster care placement. Placement in foster care versus care as usual, but not ADHD, was associated with maturation of the peak alpha frequency. Among children randomized to foster care, average theta-beta ratio was lower among those with ADHD. There was no evidence that rapid physical maturation led to atypical cortical activity. Conclusions Delayed, prolonged physical growth and atypical neurophysiology from infancy through adolescence is associated with ADHD among institutionalized children, over and above the protective effects of foster care. En ligne : https://doi.org/10.1111/jcpp.14110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562 [article] Physical and neurophysiological maturation associated with ADHD among previously institutionalized children: a randomized controlled trial [Texte imprimé et/ou numérique] / Anne B. ARNETT, Auteur ; Martín ANTÚNEZ, Auteur ; Charles ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur . - p.967-979. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.967-979 Mots-clés : Neurodevelopment  EEG  Bucharest Early Intervention Project  growth trajectory  peak alpha frequency  theta-beta ratio Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental outcome among children with a history of early institutional care. Prior research on institutionalized children suggested that accelerated physical growth in childhood is a risk factor for ADHD outcomes. Methods The current study examined physical and neurophysiological growth trajectories among institutionalized children randomized to foster care treatment (n?=?59) or care as usual (n?=?54), and never institutionalized children (n?=?64) enrolled in the Bucharest Early Intervention Project (NCT00747396, clinicaltrials.gov). Participants completed physical and electroencephalography (EEG) assessments at six time points from infancy through adolescence, as well as structured diagnostic interviews at the 54-month and 12-year time points. A series of multilevel growth models and cross-lagged path models were estimated to examine associations among physical and neurophysiological maturation, treatment group, age of foster care placement, and ADHD diagnostic outcomes. Results Twenty-seven percent of the institutionalized children met research criteria for ADHD at one or both time points. Slowed, prolonged growth of height and head circumference were associated with both ADHD and delayed foster care placement. Placement in foster care versus care as usual, but not ADHD, was associated with maturation of the peak alpha frequency. Among children randomized to foster care, average theta-beta ratio was lower among those with ADHD. There was no evidence that rapid physical maturation led to atypical cortical activity. Conclusions Delayed, prolonged physical growth and atypical neurophysiology from infancy through adolescence is associated with ADHD among institutionalized children, over and above the protective effects of foster care. En ligne : https://doi.org/10.1111/jcpp.14110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562

The development of the cortisol response to dyadic stressors in Black and White infants / Andrew DISMUKES in Development and Psychopathology, 30-5 (December 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-5 (December 2018) . - p.1995-2008 Titre : The development of the cortisol response to dyadic stressors in Black and White infants Type de document : Texte imprimé et/ou numérique Auteurs : Andrew DISMUKES, Auteur ; Elizabeth SHIRTCLIFF, Auteur ; Christopher W. JONES, Auteur ; Charles ZEANAH, Auteur ; Katherine THEALL, Auteur ; Stacy DRURY, Auteur Article en page(s) : p.1995-2008 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Acute reactivity of the stress hormone cortisol is reflective of early adversity and stress exposure, with some studies finding that the impact of adversity on the stress response differs by race. The objectives of the current study were to characterize cortisol reactivity to two dyadically based stress paradigms across the first year of life, to examine cortisol reactivity within Black and White infants, and to assess the impact of correlates of racial inequity including socioeconomic status, experiences of discrimination, and urban life stressors, as well as the buffering by racial socialization on cortisol patterns. Salivary cortisol reactivity was assessed at 4 months of age during the Still Face paradigm (N = 207) and at 12 months of age across the Strange Situation procedure (N = 129). Infants demonstrated the steepest recovery after the Still Face paradigm and steepest reactivity to the Strange Situation procedure. Race differences in cortisol were not present at 4 months but emerged at 12 months of age, with Black infants having higher cortisol. Experiences of discrimination contributed to cortisol differences within Black infants, suggesting that racial discrimination is already “under the skin” by 1 year of age. These findings suggest that race-related differences in hypothalamic–pituitary–adrenal reactivity are present in infancy, and that the first year of life is a crucial time period during which interventions and prevention efforts for maternal–infant dyads are most likely able to shape hypothalamic–pituitary–adrenal reactivity thereby mitigating health disparities early across the life course. En ligne : http://dx.doi.org/10.1017/S0954579418001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] The development of the cortisol response to dyadic stressors in Black and White infants [Texte imprimé et/ou numérique] / Andrew DISMUKES, Auteur ; Elizabeth SHIRTCLIFF, Auteur ; Christopher W. JONES, Auteur ; Charles ZEANAH, Auteur ; Katherine THEALL, Auteur ; Stacy DRURY, Auteur . - p.1995-2008. Langues : Anglais (eng) in Development and Psychopathology > 30-5 (December 2018) . - p.1995-2008 Index. décimale : PER Périodiques Résumé : Acute reactivity of the stress hormone cortisol is reflective of early adversity and stress exposure, with some studies finding that the impact of adversity on the stress response differs by race. The objectives of the current study were to characterize cortisol reactivity to two dyadically based stress paradigms across the first year of life, to examine cortisol reactivity within Black and White infants, and to assess the impact of correlates of racial inequity including socioeconomic status, experiences of discrimination, and urban life stressors, as well as the buffering by racial socialization on cortisol patterns. Salivary cortisol reactivity was assessed at 4 months of age during the Still Face paradigm (N = 207) and at 12 months of age across the Strange Situation procedure (N = 129). Infants demonstrated the steepest recovery after the Still Face paradigm and steepest reactivity to the Strange Situation procedure. Race differences in cortisol were not present at 4 months but emerged at 12 months of age, with Black infants having higher cortisol. Experiences of discrimination contributed to cortisol differences within Black infants, suggesting that racial discrimination is already “under the skin” by 1 year of age. These findings suggest that race-related differences in hypothalamic–pituitary–adrenal reactivity are present in infancy, and that the first year of life is a crucial time period during which interventions and prevention efforts for maternal–infant dyads are most likely able to shape hypothalamic–pituitary–adrenal reactivity thereby mitigating health disparities early across the life course. En ligne : http://dx.doi.org/10.1017/S0954579418001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

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