Externalising pathways to alcohol-related problems in emerging adulthood / Gemma HAMMERTON in Journal of Child Psychology and Psychiatry, 61-6 (June 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.721-731 Titre : Externalising pathways to alcohol-related problems in emerging adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Gemma HAMMERTON, Auteur ; Alexis C. EDWARDS, Auteur ; Liam MAHEDY, Auteur ; Joseph MURRAY, Auteur ; Barbara MAUGHAN, Auteur ; Kenneth S. KENDLER, Auteur ; Matthew HICKMAN, Auteur ; Jon HERON, Auteur Article en page(s) : p.721-731 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  alcohol-related problems  conduct problems  criminal behaviour  mediation Index. décimale : PER Périodiques Résumé : BACKGROUND: Both 'early-onset persistent' and 'adolescent-onset' conduct problems (CPs) are associated with alcohol-related problems in emerging adulthood. The escalation of early CPs into criminal behaviour and heavy alcohol consumption prior to emerging adulthood are both likely to be important pathways. METHODS: Data were analysed from 3,038 young people in a UK birth cohort, the Avon Longitudinal Study of Parents and Children. The exposure was developmental trajectories of CPs ('low', 'childhood-limited', 'adolescent-onset' and 'early-onset persistent') between ages 4 and 13 years. The mediator was latent classes representing heavy alcohol consumption and/ or criminal behaviour at age 15 years. For the outcome, a quadratic latent growth curve was estimated to capture nonlinear change in alcohol-related problems between ages 18 and 23 years. RESULTS: Those with 'early-onset persistent' [b(95% CI) = 1.16 (0.17, 2.14)] and 'adolescent-onset' CPs [b(95% CI) = 1.31 (0.17, 2.45)] had higher levels of alcohol-related problems at age 18 years compared to those with 'low' CPs', but there was little evidence of an association with alcohol-related problems after age 19 years. There was evidence for an indirect effect of 'early-onset persistent' CPs [b(95% CI) = 1.12 (0.52, 1.72)] on alcohol-related problems at age 18 years via the latent classes of alcohol and criminal behaviour in adolescence. This was not found for 'adolescent-onset' CPs [b(95% CI) = 0.35 (-0.36, 1.07)]. CONCLUSIONS: Strong associations exist between early CPs, adolescent alcohol consumption and criminal behaviour and alcohol-related problems at age 18 years. Associations between early CPs and alcohol-related problems weakened considerably across emerging adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Externalising pathways to alcohol-related problems in emerging adulthood [Texte imprimé et/ou numérique] / Gemma HAMMERTON, Auteur ; Alexis C. EDWARDS, Auteur ; Liam MAHEDY, Auteur ; Joseph MURRAY, Auteur ; Barbara MAUGHAN, Auteur ; Kenneth S. KENDLER, Auteur ; Matthew HICKMAN, Auteur ; Jon HERON, Auteur . - p.721-731. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.721-731 Mots-clés : Avon Longitudinal Study of Parents and Children  alcohol-related problems  conduct problems  criminal behaviour  mediation Index. décimale : PER Périodiques Résumé : BACKGROUND: Both 'early-onset persistent' and 'adolescent-onset' conduct problems (CPs) are associated with alcohol-related problems in emerging adulthood. The escalation of early CPs into criminal behaviour and heavy alcohol consumption prior to emerging adulthood are both likely to be important pathways. METHODS: Data were analysed from 3,038 young people in a UK birth cohort, the Avon Longitudinal Study of Parents and Children. The exposure was developmental trajectories of CPs ('low', 'childhood-limited', 'adolescent-onset' and 'early-onset persistent') between ages 4 and 13 years. The mediator was latent classes representing heavy alcohol consumption and/ or criminal behaviour at age 15 years. For the outcome, a quadratic latent growth curve was estimated to capture nonlinear change in alcohol-related problems between ages 18 and 23 years. RESULTS: Those with 'early-onset persistent' [b(95% CI) = 1.16 (0.17, 2.14)] and 'adolescent-onset' CPs [b(95% CI) = 1.31 (0.17, 2.45)] had higher levels of alcohol-related problems at age 18 years compared to those with 'low' CPs', but there was little evidence of an association with alcohol-related problems after age 19 years. There was evidence for an indirect effect of 'early-onset persistent' CPs [b(95% CI) = 1.12 (0.52, 1.72)] on alcohol-related problems at age 18 years via the latent classes of alcohol and criminal behaviour in adolescence. This was not found for 'adolescent-onset' CPs [b(95% CI) = 0.35 (-0.36, 1.07)]. CONCLUSIONS: Strong associations exist between early CPs, adolescent alcohol consumption and criminal behaviour and alcohol-related problems at age 18 years. Associations between early CPs and alcohol-related problems weakened considerably across emerging adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year / Séverine LANNOY in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1164-1173 Titre : Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year Type de document : Texte imprimé et/ou numérique Auteurs : Séverine LANNOY, Auteur ; Becky MARS, Auteur ; Jon HERON, Auteur ; Alexis C. EDWARDS, Auteur Année de publication : 2022 Article en page(s) : p.1164-1173 Langues : Anglais (eng) Mots-clés : Adolescent  Bullying  Female  Humans  Male  Risk Factors  Schools  Substance-Related Disorders  Suicidal Ideation  Suicide, Attempted  Alspac  environment  genes  polygenic  suicidality Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal thoughts and behaviors (STB) constitute a central public health concern in adolescence. Previous studies emphasized the difficulty to cope with negative life events during adolescence as a risk factor for STB. Familial and genetic liability has also been documented to explain STB risk. Nevertheless, less is known about aggregate genetic liability and its possible interaction with negative life events. Moreover, information is needed to understand how these factors differently affect STB in boys and girls. METHODS: We evaluated suicidal ideation at 17years old and examined the role of aggregate genetic liability, negative life events, and their interaction in a sample of 2,571 adolescents. Aggregate genetic liability was measured using a polygenic score (PGS) for suicide attempts. Negative life events were assessed in the past year and included parental divorce and hospitalizations, death of friends and relatives, bullying, failure-related events, and involvement with drugs. We conducted univariable and multivariable general linear models stratified by sex and evaluated the interactions between PGS and negative life events in subsequent models. RESULTS: Analyses showed that suicidal ideation in boys is associated with failure to achieve something important (estimate=0.198), bullying (estimate=0.285), drug use (estimate=0.325), and parental death (estimate=0.923). In girls, both aggregate genetic liability (estimate=0.041) and negative life events (failure at school [estimate=0.120], failure to achieve something important [estimate=0.279], drug use [estimate=0.395], and bullying [estimate=0.472]) were associated with suicidal ideation. Interaction analyses suggested that PGS interacted with drug use and failures at school, though this would need additional support. CONCLUSIONS: These findings represent significant contributions to the fundamental understanding of STB in adolescence, suggesting to monitor the impact of negative life events during adolescence to better prevent suicide risk. Genetic liability is also of importance in girls and might influence the way they respond to environmental threats. En ligne : http://dx.doi.org/10.1111/jcpp.13653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year [Texte imprimé et/ou numérique] / Séverine LANNOY, Auteur ; Becky MARS, Auteur ; Jon HERON, Auteur ; Alexis C. EDWARDS, Auteur . - 2022 . - p.1164-1173. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1164-1173 Mots-clés : Adolescent  Bullying  Female  Humans  Male  Risk Factors  Schools  Substance-Related Disorders  Suicidal Ideation  Suicide, Attempted  Alspac  environment  genes  polygenic  suicidality Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal thoughts and behaviors (STB) constitute a central public health concern in adolescence. Previous studies emphasized the difficulty to cope with negative life events during adolescence as a risk factor for STB. Familial and genetic liability has also been documented to explain STB risk. Nevertheless, less is known about aggregate genetic liability and its possible interaction with negative life events. Moreover, information is needed to understand how these factors differently affect STB in boys and girls. METHODS: We evaluated suicidal ideation at 17years old and examined the role of aggregate genetic liability, negative life events, and their interaction in a sample of 2,571 adolescents. Aggregate genetic liability was measured using a polygenic score (PGS) for suicide attempts. Negative life events were assessed in the past year and included parental divorce and hospitalizations, death of friends and relatives, bullying, failure-related events, and involvement with drugs. We conducted univariable and multivariable general linear models stratified by sex and evaluated the interactions between PGS and negative life events in subsequent models. RESULTS: Analyses showed that suicidal ideation in boys is associated with failure to achieve something important (estimate=0.198), bullying (estimate=0.285), drug use (estimate=0.325), and parental death (estimate=0.923). In girls, both aggregate genetic liability (estimate=0.041) and negative life events (failure at school [estimate=0.120], failure to achieve something important [estimate=0.279], drug use [estimate=0.395], and bullying [estimate=0.472]) were associated with suicidal ideation. Interaction analyses suggested that PGS interacted with drug use and failures at school, though this would need additional support. CONCLUSIONS: These findings represent significant contributions to the fundamental understanding of STB in adolescence, suggesting to monitor the impact of negative life events during adolescence to better prevent suicide risk. Genetic liability is also of importance in girls and might influence the way they respond to environmental threats. En ligne : http://dx.doi.org/10.1111/jcpp.13653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse / Mallory STEPHENSON in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1841-1855 Titre : The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse Type de document : Texte imprimé et/ou numérique Auteurs : Mallory STEPHENSON, Auteur ; Fazil ALIEV, Auteur ; Sally I. Chun KUO, Auteur ; Alexis C. EDWARDS, Auteur ; Gayathri PANDEY, Auteur ; Jinni SU, Auteur ; Chella KAMARAJAN, Auteur ; Danielle DICK, Auteur ; Jessica E. SALVATORE, Auteur Article en page(s) : p.1841-1855 Langues : Anglais (eng) Mots-clés : adolescence  alcohol  parenting  peer relationships  resistance Index. décimale : PER Périodiques Résumé : Genetic factors contribute to the intergenerational transmission of alcohol misuse, but not all individuals at high genetic risk develop problems. The present study examined adolescent relationships with parents, peers, and romantic partners as predictors of realized resistance, defined as high biological risk for disorder combined with a healthy outcome, to alcohol initiation, heavy episodic drinking, and alcohol use disorder (AUD). Data were from the Collaborative Study on the Genetics of Alcoholism (N = 1,858; 49.9% female; mean age at baseline = 13.91 years). Genetic risk, indexed using family history density and polygenic risk scores for alcohol problems and AUD, was used to define alcohol resistance. Adolescent predictors included parent-child relationship quality, parental monitoring, peer drinking, romantic partner drinking, and social competence. There was little support for the hypothesis that social relationship factors would promote alcohol resistance, with the exception that higher father-child relationship quality was associated with higher resistance to alcohol initiation ( $$\hat \beta $$ = â’0.19, 95% CI = â’0.35, â’0.03). Unexpectedly, social competence was associated with lower resistance to heavy episodic drinking ( $$\hat \beta $$ = 0.10, 95% CI = 0.01, 0.20). This pattern of largely null effects underscores how little is known about resistance processes among those at high genetic risk for AUD. En ligne : http://dx.doi.org/10.1017/S0954579422000785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse [Texte imprimé et/ou numérique] / Mallory STEPHENSON, Auteur ; Fazil ALIEV, Auteur ; Sally I. Chun KUO, Auteur ; Alexis C. EDWARDS, Auteur ; Gayathri PANDEY, Auteur ; Jinni SU, Auteur ; Chella KAMARAJAN, Auteur ; Danielle DICK, Auteur ; Jessica E. SALVATORE, Auteur . - p.1841-1855. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1841-1855 Mots-clés : adolescence  alcohol  parenting  peer relationships  resistance Index. décimale : PER Périodiques Résumé : Genetic factors contribute to the intergenerational transmission of alcohol misuse, but not all individuals at high genetic risk develop problems. The present study examined adolescent relationships with parents, peers, and romantic partners as predictors of realized resistance, defined as high biological risk for disorder combined with a healthy outcome, to alcohol initiation, heavy episodic drinking, and alcohol use disorder (AUD). Data were from the Collaborative Study on the Genetics of Alcoholism (N = 1,858; 49.9% female; mean age at baseline = 13.91 years). Genetic risk, indexed using family history density and polygenic risk scores for alcohol problems and AUD, was used to define alcohol resistance. Adolescent predictors included parent-child relationship quality, parental monitoring, peer drinking, romantic partner drinking, and social competence. There was little support for the hypothesis that social relationship factors would promote alcohol resistance, with the exception that higher father-child relationship quality was associated with higher resistance to alcohol initiation ( $$\hat \beta $$ = â’0.19, 95% CI = â’0.35, â’0.03). Unexpectedly, social competence was associated with lower resistance to heavy episodic drinking ( $$\hat \beta $$ = 0.10, 95% CI = 0.01, 0.20). This pattern of largely null effects underscores how little is known about resistance processes among those at high genetic risk for AUD. En ligne : http://dx.doi.org/10.1017/S0954579422000785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

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