Age effects on autism heritability and etiological stability of autistic traits / Agnieszka BUTWICKA ; Ebba DU RIETZ ; Aleksandra KANINA ; Mina A. ROSENQVIST ; Henrik LARSSON ; Paul LICHTENSTEIN ; Mark J. TAYLOR in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Titre : Age effects on autism heritability and etiological stability of autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.1135-1144 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Age effects on autism heritability and etiological stability of autistic traits [Texte imprimé et/ou numérique] / Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur . - p.1135-1144. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis / Anneli ANDERSSON in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1173-1183 Titre : Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Anneli ANDERSSON, Auteur ; Catherine TUVBLAD, Auteur ; Qi CHEN, Auteur ; Ebba DU RIETZ, Auteur ; Samuele CORTESE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.1173-1183 Langues : Anglais (eng) Mots-clés : Adhd  externalizing  genetic  internalizing  neurodevelopmental  overlap  twins Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with other psychiatric disorders. Twin studies have established that these co-occurrences are in part due to shared genetic risks. However, the strength of these genetic overlaps and the potential heterogeneity accounted for by type of psychiatric symptoms, age, and methods of assessment remain unclear. We conducted a systematic review to fill this gap. METHODS: We searched PubMed, PsycINFO, Embase, and Web of Science until March 07, 2019. Genetic correlations (r(g) ) were used as effect size measures. RESULTS: A total of 31 independent studies fulfilled the inclusion criteria. The pooled estimates showed that the associations between ADHD and other psychiatric symptoms were partly explained by shared genetic factors, with a pooled genetic correlation of 0.50, 95% confidence interval: 0.46-0.60. The genetic correlations (r(g) ) between ADHD and externalizing (r(g)  = .49 [0.37-0.61]), internalizing (r(g)  = .50 [0.39-0.69]), and neurodevelopmental (r(g)  = .56 [0.47-0.66]) symptoms were similar in magnitude. The genetic correlations in childhood and adulthood were r(g)  = .53 (0.43-0.63) and r(g)  = .51 (0.44-0.56), respectively. For methods of assessment, the genetic correlations were also similar in strength, self-reports r(g)  = .52 (0.47-0.58), other informants r(g)  = .55 (0.41-0.69), and combined raters r(g)  = .50 (0.33-0.65). CONCLUSIONS: These findings indicate that the co-occurrence of externalizing, internalizing, and neurodevelopmental disorder symptoms in individuals with ADHD symptoms in part is due to a shared genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis [Texte imprimé et/ou numérique] / Anneli ANDERSSON, Auteur ; Catherine TUVBLAD, Auteur ; Qi CHEN, Auteur ; Ebba DU RIETZ, Auteur ; Samuele CORTESE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Henrik LARSSON, Auteur . - p.1173-1183. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1173-1183 Mots-clés : Adhd  externalizing  genetic  internalizing  neurodevelopmental  overlap  twins Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with other psychiatric disorders. Twin studies have established that these co-occurrences are in part due to shared genetic risks. However, the strength of these genetic overlaps and the potential heterogeneity accounted for by type of psychiatric symptoms, age, and methods of assessment remain unclear. We conducted a systematic review to fill this gap. METHODS: We searched PubMed, PsycINFO, Embase, and Web of Science until March 07, 2019. Genetic correlations (r(g) ) were used as effect size measures. RESULTS: A total of 31 independent studies fulfilled the inclusion criteria. The pooled estimates showed that the associations between ADHD and other psychiatric symptoms were partly explained by shared genetic factors, with a pooled genetic correlation of 0.50, 95% confidence interval: 0.46-0.60. The genetic correlations (r(g) ) between ADHD and externalizing (r(g)  = .49 [0.37-0.61]), internalizing (r(g)  = .50 [0.39-0.69]), and neurodevelopmental (r(g)  = .56 [0.47-0.66]) symptoms were similar in magnitude. The genetic correlations in childhood and adulthood were r(g)  = .53 (0.43-0.63) and r(g)  = .51 (0.44-0.56), respectively. For methods of assessment, the genetic correlations were also similar in strength, self-reports r(g)  = .52 (0.47-0.58), other informants r(g)  = .55 (0.41-0.69), and combined raters r(g)  = .50 (0.33-0.65). CONCLUSIONS: These findings indicate that the co-occurrence of externalizing, internalizing, and neurodevelopmental disorder symptoms in individuals with ADHD symptoms in part is due to a shared genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis / Miriam I. MARTINI in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1170-1181 Titre : Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Miriam I. MARTINI, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur ; Francesca HAPPE, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.1170-1181 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  sex differences  psychiatric diagnoses  follow-up study Index. décimale : PER Périodiques Résumé : Background Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis. Methods In a nationwide cohort of all individuals born in Sweden 1990?2015 with a clinical autism diagnosis (N?=?72,331, nfemales?=?24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010?2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5?years following autism diagnosis). Results In total 54.2% of autistic females and 40.9% of autistic males received at least one preceding psychiatric diagnosis (most common: ADHD, anxiety, depression). Autistic females showed higher odds than males for most preceding psychiatric diagnoses (ORrange?=?1.29 [1.18, 1.41]?10.69 [8.06, 14.17]), except psychotic disorders (OR?=?0.91 [0.78, 1.06]) and ADHD (OR?=?0.69 [0.66, 0.71]). Sex differences in preceding diagnoses were persistent across different autism diagnosis years (2010?2020). For most conditions, females with a preceding diagnosis were diagnosed with autism later than males with the same condition. For both sexes, the stability of preceding diagnoses varied considerably (23.1%?88.9%) and was less than 50% for most diagnoses. Females showed a higher stability for anxiety, sleep disorders and self-harm (ORrange?=?1.45 [1.30, 1.62]?2.37 [1.93, 2.90]), and males for psychotic disorders (OR?=?0.60 [0.44, 0.81]). Conclusions Autistic females are more likely to be diagnosed with psychiatric conditions prior to an autism diagnosis and receive care for them post autism diagnosis. Our findings emphasize the variability of clinical presentation and importance of disentangling persistent support needs from overlapping diagnostic presentations, particularly in autistic females, to provide appropriate and timely care. En ligne : https://doi.org/10.1111/jcpp.14130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis [Texte imprimé et/ou numérique] / Miriam I. MARTINI, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur ; Francesca HAPPE, Auteur ; Mark J. TAYLOR, Auteur . - p.1170-1181. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1170-1181 Mots-clés : Autism spectrum disorder  sex differences  psychiatric diagnoses  follow-up study Index. décimale : PER Périodiques Résumé : Background Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis. Methods In a nationwide cohort of all individuals born in Sweden 1990?2015 with a clinical autism diagnosis (N?=?72,331, nfemales?=?24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010?2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5?years following autism diagnosis). Results In total 54.2% of autistic females and 40.9% of autistic males received at least one preceding psychiatric diagnosis (most common: ADHD, anxiety, depression). Autistic females showed higher odds than males for most preceding psychiatric diagnoses (ORrange?=?1.29 [1.18, 1.41]?10.69 [8.06, 14.17]), except psychotic disorders (OR?=?0.91 [0.78, 1.06]) and ADHD (OR?=?0.69 [0.66, 0.71]). Sex differences in preceding diagnoses were persistent across different autism diagnosis years (2010?2020). For most conditions, females with a preceding diagnosis were diagnosed with autism later than males with the same condition. For both sexes, the stability of preceding diagnoses varied considerably (23.1%?88.9%) and was less than 50% for most diagnoses. Females showed a higher stability for anxiety, sleep disorders and self-harm (ORrange?=?1.45 [1.30, 1.62]?2.37 [1.93, 2.90]), and males for psychotic disorders (OR?=?0.60 [0.44, 0.81]). Conclusions Autistic females are more likely to be diagnosed with psychiatric conditions prior to an autism diagnosis and receive care for them post autism diagnosis. Our findings emphasize the variability of clinical presentation and importance of disentangling persistent support needs from overlapping diagnostic presentations, particularly in autistic females, to provide appropriate and timely care. En ligne : https://doi.org/10.1111/jcpp.14130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD: a prospective register-based study / Ebba DU RIETZ in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.959-968 Titre : Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD: a prospective register-based study Type de document : Texte imprimé et/ou numérique Auteurs : Ebba DU RIETZ, Auteur ; Andreas JANGMO, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Zheng CHANG, Auteur ; Brian M. D'ONOFRIO, Auteur ; Ewa AHNEMARK, Auteur ; Tamara WERNER-KIECHLE, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.959-968 Langues : Anglais (eng) Mots-clés : Adhd  comorbidity  cost  epidemiology  healthcare Index. décimale : PER Périodiques Résumé : BACKGROUND: A better understanding of the trajectories and economic burden of psychiatric and somatic disorders (multimorbidity) in ADHD from childhood to adulthood is important for guiding more targeted areas for treatment of ADHD and prevention of multimorbidity, and for forecasting demands on the medical infrastructure. This study aimed to investigate patterns of healthcare utilization and costs of multimorbidity across young adulthood in individuals with a childhood ADHD diagnosis, and additionally in individuals who continue to have ADHD-related contact with health services (persisters) and those who do not (remitters). METHODS: We prospectively followed a cohort (N = 445,790) born 1987-1990 from the ages of 18 to 26 years. Data on healthcare utilization were obtained from the Swedish National Patient Register (inpatient and outpatient care) and the Prescribed Drug Register (medication prescriptions). RESULTS: Mean annual costs per capita from multimorbidity was €890 ($1,223) in individuals with a childhood ADHD diagnosis (persisters/remitters: €1,060[$1,456]/€609[$837]) and €304 ($418) in individuals without. Costs were largely driven by inpatient hospital admissions, mainly from drug abuse and injuries. Healthcare utilization and costs of psychiatric and somatic disorders at 18 years was significantly higher in individuals with childhood ADHD compared to those without. These group differences remained stable or increased across young adulthood for most outcomes and were generally larger in women than in men. ADHD remitters continued to show significantly greater healthcare utilization and costs compared to individuals without childhood ADHD, although their profiles were not as severe as ADHD persisters. CONCLUSIONS: Childhood ADHD has long-term associations with both psychiatric and somatic disorders. Findings demonstrate the individual and societal burden of ADHD in adulthood and highlight the importance of continued support from childhood-adolescent to adult health services and early prevention of multimorbidity. Findings also point to specific targets for intervention that may be effective, such as drug abuse and injuries. En ligne : http://dx.doi.org/10.1111/jcpp.13206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD: a prospective register-based study [Texte imprimé et/ou numérique] / Ebba DU RIETZ, Auteur ; Andreas JANGMO, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Zheng CHANG, Auteur ; Brian M. D'ONOFRIO, Auteur ; Ewa AHNEMARK, Auteur ; Tamara WERNER-KIECHLE, Auteur ; Henrik LARSSON, Auteur . - p.959-968. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.959-968 Mots-clés : Adhd  comorbidity  cost  epidemiology  healthcare Index. décimale : PER Périodiques Résumé : BACKGROUND: A better understanding of the trajectories and economic burden of psychiatric and somatic disorders (multimorbidity) in ADHD from childhood to adulthood is important for guiding more targeted areas for treatment of ADHD and prevention of multimorbidity, and for forecasting demands on the medical infrastructure. This study aimed to investigate patterns of healthcare utilization and costs of multimorbidity across young adulthood in individuals with a childhood ADHD diagnosis, and additionally in individuals who continue to have ADHD-related contact with health services (persisters) and those who do not (remitters). METHODS: We prospectively followed a cohort (N = 445,790) born 1987-1990 from the ages of 18 to 26 years. Data on healthcare utilization were obtained from the Swedish National Patient Register (inpatient and outpatient care) and the Prescribed Drug Register (medication prescriptions). RESULTS: Mean annual costs per capita from multimorbidity was €890 ($1,223) in individuals with a childhood ADHD diagnosis (persisters/remitters: €1,060[$1,456]/€609[$837]) and €304 ($418) in individuals without. Costs were largely driven by inpatient hospital admissions, mainly from drug abuse and injuries. Healthcare utilization and costs of psychiatric and somatic disorders at 18 years was significantly higher in individuals with childhood ADHD compared to those without. These group differences remained stable or increased across young adulthood for most outcomes and were generally larger in women than in men. ADHD remitters continued to show significantly greater healthcare utilization and costs compared to individuals without childhood ADHD, although their profiles were not as severe as ADHD persisters. CONCLUSIONS: Childhood ADHD has long-term associations with both psychiatric and somatic disorders. Findings demonstrate the individual and societal burden of ADHD in adulthood and highlight the importance of continued support from childhood-adolescent to adult health services and early prevention of multimorbidity. Findings also point to specific targets for intervention that may be effective, such as drug abuse and injuries. En ligne : http://dx.doi.org/10.1111/jcpp.13206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

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