Toward precision therapeutics: general and specific factors differentiate symptom change in depressed adolescents / Madison AITKEN in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.998-1008 Titre : Toward precision therapeutics: general and specific factors differentiate symptom change in depressed adolescents Type de document : texte imprimé Auteurs : Madison AITKEN, Auteur ; John D. HALTIGAN, Auteur ; Peter SZATMARI, Auteur ; Bernadka DUBICKA, Auteur ; Peter FONAGY, Auteur ; Raphael KELVIN, Auteur ; Nick MIDGLEY, Auteur ; Shirley REYNOLDS, Auteur ; Paul O. WILKINSON, Auteur ; Ian M. GOODYER, Auteur Année de publication : 2020 Article en page(s) : p.998-1008 Langues : Anglais (eng) Mots-clés : Bifactor models  adolescent  depression  psychopathology  psychotherapy Index. décimale : PER Périodiques Résumé : BACKGROUND: The longitudinal course of multiple symptom domains in adolescents treated for major depression is not known. Revealing the temporal course of general and specific psychopathology factors, including potential differences between psychotherapies, may aid therapeutic decision-making. METHODS: Participants were adolescents with major depressive disorder (aged 11-17; 75% female; N = 465) who were part of the IMPACT trial, a randomized controlled trial comparing cognitive behavioral therapy, short-term psychoanalytic psychotherapy, and brief psychosocial intervention. Self-reported symptoms at baseline and 6, 12, 36, 52, and 86 weeks postrandomization were analyzed with bifactor modeling. RESULTS: General psychopathology factor scores decreased across treatment and one-year follow-up. Specific melancholic features and depressive cognitions factors decreased from baseline to 6 weeks. Conduct problems decreased across treatment and follow-up. Anxiety increased by 6 weeks and then reverted to baseline levels. Obsessions-compulsions did not change. Changes in general and specific factors were not significantly different between the three psychotherapies during treatment. During follow-up, however, conduct problems decreased more in brief psychosocial intervention versus cognitive behavioral therapy (1.02, 95% Bayes credible interval 0.25, 1.96), but not versus short-term psychoanalytic psychotherapy. CONCLUSIONS: The clinical response signature in this trial is best revealed by rapid reductions in depression symptoms and general psychopathology. Protracted improvements in general psychopathology and conduct problems subsequently occur. Psychosocial treatments for adolescent depression have comparable effects on general and specific psychopathology, although a psychoeducational, goal-focused approach may be indicated for youth with comorbid conduct problems. En ligne : http://dx.doi.org/10.1111/jcpp.13194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Toward precision therapeutics: general and specific factors differentiate symptom change in depressed adolescents [texte imprimé] / Madison AITKEN, Auteur ; John D. HALTIGAN, Auteur ; Peter SZATMARI, Auteur ; Bernadka DUBICKA, Auteur ; Peter FONAGY, Auteur ; Raphael KELVIN, Auteur ; Nick MIDGLEY, Auteur ; Shirley REYNOLDS, Auteur ; Paul O. WILKINSON, Auteur ; Ian M. GOODYER, Auteur . - 2020 . - p.998-1008. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.998-1008 Mots-clés : Bifactor models  adolescent  depression  psychopathology  psychotherapy Index. décimale : PER Périodiques Résumé : BACKGROUND: The longitudinal course of multiple symptom domains in adolescents treated for major depression is not known. Revealing the temporal course of general and specific psychopathology factors, including potential differences between psychotherapies, may aid therapeutic decision-making. METHODS: Participants were adolescents with major depressive disorder (aged 11-17; 75% female; N = 465) who were part of the IMPACT trial, a randomized controlled trial comparing cognitive behavioral therapy, short-term psychoanalytic psychotherapy, and brief psychosocial intervention. Self-reported symptoms at baseline and 6, 12, 36, 52, and 86 weeks postrandomization were analyzed with bifactor modeling. RESULTS: General psychopathology factor scores decreased across treatment and one-year follow-up. Specific melancholic features and depressive cognitions factors decreased from baseline to 6 weeks. Conduct problems decreased across treatment and follow-up. Anxiety increased by 6 weeks and then reverted to baseline levels. Obsessions-compulsions did not change. Changes in general and specific factors were not significantly different between the three psychotherapies during treatment. During follow-up, however, conduct problems decreased more in brief psychosocial intervention versus cognitive behavioral therapy (1.02, 95% Bayes credible interval 0.25, 1.96), but not versus short-term psychoanalytic psychotherapy. CONCLUSIONS: The clinical response signature in this trial is best revealed by rapid reductions in depression symptoms and general psychopathology. Protracted improvements in general psychopathology and conduct problems subsequently occur. Psychosocial treatments for adolescent depression have comparable effects on general and specific psychopathology, although a psychoeducational, goal-focused approach may be indicated for youth with comorbid conduct problems. En ligne : http://dx.doi.org/10.1111/jcpp.13194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Trajectories of parent criticism across treatment for youth self-harm / Madison AITKEN in Journal of Child Psychology and Psychiatry, 66-10 (October 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1449-1460 Titre : Trajectories of parent criticism across treatment for youth self-harm Type de document : texte imprimé Auteurs : Madison AITKEN, Auteur ; Florence PERQUIER, Auteur ; Bomi PARK, Auteur ; Daniela CARVALHO, Auteur ; Alexandra WRIGHT-HUGHES, Auteur ; David COTTRELL, Auteur ; Peter SZATMARI, Auteur Article en page(s) : p.1449-1460 Langues : Anglais (eng) Mots-clés : Parent–child relationships  adolescence  self-harm  psychotherapy  expressed emotion Index. décimale : PER Périodiques Résumé : Background Criticism from parents is a risk factor for poor youth mental health, including self-harm and limited response to psychosocial interventions. We identified trajectories of change in parent criticism across treatment for youth self-harm (suicide attempts and non-suicidal self-injury) and compared these trajectories on treatment outcomes. Methods This is a preregistered secondary analysis of data from the Self-harm Intervention: Family Therapy trial. Participants (N 831, 11 17 years; 89% girls, 11% boys; 84% White) were clinically referred for self-harm and randomly assigned to family therapy or usual care. A growth mixture model identified trajectories of parent self-reported criticism across baseline, 3, and 6 months. Trajectories were compared on youth self-harm, suicidal ideation, depression, and hopelessness, and parent mental distress (baseline, and change from baseline to 12 and 12 18 months). Results Four trajectories of parent criticism were identified: High and remaining elevated despite a small decrease (51.6%); sharply decreasing (7.6%); low/stable (37.2%); and increasing (3.6%). Youth with parents in the high with small decrease class had more severe baseline suicidal behavior. Treatment type was not related to criticism trajectory. Parent mental distress increased in the increasing criticism class. Youth with parents in the increasing class showed less improvement in suicidal ideation at 12-month follow-up compared to the high with small decrease and sharply decreasing classes. Conclusions Current treatments for youth self-harm may not reduce parent criticism to subclinical levels. Increasing parent criticism may forecast poorer response to a range of treatments for youth self-harm and be indicative of increases in parent mental distress. En ligne : https://doi.org/10.1111/jcpp.14144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Trajectories of parent criticism across treatment for youth self-harm [texte imprimé] / Madison AITKEN, Auteur ; Florence PERQUIER, Auteur ; Bomi PARK, Auteur ; Daniela CARVALHO, Auteur ; Alexandra WRIGHT-HUGHES, Auteur ; David COTTRELL, Auteur ; Peter SZATMARI, Auteur . - p.1449-1460. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1449-1460 Mots-clés : Parent–child relationships  adolescence  self-harm  psychotherapy  expressed emotion Index. décimale : PER Périodiques Résumé : Background Criticism from parents is a risk factor for poor youth mental health, including self-harm and limited response to psychosocial interventions. We identified trajectories of change in parent criticism across treatment for youth self-harm (suicide attempts and non-suicidal self-injury) and compared these trajectories on treatment outcomes. Methods This is a preregistered secondary analysis of data from the Self-harm Intervention: Family Therapy trial. Participants (N 831, 11 17 years; 89% girls, 11% boys; 84% White) were clinically referred for self-harm and randomly assigned to family therapy or usual care. A growth mixture model identified trajectories of parent self-reported criticism across baseline, 3, and 6 months. Trajectories were compared on youth self-harm, suicidal ideation, depression, and hopelessness, and parent mental distress (baseline, and change from baseline to 12 and 12 18 months). Results Four trajectories of parent criticism were identified: High and remaining elevated despite a small decrease (51.6%); sharply decreasing (7.6%); low/stable (37.2%); and increasing (3.6%). Youth with parents in the high with small decrease class had more severe baseline suicidal behavior. Treatment type was not related to criticism trajectory. Parent mental distress increased in the increasing criticism class. Youth with parents in the increasing class showed less improvement in suicidal ideation at 12-month follow-up compared to the high with small decrease and sharply decreasing classes. Conclusions Current treatments for youth self-harm may not reduce parent criticism to subclinical levels. Increasing parent criticism may forecast poorer response to a range of treatments for youth self-harm and be indicative of increases in parent mental distress. En ligne : https://doi.org/10.1111/jcpp.14144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

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