Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study / Masoud AMIRI in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1582-1600 Titre : Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study Type de document : texte imprimé Auteurs : Masoud AMIRI, Auteur ; Sander LAMBALLAIS, Auteur ; Eloy GEENJAAR, Auteur ; Laura M.E. BLANKEN, Auteur ; Hanan EL MARROUN, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur Article en page(s) : p.1582-1600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data-driven environmental-wide association study of pre- and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6-year-old children from a birth cohort with pre- and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a test set (921). Multiple linear regression analyses were performed for each of 920 variables, correcting for six of the most common covariates in epidemiological studies. We found 111 different pre- and perinatal factors associated with autistic traits during childhood. In secondary analyses where we controlled for parental psychopathology, 23 variables in the domains of family and interpersonal relationships were associated with the development of autistic symptoms during childhood. In conclusion, a data-driven approach was used to identify a number of pre- and perinatal risk factors associating with higher childhood autistic symptoms. These factors include measures of parental psychopathology and family and interpersonal relationships. These measures could potentially be used for the early identification of those at increased risk to develop ASD. Lay Summary A combination of genetic and environmental factors contributes to the development of autism spectrum disorder (ASD). Each environmental factor may affect the risk of ASD. In a study on 6-year-old children, a number of pre- and perinatal risk factors were identified that are associated with autistic symptoms in childhood. These factors include measures of parental psychopathology and family and interpersonal relationships. These variables could potentially serve as markers to identify those at increased risk to develop ASD or autistic symptoms. Autism Res 2020, 13: 1582–1600. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study [texte imprimé] / Masoud AMIRI, Auteur ; Sander LAMBALLAIS, Auteur ; Eloy GEENJAAR, Auteur ; Laura M.E. BLANKEN, Auteur ; Hanan EL MARROUN, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur . - p.1582-1600. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1582-1600 Index. décimale : PER Périodiques Résumé : Abstract A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data-driven environmental-wide association study of pre- and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6-year-old children from a birth cohort with pre- and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a test set (921). Multiple linear regression analyses were performed for each of 920 variables, correcting for six of the most common covariates in epidemiological studies. We found 111 different pre- and perinatal factors associated with autistic traits during childhood. In secondary analyses where we controlled for parental psychopathology, 23 variables in the domains of family and interpersonal relationships were associated with the development of autistic symptoms during childhood. In conclusion, a data-driven approach was used to identify a number of pre- and perinatal risk factors associating with higher childhood autistic symptoms. These factors include measures of parental psychopathology and family and interpersonal relationships. These measures could potentially be used for the early identification of those at increased risk to develop ASD. Lay Summary A combination of genetic and environmental factors contributes to the development of autism spectrum disorder (ASD). Each environmental factor may affect the risk of ASD. In a study on 6-year-old children, a number of pre- and perinatal risk factors were identified that are associated with autistic symptoms in childhood. These factors include measures of parental psychopathology and family and interpersonal relationships. These variables could potentially serve as markers to identify those at increased risk to develop ASD or autistic symptoms. Autism Res 2020, 13: 1582–1600. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

A prospective study of fetal head growth, autistic traits and autism spectrum disorder / Laura M.E. BLANKEN in Autism Research, 11-4 (April 2018)  

Public ISBD [article]  inAutism Research > 11-4 (April 2018) . - p.602-612 Titre : A prospective study of fetal head growth, autistic traits and autism spectrum disorder Type de document : texte imprimé Auteurs : Laura M.E. BLANKEN, Auteur ; Alena DASS, Auteur ; Gail A. ALVARES, Auteur ; Jan VAN DER ENDE, Auteur ; Nikita K. SCHOEMAKER, Auteur ; Hanan EL MARROUN, Auteur ; Martha HICKEY, Auteur ; Craig E. PENNELL, Auteur ; Sarah WHITE, Auteur ; Murray T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur ; Will MCINTOSH, Auteur ; Tiffany C. WHITE, Auteur ; Andrew J.O. WHITEHOUSE, Auteur Article en page(s) : p.602-612 Langues : Anglais (eng) Mots-clés : brain growth  head circumference  pregnancy  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population-based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism-Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population-based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602-612. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. En ligne : http://dx.doi.org/10.1002/aur.1921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] A prospective study of fetal head growth, autistic traits and autism spectrum disorder [texte imprimé] / Laura M.E. BLANKEN, Auteur ; Alena DASS, Auteur ; Gail A. ALVARES, Auteur ; Jan VAN DER ENDE, Auteur ; Nikita K. SCHOEMAKER, Auteur ; Hanan EL MARROUN, Auteur ; Martha HICKEY, Auteur ; Craig E. PENNELL, Auteur ; Sarah WHITE, Auteur ; Murray T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur ; Will MCINTOSH, Auteur ; Tiffany C. WHITE, Auteur ; Andrew J.O. WHITEHOUSE, Auteur . - p.602-612. Langues : Anglais (eng) in Autism Research > 11-4 (April 2018) . - p.602-612 Mots-clés : brain growth  head circumference  pregnancy  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population-based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism-Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population-based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602-612. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. En ligne : http://dx.doi.org/10.1002/aur.1921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

Timing and type of adverse life events: Impact on substance use among high-risk adolescents / Milan ZARCHEV in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1606-1615 Titre : Timing and type of adverse life events: Impact on substance use among high-risk adolescents Type de document : texte imprimé Auteurs : Milan ZARCHEV, Auteur ; Astrid M. KAMPERMAN, Auteur ; Hanan EL MARROUN, Auteur ; Anthony BLOEMENDAAL, Auteur ; Cornelis L. MULDER, Auteur ; Witte J.G. HOOGENDIJK, Auteur ; Nina H. GROOTENDORST-VAN MIL, Auteur Article en page(s) : p.1606-1615 Langues : Anglais (eng) Mots-clés : adolescents  adverse life events  severity  substance use  timing Index. décimale : PER Périodiques Résumé : A robust association has been reported between childhood adverse life events (ALEs) and risky substance use in adolescence. It remains unclear, however, what the impact of type and timing of these ALEs is. We investigated the association between ALEs and substance use in adolescents. ALEs were operationalized as broad (e.g., moving, parental divorce, family sickness) or physically threatening (physical and/or sexual abuse). First, we examined lifetime ALEs, followed by an investigation into their timing. The sample consisted of 909 adolescents (aged 12-18 years) from a cohort oversampled on high levels of emotional and behavioral problems. The primary caregiver indicated which ALEs each adolescent experienced across their lifetime. Adolescents self-reported on number and frequency of substances used. Poisson and ordinal regression models were used to model the associations. The associations between lifetime ALEs and a substance used were observed only for physical ALEs (incidence rate ratio 1.18 [1.03, 1.35], p = 0.02). When investigating timing, physical ALEs after the age of 12 predicted number of substances used (IRR 1.36 [1.13, 1.63], p < .001). Recent ALEs (occurring after age 12) seem to have considerable impact on substance use. Alcohol and drugs as a coping mechanism were considered a plausible explanation for the results. En ligne : https://dx.doi.org/10.1017/S095457942300086X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Timing and type of adverse life events: Impact on substance use among high-risk adolescents [texte imprimé] / Milan ZARCHEV, Auteur ; Astrid M. KAMPERMAN, Auteur ; Hanan EL MARROUN, Auteur ; Anthony BLOEMENDAAL, Auteur ; Cornelis L. MULDER, Auteur ; Witte J.G. HOOGENDIJK, Auteur ; Nina H. GROOTENDORST-VAN MIL, Auteur . - p.1606-1615. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1606-1615 Mots-clés : adolescents  adverse life events  severity  substance use  timing Index. décimale : PER Périodiques Résumé : A robust association has been reported between childhood adverse life events (ALEs) and risky substance use in adolescence. It remains unclear, however, what the impact of type and timing of these ALEs is. We investigated the association between ALEs and substance use in adolescents. ALEs were operationalized as broad (e.g., moving, parental divorce, family sickness) or physically threatening (physical and/or sexual abuse). First, we examined lifetime ALEs, followed by an investigation into their timing. The sample consisted of 909 adolescents (aged 12-18 years) from a cohort oversampled on high levels of emotional and behavioral problems. The primary caregiver indicated which ALEs each adolescent experienced across their lifetime. Adolescents self-reported on number and frequency of substances used. Poisson and ordinal regression models were used to model the associations. The associations between lifetime ALEs and a substance used were observed only for physical ALEs (incidence rate ratio 1.18 [1.03, 1.35], p = 0.02). When investigating timing, physical ALEs after the age of 12 predicted number of substances used (IRR 1.36 [1.13, 1.63], p < .001). Recent ALEs (occurring after age 12) seem to have considerable impact on substance use. Alcohol and drugs as a coping mechanism were considered a plausible explanation for the results. En ligne : https://dx.doi.org/10.1017/S095457942300086X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

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