Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation / Michelle PEARL in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70344 Titre : Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation Type de document : texte imprimé Auteurs : Michelle PEARL, Auteur ; Kimberly BERGER, Auteur ; Piera M. CIRILLO, Auteur ; Nickilou Y. KRIGBAUM, Auteur ; Victor POON, Auteur ; Gayle C. WINDHAM, Auteur ; Barbara A. COHN, Auteur Année de publication : 2026 Article en page(s) : p.e70344 Langues : Anglais (eng) Mots-clés : alcoholic beverages  autism spectrum disorder  coffee  grandparents  prenatal exposure delayed effects  smoking  tea Index. décimale : PER Périodiques Résumé : ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD). Pregnant participants (grandparent generation) in the Child Health and Development Studies (CHDS) were interviewed between 1959 and 1967 about their own and their partners' smoking and consumption of alcohol, coffee, and tea. CHDS participant records were linked to 18,053 third-generation California births from 1989 to 2014, from which ASD cases were identified from Department of Developmental Services records. We estimated adjusted relative risk (aRR) of ASD associated with grandparents' smoking and consumption of alcoholic beverages, coffee, and tea from log-binomial regression models adjusted for grandparents' age, education, and grandmother's race. Grandfather's overall tobacco smoking (including pipes and cigars) during their partner's pregnancy was related to grandchild ASD (aRR?=?1.76, 95% confidence interval [1.05, 2.96]), as was grandfathers' cigarette smoking (aRR?=?1.67 [1.01, 2.76]), particularly smoking 20 or more cigarettes per day (aRR?=?1.91 [1.03, 3.55]), relative to no smoking. Alcohol consumption of five or more drinks of hard liquor per week by grandfathers was associated with ASD in grandchildren (aRR?=?2.90 [1.24, 6.79], relative to none), as was total consumption of nine or more total alcoholic drinks (aRR?=?1.87 [1.00, 3.51] relative to En ligne : https://doi.org/10.1002/aur.70344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation [texte imprimé] / Michelle PEARL, Auteur ; Kimberly BERGER, Auteur ; Piera M. CIRILLO, Auteur ; Nickilou Y. KRIGBAUM, Auteur ; Victor POON, Auteur ; Gayle C. WINDHAM, Auteur ; Barbara A. COHN, Auteur . - 2026 . - p.e70344. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70344 Mots-clés : alcoholic beverages  autism spectrum disorder  coffee  grandparents  prenatal exposure delayed effects  smoking  tea Index. décimale : PER Périodiques Résumé : ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD). Pregnant participants (grandparent generation) in the Child Health and Development Studies (CHDS) were interviewed between 1959 and 1967 about their own and their partners' smoking and consumption of alcohol, coffee, and tea. CHDS participant records were linked to 18,053 third-generation California births from 1989 to 2014, from which ASD cases were identified from Department of Developmental Services records. We estimated adjusted relative risk (aRR) of ASD associated with grandparents' smoking and consumption of alcoholic beverages, coffee, and tea from log-binomial regression models adjusted for grandparents' age, education, and grandmother's race. Grandfather's overall tobacco smoking (including pipes and cigars) during their partner's pregnancy was related to grandchild ASD (aRR?=?1.76, 95% confidence interval [1.05, 2.96]), as was grandfathers' cigarette smoking (aRR?=?1.67 [1.01, 2.76]), particularly smoking 20 or more cigarettes per day (aRR?=?1.91 [1.03, 3.55]), relative to no smoking. Alcohol consumption of five or more drinks of hard liquor per week by grandfathers was associated with ASD in grandchildren (aRR?=?2.90 [1.24, 6.79], relative to none), as was total consumption of nine or more total alcoholic drinks (aRR?=?1.87 [1.00, 3.51] relative to En ligne : https://doi.org/10.1002/aur.70344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups / Gayle C. WINDHAM in Autism Research, 13-12 (December 2020)  

Public ISBD [article]  inAutism Research > 13-12 (December 2020) . - p.2216-2229 Titre : Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups Type de document : texte imprimé Auteurs : Gayle C. WINDHAM, Auteur ; Michelle PEARL, Auteur ; Victor POON, Auteur ; Kimberly BERGER, Auteur ; Jasmine W. SORIANO, Auteur ; Darryl EYLES, Auteur ; Kristen LYALL, Auteur ; Martin KHARRAZI, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.2216-2229 Langues : Anglais (eng) Mots-clés : 25(oh)d  Asd  autism  hydroxy-vitamin D  intellectual disability  race/ethnic differences  sex differences  vitamin D Index. décimale : PER Périodiques Résumé : Increasing vitamin D deficiency and evidence for vitamin D's role in brain and immune function have recently led to studies of neurodevelopment; however, few are specific to autism spectrum disorder (ASD) and vitamin D in pregnancy, a likely susceptibility period. We examined this in a case-control study of 2000-2003 Southern Californian births; ASD and intellectual disability (ID) were identified through the Department of Developmental Services and controls from birth certificates (N = 534, 181, and 421, respectively, in this analysis). Total 25-Hydroxyvitamin D (25(OH)D) was measured in mid-pregnancy serum, categorized as deficient (<50 nmol/L), insufficient (50-74 nmol/L), or sufficient (≥75 nmol/L, referent category), and examined continuously (per 25 nmol/L). Crude and adjusted odds ratios (AORs) and 95% confidence intervals (95% CI) were calculated. Non-linearity was examined with cubic splines. AORs (95% CI) for ASD were 0.79 (0.49-1.3) for maternal deficiency (9.5%), 0.93 (0.68-1.3) for insufficiency (25.6%), and 0.95 (0.86, 1.05) for linear continuous 25(OH)D. Results were similarly null for ASD with or without ID, and ID only. Interactions were observed; non-Hispanic whites (NHW) (AOR = 0.82, 95% CI = 0.69-0.98) and males (AOR = 0.89, 95% CI = 0.80-0.99) had protective associations for ASD with continuous 25(OH)D. A positive association with ASD was observed in females (AOR = 1.40, 95% CI = 1.06-1.85). With splines, a non-linear inverted j-shaped pattern was seen overall (P = 0.009 for non-linearity), with the peak around 100 nmol/L; a non-linear pattern was not observed among NHW, females, nor for ID. Our findings from a large study of ASD and prenatal vitamin D levels indicate that further research is needed to investigate non-linear patterns and potentially vulnerable sub-groups. LAY SUMMARY: We studied whether mothers' vitamin D levels during pregnancy were related to their children having autism (or low IQ) later. Low vitamin D levels were not related to greater risk of autism or low IQ in children overall. With higher levels of mothers' vitamin D, risk of autism went down in boys, but went up in girls. Risk of autism also went down in children of non-Hispanic white mothers with higher vitamin D levels, but we did not find a relation in other race/ethnic groups. En ligne : http://dx.doi.org/10.1002/aur.2424 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups [texte imprimé] / Gayle C. WINDHAM, Auteur ; Michelle PEARL, Auteur ; Victor POON, Auteur ; Kimberly BERGER, Auteur ; Jasmine W. SORIANO, Auteur ; Darryl EYLES, Auteur ; Kristen LYALL, Auteur ; Martin KHARRAZI, Auteur ; Lisa A. CROEN, Auteur . - p.2216-2229. Langues : Anglais (eng) in Autism Research > 13-12 (December 2020) . - p.2216-2229 Mots-clés : 25(oh)d  Asd  autism  hydroxy-vitamin D  intellectual disability  race/ethnic differences  sex differences  vitamin D Index. décimale : PER Périodiques Résumé : Increasing vitamin D deficiency and evidence for vitamin D's role in brain and immune function have recently led to studies of neurodevelopment; however, few are specific to autism spectrum disorder (ASD) and vitamin D in pregnancy, a likely susceptibility period. We examined this in a case-control study of 2000-2003 Southern Californian births; ASD and intellectual disability (ID) were identified through the Department of Developmental Services and controls from birth certificates (N = 534, 181, and 421, respectively, in this analysis). Total 25-Hydroxyvitamin D (25(OH)D) was measured in mid-pregnancy serum, categorized as deficient (<50 nmol/L), insufficient (50-74 nmol/L), or sufficient (≥75 nmol/L, referent category), and examined continuously (per 25 nmol/L). Crude and adjusted odds ratios (AORs) and 95% confidence intervals (95% CI) were calculated. Non-linearity was examined with cubic splines. AORs (95% CI) for ASD were 0.79 (0.49-1.3) for maternal deficiency (9.5%), 0.93 (0.68-1.3) for insufficiency (25.6%), and 0.95 (0.86, 1.05) for linear continuous 25(OH)D. Results were similarly null for ASD with or without ID, and ID only. Interactions were observed; non-Hispanic whites (NHW) (AOR = 0.82, 95% CI = 0.69-0.98) and males (AOR = 0.89, 95% CI = 0.80-0.99) had protective associations for ASD with continuous 25(OH)D. A positive association with ASD was observed in females (AOR = 1.40, 95% CI = 1.06-1.85). With splines, a non-linear inverted j-shaped pattern was seen overall (P = 0.009 for non-linearity), with the peak around 100 nmol/L; a non-linear pattern was not observed among NHW, females, nor for ID. Our findings from a large study of ASD and prenatal vitamin D levels indicate that further research is needed to investigate non-linear patterns and potentially vulnerable sub-groups. LAY SUMMARY: We studied whether mothers' vitamin D levels during pregnancy were related to their children having autism (or low IQ) later. Low vitamin D levels were not related to greater risk of autism or low IQ in children overall. With higher levels of mothers' vitamin D, risk of autism went down in boys, but went up in girls. Risk of autism also went down in children of non-Hispanic white mothers with higher vitamin D levels, but we did not find a relation in other race/ethnic groups. En ligne : http://dx.doi.org/10.1002/aur.2424 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder / Kimberly BERGER in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.2017-2026 Titre : The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Kimberly BERGER, Auteur ; Michelle PEARL, Auteur ; Martin KHARRAZI, Auteur ; Ying LI, Auteur ; Josephine DEGUZMAN, Auteur ; Jianwen SHE, Auteur ; Paramjit BEHNIWAL, Auteur ; Kristen LYALL, Auteur ; Gayle WINDHAM, Auteur Année de publication : 2021 Article en page(s) : p.2017-2026 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Child  Cotinine  Female  Humans  Maternal Exposure/adverse effects  Pregnancy  Smoking  Tobacco Smoke Pollution/adverse effects/analysis  Autism Spectrum Disorder  cotinine  pregnancy  smoking  tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (≥3.08 ng/ml vs. <3.08 ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder [texte imprimé] / Kimberly BERGER, Auteur ; Michelle PEARL, Auteur ; Martin KHARRAZI, Auteur ; Ying LI, Auteur ; Josephine DEGUZMAN, Auteur ; Jianwen SHE, Auteur ; Paramjit BEHNIWAL, Auteur ; Kristen LYALL, Auteur ; Gayle WINDHAM, Auteur . - 2021 . - p.2017-2026. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.2017-2026 Mots-clés : Autism Spectrum Disorder/epidemiology/etiology  Child  Cotinine  Female  Humans  Maternal Exposure/adverse effects  Pregnancy  Smoking  Tobacco Smoke Pollution/adverse effects/analysis  Autism Spectrum Disorder  cotinine  pregnancy  smoking  tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (≥3.08 ng/ml vs. <3.08 ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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