Common and unique multimodal covarying patterns in autism spectrum disorder subtypes / Shile QI in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Common and unique multimodal covarying patterns in autism spectrum disorder subtypes Type de document : Texte imprimé et/ou numérique Auteurs : Shile QI, Auteur ; Robin MORRIS, Auteur ; Jessica A TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur Année de publication : 2020 Langues : Anglais (eng) Mots-clés : Asperger’s disorder  Autism spectrum disorder  Autistic disorder  Heterogeneity  Multimodal fusion  Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n?=?79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n?=?58) and Autistic disorder (n?=?92) from ABIDE II were used as discovery cohort, and ABIDE I (n?=?400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Common and unique multimodal covarying patterns in autism spectrum disorder subtypes [Texte imprimé et/ou numérique] / Shile QI, Auteur ; Robin MORRIS, Auteur ; Jessica A TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur . - 2020. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : Asperger’s disorder  Autism spectrum disorder  Autistic disorder  Heterogeneity  Multimodal fusion  Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n?=?79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n?=?58) and Autistic disorder (n?=?92) from ABIDE II were used as discovery cohort, and ABIDE I (n?=?400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Enhanced parietal cortex activation during location detection in children with autism / Thomas P. DERAMUS in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.37 Titre : Enhanced parietal cortex activation during location detection in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Thomas P. DERAMUS, Auteur ; Briley S. BLACK, Auteur ; M. R. PENNICK, Auteur ; R. K. KANA, Auteur Article en page(s) : p.37 Langues : Anglais (eng) Mots-clés : Autism  Dorsal  Functional connectivity  Location detection  Object recognition  Ventral  Visual system  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Visuospatial processing has been found to be mediated primarily by two cortical routes, one of which is unique to recognizing objects (occipital-temporal, ventral or "what" pathway) and the other to detecting the location of objects in space (parietal-occipital, dorsal or "where" pathway). Considering previous findings of relative advantage in people with autism in visuospatial processing, this functional MRI study examined the connectivity in the dorsal and ventral pathways in high-functioning children with autism. METHODS: Seventeen high-functioning children and adolescents with autism spectrum disorders (ASD) and 19 age-and-IQ-matched typically developing (TD) participants took part in this study. A simple visual task involving object recognition and location detection was used. In the MRI scanner, participants were shown grey scale pictures of objects (e.g., toys, household items, etc.) and were asked to identify the objects presented or to specify the location of objects relative to a cross at the center of the screen. RESULTS: Children with ASD, relative to TD children, displayed significantly greater activation in the left inferior parietal lobule (especially the angular gyrus) while detecting the location of objects. However, there were no group differences in brain activity during object recognition. There were also differences in functional connectivity, with the ASD participants showing decreased connectivity of the inferior temporal area with parietal and occipital areas during location detection. CONCLUSIONS: The results of this study underscore previous findings of an increased reliance on visuospatial processing (increased parietal activation) for information processing in ASD individuals. In addition, such processing may be more local, focal, and detailed in ASD as evidenced from the weaker functional connectivity. En ligne : http://dx.doi.org/10.1186/1866-1955-6-37 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] Enhanced parietal cortex activation during location detection in children with autism [Texte imprimé et/ou numérique] / Thomas P. DERAMUS, Auteur ; Briley S. BLACK, Auteur ; M. R. PENNICK, Auteur ; R. K. KANA, Auteur . - p.37. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.37 Mots-clés : Autism  Dorsal  Functional connectivity  Location detection  Object recognition  Ventral  Visual system  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Visuospatial processing has been found to be mediated primarily by two cortical routes, one of which is unique to recognizing objects (occipital-temporal, ventral or "what" pathway) and the other to detecting the location of objects in space (parietal-occipital, dorsal or "where" pathway). Considering previous findings of relative advantage in people with autism in visuospatial processing, this functional MRI study examined the connectivity in the dorsal and ventral pathways in high-functioning children with autism. METHODS: Seventeen high-functioning children and adolescents with autism spectrum disorders (ASD) and 19 age-and-IQ-matched typically developing (TD) participants took part in this study. A simple visual task involving object recognition and location detection was used. In the MRI scanner, participants were shown grey scale pictures of objects (e.g., toys, household items, etc.) and were asked to identify the objects presented or to specify the location of objects relative to a cross at the center of the screen. RESULTS: Children with ASD, relative to TD children, displayed significantly greater activation in the left inferior parietal lobule (especially the angular gyrus) while detecting the location of objects. However, there were no group differences in brain activity during object recognition. There were also differences in functional connectivity, with the ASD participants showing decreased connectivity of the inferior temporal area with parietal and occipital areas during location detection. CONCLUSIONS: The results of this study underscore previous findings of an increased reliance on visuospatial processing (increased parietal activation) for information processing in ASD individuals. In addition, such processing may be more local, focal, and detailed in ASD as evidenced from the weaker functional connectivity. En ligne : http://dx.doi.org/10.1186/1866-1955-6-37 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

Hemispheric differences in language processing in autism spectrum disorders: A meta-analysis of neuroimaging studies / Abbey J. HERRINGSHAW in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1046-1057 Titre : Hemispheric differences in language processing in autism spectrum disorders: A meta-analysis of neuroimaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Abbey J. HERRINGSHAW, Auteur ; Carla J. AMMONS, Auteur ; Thomas P. DERAMUS, Auteur ; Rajesh K. KANA, Auteur Article en page(s) : p.1046-1057 Langues : Anglais (eng) Mots-clés : activation likelihood estimation  language processing  language brain  meta-analysis  autism  neuroimaging  brain Index. décimale : PER Périodiques Résumé : Language impairments, a hallmark feature of autism spectrum disorders (ASD), have been related to neuroanatomical and functional abnormalities. Abnormal lateralization of the functional language network, increased reliance on visual processing areas, and increased posterior brain activation have all been reported in ASD and proposed as explanatory models of language difficulties. Nevertheless, inconsistent findings across studies have prevented a comprehensive characterization of the functional language network in ASD. The aim of this study was to quantify common and consistent patterns of brain activation during language processing in ASD and typically developing control (TD) participants using a meta-analytic approach. Activation likelihood estimation (ALE) meta-analysis was used to examine 22 previously published functional Magnetic Resonance Imaging (fMRI)/positron emission tomography studies of language processing (ASD: N?=?328; TD: N?=?324). Tasks included in this study addressed semantic processing, sentence comprehension, processing figurative language, and speech production. Within-group analysis showed largely overlapping patterns of language-related activation in ASD and TD groups. However, the ASD participants, relative to TD participants, showed: (1) more right hemisphere activity in core language areas (i.e., superior temporal gyrus and inferior frontal gyrus), particularly in tasks where they had poorer performance accuracy; (2) bilateral MTG hypo-activation across many different paradigms; and (3) increased activation of the left lingual gyrus in tasks where they had intact performance. These findings show that the hypotheses reviewed here address the neural and cognitive aspects of language difficulties in ASD across all tasks only in a limited way. Instead, our findings suggest the nuances of language and brain in ASD in terms of its context-dependency. En ligne : http://dx.doi.org/10.1002/aur.1599 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Hemispheric differences in language processing in autism spectrum disorders: A meta-analysis of neuroimaging studies [Texte imprimé et/ou numérique] / Abbey J. HERRINGSHAW, Auteur ; Carla J. AMMONS, Auteur ; Thomas P. DERAMUS, Auteur ; Rajesh K. KANA, Auteur . - p.1046-1057. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1046-1057 Mots-clés : activation likelihood estimation  language processing  language brain  meta-analysis  autism  neuroimaging  brain Index. décimale : PER Périodiques Résumé : Language impairments, a hallmark feature of autism spectrum disorders (ASD), have been related to neuroanatomical and functional abnormalities. Abnormal lateralization of the functional language network, increased reliance on visual processing areas, and increased posterior brain activation have all been reported in ASD and proposed as explanatory models of language difficulties. Nevertheless, inconsistent findings across studies have prevented a comprehensive characterization of the functional language network in ASD. The aim of this study was to quantify common and consistent patterns of brain activation during language processing in ASD and typically developing control (TD) participants using a meta-analytic approach. Activation likelihood estimation (ALE) meta-analysis was used to examine 22 previously published functional Magnetic Resonance Imaging (fMRI)/positron emission tomography studies of language processing (ASD: N?=?328; TD: N?=?324). Tasks included in this study addressed semantic processing, sentence comprehension, processing figurative language, and speech production. Within-group analysis showed largely overlapping patterns of language-related activation in ASD and TD groups. However, the ASD participants, relative to TD participants, showed: (1) more right hemisphere activity in core language areas (i.e., superior temporal gyrus and inferior frontal gyrus), particularly in tasks where they had poorer performance accuracy; (2) bilateral MTG hypo-activation across many different paradigms; and (3) increased activation of the left lingual gyrus in tasks where they had intact performance. These findings show that the hypotheses reviewed here address the neural and cognitive aspects of language difficulties in ASD across all tasks only in a limited way. Instead, our findings suggest the nuances of language and brain in ASD in terms of its context-dependency. En ligne : http://dx.doi.org/10.1002/aur.1599 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

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