Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort / Dina TERLOYEVA in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort Type de document : texte imprimé Auteurs : Dina TERLOYEVA, Auteur ; Alexander J. FREY, Auteur ; Bo-Yong PARK, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Leny MATHEW, Auteur ; Anna BOSTWICK, Auteur ; Erika L. VARNER, Auteur ; Brian K. LEE, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur ; Nathaniel W. SNYDER, Auteur Langues : Anglais (eng) Mots-clés : Androgen  Autism-related traits  Meconium  Prenatal exposure  Sex difference  Sibling Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has been examined by measurement of steroids in amniotic fluid, cord blood, saliva, and blood with mixed results. METHODS: To provide an orthogonal measure of fetal exposure, this study used meconium, the first stool of a newborn, to measure prenatal androgen exposure from infants in the Early Autism Risk Longitudinal Investigation (EARLI). EARLI is a familial-enriched risk cohort that enrolled pregnant mothers who already had a child with an ASD diagnosis. In the younger child, we investigated the association between meconium unconjugated (u) and total (t) concentrations of major androgens testosterone (T), dehydroepiandrosterone (DHEA), and androstenedione (A4), and ASD-related traits at 12 and 36 months of age. Traits were measured at 12 months with Autism Observation Scale for Infants (AOSI) and at 36 months with total score on the Social Responsiveness Scale (SRS). One hundred and seventy children had meconium and AOSI, 140 had meconium and SRS, and 137 had meconium and both AOSI and SRS. RESULTS: Separate robust linear regressions between each of the log-transformed androgens and log-transformed SRS scores revealed three-way interaction between sex of the child, sex of the proband, and testosterone concentration. In the adjusted analyses, t-T, u-A4, and u-DHEA (P ≤ 0.01) were positively associated with AOSI scores, while u-T (P = 0.004) and u-DHEA (P = 0.007) were positively associated with SRS total score among females with female probands (n = 10). Additionally, higher concentrations of u-T (P = 0.01) and t-T (P = 0.01) predicted higher SRS total score in males with male probands (n = 63). Limitations Since we explored three-way interactions, this resulted in a limited sample size for some analyses. This study was from an enriched-risk cohort which may limit generalizability, and this study used ASD-assessment scales as outcomes instead of diagnostic categories. Additionally, the novel use of meconium in this study limits the ability to compare the results in this cohort to others due to the paucity of research on meconium. CONCLUSIONS: This study supports the utility of meconium for studies of endogenous fetal metabolism and suggests the sex of older siblings with autism should be considered as a biological variable in relevant studies. En ligne : http://dx.doi.org/10.1186/s13229-020-00395-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort [texte imprimé] / Dina TERLOYEVA, Auteur ; Alexander J. FREY, Auteur ; Bo-Yong PARK, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Leny MATHEW, Auteur ; Anna BOSTWICK, Auteur ; Erika L. VARNER, Auteur ; Brian K. LEE, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur ; Nathaniel W. SNYDER, Auteur. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : Androgen  Autism-related traits  Meconium  Prenatal exposure  Sex difference  Sibling Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has been examined by measurement of steroids in amniotic fluid, cord blood, saliva, and blood with mixed results. METHODS: To provide an orthogonal measure of fetal exposure, this study used meconium, the first stool of a newborn, to measure prenatal androgen exposure from infants in the Early Autism Risk Longitudinal Investigation (EARLI). EARLI is a familial-enriched risk cohort that enrolled pregnant mothers who already had a child with an ASD diagnosis. In the younger child, we investigated the association between meconium unconjugated (u) and total (t) concentrations of major androgens testosterone (T), dehydroepiandrosterone (DHEA), and androstenedione (A4), and ASD-related traits at 12 and 36 months of age. Traits were measured at 12 months with Autism Observation Scale for Infants (AOSI) and at 36 months with total score on the Social Responsiveness Scale (SRS). One hundred and seventy children had meconium and AOSI, 140 had meconium and SRS, and 137 had meconium and both AOSI and SRS. RESULTS: Separate robust linear regressions between each of the log-transformed androgens and log-transformed SRS scores revealed three-way interaction between sex of the child, sex of the proband, and testosterone concentration. In the adjusted analyses, t-T, u-A4, and u-DHEA (P ≤ 0.01) were positively associated with AOSI scores, while u-T (P = 0.004) and u-DHEA (P = 0.007) were positively associated with SRS total score among females with female probands (n = 10). Additionally, higher concentrations of u-T (P = 0.01) and t-T (P = 0.01) predicted higher SRS total score in males with male probands (n = 63). Limitations Since we explored three-way interactions, this resulted in a limited sample size for some analyses. This study was from an enriched-risk cohort which may limit generalizability, and this study used ASD-assessment scales as outcomes instead of diagnostic categories. Additionally, the novel use of meconium in this study limits the ability to compare the results in this cohort to others due to the paucity of research on meconium. CONCLUSIONS: This study supports the utility of meconium for studies of endogenous fetal metabolism and suggests the sex of older siblings with autism should be considered as a biological variable in relevant studies. En ligne : http://dx.doi.org/10.1186/s13229-020-00395-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies / Rachel VECCHIONE in Journal of Autism and Developmental Disorders, 51-2 (February 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.487-500 Titre : The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies Type de document : texte imprimé Auteurs : Rachel VECCHIONE, Auteur ; Chelsea VIGNA, Auteur ; Casey WHITMAN, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Ghassan B. HAMRA, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.487-500 Langues : Anglais (eng) Mots-clés : Autism  Maternal fish intake  Prenatal diet  Quantitative traits  Social responsiveness scale Index. décimale : PER Périodiques Résumé : We examined the association between prenatal fish intake and child autism-related traits according to Social Responsiveness Scale (SRS) and cognitive development scores in two US prospective pregnancy cohorts. In adjusted linear regression analyses, higher maternal fish intake in the second half of pregnancy was associated with increased child autism traits (higher raw SRS scores; ß = 5.60, 95%CI 1.76, 12.97). Differences by fish type were suggested; shellfish and large fish species were associated with increases, and salmon with decreases, in child SRS scores. Clear patterns with cognitive scores in the two cohorts were not observed. Future work should further evaluate potential critical windows of prenatal fish intake, and the role of different fish types in association with child autism-related outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04546-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies [texte imprimé] / Rachel VECCHIONE, Auteur ; Chelsea VIGNA, Auteur ; Casey WHITMAN, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Ghassan B. HAMRA, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.487-500. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.487-500 Mots-clés : Autism  Maternal fish intake  Prenatal diet  Quantitative traits  Social responsiveness scale Index. décimale : PER Périodiques Résumé : We examined the association between prenatal fish intake and child autism-related traits according to Social Responsiveness Scale (SRS) and cognitive development scores in two US prospective pregnancy cohorts. In adjusted linear regression analyses, higher maternal fish intake in the second half of pregnancy was associated with increased child autism traits (higher raw SRS scores; ß = 5.60, 95%CI 1.76, 12.97). Differences by fish type were suggested; shellfish and large fish species were associated with increases, and salmon with decreases, in child SRS scores. Clear patterns with cognitive scores in the two cohorts were not observed. Future work should further evaluate potential critical windows of prenatal fish intake, and the role of different fish types in association with child autism-related outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04546-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism / Kristen LYALL in Autism Research, 13-6 (June 2020)  

Public ISBD [article]  inAutism Research > 13-6 (June 2020) . - p.998-1010 Titre : The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism Type de document : texte imprimé Auteurs : Kristen LYALL, Auteur ; Lanxin SONG, Auteur ; Kelly N. BOTTERON, Auteur ; Lisa A. CROEN, Auteur ; Stephen R. DAGER, Auteur ; M. Daniele FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Rebecca LANDA, Auteur ; Christine LADD-ACOSTA, Auteur ; Daniel S. MESSINGER, Auteur ; Sally OZONOFF, Auteur ; Juhi PANDEY, Auteur ; Joseph PIVEN, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robert T. SCHULTZ, Auteur ; Wendy L. STONE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Heather E. VOLK, Auteur Article en page(s) : p.998-1010 Langues : Anglais (eng) Mots-clés : autism  autism-related traits  high familial risk  parental age Index. décimale : PER Périodiques Résumé : Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age < 30 years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30 years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted β = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted β associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism. En ligne : http://dx.doi.org/10.1002/aur.2303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism [texte imprimé] / Kristen LYALL, Auteur ; Lanxin SONG, Auteur ; Kelly N. BOTTERON, Auteur ; Lisa A. CROEN, Auteur ; Stephen R. DAGER, Auteur ; M. Daniele FALLIN, Auteur ; Heather C. HAZLETT, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Rebecca LANDA, Auteur ; Christine LADD-ACOSTA, Auteur ; Daniel S. MESSINGER, Auteur ; Sally OZONOFF, Auteur ; Juhi PANDEY, Auteur ; Joseph PIVEN, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robert T. SCHULTZ, Auteur ; Wendy L. STONE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Heather E. VOLK, Auteur . - p.998-1010. Langues : Anglais (eng) in Autism Research > 13-6 (June 2020) . - p.998-1010 Mots-clés : autism  autism-related traits  high familial risk  parental age Index. décimale : PER Périodiques Résumé : Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age < 30 years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30 years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted β = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted β associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism. En ligne : http://dx.doi.org/10.1002/aur.2303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

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