Dépouillements

Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 / Allen J. ROSENSPIRE in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.242-249 Titre : Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 Type de document : Texte imprimé et/ou numérique Auteurs : Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur Année de publication : 2011 Article en page(s) : p.242-249 Langues : Anglais (eng) Mots-clés : immunology  anti-transglutaminase antibody  pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 [Texte imprimé et/ou numérique] / Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur . - 2011 . - p.242-249. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.242-249 Mots-clés : immunology  anti-transglutaminase antibody  pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

MAOA, DBH, and SLC6A4 variants in CHARGE: a case–control study of autism spectrum disorders / Flora TASSONE in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.250-261 Titre : MAOA, DBH, and SLC6A4 variants in CHARGE: a case–control study of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Flora TASSONE, Auteur ; Lihong QI, Auteur ; Wenting ZHANG, Auteur ; David J. HANSEN, Auteur ; Isaac N. PESSAH, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Année de publication : 2011 Article en page(s) : p.250-261 Langues : Anglais (eng) Mots-clés : ASD  polymorphisms  SLC6A4  MAOA  DBH Index. décimale : PER Périodiques Résumé : Genetic factors are established to contribute to the development of autism. We examined three loci, serotonin transporter (SLC6A4), dopamine β-hydroxylase (DBH), and the variable number of tandem repeat promoter of the monoamine oxidase A (MAOA) for association with autism in participants from the Childhood Autism Risks from Genetics and the Environment (CHARGE ) Study, the first large-scale population-based case–control investigation of both environmental and genetic contributions to autism risk. Among male children enrolled in the CHARGE study we tested associations between each of the three polymorphisms and autism (AU) (n = 119), or a combined group of autism and other autism spectrum disorders (AU+ASD, which includes an additional n = 53) as compared with typically developing controls (TD, n = 137). The case–control association analysis showed neither SLC6A4 nor DBH to be statistically significantly associated with AU or ASD. However, the male children carrying 4 tandem repeats in the promoter region of the MAOA gene showed a two-fold higher risk of AU (or AU+ASD) than those carrying allele 3, adjusted for confounders (OR = 2.02, 95% CI = 1.12, 3.65, P = 0.02 for AU vs. TD, and OR = 2.05, 95% CI = 1.19, 3.53, P = 0.01 for ASD vs. TD). In addition, children of mothers homozygous for the 4 tandem repeat allele showed at least a three-fold higher risk of AU (or AU+ASD) than those with mothers homozygous for allele 3 (OR = 3.07, 95% CI = 1.19, 7.91, P = 0.02 for AU vs. TD, and OR = 3.26, 95% CI = 1.35, 7.89, P = 0.009 for AU+ASD vs. TD). These results suggest a potential role of the functional MAOA promoter alleles in the male child, the mother, or both in ASD. En ligne : http://dx.doi.org/10.1002/aur.196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] MAOA, DBH, and SLC6A4 variants in CHARGE: a case–control study of autism spectrum disorders [Texte imprimé et/ou numérique] / Flora TASSONE, Auteur ; Lihong QI, Auteur ; Wenting ZHANG, Auteur ; David J. HANSEN, Auteur ; Isaac N. PESSAH, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - 2011 . - p.250-261. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.250-261 Mots-clés : ASD  polymorphisms  SLC6A4  MAOA  DBH Index. décimale : PER Périodiques Résumé : Genetic factors are established to contribute to the development of autism. We examined three loci, serotonin transporter (SLC6A4), dopamine β-hydroxylase (DBH), and the variable number of tandem repeat promoter of the monoamine oxidase A (MAOA) for association with autism in participants from the Childhood Autism Risks from Genetics and the Environment (CHARGE ) Study, the first large-scale population-based case–control investigation of both environmental and genetic contributions to autism risk. Among male children enrolled in the CHARGE study we tested associations between each of the three polymorphisms and autism (AU) (n = 119), or a combined group of autism and other autism spectrum disorders (AU+ASD, which includes an additional n = 53) as compared with typically developing controls (TD, n = 137). The case–control association analysis showed neither SLC6A4 nor DBH to be statistically significantly associated with AU or ASD. However, the male children carrying 4 tandem repeats in the promoter region of the MAOA gene showed a two-fold higher risk of AU (or AU+ASD) than those carrying allele 3, adjusted for confounders (OR = 2.02, 95% CI = 1.12, 3.65, P = 0.02 for AU vs. TD, and OR = 2.05, 95% CI = 1.19, 3.53, P = 0.01 for ASD vs. TD). In addition, children of mothers homozygous for the 4 tandem repeat allele showed at least a three-fold higher risk of AU (or AU+ASD) than those with mothers homozygous for allele 3 (OR = 3.07, 95% CI = 1.19, 7.91, P = 0.02 for AU vs. TD, and OR = 3.26, 95% CI = 1.35, 7.89, P = 0.009 for AU+ASD vs. TD). These results suggest a potential role of the functional MAOA promoter alleles in the male child, the mother, or both in ASD. En ligne : http://dx.doi.org/10.1002/aur.196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity—implications for autism / Madhabi BARUA in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.262-270 Titre : Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity—implications for autism Type de document : Texte imprimé et/ou numérique Auteurs : Madhabi BARUA, Auteur ; Edmund C. JENKINS, Auteur ; Wenqiang CHEN, Auteur ; Salomon KUIZON, Auteur ; Raju K. PULLARKAT, Auteur ; Mohammed A. JUNAID, Auteur Année de publication : 2011 Article en page(s) : p.262-270 Langues : Anglais (eng) Mots-clés : autism  glyoxalase I  SNP  advanced glycation endproducts (AGEs)  receptor for advanced glycation end products (RAGEs)  methylglyoxal Index. décimale : PER Périodiques Résumé : Autism is a pervasive, heterogeneous, neurodevelopmental disability characterized by impairments in verbal communications, reciprocal social interactions, and restricted repetitive stereotyped behaviors. Evidence suggests the involvement of multiple genetic factors in the etiology of autism, and extensive genome-wide association studies have revealed several candidate genes that bear single nucleotide polymorphisms (SNPs) in non-coding and coding regions. We have shown that a non-conservative, non-synonymous SNP in the glyoxalase I gene, GLOI, may be an autism susceptibility factor. The GLOI rs2736654 SNP is a C→A change that causes an Ala111Glu change in the Glo1 enzyme. To identify the significance of the SNP, we have conducted functional assays for Glo1. We now present evidence that the presence of the A-allele at rs2736654 results in reduced enzyme activity. Glo1 activity is decreased in lymphoblastoid cells that are homozygous for the A allele. The Glu-isoform of Glo1 in these cells is hyperphosphorylated. Direct HPLC measurements of the glyoxalase I substrate, methylglyoxal (MG), show an increase in MG in these cells. Western blot analysis revealed elevated levels of the receptor for advanced glycation end products (RAGEs). We also show that MG is toxic to the developing neuronal cells. We suggest that accumulation of MG results in the formation of AGEs, which induce expression of the RAGE that during crucial neuronal development may be a factor in the pathology of autism. En ligne : http://dx.doi.org/10.1002/aur.197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity—implications for autism [Texte imprimé et/ou numérique] / Madhabi BARUA, Auteur ; Edmund C. JENKINS, Auteur ; Wenqiang CHEN, Auteur ; Salomon KUIZON, Auteur ; Raju K. PULLARKAT, Auteur ; Mohammed A. JUNAID, Auteur . - 2011 . - p.262-270. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.262-270 Mots-clés : autism  glyoxalase I  SNP  advanced glycation endproducts (AGEs)  receptor for advanced glycation end products (RAGEs)  methylglyoxal Index. décimale : PER Périodiques Résumé : Autism is a pervasive, heterogeneous, neurodevelopmental disability characterized by impairments in verbal communications, reciprocal social interactions, and restricted repetitive stereotyped behaviors. Evidence suggests the involvement of multiple genetic factors in the etiology of autism, and extensive genome-wide association studies have revealed several candidate genes that bear single nucleotide polymorphisms (SNPs) in non-coding and coding regions. We have shown that a non-conservative, non-synonymous SNP in the glyoxalase I gene, GLOI, may be an autism susceptibility factor. The GLOI rs2736654 SNP is a C→A change that causes an Ala111Glu change in the Glo1 enzyme. To identify the significance of the SNP, we have conducted functional assays for Glo1. We now present evidence that the presence of the A-allele at rs2736654 results in reduced enzyme activity. Glo1 activity is decreased in lymphoblastoid cells that are homozygous for the A allele. The Glu-isoform of Glo1 in these cells is hyperphosphorylated. Direct HPLC measurements of the glyoxalase I substrate, methylglyoxal (MG), show an increase in MG in these cells. Western blot analysis revealed elevated levels of the receptor for advanced glycation end products (RAGEs). We also show that MG is toxic to the developing neuronal cells. We suggest that accumulation of MG results in the formation of AGEs, which induce expression of the RAGE that during crucial neuronal development may be a factor in the pathology of autism. En ligne : http://dx.doi.org/10.1002/aur.197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Bridging autism, science and society: moving toward an ethically informed approach to autism research / Elizabeth PELLICANO in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.271-282 Titre : Bridging autism, science and society: moving toward an ethically informed approach to autism research Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth PELLICANO, Auteur ; Marc STEARS, Auteur Année de publication : 2011 Article en page(s) : p.271-282 Langues : Anglais (eng) Mots-clés : autism  ethics  genetics  neuroscience  neurodiversity  activism Index. décimale : PER Périodiques Résumé : Recent developments in the science of autism have provoked widespread unease among autism activists. Drawing on the findings of a major international gathering of researchers, ethicists, and activists, this paper presents the first major analysis of the ethical questions arising from this unease. We outline the scientific developments that have provoked the most discomfort, analyze the response to these developments from within and without the autism community, and trace the current state of the ethical debate. Having done so, we contend that these ethical questions are unlikely to be resolved as they depend on fundamentally conflicting assumptions about the nature and desirability of neurocognitive difference. We conclude by arguing for a new range of democratic mechanisms that could enable the scientific community, autistics, and other concerned parties to respond collectively to such entrenched ethical disputes. En ligne : http://dx.doi.org/10.1002/aur.201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Bridging autism, science and society: moving toward an ethically informed approach to autism research [Texte imprimé et/ou numérique] / Elizabeth PELLICANO, Auteur ; Marc STEARS, Auteur . - 2011 . - p.271-282. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.271-282 Mots-clés : autism  ethics  genetics  neuroscience  neurodiversity  activism Index. décimale : PER Périodiques Résumé : Recent developments in the science of autism have provoked widespread unease among autism activists. Drawing on the findings of a major international gathering of researchers, ethicists, and activists, this paper presents the first major analysis of the ethical questions arising from this unease. We outline the scientific developments that have provoked the most discomfort, analyze the response to these developments from within and without the autism community, and trace the current state of the ethical debate. Having done so, we contend that these ethical questions are unlikely to be resolved as they depend on fundamentally conflicting assumptions about the nature and desirability of neurocognitive difference. We conclude by arguing for a new range of democratic mechanisms that could enable the scientific community, autistics, and other concerned parties to respond collectively to such entrenched ethical disputes. En ligne : http://dx.doi.org/10.1002/aur.201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Perceptual grouping abilities in individuals with autism spectrum disorder; exploring patterns of ability in relation to grouping type and levels of development / Emily K. FARRAN in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.283-292 Titre : Perceptual grouping abilities in individuals with autism spectrum disorder; exploring patterns of ability in relation to grouping type and levels of development Type de document : Texte imprimé et/ou numérique Auteurs : Emily K. FARRAN, Auteur ; Mark BROSNAN, Auteur Année de publication : 2011 Article en page(s) : p.283-292 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study further investigates findings of impairment in Gestalt, but not global processing in Autism Spectrum Disorder (ASD) [Brosnan, Scott, Fox, & Pye, 2004]. Nineteen males with ASD and nineteen typically developing (TD) males matched by nonverbal ability, took part in five Gestalt perceptual grouping tasks. Results showed that performance differed according to grouping type. The ASD group showed typical performance for grouping by proximity and by alignment, impairment on low difficulty trials for orientation and luminance similarity, and general impairment for grouping by shape similarity. Group differences were also observed developmentally; for the ASD group, with the exception of grouping by shape similarity, perceptual grouping performance was poorer at lower than higher levels of nonverbal ability. In contrast, no developmental progression was observed in the TD controls. En ligne : http://dx.doi.org/10.1002/aur.202 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Perceptual grouping abilities in individuals with autism spectrum disorder; exploring patterns of ability in relation to grouping type and levels of development [Texte imprimé et/ou numérique] / Emily K. FARRAN, Auteur ; Mark BROSNAN, Auteur . - 2011 . - p.283-292. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.283-292 Index. décimale : PER Périodiques Résumé : This study further investigates findings of impairment in Gestalt, but not global processing in Autism Spectrum Disorder (ASD) [Brosnan, Scott, Fox, & Pye, 2004]. Nineteen males with ASD and nineteen typically developing (TD) males matched by nonverbal ability, took part in five Gestalt perceptual grouping tasks. Results showed that performance differed according to grouping type. The ASD group showed typical performance for grouping by proximity and by alignment, impairment on low difficulty trials for orientation and luminance similarity, and general impairment for grouping by shape similarity. Group differences were also observed developmentally; for the ASD group, with the exception of grouping by shape similarity, perceptual grouping performance was poorer at lower than higher levels of nonverbal ability. In contrast, no developmental progression was observed in the TD controls. En ligne : http://dx.doi.org/10.1002/aur.202 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set / Kristina ALLEN-BRADY in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.293-296 Titre : No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set Type de document : Texte imprimé et/ou numérique Auteurs : Kristina ALLEN-BRADY, Auteur ; Guiqing CAI, Auteur ; Dale CANNON, Auteur ; Reid ROBISON, Auteur ; William M. MCMAHON, Auteur ; Hilary H. COON, Auteur ; Joseph D. BUXBAUM, Auteur Année de publication : 2011 Article en page(s) : p.293-296 Langues : Anglais (eng) Mots-clés : behavioral analysis of animal models  developmental neurobiology  sex differences  testosterone  androgen receptor Index. décimale : PER Périodiques Résumé : Finding predisposition genes for Autism Spectrum Disorder (ASD) has proven challenging, and new methods are needed to aid the process. Using pedigree structure as a strategy to identify ASD predisposition genes, we previously performed a genome-wide linkage scan of 86 selected families from the Autism Resource Exchange (AGRE) that appeared to inherit ASD in a dominant manner. We identified a suggestive linkage peak on chromosome Xp22.11-p21.2 that encompasses the IL1RAPL1 gene, a strong candidate gene for ASD. In this follow-up study, we sequenced the coding regions of the IL1RAPL1 gene in 14 male cases representing one case from each pedigree that showed at least nominal linkage evidence on per pedigree basis to the chromosome X region. We observed no deleterious mutations or deletions in the IL1RAPL1 gene in these 14 ASD cases. A SNP was identified in exon 2 in five cases and a variant of unknown significance was identified in intron 6 in a single case. In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region. En ligne : http://dx.doi.org/10.1002/aur.195 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set [Texte imprimé et/ou numérique] / Kristina ALLEN-BRADY, Auteur ; Guiqing CAI, Auteur ; Dale CANNON, Auteur ; Reid ROBISON, Auteur ; William M. MCMAHON, Auteur ; Hilary H. COON, Auteur ; Joseph D. BUXBAUM, Auteur . - 2011 . - p.293-296. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.293-296 Mots-clés : behavioral analysis of animal models  developmental neurobiology  sex differences  testosterone  androgen receptor Index. décimale : PER Périodiques Résumé : Finding predisposition genes for Autism Spectrum Disorder (ASD) has proven challenging, and new methods are needed to aid the process. Using pedigree structure as a strategy to identify ASD predisposition genes, we previously performed a genome-wide linkage scan of 86 selected families from the Autism Resource Exchange (AGRE) that appeared to inherit ASD in a dominant manner. We identified a suggestive linkage peak on chromosome Xp22.11-p21.2 that encompasses the IL1RAPL1 gene, a strong candidate gene for ASD. In this follow-up study, we sequenced the coding regions of the IL1RAPL1 gene in 14 male cases representing one case from each pedigree that showed at least nominal linkage evidence on per pedigree basis to the chromosome X region. We observed no deleterious mutations or deletions in the IL1RAPL1 gene in these 14 ASD cases. A SNP was identified in exon 2 in five cases and a variant of unknown significance was identified in intron 6 in a single case. In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region. En ligne : http://dx.doi.org/10.1002/aur.195 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

The development of perceptual expertise for faces and objects in autism spectrum conditions / Cara R. DAMIANO in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.297-301 Titre : The development of perceptual expertise for faces and objects in autism spectrum conditions Type de document : Texte imprimé et/ou numérique Auteurs : Cara R. DAMIANO, Auteur ; Owen CHURCHES, Auteur ; Howard RING, Auteur ; Simon BARON-COHEN, Auteur Année de publication : 2011 Article en page(s) : p.297-301 Langues : Anglais (eng) Mots-clés : face processing  object processing  autism spectrum conditions  inversion effect  perceptual expertise  configural processing  local processing Index. décimale : PER Périodiques Résumé : Previous research indicates that individuals with autism spectrum conditions (ASC) do not develop face expertise to the same extent as typical individuals. Yet it remains unclear whether this atypicality is specific to faces or related to more pervasive perceptual or cognitive deficits involved in the actual process of gaining expertise. To address this question, we examined the extent to which adults with ASC were capable of developing expertise with non-face objects. To become experts, all participants completed a 2-week training program with novel objects, known as Greebles. Level of expertise was assessed throughout training by measuring the ability to identify Greebles on an individual level. The perceptual strategies acquired as a result of expertise were measured through an inversion effect task completed before and after training, in which performance with upright Greebles and faces was compared to performance with inverted Greebles and faces. After expertise training, it was found that individuals in both the ASC and the typical group successfully achieved expertise and showed an enhanced Greeble inversion effect as a result of training. The development of an inversion effect with Greebles suggests that individuals with ASC may employ the same processing strategies as the typical group. Although exploratory, these findings have implications for understanding the nature of the face processing deficit in ASC as well as offering potential insights into face processing interventions for individuals with ASC. En ligne : http://dx.doi.org/10.1002/aur.205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] The development of perceptual expertise for faces and objects in autism spectrum conditions [Texte imprimé et/ou numérique] / Cara R. DAMIANO, Auteur ; Owen CHURCHES, Auteur ; Howard RING, Auteur ; Simon BARON-COHEN, Auteur . - 2011 . - p.297-301. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.297-301 Mots-clés : face processing  object processing  autism spectrum conditions  inversion effect  perceptual expertise  configural processing  local processing Index. décimale : PER Périodiques Résumé : Previous research indicates that individuals with autism spectrum conditions (ASC) do not develop face expertise to the same extent as typical individuals. Yet it remains unclear whether this atypicality is specific to faces or related to more pervasive perceptual or cognitive deficits involved in the actual process of gaining expertise. To address this question, we examined the extent to which adults with ASC were capable of developing expertise with non-face objects. To become experts, all participants completed a 2-week training program with novel objects, known as Greebles. Level of expertise was assessed throughout training by measuring the ability to identify Greebles on an individual level. The perceptual strategies acquired as a result of expertise were measured through an inversion effect task completed before and after training, in which performance with upright Greebles and faces was compared to performance with inverted Greebles and faces. After expertise training, it was found that individuals in both the ASC and the typical group successfully achieved expertise and showed an enhanced Greeble inversion effect as a result of training. The development of an inversion effect with Greebles suggests that individuals with ASC may employ the same processing strategies as the typical group. Although exploratory, these findings have implications for understanding the nature of the face processing deficit in ASC as well as offering potential insights into face processing interventions for individuals with ASC. En ligne : http://dx.doi.org/10.1002/aur.205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Autism and cancer risk / Bernard CRESPI in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.302-310 Titre : Autism and cancer risk Type de document : Texte imprimé et/ou numérique Auteurs : Bernard CRESPI, Auteur Année de publication : 2011 Article en page(s) : p.302-310 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A literature review was conducted on the genetic and developmental bases of autism in relation to genes and pathways associated with cancer risk. Convergent lines of evidence from four types of analysis: (1) recent theoretical studies on the causes of autism, (2) epidemiological studies, (3) genetic analyses linking autism with mutations in tumor suppressor genes and other cancer-associated genes and pathways, and (4) contrasts with schizophrenia, Parkinson's, and Alzheimer's disease indicate that autism may involve altered cancer risk. This evidence should motivate further epidemiological studies, and it provides useful insights into the nature of the genetic, epigenetic, and environmental factors underlying the etiologies of autism, other neurological conditions, and carcinogenesis. En ligne : http://dx.doi.org/10.1002/aur.208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Autism and cancer risk [Texte imprimé et/ou numérique] / Bernard CRESPI, Auteur . - 2011 . - p.302-310. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.302-310 Index. décimale : PER Périodiques Résumé : A literature review was conducted on the genetic and developmental bases of autism in relation to genes and pathways associated with cancer risk. Convergent lines of evidence from four types of analysis: (1) recent theoretical studies on the causes of autism, (2) epidemiological studies, (3) genetic analyses linking autism with mutations in tumor suppressor genes and other cancer-associated genes and pathways, and (4) contrasts with schizophrenia, Parkinson's, and Alzheimer's disease indicate that autism may involve altered cancer risk. This evidence should motivate further epidemiological studies, and it provides useful insights into the nature of the genetic, epigenetic, and environmental factors underlying the etiologies of autism, other neurological conditions, and carcinogenesis. En ligne : http://dx.doi.org/10.1002/aur.208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Lay abstracts in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.311-313 Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2011 Article en page(s) : p.311-313 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 [article] Lay abstracts [Texte imprimé et/ou numérique] . - 2011 . - p.311-313. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.311-313 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142

Erratum: A genotype resource for postmortem brain samples from the Autism Tissue Program / Richard F. WINTLE in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.314 Titre : Erratum: A genotype resource for postmortem brain samples from the Autism Tissue Program Type de document : Texte imprimé et/ou numérique Auteurs : Richard F. WINTLE, Auteur ; Anath C. LIONEL, Auteur ; Pingzhao HU, Auteur ; Stephen D. GINSBERG, Auteur ; Dalila PINTO, Auteur ; Bhooma THIRUVAHINDRAPDURAM, Auteur ; John WEI, Auteur ; Christian R. MARSHALL, Auteur ; Jane PICKETT, Auteur ; Edwin H. Jr COOK, Auteur ; Stephen SCHERER, Auteur Année de publication : 2011 Article en page(s) : p.314 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 [article] Erratum: A genotype resource for postmortem brain samples from the Autism Tissue Program [Texte imprimé et/ou numérique] / Richard F. WINTLE, Auteur ; Anath C. LIONEL, Auteur ; Pingzhao HU, Auteur ; Stephen D. GINSBERG, Auteur ; Dalila PINTO, Auteur ; Bhooma THIRUVAHINDRAPDURAM, Auteur ; John WEI, Auteur ; Christian R. MARSHALL, Auteur ; Jane PICKETT, Auteur ; Edwin H. Jr COOK, Auteur ; Stephen SCHERER, Auteur . - 2011 . - p.314. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.314 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142

International Society for Autism Research News in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.315 Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2011 Article en page(s) : p.315 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 [article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2011 . - p.315. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.315 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142