Interplay of circadian clock and melatonin pathway gene variants in adults with autism, intellectual disability and sleep problems / Pura BALLESTER-NAVARRO in Research in Autism Spectrum Disorders, 81 (March 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 81 (March 2021) . - 101715 Titre : Interplay of circadian clock and melatonin pathway gene variants in adults with autism, intellectual disability and sleep problems Type de document : Texte imprimé et/ou numérique Auteurs : Pura BALLESTER-NAVARRO, Auteur ; María José MARTÍNEZ-MADRID, Auteur ; Auxiliadora JAVALOYES-SANCHÍS, Auteur ; César BELDA-CANTÓ, Auteur ; Víctor AGUILAR, Auteur ; María-del-Mar INDA, Auteur ; Amanda L. RICHDALE, Auteur ; Javier MURIEL, Auteur ; Domingo MORALES, Auteur ; Ana M. PEIRÓ, Auteur Article en page(s) : 101715 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Sleep problems  genes  Ambulatory circadian monitoring Index. décimale : PER Périodiques Résumé : Background People diagnosed with Autism Spectrum Disorder and intellectual disability (ID) usually experience sleep problems, where circadian clock and melatonin pathway genes may play a role. Method Our aim was to analyze the influence of genetic variants PER1, ASMT, NPAS2, and MTNR1A by MassARRAY, in sleep-wake rhythms in a group of autistic adults with ID, cases (n = 83) and controls (n = 25). Sleep-wake rhythms were evaluated with ambulatory circadian monitoring. Results In autistic cases (age 18?41years), PER1 rs6416892-GG and ASMT rs5989681-GG genotypes had a better sleep pattern according to sleep onset latency and awakenings; together with a worse sleep and/or temperature rhythm. Furthermore, diurnal temperature values were affected by NPAS2 rs1811399-CC genotype. Conclusions Normal and abnormal sleep-wake rhythms could be related to circadian clock (PER1) and melatonin pathway (ASMT) gene variants. There is a need for further research to translate this data into clinical decisions or risk profiles. En ligne : https://doi.org/10.1016/j.rasd.2020.101715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Interplay of circadian clock and melatonin pathway gene variants in adults with autism, intellectual disability and sleep problems [Texte imprimé et/ou numérique] / Pura BALLESTER-NAVARRO, Auteur ; María José MARTÍNEZ-MADRID, Auteur ; Auxiliadora JAVALOYES-SANCHÍS, Auteur ; César BELDA-CANTÓ, Auteur ; Víctor AGUILAR, Auteur ; María-del-Mar INDA, Auteur ; Amanda L. RICHDALE, Auteur ; Javier MURIEL, Auteur ; Domingo MORALES, Auteur ; Ana M. PEIRÓ, Auteur . - 101715. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 81 (March 2021) . - 101715 Mots-clés : Autism spectrum disorder  Sleep problems  genes  Ambulatory circadian monitoring Index. décimale : PER Périodiques Résumé : Background People diagnosed with Autism Spectrum Disorder and intellectual disability (ID) usually experience sleep problems, where circadian clock and melatonin pathway genes may play a role. Method Our aim was to analyze the influence of genetic variants PER1, ASMT, NPAS2, and MTNR1A by MassARRAY, in sleep-wake rhythms in a group of autistic adults with ID, cases (n = 83) and controls (n = 25). Sleep-wake rhythms were evaluated with ambulatory circadian monitoring. Results In autistic cases (age 18?41years), PER1 rs6416892-GG and ASMT rs5989681-GG genotypes had a better sleep pattern according to sleep onset latency and awakenings; together with a worse sleep and/or temperature rhythm. Furthermore, diurnal temperature values were affected by NPAS2 rs1811399-CC genotype. Conclusions Normal and abnormal sleep-wake rhythms could be related to circadian clock (PER1) and melatonin pathway (ASMT) gene variants. There is a need for further research to translate this data into clinical decisions or risk profiles. En ligne : https://doi.org/10.1016/j.rasd.2020.101715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

Sleep-Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions / Ana María GARCÍA-MUÑOZ ; María Luisa Sánchez DE OCAÑA-MORENO ; Amanda L. RICHDALE ; Laura GISBERT-GUSTEMPS ; Jorge LUGO-MARÍN ; Beatriz RODRÍGUEZ-MORILLAS ; Ana María PEIRÓ-PEIRÓ ; Desirée VICTORIA-MONTESINOS ; Cristina LÓPEZ-ANGUAS ; María Dolores MESEGUER-ILLÁN ; Pura BALLESTER-NAVARRO in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1369-1380 Titre : Sleep-Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Ana María GARCÍA-MUÑOZ, Auteur ; María Luisa Sánchez DE OCAÑA-MORENO, Auteur ; Amanda L. RICHDALE, Auteur ; Laura GISBERT-GUSTEMPS, Auteur ; Jorge LUGO-MARÍN, Auteur ; Beatriz RODRÍGUEZ-MORILLAS, Auteur ; Ana María PEIRÓ-PEIRÓ, Auteur ; Desirée VICTORIA-MONTESINOS, Auteur ; Cristina LÓPEZ-ANGUAS, Auteur ; María Dolores MESEGUER-ILLÁN, Auteur ; Pura BALLESTER-NAVARRO, Auteur Article en page(s) : p.1369-1380 Langues : Anglais (eng) Mots-clés : age  ambulatory circadian monitoring  autism spectrum disorder  intellectual disability  sleep problems Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep problems among individuals with autism spectrum disorder (ASD) are a persistent issue that spans from early childhood to adulthood. The present study aimed to objectively investigate sleep continuity and alignment using ambulatory circadian monitoring (ACM) in a group of autistic individuals, with and without intellectual disabilities. We studied 214 participants. Sleep continuity and alignment were assessed using a minimum of 3?days of ACM. Participants were divided into four groups: (1) age? En ligne : https://doi.org/10.1002/aur.70058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Sleep-Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions [Texte imprimé et/ou numérique] / Ana María GARCÍA-MUÑOZ, Auteur ; María Luisa Sánchez DE OCAÑA-MORENO, Auteur ; Amanda L. RICHDALE, Auteur ; Laura GISBERT-GUSTEMPS, Auteur ; Jorge LUGO-MARÍN, Auteur ; Beatriz RODRÍGUEZ-MORILLAS, Auteur ; Ana María PEIRÓ-PEIRÓ, Auteur ; Desirée VICTORIA-MONTESINOS, Auteur ; Cristina LÓPEZ-ANGUAS, Auteur ; María Dolores MESEGUER-ILLÁN, Auteur ; Pura BALLESTER-NAVARRO, Auteur . - p.1369-1380. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1369-1380 Mots-clés : age  ambulatory circadian monitoring  autism spectrum disorder  intellectual disability  sleep problems Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep problems among individuals with autism spectrum disorder (ASD) are a persistent issue that spans from early childhood to adulthood. The present study aimed to objectively investigate sleep continuity and alignment using ambulatory circadian monitoring (ACM) in a group of autistic individuals, with and without intellectual disabilities. We studied 214 participants. Sleep continuity and alignment were assessed using a minimum of 3?days of ACM. Participants were divided into four groups: (1) age? En ligne : https://doi.org/10.1002/aur.70058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

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