All-cause mortality and suicide mortality in autistic individuals: An entire population longitudinal study in Taiwan / Shih-Jen TSAI in Autism, 27-8 (November 2023)  

Public ISBD [article]  inAutism > 27-8 (November 2023) . - p.2496-2506 Titre : All-cause mortality and suicide mortality in autistic individuals: An entire population longitudinal study in Taiwan Type de document : texte imprimé Auteurs : Shih-Jen TSAI, Auteur ; Wen-Han CHANG, Auteur ; Chih-Ming CHENG, Auteur ; Chih-Sung LIANG, Auteur ; Ya-Mei BAI, Auteur ; Ju-Wei HSU, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : p.2496-2506 Mots-clés : autism  mortality  suicide  Taiwan Index. décimale : PER Périodiques Résumé : Evidence suggests increased mortality rates among autistic individuals. However, risks of mortality, including natural-cause, suicide, and accident mortalities, among autistic individuals remain unclear. Among the entire Taiwanese population (N 29,253,529), between 2003 and 2017, 45,398 autistic individuals were identified and 1:4 matched to 181,592 non-autistic individuals based on birth year and sex. All-cause mortality, including natural-cause, accident, and suicide mortalities, was assessed from 2003 to 2017 between the two cohorts. Cox regression models were used to investigate the mortality risk between autistic and non-autistic individuals. Autistic individuals had increased likelihoods (hazard ratio, 95% confidence interval) of all-cause mortality (3.43, 3.00-3.92), natural-cause mortality (4.73, 3.99-5.60), and suicide mortality (3.67, 2.37-5.68) compared with non-autistic individuals. In particular, autistic males were more likely to die by suicide (hazard ratio: 3.81, 95% confidence interval: 2.37-6.13), and autistic females were more likely to die of accident (hazard ratio: 5.07, 95% confidence interval: 2.54-10.13) compared with non-autistic individuals. Appropriate and effective medical and mental health care is recommended for autistic individuals.Lay abstractOur study was the first population-based study in an Asian country to investigate the mortality rates among autistic individuals. Among the entire Taiwanese population (N 29,253,529), between 2003 and 2017, 45,398 autistic individuals were identified and 1:4 age-/sex-matched to 181,592 non-autistic individuals. We found that autistic individuals had increased risks of all-cause mortality, natural-cause mortality, and suicide mortality compared with non-autistic individuals. Furthermore, autistic males were more likely to die by suicide, and autistic females were more likely to die of accident compared with the non-autistic individuals. En ligne : http://dx.doi.org/10.1177/13623613231167287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] All-cause mortality and suicide mortality in autistic individuals: An entire population longitudinal study in Taiwan [texte imprimé] / Shih-Jen TSAI, Auteur ; Wen-Han CHANG, Auteur ; Chih-Ming CHENG, Auteur ; Chih-Sung LIANG, Auteur ; Ya-Mei BAI, Auteur ; Ju-Wei HSU, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - p.2496-2506. in Autism > 27-8 (November 2023) . - p.2496-2506 Mots-clés : autism  mortality  suicide  Taiwan Index. décimale : PER Périodiques Résumé : Evidence suggests increased mortality rates among autistic individuals. However, risks of mortality, including natural-cause, suicide, and accident mortalities, among autistic individuals remain unclear. Among the entire Taiwanese population (N 29,253,529), between 2003 and 2017, 45,398 autistic individuals were identified and 1:4 matched to 181,592 non-autistic individuals based on birth year and sex. All-cause mortality, including natural-cause, accident, and suicide mortalities, was assessed from 2003 to 2017 between the two cohorts. Cox regression models were used to investigate the mortality risk between autistic and non-autistic individuals. Autistic individuals had increased likelihoods (hazard ratio, 95% confidence interval) of all-cause mortality (3.43, 3.00-3.92), natural-cause mortality (4.73, 3.99-5.60), and suicide mortality (3.67, 2.37-5.68) compared with non-autistic individuals. In particular, autistic males were more likely to die by suicide (hazard ratio: 3.81, 95% confidence interval: 2.37-6.13), and autistic females were more likely to die of accident (hazard ratio: 5.07, 95% confidence interval: 2.54-10.13) compared with non-autistic individuals. Appropriate and effective medical and mental health care is recommended for autistic individuals.Lay abstractOur study was the first population-based study in an Asian country to investigate the mortality rates among autistic individuals. Among the entire Taiwanese population (N 29,253,529), between 2003 and 2017, 45,398 autistic individuals were identified and 1:4 age-/sex-matched to 181,592 non-autistic individuals. We found that autistic individuals had increased risks of all-cause mortality, natural-cause mortality, and suicide mortality compared with non-autistic individuals. Furthermore, autistic males were more likely to die by suicide, and autistic females were more likely to die of accident compared with the non-autistic individuals. En ligne : http://dx.doi.org/10.1177/13623613231167287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study / Yu TUAN in Journal of Autism and Developmental Disorders, 55-12 (December 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-12 (December 2025) . - p.4304-4311 Titre : Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study Type de document : texte imprimé Auteurs : Yu TUAN, Auteur ; Li-Chi CHEN, Auteur ; I. Chun CHEN, Auteur ; Shih-Jen TSAI, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : p.4304-4311 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The mean diagnosis age of autism was about 5 years in Taiwan. Whether the delayed diagnosis of autism (≥ 6 years) was associated with parental severe mental disorders remained unknown. The parents of 22,859 autistic individuals and 228,590 age- and sex-matched nonautistic individuals were assessed for the presence of severe mental disorders (schizophrenia, bipolar disorder, major depressive disorder, alcohol use disorder, and substance use disorder). The timing of autism diagnosis was classified into three age categories: < 6 years, 6-11 years, and ≥ 12 years. Logistic regression models were used to examine associations between parental severe mental disorders and these age categories of autism diagnosis. Parental schizophrenia and substance use disorders were associated with the delayed diagnosis of autism, both diagnosis at ≥ 12 years (odds ratio [OR]: 2.14; 1.57) and at 6-11 years (1.87; 1.38). Parental bipolar disorder and major depressive disorder were also associated with the delayed diagnosis of autism, especially diagnosis at 6-11 years (OR 1.98; 1.86). Our findings underscore the need for clinicians to monitor the neurodevelopmental conditions of offspring born to parents with severe mental disorders during the early stages of their life. En ligne : https://doi.org/10.1007/s10803-024-06518-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study [texte imprimé] / Yu TUAN, Auteur ; Li-Chi CHEN, Auteur ; I. Chun CHEN, Auteur ; Shih-Jen TSAI, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - p.4304-4311. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-12 (December 2025) . - p.4304-4311 Index. décimale : PER Périodiques Résumé : The mean diagnosis age of autism was about 5 years in Taiwan. Whether the delayed diagnosis of autism (≥ 6 years) was associated with parental severe mental disorders remained unknown. The parents of 22,859 autistic individuals and 228,590 age- and sex-matched nonautistic individuals were assessed for the presence of severe mental disorders (schizophrenia, bipolar disorder, major depressive disorder, alcohol use disorder, and substance use disorder). The timing of autism diagnosis was classified into three age categories: < 6 years, 6-11 years, and ≥ 12 years. Logistic regression models were used to examine associations between parental severe mental disorders and these age categories of autism diagnosis. Parental schizophrenia and substance use disorders were associated with the delayed diagnosis of autism, both diagnosis at ≥ 12 years (odds ratio [OR]: 2.14; 1.57) and at 6-11 years (1.87; 1.38). Parental bipolar disorder and major depressive disorder were also associated with the delayed diagnosis of autism, especially diagnosis at 6-11 years (OR 1.98; 1.86). Our findings underscore the need for clinicians to monitor the neurodevelopmental conditions of offspring born to parents with severe mental disorders during the early stages of their life. En ligne : https://doi.org/10.1007/s10803-024-06518-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study / Ju-Wei HSU in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2192-2199 Titre : Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study Type de document : texte imprimé Auteurs : Ju-Wei HSU, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : p.2192-2199 Langues : Anglais (eng) Mots-clés : Child  Adolescent  Humans  Autism Spectrum Disorder/drug therapy  Longitudinal Studies  Analgesics, Opioid/adverse effects  Chronic Pain/complications/drug therapy  Prescriptions  autism  medical conditions  mental disorders  prescription opioids Index. décimale : PER Périodiques Résumé : Whether children and adolescents with autism spectrum disorder (ASD) are more likely to be exposed to prescription opioids than others remains unknown. The Taiwan National Health Insurance Research Database was employed, and 14,849 children and adolescents with ASD and 148,490 age- and sex-matched non-ASD controls were enrolled between 2001 and 2009 and followed up till the end of 2011. Those exposed to prescription opioids during the follow-up period were identified. Patients with ASD were more likely to be exposed to prescription opioids (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 4.50-5.45), including intravenous or intramuscular opioids (HR: 5.80, 95% CI: 5.23-6.43) and oral or transcutaneous opioids (HR: 2.32, 95% CI: 1.87-2.89), than were non-ASD controls. Furthermore, the ASD cohort had the increased likelihood of cumulative exposure of>14 days (HR: 6.19, 95% CI: 4.91-7.79) and>30 days (HR: 7.17, 95% CI: 5.19-9.90) to prescription opioids compared with the control cohort. ASD was a risk factor for exposure to prescription opioids. Close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. We found that patients with ASD were more likely to be exposed to prescription opioids, including intravenous or intramuscular opioids and oral or transcutaneous opioids, than were non-ASD controls. We suggest that close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. En ligne : http://dx.doi.org/10.1002/aur.2806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study [texte imprimé] / Ju-Wei HSU, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - p.2192-2199. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2192-2199 Mots-clés : Child  Adolescent  Humans  Autism Spectrum Disorder/drug therapy  Longitudinal Studies  Analgesics, Opioid/adverse effects  Chronic Pain/complications/drug therapy  Prescriptions  autism  medical conditions  mental disorders  prescription opioids Index. décimale : PER Périodiques Résumé : Whether children and adolescents with autism spectrum disorder (ASD) are more likely to be exposed to prescription opioids than others remains unknown. The Taiwan National Health Insurance Research Database was employed, and 14,849 children and adolescents with ASD and 148,490 age- and sex-matched non-ASD controls were enrolled between 2001 and 2009 and followed up till the end of 2011. Those exposed to prescription opioids during the follow-up period were identified. Patients with ASD were more likely to be exposed to prescription opioids (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 4.50-5.45), including intravenous or intramuscular opioids (HR: 5.80, 95% CI: 5.23-6.43) and oral or transcutaneous opioids (HR: 2.32, 95% CI: 1.87-2.89), than were non-ASD controls. Furthermore, the ASD cohort had the increased likelihood of cumulative exposure of>14 days (HR: 6.19, 95% CI: 4.91-7.79) and>30 days (HR: 7.17, 95% CI: 5.19-9.90) to prescription opioids compared with the control cohort. ASD was a risk factor for exposure to prescription opioids. Close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. We found that patients with ASD were more likely to be exposed to prescription opioids, including intravenous or intramuscular opioids and oral or transcutaneous opioids, than were non-ASD controls. We suggest that close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. En ligne : http://dx.doi.org/10.1002/aur.2806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Risk of migraine development among children and adolescents with autism spectrum disorder: A nationwide longitudinal study / Ting-Yi LEE in Research in Autism Spectrum Disorders, 89 (November 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 89 (November 2021) . - 101880 Titre : Risk of migraine development among children and adolescents with autism spectrum disorder: A nationwide longitudinal study Type de document : texte imprimé Auteurs : Ting-Yi LEE, Auteur ; Shih-Jen TSAI, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : 101880 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Migraine  Comorbidity Index. décimale : PER Périodiques Résumé : Objective Studies have suggested that impaired sensory processing is a shared characteristic of autism spectrum disorder (ASD) and migraine. However, the association between ASD and migraine remains unclear. Methods We examined 18,035 children and adolescents with ASD and 18,035 age- and sex-matched controls whose data were recorded in the Taiwan National Health Insurance Research Database between 2001 and 2011. We monitored the individuals until the end of 2011 and identified those who developed migraine during the follow-up period. Results After adjustment for medical and psychiatric comorbidities, children and adolescents with ASD had a significantly higher risk of developing migraine than did those without ASD (hazard ratio [HR]: 2.71, 95 % confidence interval [CI]: 1.63–4.51). Sensitivity analysis after the exclusion of the first year of the observation period (HR: 2.31, 95 % CI: 1.38–3.89) or medical and psychiatric comorbidities (HR: 2.38, 95 % CI: 1.11–5.15) revealed comparable between-group results. Conclusions Children and adolescents with ASD were more likely to develop migraine later in life compared with those without ASD. ASD is an independent risk factor for migraine, regardless of the psychiatric and medical comorbidities involved. Research on the mechanisms underlying the association between ASD and migraine is warranted. En ligne : https://doi.org/10.1016/j.rasd.2021.101880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Risk of migraine development among children and adolescents with autism spectrum disorder: A nationwide longitudinal study [texte imprimé] / Ting-Yi LEE, Auteur ; Shih-Jen TSAI, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - 101880. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 89 (November 2021) . - 101880 Mots-clés : Autism spectrum disorder  Migraine  Comorbidity Index. décimale : PER Périodiques Résumé : Objective Studies have suggested that impaired sensory processing is a shared characteristic of autism spectrum disorder (ASD) and migraine. However, the association between ASD and migraine remains unclear. Methods We examined 18,035 children and adolescents with ASD and 18,035 age- and sex-matched controls whose data were recorded in the Taiwan National Health Insurance Research Database between 2001 and 2011. We monitored the individuals until the end of 2011 and identified those who developed migraine during the follow-up period. Results After adjustment for medical and psychiatric comorbidities, children and adolescents with ASD had a significantly higher risk of developing migraine than did those without ASD (hazard ratio [HR]: 2.71, 95 % confidence interval [CI]: 1.63–4.51). Sensitivity analysis after the exclusion of the first year of the observation period (HR: 2.31, 95 % CI: 1.38–3.89) or medical and psychiatric comorbidities (HR: 2.38, 95 % CI: 1.11–5.15) revealed comparable between-group results. Conclusions Children and adolescents with ASD were more likely to develop migraine later in life compared with those without ASD. ASD is an independent risk factor for migraine, regardless of the psychiatric and medical comorbidities involved. Research on the mechanisms underlying the association between ASD and migraine is warranted. En ligne : https://doi.org/10.1016/j.rasd.2021.101880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study / Yu-Han LIN in Journal of Autism and Developmental Disorders, 55-11 (November 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-11 (November 2025) . - p.4009-4017 Titre : Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study Type de document : texte imprimé Auteurs : Yu-Han LIN, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : p.4009-4017 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies have reported inconsistent results regarding associations between parental depression and offspring neurodevelopmental disorders, such as developmental delay and autism spectrum disorder (ASD). In all, 7,593 children who were born between 1996 and 2010 in Taiwan and had at least one parent with major depressive disorder and 75,930 birth-year- and sex-matched children of parents without major depressive disorder were followed from 1996 or time of birth to the end of 2011. Intergroup differences in neurodevelopmental conditions—including ASD, attention-deficit hyperactivity disorder (ADHD), tic disorder, developmental delay, and intellectual disability (ID)—were assessed. Compared with the children in the control group, the children of parents with major depression were more likely [hazard ratio (HR), 95% confidence interval (CI)] to develop ADHD (1.98, 1.80–2.18), ASD (1.52, 1.16–1.94), tic disorder (1.40, 1.08–1.81), developmental delay (1.32, 1.20–1.45), and ID (1.26, 1.02–1.55). Parental depression was associated with offspring neurodevelopmental disorders, specifically ASD, ADHD, developmental delay, ID, and tic disorder. Therefore, clinicians should closely monitor the neurodevelopmental conditions of children of parents with depression. En ligne : https://doi.org/10.1007/s10803-024-06502-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study [texte imprimé] / Yu-Han LIN, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - p.4009-4017. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-11 (November 2025) . - p.4009-4017 Index. décimale : PER Périodiques Résumé : Studies have reported inconsistent results regarding associations between parental depression and offspring neurodevelopmental disorders, such as developmental delay and autism spectrum disorder (ASD). In all, 7,593 children who were born between 1996 and 2010 in Taiwan and had at least one parent with major depressive disorder and 75,930 birth-year- and sex-matched children of parents without major depressive disorder were followed from 1996 or time of birth to the end of 2011. Intergroup differences in neurodevelopmental conditions—including ASD, attention-deficit hyperactivity disorder (ADHD), tic disorder, developmental delay, and intellectual disability (ID)—were assessed. Compared with the children in the control group, the children of parents with major depression were more likely [hazard ratio (HR), 95% confidence interval (CI)] to develop ADHD (1.98, 1.80–2.18), ASD (1.52, 1.16–1.94), tic disorder (1.40, 1.08–1.81), developmental delay (1.32, 1.20–1.45), and ID (1.26, 1.02–1.55). Parental depression was associated with offspring neurodevelopmental disorders, specifically ASD, ADHD, developmental delay, ID, and tic disorder. Therefore, clinicians should closely monitor the neurodevelopmental conditions of children of parents with depression. En ligne : https://doi.org/10.1007/s10803-024-06502-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Sexually Transmitted Infection Among Adolescents and Young Adults with Autism Spectrum Disorder: A Nationwide Longitudinal Study / Juo-Chi LI in Journal of Autism and Developmental Disorders, 53-11 (November 2023)  

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Timing of the Diagnoses of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder in Taiwan / Han-Ting WEI in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

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