Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium / Lisa KURTH in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium Type de document : texte imprimé Auteurs : Lisa KURTH, Auteur ; T. Michael O'SHEA, Auteur ; Irina BURD, Auteur ; Anne L. DUNLOP, Auteur ; Lisa CROEN, Auteur ; Greta WILKENING, Auteur ; Ting-Ju HSU, Auteur ; Stephan EHRHARDT, Auteur ; Arvind PALANISAMY, Auteur ; Monica MCGRATH, Auteur ; Marie L. CHURCHILL, Auteur ; Daniel WEINBERGER, Auteur ; Marco GRADOS, Auteur ; Dana DABELEA, Auteur Langues : Anglais (eng) Mots-clés : Humans  Female  Pregnancy  Oxytocin  Male  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Child  Body Mass Index  Autism Spectrum Disorder/epidemiology/etiology  Prenatal Exposure Delayed Effects  Adult  Pregnancy in Obesity/epidemiology  Child, Preschool  Cohort Studies  Obesity/epidemiology  Adhd  Asd  Autism  Bmi  Neurodevelopment  Obesity  Synthetic oxytocin Index. décimale : PER Périodiques Résumé : BACKGROUND: Synthetic oxytocin (sOT) is frequently administered during parturition. Studies have raised concerns that fetal exposure to sOT may be associated with altered brain development and risk of neurodevelopmental disorders. In a large and diverse sample of children with data about intrapartum sOT exposure and subsequent diagnoses of two prevalent neurodevelopmental disorders, i.e., attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), we tested the following hypotheses: (1) Intrapartum sOT exposure is associated with increased odds of child ADHD or ASD; (2) associations differ across sex; (3) associations between intrapartum sOT exposure and ADHD or ASD are accentuated in offspring of mothers with pre-pregnancy obesity. METHODS: The study sample comprised 12,503 participants from 44 cohort sites included in the Environmental Influences on Child Health Outcomes (ECHO) consortium. Mixed-effects logistic regression analyses were used to estimate the association between intrapartum sOT exposure and offspring ADHD or ASD (in separate models). Maternal obesity (pre-pregnancy BMI ≥ 30 kg/m(2)) and child sex were evaluated for effect modification. RESULTS: Intrapartum sOT exposure was present in 48% of participants. sOT exposure was not associated with increased odds of ASD (adjusted odds ratio [aOR] 0.86; 95% confidence interval [CI], 0.71-1.03) or ADHD (aOR 0.89; 95% CI, 0.76-1.04). Associations did not differ by child sex. Among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of offspring ADHD (aOR 0.72; 95% CI, 0.55-0.96). No association was found among mothers without obesity (aOR 0.97; 95% CI, 0.80-1.18). CONCLUSIONS: In a large, diverse sample, we found no evidence of an association between intrapartum exposure to sOT and odds of ADHD or ASD in either male or female offspring. Contrary to our hypothesis, among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of child ADHD diagnosis. En ligne : https://dx.doi.org/10.1186/s11689-024-09540-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium [texte imprimé] / Lisa KURTH, Auteur ; T. Michael O'SHEA, Auteur ; Irina BURD, Auteur ; Anne L. DUNLOP, Auteur ; Lisa CROEN, Auteur ; Greta WILKENING, Auteur ; Ting-Ju HSU, Auteur ; Stephan EHRHARDT, Auteur ; Arvind PALANISAMY, Auteur ; Monica MCGRATH, Auteur ; Marie L. CHURCHILL, Auteur ; Daniel WEINBERGER, Auteur ; Marco GRADOS, Auteur ; Dana DABELEA, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Female  Pregnancy  Oxytocin  Male  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Child  Body Mass Index  Autism Spectrum Disorder/epidemiology/etiology  Prenatal Exposure Delayed Effects  Adult  Pregnancy in Obesity/epidemiology  Child, Preschool  Cohort Studies  Obesity/epidemiology  Adhd  Asd  Autism  Bmi  Neurodevelopment  Obesity  Synthetic oxytocin Index. décimale : PER Périodiques Résumé : BACKGROUND: Synthetic oxytocin (sOT) is frequently administered during parturition. Studies have raised concerns that fetal exposure to sOT may be associated with altered brain development and risk of neurodevelopmental disorders. In a large and diverse sample of children with data about intrapartum sOT exposure and subsequent diagnoses of two prevalent neurodevelopmental disorders, i.e., attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), we tested the following hypotheses: (1) Intrapartum sOT exposure is associated with increased odds of child ADHD or ASD; (2) associations differ across sex; (3) associations between intrapartum sOT exposure and ADHD or ASD are accentuated in offspring of mothers with pre-pregnancy obesity. METHODS: The study sample comprised 12,503 participants from 44 cohort sites included in the Environmental Influences on Child Health Outcomes (ECHO) consortium. Mixed-effects logistic regression analyses were used to estimate the association between intrapartum sOT exposure and offspring ADHD or ASD (in separate models). Maternal obesity (pre-pregnancy BMI ≥ 30 kg/m(2)) and child sex were evaluated for effect modification. RESULTS: Intrapartum sOT exposure was present in 48% of participants. sOT exposure was not associated with increased odds of ASD (adjusted odds ratio [aOR] 0.86; 95% confidence interval [CI], 0.71-1.03) or ADHD (aOR 0.89; 95% CI, 0.76-1.04). Associations did not differ by child sex. Among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of offspring ADHD (aOR 0.72; 95% CI, 0.55-0.96). No association was found among mothers without obesity (aOR 0.97; 95% CI, 0.80-1.18). CONCLUSIONS: In a large, diverse sample, we found no evidence of an association between intrapartum exposure to sOT and odds of ADHD or ASD in either male or female offspring. Contrary to our hypothesis, among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of child ADHD diagnosis. En ligne : https://dx.doi.org/10.1186/s11689-024-09540-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Repetitive and Self-injurious Behaviors in Children with Cornelia de Lange Syndrome / Siddharth SRIVASTAVA in Journal of Autism and Developmental Disorders, 51-5 (May 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-5 (May 2021) . - p.1748-1758 Titre : Repetitive and Self-injurious Behaviors in Children with Cornelia de Lange Syndrome Type de document : texte imprimé Auteurs : Siddharth SRIVASTAVA, Auteur ; Bennett CLARK, Auteur ; Colleen LANDY-SCHMITT, Auteur ; Elizabeth A. OFFERMANN, Auteur ; Antonie D. KLINE, Auteur ; Samuel T. WILKINSON, Auteur ; Marco A. GRADOS, Auteur Article en page(s) : p.1748-1758 Langues : Anglais (eng) Mots-clés : Cornelia de Lange syndrome  Repetitive behaviors  Self-injurious behaviors  Stereotypies Index. décimale : PER Périodiques Résumé : Cornelia de Lange syndrome (CdLS) is associated with repetitive and self-injurious behaviors (RBs, SIB). Evaluating children with CdLS, this study: (1) characterizes the spectrum of RBs; (2) characterizes the impact and severity of RBs including SIB; (3) describes how age and adaptive functioning relate to RBs including SIB. Fifty children (5-17 years) with CdLS were assessed with Children's Yale-Brown Obsessive Compulsive Scale Modified for PDD; Aberrant Behavior Checklist (ABC); Vineland Adaptive Behaviors Scales (VABS). All children had ≥ 1 type of RB; 44% had some form of SIB. 64% spent > 1 h/day displaying RBs. Lower VABS adaptive functioning was associated with higher stereotypy and SIB scores (ABC). In children with CdLS, RBs including SIB are common, impactful, and associated with lower adaptive functioning. En ligne : http://dx.doi.org/10.1007/s10803-020-04617-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Repetitive and Self-injurious Behaviors in Children with Cornelia de Lange Syndrome [texte imprimé] / Siddharth SRIVASTAVA, Auteur ; Bennett CLARK, Auteur ; Colleen LANDY-SCHMITT, Auteur ; Elizabeth A. OFFERMANN, Auteur ; Antonie D. KLINE, Auteur ; Samuel T. WILKINSON, Auteur ; Marco A. GRADOS, Auteur . - p.1748-1758. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-5 (May 2021) . - p.1748-1758 Mots-clés : Cornelia de Lange syndrome  Repetitive behaviors  Self-injurious behaviors  Stereotypies Index. décimale : PER Périodiques Résumé : Cornelia de Lange syndrome (CdLS) is associated with repetitive and self-injurious behaviors (RBs, SIB). Evaluating children with CdLS, this study: (1) characterizes the spectrum of RBs; (2) characterizes the impact and severity of RBs including SIB; (3) describes how age and adaptive functioning relate to RBs including SIB. Fifty children (5-17 years) with CdLS were assessed with Children's Yale-Brown Obsessive Compulsive Scale Modified for PDD; Aberrant Behavior Checklist (ABC); Vineland Adaptive Behaviors Scales (VABS). All children had ≥ 1 type of RB; 44% had some form of SIB. 64% spent > 1 h/day displaying RBs. Lower VABS adaptive functioning was associated with higher stereotypy and SIB scores (ABC). In children with CdLS, RBs including SIB are common, impactful, and associated with lower adaptive functioning. En ligne : http://dx.doi.org/10.1007/s10803-020-04617-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Sleep Problems and Their Relationship to Maladaptive Behavior Severity in Psychiatrically Hospitalized Children with Autism Spectrum Disorder (ASD) / Elise M. SANNAR in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3720-3726 Titre : Sleep Problems and Their Relationship to Maladaptive Behavior Severity in Psychiatrically Hospitalized Children with Autism Spectrum Disorder (ASD) Type de document : texte imprimé Auteurs : Elise M. SANNAR, Auteur ; Tamara PALKA, Auteur ; Carol BERESFORD, Auteur ; Christine PEURA, Auteur ; Desmond KAPLAN, Auteur ; Mary VERDI, Auteur ; Matthew SIEGEL, Auteur ; Shir KAPLAN, Auteur ; Marco GRADOS, Auteur Article en page(s) : p.3720-3726 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Behavior problems  Children and adolescents  Sleep Index. décimale : PER Périodiques Résumé : We examined the relationship between sleep duration and awakenings to Aberrant Behavior Checklist-Community (ABC-C) and Autism Diagnostic Observation Schedule (ADOS-2) scores in hospitalized youth with ASD and behavioral disturbance. Participants included 106 patients with a stay of at least 10 nights. Sleep in the hospital was recorded by staff observation. Higher scores on the ABC-C (irritability, stereotypy, and hyperactivity subscales) at admission were significantly associated with fewer minutes slept during the last five nights of hospitalization. There was no association between total awakenings and ABC-C scores or ADOS-2 comparison scores. Improved understanding of the relationship between sleep quality and maladaptive behavior in this challenging cohort of patients with ASD is vital to the definition and design of future effective interventions. En ligne : http://dx.doi.org/10.1007/s10803-017-3362-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Sleep Problems and Their Relationship to Maladaptive Behavior Severity in Psychiatrically Hospitalized Children with Autism Spectrum Disorder (ASD) [texte imprimé] / Elise M. SANNAR, Auteur ; Tamara PALKA, Auteur ; Carol BERESFORD, Auteur ; Christine PEURA, Auteur ; Desmond KAPLAN, Auteur ; Mary VERDI, Auteur ; Matthew SIEGEL, Auteur ; Shir KAPLAN, Auteur ; Marco GRADOS, Auteur . - p.3720-3726. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3720-3726 Mots-clés : Autism spectrum disorder  Behavior problems  Children and adolescents  Sleep Index. décimale : PER Périodiques Résumé : We examined the relationship between sleep duration and awakenings to Aberrant Behavior Checklist-Community (ABC-C) and Autism Diagnostic Observation Schedule (ADOS-2) scores in hospitalized youth with ASD and behavioral disturbance. Participants included 106 patients with a stay of at least 10 nights. Sleep in the hospital was recorded by staff observation. Higher scores on the ABC-C (irritability, stereotypy, and hyperactivity subscales) at admission were significantly associated with fewer minutes slept during the last five nights of hospitalization. There was no association between total awakenings and ABC-C scores or ADOS-2 comparison scores. Improved understanding of the relationship between sleep quality and maladaptive behavior in this challenging cohort of patients with ASD is vital to the definition and design of future effective interventions. En ligne : http://dx.doi.org/10.1007/s10803-017-3362-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

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