Annual Research Review: Prevention of psychosis in adolescents - systematic review and meta-analysis of advances in detection, prognosis and intervention / Ana CATALAN in Journal of Child Psychology and Psychiatry, 62-5 (May 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.657-673 Titre : Annual Research Review: Prevention of psychosis in adolescents - systematic review and meta-analysis of advances in detection, prognosis and intervention Type de document : texte imprimé Auteurs : Ana CATALAN, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Julio VAQUERIZO SERRANO, Auteur ; Pierluca MOSILLO, Auteur ; Helen BALDWIN, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Carmen MORENO, Auteur ; Celso ARANGO, Auteur ; Christoph U. CORRELL, Auteur ; Ilaria BONOLDI, Auteur ; Paolo FUSAR-POLI, Auteur Article en page(s) : p.657-673 Langues : Anglais (eng) Mots-clés : Psychosis  adolescence  childhood  clinical high-risk state for psychosis  evidence  first-episode  meta-analysis  prediction  prevention  psychosis risk  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less established. METHODS: We performed a PRISMA/MOOSE-compliant systematic review of the Web of Science database, from inception until 7 October 2019, to identify original studies conducted in CHR-P children and adolescents (mean age <18 years). Findings were systematically appraised around core themes: detection, prognosis and intervention. We performed meta-analyses (employing Q statistics and I (2) test) regarding the proportion of CHR-P subgroups, the prevalence of baseline comorbid mental disorders, the risk of psychosis onset and the type of interventions received at baseline. Quality assessment and publication bias were also analysed. RESULTS: Eighty-seven articles were included (n = 4,667 CHR-P individuals). Quality of studies ranged from 3.5 to 8 (median 5.5) on a modified Newcastle-Ottawa scale. Detection: Individuals were aged 15.6 ± 1.2 years (51.5% males), mostly (83%) presenting with attenuated positive psychotic symptoms. CHR-P psychometric accuracy improved when caregivers served as additional informants. Comorbid mood (46.4%) and anxiety (31.4%) disorders were highly prevalent. Functioning and cognition were impaired. Neurobiological studies were inconclusive. PROGNOSIS: Risk for psychosis was 10.4% (95%CI: 5.8%-18.1%) at 6 months, 20% (95%CI: 15%-26%) at 12 months, 23% (95%CI: 18%-29%) at 24 months and 23.3% (95%CI: 17.3%-30.7%) at ≥36 months. INTERVENTIONS: There was not enough evidence to recommend one specific treatment (including cognitive behavioural therapy) over the others (including control conditions) to prevent the transition to psychosis in this population. Randomised controlled trials suggested that family interventions, cognitive remediation and fish oil supplementation may improve cognition, symptoms and functioning. At baseline, 30% of CHR-P adolescents were prescribed antipsychotics and 60% received psychotherapy. CONCLUSIONS: It is possible to detect and formulate a group-level prognosis in adolescents at risk for psychosis. Future interventional research is required. En ligne : http://dx.doi.org/10.1111/jcpp.13322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Annual Research Review: Prevention of psychosis in adolescents - systematic review and meta-analysis of advances in detection, prognosis and intervention [texte imprimé] / Ana CATALAN, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Julio VAQUERIZO SERRANO, Auteur ; Pierluca MOSILLO, Auteur ; Helen BALDWIN, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Carmen MORENO, Auteur ; Celso ARANGO, Auteur ; Christoph U. CORRELL, Auteur ; Ilaria BONOLDI, Auteur ; Paolo FUSAR-POLI, Auteur . - p.657-673. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.657-673 Mots-clés : Psychosis  adolescence  childhood  clinical high-risk state for psychosis  evidence  first-episode  meta-analysis  prediction  prevention  psychosis risk  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less established. METHODS: We performed a PRISMA/MOOSE-compliant systematic review of the Web of Science database, from inception until 7 October 2019, to identify original studies conducted in CHR-P children and adolescents (mean age <18 years). Findings were systematically appraised around core themes: detection, prognosis and intervention. We performed meta-analyses (employing Q statistics and I (2) test) regarding the proportion of CHR-P subgroups, the prevalence of baseline comorbid mental disorders, the risk of psychosis onset and the type of interventions received at baseline. Quality assessment and publication bias were also analysed. RESULTS: Eighty-seven articles were included (n = 4,667 CHR-P individuals). Quality of studies ranged from 3.5 to 8 (median 5.5) on a modified Newcastle-Ottawa scale. Detection: Individuals were aged 15.6 ± 1.2 years (51.5% males), mostly (83%) presenting with attenuated positive psychotic symptoms. CHR-P psychometric accuracy improved when caregivers served as additional informants. Comorbid mood (46.4%) and anxiety (31.4%) disorders were highly prevalent. Functioning and cognition were impaired. Neurobiological studies were inconclusive. PROGNOSIS: Risk for psychosis was 10.4% (95%CI: 5.8%-18.1%) at 6 months, 20% (95%CI: 15%-26%) at 12 months, 23% (95%CI: 18%-29%) at 24 months and 23.3% (95%CI: 17.3%-30.7%) at ≥36 months. INTERVENTIONS: There was not enough evidence to recommend one specific treatment (including cognitive behavioural therapy) over the others (including control conditions) to prevent the transition to psychosis in this population. Randomised controlled trials suggested that family interventions, cognitive remediation and fish oil supplementation may improve cognition, symptoms and functioning. At baseline, 30% of CHR-P adolescents were prescribed antipsychotics and 60% received psychotherapy. CONCLUSIONS: It is possible to detect and formulate a group-level prognosis in adolescents at risk for psychosis. Future interventional research is required. En ligne : http://dx.doi.org/10.1111/jcpp.13322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis / Julio VAQUERIZO SERRANO in Journal of Autism and Developmental Disorders, 52-4 (April 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1568-1586 Titre : Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis Type de document : texte imprimé Auteurs : Julio VAQUERIZO SERRANO, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Jatinder SINGH, Auteur ; Paramala SANTOSH, Auteur Article en page(s) : p.1568-1586 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Child  Humans  Psychotic Disorders/diagnosis  Syndrome  Autism spectrum disorders  Clinical high-risk for psychosis  Meta-analysis  Prodromal psychosis  Psychosis  Systematic review Index. décimale : PER Périodiques Résumé : Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05046-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis [texte imprimé] / Julio VAQUERIZO SERRANO, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Jatinder SINGH, Auteur ; Paramala SANTOSH, Auteur . - p.1568-1586. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1568-1586 Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Child  Humans  Psychotic Disorders/diagnosis  Syndrome  Autism spectrum disorders  Clinical high-risk for psychosis  Meta-analysis  Prodromal psychosis  Psychosis  Systematic review Index. décimale : PER Périodiques Résumé : Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05046-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

The role of obstetric adversities in neurodevelopmental conditions: A sibling study / Sandra GÓMEZ-VALLEJO in Autism, 29-12 (December 2025)  

Public ISBD [article]  inAutism > 29-12 (December 2025) . - p.3072-3082 Titre : The role of obstetric adversities in neurodevelopmental conditions: A sibling study Type de document : texte imprimé Auteurs : Sandra GÓMEZ-VALLEJO, Auteur ; Oaia IRIONDO-BLANCO, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Rosa CALVO ESCALONA, Auteur ; Luisa LÁZARO GARCÍA, Auteur Article en page(s) : p.3072-3082 Langues : Anglais (eng) Mots-clés : attention-deficit/hyperactivity disorder  autism  neurodevelopmental conditions  obstetric complications  sibling studies Index. décimale : PER Périodiques Résumé : Neurodevelopmental conditions (NDC) are highly heritable. Obstetric complications (OC) have been studied as potential predictors for NDC, although results are inconsistent. Inconsistencies might be related to biases such as family confounders. While some studies using sibling and twin designs have examined the association between OC and NDC, this body of research remains limited, and findings to date remain inconsistent. We used a case-control sibling study including children aged 6-17 years across five groups: those diagnosed with autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), co-occurring ASD + ADHD, their unaffected siblings and a comparison group without NDC. For analytic purposes, we created a combined NDC group including all individuals with ASD, ADHD or both. Participants were recruited between 2021 and 2022 from a tertiary hospital in Spain. We examined the association of NDC and OC using single predictors and cumulative OC. The study adheres to the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) guidelines. A total of 238 participants were included (NDC = 117, unaffected siblings = 82, comparison group = 39). We found that NDC individuals showed more neonatal complications than the comparison group (β = 1.73, 95% CI = 1.00-2.98, p = 0.04), which remained significant in the sibling analysis (β = 1.43, 95% CI = 1.02-2.00, p = 0.04). This study supports that the cumulative neonatal complications, rather than specific factors, are associated with increased likelihood of being diagnosed with NDC, beyond familial confounding. Results highlight the neonatal period as a relevant window of vulnerability.Lay Abstract The role of complications during pregnancy in neurodevelopmental disorders: a sibling studyThis study examined the association between complications during pregnancy and autism, attention-deficit/hyperactivity disorder and the combination of both conditions. We compared children with these conditions and their siblings, as well as a group comparison without diagnosed neurodevelopmental disorders. We gathered information through parents' interviews. We found that children with autism or attention-deficit/hyperactivity disorder presented more problems in the first 4 weeks of the child’s life than their siblings and the group of comparison. We did not find that children with these conditions present more complications during pregnancy. In addition, we observed that the probability of being diagnosed with these conditions is increased due to cumulative problems rather than specific problems. En ligne : https://dx.doi.org/10.1177/13623613251359317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] The role of obstetric adversities in neurodevelopmental conditions: A sibling study [texte imprimé] / Sandra GÓMEZ-VALLEJO, Auteur ; Oaia IRIONDO-BLANCO, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Rosa CALVO ESCALONA, Auteur ; Luisa LÁZARO GARCÍA, Auteur . - p.3072-3082. Langues : Anglais (eng) in Autism > 29-12 (December 2025) . - p.3072-3082 Mots-clés : attention-deficit/hyperactivity disorder  autism  neurodevelopmental conditions  obstetric complications  sibling studies Index. décimale : PER Périodiques Résumé : Neurodevelopmental conditions (NDC) are highly heritable. Obstetric complications (OC) have been studied as potential predictors for NDC, although results are inconsistent. Inconsistencies might be related to biases such as family confounders. While some studies using sibling and twin designs have examined the association between OC and NDC, this body of research remains limited, and findings to date remain inconsistent. We used a case-control sibling study including children aged 6-17 years across five groups: those diagnosed with autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), co-occurring ASD + ADHD, their unaffected siblings and a comparison group without NDC. For analytic purposes, we created a combined NDC group including all individuals with ASD, ADHD or both. Participants were recruited between 2021 and 2022 from a tertiary hospital in Spain. We examined the association of NDC and OC using single predictors and cumulative OC. The study adheres to the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) guidelines. A total of 238 participants were included (NDC = 117, unaffected siblings = 82, comparison group = 39). We found that NDC individuals showed more neonatal complications than the comparison group (β = 1.73, 95% CI = 1.00-2.98, p = 0.04), which remained significant in the sibling analysis (β = 1.43, 95% CI = 1.02-2.00, p = 0.04). This study supports that the cumulative neonatal complications, rather than specific factors, are associated with increased likelihood of being diagnosed with NDC, beyond familial confounding. Results highlight the neonatal period as a relevant window of vulnerability.Lay Abstract The role of complications during pregnancy in neurodevelopmental disorders: a sibling studyThis study examined the association between complications during pregnancy and autism, attention-deficit/hyperactivity disorder and the combination of both conditions. We compared children with these conditions and their siblings, as well as a group comparison without diagnosed neurodevelopmental disorders. We gathered information through parents' interviews. We found that children with autism or attention-deficit/hyperactivity disorder presented more problems in the first 4 weeks of the child’s life than their siblings and the group of comparison. We did not find that children with these conditions present more complications during pregnancy. In addition, we observed that the probability of being diagnosed with these conditions is increased due to cumulative problems rather than specific problems. En ligne : https://dx.doi.org/10.1177/13623613251359317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

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