Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder / S. KITAMURA in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1886-1895 Titre : Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.1886-1895 Langues : Anglais (eng) Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder [Texte imprimé et/ou numérique] / S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur . - p.1886-1895. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1886-1895 Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder / T. YAMAUCHI in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2330-2341 Titre : Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. YAMAUCHI, Auteur ; M. MAKINODAN, Auteur ; M. TORITSUKA, Auteur ; K. OKUMURA, Auteur ; Y. KAYASHIMA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; M. TAKAHASHI, Auteur ; T. KOMORI, Auteur ; Y. YAMAGUCHI, Auteur ; R. TAKADA, Auteur ; K. YAMAMURO, Auteur ; S. KIMOTO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.2330-2341 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Cytokines  Humans  Macrophages  Monocytes  Tumor Necrosis Factor-alpha  Tnf-?  diagnosis  inflammation  macrophage  monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-? (TNF-?), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-? expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-? expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-? expression in M1 macrophages and the TNF-? expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-? expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-? expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-? expression in differentiated M1 macrophages and TNF-? expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-? expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / T. YAMAUCHI, Auteur ; M. MAKINODAN, Auteur ; M. TORITSUKA, Auteur ; K. OKUMURA, Auteur ; Y. KAYASHIMA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; M. TAKAHASHI, Auteur ; T. KOMORI, Auteur ; Y. YAMAGUCHI, Auteur ; R. TAKADA, Auteur ; K. YAMAMURO, Auteur ; S. KIMOTO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. KISHIMOTO, Auteur . - p.2330-2341. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2330-2341 Mots-clés : Adult  Autism Spectrum Disorder  Cytokines  Humans  Macrophages  Monocytes  Tumor Necrosis Factor-alpha  Tnf-?  diagnosis  inflammation  macrophage  monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-? (TNF-?), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-? expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-? expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-? expression in M1 macrophages and the TNF-? expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-? expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-? expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-? expression in differentiated M1 macrophages and TNF-? expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-? expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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