Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes / Blake A. GIMBEL in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes Type de document : texte imprimé Auteurs : Blake A. GIMBEL, Auteur ; Mary E. ANTHONY, Auteur ; Abigail M. ERNST, Auteur ; Donovan J. ROEDIGER, Auteur ; Erik DE WATER, Auteur ; Judith K. ECKERLE, Auteur ; Christopher J. BOYS, Auteur ; Joshua P. RADKE, Auteur ; Bryon A. MUELLER, Auteur ; Anita J. FUGLESTAD, Auteur ; Steven H. ZEISEL, Auteur ; Michael K. GEORGIEFF, Auteur ; Jeffrey R. WOZNIAK, Auteur Langues : Anglais (eng) Mots-clés : Child  Pregnancy  Female  Humans  Child, Preschool  Fetal Alcohol Spectrum Disorders/drug therapy  Choline/therapeutic use  Corpus Callosum/diagnostic imaging  Follow-Up Studies  White Matter/diagnostic imaging  Choline  Cognition  Diffusion MRI  Fetal alcohol spectrum disorders  Longitudinal studies  Neurite orientation dispersion and density imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal alcohol spectrum disorder (FASD) is a lifelong condition. Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age during childhood. We present a long-term follow-up study evaluating the neurodevelopmental effects of early choline supplementation in children with FASD approximately 7 years on average after an initial efficacy trial. METHODS: The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2.5 to 5 year olds with FASD. Participants in this long-term follow-up study include 18 children (9 placebo; 9 choline) seen 7 years on average following initial trial completion. The mean age at follow-up was 11.0 years old. Diagnoses were 28% fetal alcohol syndrome (FAS), 28% partial FAS, and 44% alcohol-related neurodevelopmental disorder. The follow-up included measures of executive functioning and an MRI scan. RESULTS: Children who received choline had better performance on several tasks of lower-order executive function (e.g., processing speed) and showed higher white matter microstructure organization (i.e., greater axon coherence) in the splenium of the corpus callosum compared to the placebo group. CONCLUSIONS: These preliminary findings, although exploratory at this stage, highlight potential long-term benefits of choline as a neurodevelopmental intervention for FASD and suggest that choline may affect white matter development, representing a potential target of choline in this population. TRIAL REGISTRATION: Prior to enrollment, this trial was registered with clinicaltrials.gov ( NCT01149538 ) on June 23, 2010. En ligne : https://dx.doi.org/10.1186/s11689-022-09470-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes [texte imprimé] / Blake A. GIMBEL, Auteur ; Mary E. ANTHONY, Auteur ; Abigail M. ERNST, Auteur ; Donovan J. ROEDIGER, Auteur ; Erik DE WATER, Auteur ; Judith K. ECKERLE, Auteur ; Christopher J. BOYS, Auteur ; Joshua P. RADKE, Auteur ; Bryon A. MUELLER, Auteur ; Anita J. FUGLESTAD, Auteur ; Steven H. ZEISEL, Auteur ; Michael K. GEORGIEFF, Auteur ; Jeffrey R. WOZNIAK, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Child  Pregnancy  Female  Humans  Child, Preschool  Fetal Alcohol Spectrum Disorders/drug therapy  Choline/therapeutic use  Corpus Callosum/diagnostic imaging  Follow-Up Studies  White Matter/diagnostic imaging  Choline  Cognition  Diffusion MRI  Fetal alcohol spectrum disorders  Longitudinal studies  Neurite orientation dispersion and density imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal alcohol spectrum disorder (FASD) is a lifelong condition. Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age during childhood. We present a long-term follow-up study evaluating the neurodevelopmental effects of early choline supplementation in children with FASD approximately 7 years on average after an initial efficacy trial. METHODS: The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2.5 to 5 year olds with FASD. Participants in this long-term follow-up study include 18 children (9 placebo; 9 choline) seen 7 years on average following initial trial completion. The mean age at follow-up was 11.0 years old. Diagnoses were 28% fetal alcohol syndrome (FAS), 28% partial FAS, and 44% alcohol-related neurodevelopmental disorder. The follow-up included measures of executive functioning and an MRI scan. RESULTS: Children who received choline had better performance on several tasks of lower-order executive function (e.g., processing speed) and showed higher white matter microstructure organization (i.e., greater axon coherence) in the splenium of the corpus callosum compared to the placebo group. CONCLUSIONS: These preliminary findings, although exploratory at this stage, highlight potential long-term benefits of choline as a neurodevelopmental intervention for FASD and suggest that choline may affect white matter development, representing a potential target of choline in this population. TRIAL REGISTRATION: Prior to enrollment, this trial was registered with clinicaltrials.gov ( NCT01149538 ) on June 23, 2010. En ligne : https://dx.doi.org/10.1186/s11689-022-09470-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury / Zeynep BAÅžGÖZE in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Titre : Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury Type de document : texte imprimé Auteurs : Zeynep BAÅžGÖZE, Auteur ; Salahudeen MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur Article en page(s) : p.1774-1792 Langues : Anglais (eng) Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury [texte imprimé] / Zeynep BAÅžGÖZE, Auteur ; Salahudeen MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur . - p.1774-1792. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure / Blake A. GIMBEL in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure Type de document : texte imprimé Auteurs : Blake A. GIMBEL, Auteur ; Jeffrey R. WOZNIAK, Auteur ; Bryon A. MUELLER, Auteur ; Kent A. TUOMINEN, Auteur ; Abigail M. ERNST, Auteur ; Mary E. ANTHONY, Auteur ; Erik DE WATER, Auteur ; CIFASD, Auteur ; Donovan J. ROEDIGER, Auteur Langues : Anglais (eng) Mots-clés : Humans  Hippocampus/diagnostic imaging/pathology/abnormalities  Female  Child  Adolescent  Male  Magnetic Resonance Imaging  Fetal Alcohol Spectrum Disorders/diagnostic imaging/pathology  Pregnancy  Prenatal Exposure Delayed Effects/diagnostic imaging/pathology  Neuropsychological Tests  Cognition  Fetal alcohol spectrum disorders  Hippocampal gyrification  Hippocampal thickness  Memory  Prenatal alcohol exposure  study were approved by the University of Minnesota IRB and all participants'  parents/guardians participated in a comprehensive informed consent procedure and  signed consent forms. Consent for publication: Not applicable. Competing  interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory and decision-making in affected individuals. Here, we evaluate hippocampal anomalies in children with PAE and an unexposed comparison group using advanced MRI methods that characterize hippocampal curvature and thickness. METHODS: Participants, ages 8 to 16 years, included children with PAE (n = 48) and an unexposed comparison group (n = 46) who underwent a dysmorphology exam, neuropsychological assessment, and an MRI scan. Height, weight, head circumference, and dysmorphic facial features were evaluated. Of those with PAE, 4.2% had fetal alcohol syndrome (FAS), 22.9% had partial FAS, and 72.9% had alcohol-related neurodevelopmental disorder. Neuropsychological testing included measures of intelligence and memory functioning. T1-weighted anatomical data were processed with the Hippunfold pipeline, which "unfolds" the complex hippocampal structure onto a template surface and provides measures of thickness and gyrification/curvature at each vertex. Permutation Analysis of Linear Models (PALM) was used to test for group differences (PAE vs. comparison) in hippocampal thickness and gyrification at each vertex and also to assess correlations with cognitive functioning. RESULTS: There were significant regional differences in thickness and gyrification across bilateral hippocampi, with the PAE group showing substantially thinner tissue and less curvature than the comparison group, especially in CA1 and subiculum regions. For those with PAE, thinner subicular tissue (bilateral) was associated with lower IQ. Also in the PAE group, lower episodic memory performance was associated with thinness in the right hippocampus, especially in the subiculum region. There were no significant regional hippocampal patterns that were associated with cognitive functioning for individuals in the unexposed comparison group. CONCLUSIONS: We used a novel MRI method to evaluate hippocampal structure in children with PAE and an unexposed comparison group. The data suggest that PAE disrupts hippocampal development, impacting both the early-stage folding of the structure and its ultimate thickness. The data also demonstrate that these developmental anomalies have functional consequences in terms of core memory functions as well as global intellectual functioning in children with PAE. En ligne : https://dx.doi.org/10.1186/s11689-025-09595-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure [texte imprimé] / Blake A. GIMBEL, Auteur ; Jeffrey R. WOZNIAK, Auteur ; Bryon A. MUELLER, Auteur ; Kent A. TUOMINEN, Auteur ; Abigail M. ERNST, Auteur ; Mary E. ANTHONY, Auteur ; Erik DE WATER, Auteur ; CIFASD, Auteur ; Donovan J. ROEDIGER, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Hippocampus/diagnostic imaging/pathology/abnormalities  Female  Child  Adolescent  Male  Magnetic Resonance Imaging  Fetal Alcohol Spectrum Disorders/diagnostic imaging/pathology  Pregnancy  Prenatal Exposure Delayed Effects/diagnostic imaging/pathology  Neuropsychological Tests  Cognition  Fetal alcohol spectrum disorders  Hippocampal gyrification  Hippocampal thickness  Memory  Prenatal alcohol exposure  study were approved by the University of Minnesota IRB and all participants'  parents/guardians participated in a comprehensive informed consent procedure and  signed consent forms. Consent for publication: Not applicable. Competing  interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory and decision-making in affected individuals. Here, we evaluate hippocampal anomalies in children with PAE and an unexposed comparison group using advanced MRI methods that characterize hippocampal curvature and thickness. METHODS: Participants, ages 8 to 16 years, included children with PAE (n = 48) and an unexposed comparison group (n = 46) who underwent a dysmorphology exam, neuropsychological assessment, and an MRI scan. Height, weight, head circumference, and dysmorphic facial features were evaluated. Of those with PAE, 4.2% had fetal alcohol syndrome (FAS), 22.9% had partial FAS, and 72.9% had alcohol-related neurodevelopmental disorder. Neuropsychological testing included measures of intelligence and memory functioning. T1-weighted anatomical data were processed with the Hippunfold pipeline, which "unfolds" the complex hippocampal structure onto a template surface and provides measures of thickness and gyrification/curvature at each vertex. Permutation Analysis of Linear Models (PALM) was used to test for group differences (PAE vs. comparison) in hippocampal thickness and gyrification at each vertex and also to assess correlations with cognitive functioning. RESULTS: There were significant regional differences in thickness and gyrification across bilateral hippocampi, with the PAE group showing substantially thinner tissue and less curvature than the comparison group, especially in CA1 and subiculum regions. For those with PAE, thinner subicular tissue (bilateral) was associated with lower IQ. Also in the PAE group, lower episodic memory performance was associated with thinness in the right hippocampus, especially in the subiculum region. There were no significant regional hippocampal patterns that were associated with cognitive functioning for individuals in the unexposed comparison group. CONCLUSIONS: We used a novel MRI method to evaluate hippocampal structure in children with PAE and an unexposed comparison group. The data suggest that PAE disrupts hippocampal development, impacting both the early-stage folding of the structure and its ultimate thickness. The data also demonstrate that these developmental anomalies have functional consequences in terms of core memory functions as well as global intellectual functioning in children with PAE. En ligne : https://dx.doi.org/10.1186/s11689-025-09595-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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