Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder / Blythe A. CORBETT ; Alexandra P. KEY ; Mark E. KLEMENCIC ; Rachael A. MUSCATELLO ; Dorita JONES ; Jennifer Pilkington ; Christina BURROUGHS ; Simon VANDEKAR in Journal of Autism and Developmental Disorders, 55-1 (January 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.130-146 Titre : Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Mark E. KLEMENCIC, Auteur ; Rachael A. MUSCATELLO, Auteur ; Dorita JONES, Auteur ; Jennifer Pilkington, Auteur ; Christina BURROUGHS, Auteur ; Simon VANDEKAR, Auteur Article en page(s) : p.130-146 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by challenges in social competence that persist in adulthood, yet few treatment options exist. A pilot randomized clinical trial (RCT) of a peer-mediated, theatre-based intervention with established efficacy in youth with ASD was examined in autistic adults. The final sample consisted of forty-seven 18-to-40-year-old participants randomized to the experimental (EXP N = 23) or waitlist control (WLC N = 24) condition. A multimodal, social interdependent model was employed to examine social competence changes in brain (incidental face memory (IFM) using event-related potentials), cognition (Wechsler Memory Scale-III), behavior (Contextual Assessment of Social Skills) and function (Social Responsiveness Scale (SRS); Adaptive Behavior Assessment Scale (ABAS) Social Composite). Using analysis of covariance in which pretest was controlled in the model, posttest between-group differences were observed on IFM (p = 0.016, ?2 = 0.139, d = 0.79) and several social and adaptive functional (SRS, ABAS) outcomes in social communication and interaction (SCI) (p = 0.019, ?2 = 0.121, d = -00.45), communication (p = 0.044 ?2 = 0.09, d = -00.31), and motivation (p = 0.001, ?2 = 0.229, d = -0.79) domains. At two-month follow-up, gains in social motivation remained (p = 0.041, ?2 = 0.100, d = -0.77). The results offer preliminary support for a unique theatre-based social skills intervention for autistic adults who have few treatment options to enhance social competence. The trial was pre-registered with ClinicalTrials.gov (Identifier: NCT04349644). En ligne : https://doi.org/10.1007/s10803-023-06214-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Mark E. KLEMENCIC, Auteur ; Rachael A. MUSCATELLO, Auteur ; Dorita JONES, Auteur ; Jennifer Pilkington, Auteur ; Christina BURROUGHS, Auteur ; Simon VANDEKAR, Auteur . - p.130-146. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.130-146 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by challenges in social competence that persist in adulthood, yet few treatment options exist. A pilot randomized clinical trial (RCT) of a peer-mediated, theatre-based intervention with established efficacy in youth with ASD was examined in autistic adults. The final sample consisted of forty-seven 18-to-40-year-old participants randomized to the experimental (EXP N = 23) or waitlist control (WLC N = 24) condition. A multimodal, social interdependent model was employed to examine social competence changes in brain (incidental face memory (IFM) using event-related potentials), cognition (Wechsler Memory Scale-III), behavior (Contextual Assessment of Social Skills) and function (Social Responsiveness Scale (SRS); Adaptive Behavior Assessment Scale (ABAS) Social Composite). Using analysis of covariance in which pretest was controlled in the model, posttest between-group differences were observed on IFM (p = 0.016, ?2 = 0.139, d = 0.79) and several social and adaptive functional (SRS, ABAS) outcomes in social communication and interaction (SCI) (p = 0.019, ?2 = 0.121, d = -00.45), communication (p = 0.044 ?2 = 0.09, d = -00.31), and motivation (p = 0.001, ?2 = 0.229, d = -0.79) domains. At two-month follow-up, gains in social motivation remained (p = 0.041, ?2 = 0.100, d = -0.77). The results offer preliminary support for a unique theatre-based social skills intervention for autistic adults who have few treatment options to enhance social competence. The trial was pre-registered with ClinicalTrials.gov (Identifier: NCT04349644). En ligne : https://doi.org/10.1007/s10803-023-06214-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Sex differences in automatic emotion regulation in adolescents with autism spectrum disorder / Alexandra P. KEY in Autism Research, 15-4 (April 2022)  

Public ISBD [article]  inAutism Research > 15-4 (April 2022) . - p.712-728 Titre : Sex differences in automatic emotion regulation in adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra P. KEY, Auteur ; Dorita JONES, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.712-728 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Child  Emotional Regulation  Emotions/physiology  Evoked Potentials/physiology  Facial Expression  Female  Humans  Male  Sex Characteristics  autism  emotion  face  inhibition  sex  target detection Index. décimale : PER Périodiques Résumé : Autism may be underdiagnosed in females because their social difficulties are often less noticeable. This study explored sex differences in automatic facial emotion processing in 45 adolescents with autism spectrum disorder (22 female, 23 male), age 10-16?years, performing active target detection task and Go/NoGo tasks where faces with positive and negative emotional expressions served as irrelevant distractors. The combined sample demonstrated more accurate performance on the target detection (response initiation) than the Go/NoGo task (response inhibition), replicating findings previously reported in typical participants. Females exhibited greater difficulty than males with response initiation in the target detection task, especially in the context of angry faces, while males found withholding a response in the Go/NoGo block with happy faces more challenging. Electrophysiological data revealed no sex differences or emotion discrimination effects during the early perceptual processing of faces indexed by the occipitotemporal N170. Autistic males demonstrated increased frontal N2 and parietal P3 amplitudes compared to females, suggesting greater neural resource allocation to automatic emotion regulation processes. The associations between standardized behavioral measures (autism severity, theory of mind skills) and brain responses also varied by sex: more adaptive social functioning was related to the speed of perceptual processing (N170 latency) in females and the extent of deliberate attention allocation (P3 amplitudes) in males. Together, these findings suggest that males and females with autism may rely on different strategies for social functioning and highlight the importance of considering sex differences in autism. LAY SUMMARY: Females with autism may exhibit less noticeable social difficulties than males. This study demonstrates that autistic females are more successful than males at inhibiting behavioral responses in emotional contexts, while males are more likely to initiate a response. At the neural level, social functioning in females is related to the speed of automatic perceptual processing of facial cues, and in males, to the extent of active attention allocation to the stimuli. These findings highlight the importance of considering sex differences in autism diagnosis and treatment selection. En ligne : https://dx.doi.org/10.1002/aur.2678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Sex differences in automatic emotion regulation in adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Alexandra P. KEY, Auteur ; Dorita JONES, Auteur ; Blythe A. CORBETT, Auteur . - p.712-728. Langues : Anglais (eng) in Autism Research > 15-4 (April 2022) . - p.712-728 Mots-clés : Adolescent  Autism Spectrum Disorder  Child  Emotional Regulation  Emotions/physiology  Evoked Potentials/physiology  Facial Expression  Female  Humans  Male  Sex Characteristics  autism  emotion  face  inhibition  sex  target detection Index. décimale : PER Périodiques Résumé : Autism may be underdiagnosed in females because their social difficulties are often less noticeable. This study explored sex differences in automatic facial emotion processing in 45 adolescents with autism spectrum disorder (22 female, 23 male), age 10-16?years, performing active target detection task and Go/NoGo tasks where faces with positive and negative emotional expressions served as irrelevant distractors. The combined sample demonstrated more accurate performance on the target detection (response initiation) than the Go/NoGo task (response inhibition), replicating findings previously reported in typical participants. Females exhibited greater difficulty than males with response initiation in the target detection task, especially in the context of angry faces, while males found withholding a response in the Go/NoGo block with happy faces more challenging. Electrophysiological data revealed no sex differences or emotion discrimination effects during the early perceptual processing of faces indexed by the occipitotemporal N170. Autistic males demonstrated increased frontal N2 and parietal P3 amplitudes compared to females, suggesting greater neural resource allocation to automatic emotion regulation processes. The associations between standardized behavioral measures (autism severity, theory of mind skills) and brain responses also varied by sex: more adaptive social functioning was related to the speed of perceptual processing (N170 latency) in females and the extent of deliberate attention allocation (P3 amplitudes) in males. Together, these findings suggest that males and females with autism may rely on different strategies for social functioning and highlight the importance of considering sex differences in autism. LAY SUMMARY: Females with autism may exhibit less noticeable social difficulties than males. This study demonstrates that autistic females are more successful than males at inhibiting behavioral responses in emotional contexts, while males are more likely to initiate a response. At the neural level, social functioning in females is related to the speed of automatic perceptual processing of facial cues, and in males, to the extent of active attention allocation to the stimuli. These findings highlight the importance of considering sex differences in autism diagnosis and treatment selection. En ligne : https://dx.doi.org/10.1002/aur.2678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

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