Adaptive and Behavioral Profiles in Down Syndrome and Co-Occurring Autism Spectrum Disorder: A Case-Control Study / Elisa FUCA ; Stefano VICARI ; Floriana COSTANZO in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.362-369 Titre : Adaptive and Behavioral Profiles in Down Syndrome and Co-Occurring Autism Spectrum Disorder: A Case-Control Study : Autism Research Type de document : texte imprimé Auteurs : Elisa FUCA, Auteur ; Stefano VICARI, Auteur ; Floriana COSTANZO, Auteur Article en page(s) : p.362-369 Langues : Anglais (eng) Mots-clés : Aberrant Behavior Checklist diagnosis intellectual disability repetitive behaviors Index. décimale : PER Périodiques Résumé : ABSTRACT Down syndrome (DS) is the most frequent genetic cause of intellectual disability (ID). Individuals with DS exhibit an elevated risk of other neurodevelopmental disorders, including autism spectrum disorder (ASD). The primary objective of this study was to explore the clinical characteristics of co-occurring ASD in children and adolescents with DS using a case?control approach. We compared the adaptive and behavioral profiles of a group of participants with both DS and ASD (ASD group) with a group of participants with DS-only matched by age, sex, and IQ (CON group). Participants in the ASD group exhibited significantly lower adaptive skills than the CON group, despite the IQ-matching in the moderate/severe ID range. No group differences emerged on internalizing or externalizing behavioral symptoms, but participants in the ASD group exhibited significantly higher social withdrawal, stereotyped behavior, and restricted interests. These findings indicate that, although children with DS?with or without ASD?who have similar low cognitive functioning often exhibit common behavioral traits, paying close attention to the elevation of stereotyped behaviors or restricted interests can improve the detection of co-occurring ASD in this population, enabling more personalized interventions. Conversely, the presence of ritualistic behaviors or behaviors related to insistence on sameness may not be a strong indicator of underlying ASD in children with DS. Additionally, acknowledging that the presence of ASD contributes to adaptive behavior deficits beyond the impact of moderate-to-severe ID alone highlights the critical need for early interventions to enhance daily living skills in this population. En ligne : https://doi.org/10.1002/aur.3294 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Adaptive and Behavioral Profiles in Down Syndrome and Co-Occurring Autism Spectrum Disorder: A Case-Control Study : Autism Research [texte imprimé] / Elisa FUCA, Auteur ; Stefano VICARI, Auteur ; Floriana COSTANZO, Auteur . - p.362-369. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.362-369 Mots-clés : Aberrant Behavior Checklist diagnosis intellectual disability repetitive behaviors Index. décimale : PER Périodiques Résumé : ABSTRACT Down syndrome (DS) is the most frequent genetic cause of intellectual disability (ID). Individuals with DS exhibit an elevated risk of other neurodevelopmental disorders, including autism spectrum disorder (ASD). The primary objective of this study was to explore the clinical characteristics of co-occurring ASD in children and adolescents with DS using a case?control approach. We compared the adaptive and behavioral profiles of a group of participants with both DS and ASD (ASD group) with a group of participants with DS-only matched by age, sex, and IQ (CON group). Participants in the ASD group exhibited significantly lower adaptive skills than the CON group, despite the IQ-matching in the moderate/severe ID range. No group differences emerged on internalizing or externalizing behavioral symptoms, but participants in the ASD group exhibited significantly higher social withdrawal, stereotyped behavior, and restricted interests. These findings indicate that, although children with DS?with or without ASD?who have similar low cognitive functioning often exhibit common behavioral traits, paying close attention to the elevation of stereotyped behaviors or restricted interests can improve the detection of co-occurring ASD in this population, enabling more personalized interventions. Conversely, the presence of ritualistic behaviors or behaviors related to insistence on sameness may not be a strong indicator of underlying ASD in children with DS. Additionally, acknowledging that the presence of ASD contributes to adaptive behavior deficits beyond the impact of moderate-to-severe ID alone highlights the critical need for early interventions to enhance daily living skills in this population. En ligne : https://doi.org/10.1002/aur.3294 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Cross-cultural similarities and differences in reporting autistic symptoms in toddlers: A study synthesizing M-CHAT(-R) data from ten countries / Dejan STEVANOVIĆ in Research in Autism Spectrum Disorders, 95 (July 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 95 (July 2022) . - 101984 Titre : Cross-cultural similarities and differences in reporting autistic symptoms in toddlers: A study synthesizing M-CHAT(-R) data from ten countries Type de document : texte imprimé Auteurs : Dejan STEVANOVIĆ, Auteur ; Diana L. ROBINS, Auteur ; Floriana COSTANZO, Auteur ; Elisa FUCA, Auteur ; Giovanni VALERI, Auteur ; Stefano VICARI, Auteur ; Handan OZEK ERKURAN, Auteur ; Ferhat YAYLACI, Auteur ; Lilia ALBORES-GALLO, Auteur ; Gabriel GATICA-BAHAMONDE, Auteur ; Maia GABUNIA, Auteur ; Medea ZIRAKASHVILI, Auteur ; Tony CHARMAN, Auteur ; Sayyed Ali SAMADI, Auteur ; Teck-Hock TOH, Auteur ; Gayle WINDHAM, Auteur ; Laura A. BRENNAN, Auteur ; Tatjana ZORCEC, Auteur ; Alejandra AUZA, Auteur ; Maretha V. DE JONGE, Auteur ; Noordeen SHOQIRAT, Auteur ; Rajna KNEZ, Auteur Article en page(s) : 101984 Langues : Anglais (eng) Mots-clés : Toddlers  Autism  Screening  Culture  Equivalence Index. décimale : PER Périodiques Résumé : Background This study aimed to evaluate the endorsement rates of M-CHAT(-R) items by parents/caregivers of toddlers with autism spectrum disorder (ASD) synthesizing data from ten countries: Albania, Chile, Georgia, Macedonia, Malaysia, Mexico, Serbia, Turkey, United Kingdom, and the United States of America. Method Data were aggregated for toddlers aged 14 36 months who participated in previous studies or completed clinical screening. An item with < 30% of endorsements was classified as low endorsement, an item falling within the range of 30 60% as moderate endorsement, and an item with > 60% as high endorsement. Results All items had a low endorsement rate in at least one country and moderate to high in others. Of 20 items, 14 had a moderate to high endorsement rate in seven to nine countries. Of particular relevance are items with moderate to high endorsement rates in all countries excluding Malaysia, such as points to get help, points to show, brings things to show, follows a point, follows your gaze, and understands what is said. On the other hand, makes eye contact, responds to name, hearing concerns, and reciprocal smile were interpreted differently across the countries. Conclusions This study showed differences in parent/caregiver responding to M-CHAT(-R) items across ten countries, which may indicate cross-country variations in the recognition and evaluation of autistic symptoms in toddlers. Items related to joint attention, social engagement, and language comprehension were reported in a similar manner across countries and could be interpreted as universal autistic symptoms in toddlers. En ligne : https://doi.org/10.1016/j.rasd.2022.101984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Cross-cultural similarities and differences in reporting autistic symptoms in toddlers: A study synthesizing M-CHAT(-R) data from ten countries [texte imprimé] / Dejan STEVANOVIĆ, Auteur ; Diana L. ROBINS, Auteur ; Floriana COSTANZO, Auteur ; Elisa FUCA, Auteur ; Giovanni VALERI, Auteur ; Stefano VICARI, Auteur ; Handan OZEK ERKURAN, Auteur ; Ferhat YAYLACI, Auteur ; Lilia ALBORES-GALLO, Auteur ; Gabriel GATICA-BAHAMONDE, Auteur ; Maia GABUNIA, Auteur ; Medea ZIRAKASHVILI, Auteur ; Tony CHARMAN, Auteur ; Sayyed Ali SAMADI, Auteur ; Teck-Hock TOH, Auteur ; Gayle WINDHAM, Auteur ; Laura A. BRENNAN, Auteur ; Tatjana ZORCEC, Auteur ; Alejandra AUZA, Auteur ; Maretha V. DE JONGE, Auteur ; Noordeen SHOQIRAT, Auteur ; Rajna KNEZ, Auteur . - 101984. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 95 (July 2022) . - 101984 Mots-clés : Toddlers  Autism  Screening  Culture  Equivalence Index. décimale : PER Périodiques Résumé : Background This study aimed to evaluate the endorsement rates of M-CHAT(-R) items by parents/caregivers of toddlers with autism spectrum disorder (ASD) synthesizing data from ten countries: Albania, Chile, Georgia, Macedonia, Malaysia, Mexico, Serbia, Turkey, United Kingdom, and the United States of America. Method Data were aggregated for toddlers aged 14 36 months who participated in previous studies or completed clinical screening. An item with < 30% of endorsements was classified as low endorsement, an item falling within the range of 30 60% as moderate endorsement, and an item with > 60% as high endorsement. Results All items had a low endorsement rate in at least one country and moderate to high in others. Of 20 items, 14 had a moderate to high endorsement rate in seven to nine countries. Of particular relevance are items with moderate to high endorsement rates in all countries excluding Malaysia, such as points to get help, points to show, brings things to show, follows a point, follows your gaze, and understands what is said. On the other hand, makes eye contact, responds to name, hearing concerns, and reciprocal smile were interpreted differently across the countries. Conclusions This study showed differences in parent/caregiver responding to M-CHAT(-R) items across ten countries, which may indicate cross-country variations in the recognition and evaluation of autistic symptoms in toddlers. Items related to joint attention, social engagement, and language comprehension were reported in a similar manner across countries and could be interpreted as universal autistic symptoms in toddlers. En ligne : https://doi.org/10.1016/j.rasd.2022.101984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries / Dejan STEVANOVIĆ in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2544-2554 Titre : Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries Type de document : texte imprimé Auteurs : Dejan STEVANOVIĆ, Auteur ; Floriana COSTANZO, Auteur ; Elisa FUCA, Auteur ; Giovanni VALERI, Auteur ; Stefano VICARI, Auteur ; Diana L. ROBINS, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Handan OZEK ERKURAN, Auteur ; Ferhat YAYLACI, Auteur ; Smita N. DESHPANDE, Auteur ; V. DESHMUKH, Auteur ; Narendra K. ARORA, Auteur ; Lilia ALBORES-GALLO, Auteur ; Cristina GARCIA-LOPEZ, Auteur ; Gabriel GATICA-BAHAMONDE, Auteur ; Maia GABUNIA, Auteur ; Medea ZIRAKASHVILI, Auteur ; Fernanda Prada MACHADO, Auteur ; Miruna RADAN, Auteur ; Sayyed Ali SAMADI, Auteur ; Teck-Hock TOH, Auteur ; Windham GAYLE, Auteur ; Lynn BRENNAN, Auteur ; Tatjana ZORCEC, Auteur ; Alejandra AUZA, Auteur ; Maretha V. DE JONGE, Auteur ; Noordeen SHOQIRAT, Auteur ; Anita MARINI, Auteur ; Rajna KNEZ, Auteur Article en page(s) : p.2544-2554 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Bayes Theorem  Child  Cross-Cultural Comparison  Humans  Psychometrics  United States  assessment  children  cross-cultural validity  differential item functioning Index. décimale : PER Périodiques Résumé : The Childhood Autism Rating Scale (CARS) is a simple and inexpensive tool for Autism spectrum disorder (ASD) assessments, with evidenced psychometric data from different countries. However, it is still unclear whether ASD symptoms are measured the same way across different societies and world regions with this tool, since data on its cross-cultural validity are lacking. This study evaluated the cross-cultural measurement invariance of the CARS among children with ASD from six countries, for whom data were aggregated from previous studies in India (n = 101), Jamaica (n = 139), Mexico (n = 72), Spain (n = 99), Turkey (n = 150), and the United States of America (n = 186). We analyzed the approximate measurement invariance based on Bayesian structural equation modeling. The model did not fit the data and its measurement invariance did not hold, with all items found non-invariant across the countries. Items related to social communication and interaction (i.e., relating to people, imitation, emotional response, and verbal and nonverbal communication) displayed lower levels of cross-country non-invariance compared to items about stereotyped behaviors/sensory sensitivity (i.e., body and object use, adaptation to change, or taste, smell, and touch response). This study found that the CARS may not provide cross-culturally valid ASD assessments. Thus, cross-cultural comparisons with the CARS should consider first which items operate differently across samples of interest, since its cross-cultural measurement non-invariance could be a source of cross-cultural variability in ASD presentations. Additional studies are needed before drawing valid recommendations in relation to the cultural sensitivity of particular items. En ligne : http://dx.doi.org/10.1002/aur.2586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries [texte imprimé] / Dejan STEVANOVIĆ, Auteur ; Floriana COSTANZO, Auteur ; Elisa FUCA, Auteur ; Giovanni VALERI, Auteur ; Stefano VICARI, Auteur ; Diana L. ROBINS, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Handan OZEK ERKURAN, Auteur ; Ferhat YAYLACI, Auteur ; Smita N. DESHPANDE, Auteur ; V. DESHMUKH, Auteur ; Narendra K. ARORA, Auteur ; Lilia ALBORES-GALLO, Auteur ; Cristina GARCIA-LOPEZ, Auteur ; Gabriel GATICA-BAHAMONDE, Auteur ; Maia GABUNIA, Auteur ; Medea ZIRAKASHVILI, Auteur ; Fernanda Prada MACHADO, Auteur ; Miruna RADAN, Auteur ; Sayyed Ali SAMADI, Auteur ; Teck-Hock TOH, Auteur ; Windham GAYLE, Auteur ; Lynn BRENNAN, Auteur ; Tatjana ZORCEC, Auteur ; Alejandra AUZA, Auteur ; Maretha V. DE JONGE, Auteur ; Noordeen SHOQIRAT, Auteur ; Anita MARINI, Auteur ; Rajna KNEZ, Auteur . - p.2544-2554. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2544-2554 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Bayes Theorem  Child  Cross-Cultural Comparison  Humans  Psychometrics  United States  assessment  children  cross-cultural validity  differential item functioning Index. décimale : PER Périodiques Résumé : The Childhood Autism Rating Scale (CARS) is a simple and inexpensive tool for Autism spectrum disorder (ASD) assessments, with evidenced psychometric data from different countries. However, it is still unclear whether ASD symptoms are measured the same way across different societies and world regions with this tool, since data on its cross-cultural validity are lacking. This study evaluated the cross-cultural measurement invariance of the CARS among children with ASD from six countries, for whom data were aggregated from previous studies in India (n = 101), Jamaica (n = 139), Mexico (n = 72), Spain (n = 99), Turkey (n = 150), and the United States of America (n = 186). We analyzed the approximate measurement invariance based on Bayesian structural equation modeling. The model did not fit the data and its measurement invariance did not hold, with all items found non-invariant across the countries. Items related to social communication and interaction (i.e., relating to people, imitation, emotional response, and verbal and nonverbal communication) displayed lower levels of cross-country non-invariance compared to items about stereotyped behaviors/sensory sensitivity (i.e., body and object use, adaptation to change, or taste, smell, and touch response). This study found that the CARS may not provide cross-culturally valid ASD assessments. Thus, cross-cultural comparisons with the CARS should consider first which items operate differently across samples of interest, since its cross-cultural measurement non-invariance could be a source of cross-cultural variability in ASD presentations. Additional studies are needed before drawing valid recommendations in relation to the cultural sensitivity of particular items. En ligne : http://dx.doi.org/10.1002/aur.2586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

The role of social motivation in sharing and fairness: insights from Williams syndrome / Francesca FOTI in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : The role of social motivation in sharing and fairness: insights from Williams syndrome Type de document : texte imprimé Auteurs : Francesca FOTI, Auteur ; Floriana COSTANZO, Auteur ; Carlo FABRIZIO, Auteur ; Andrea TERMINE, Auteur ; Deny MENGHINI, Auteur ; Tiziana IAQUINTA, Auteur ; Stefano VICARI, Auteur ; Laura PETROSINI, Auteur ; Peter R. BLAKE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Williams Syndrome/physiopathology/psychology  Motivation/physiology  Male  Female  Child  Social Behavior  Games, Experimental  Adult  Behavioral phenotype  Children  Developmental disorders  Dictator game  Fairness  Inequity aversion  Inequity game  Resource distribution  Social cognition  Social phenotype  Williams syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Sharing and fairness are important prosocial behaviors that help us navigate the social world. However, little is known about how and whether individuals with Williams Syndrome (WS) engage in these behaviors. The unique phenotype of individuals with WS, consisting of high social motivation and limited social cognition, can also offer insight into the role of social motivation in sharing and fairness when compared to typically developing (TD) individuals. The current study used established experimental paradigms to examine sharing and fairness in individuals with WS and TD individuals. METHODS: We compared a sample of patients with WS to TD children (6-year-olds) matched by mental age (MA) on two experimental tasks: the Dictator Game (DG, Experiment 1, N = 17 WS, 20 TD) with adults modeling giving behaviors used to test sharing and the Inequity Game (IG, Experiment 2, N = 14 WS, 17 TD) used to test fairness. RESULTS: Results showed that the WS group behaved similarly to the TD group for baseline giving in the DG and in the IG, rejecting disadvantageous offers but accepting advantageous ones. However, after viewing an adult model giving behavior, the WS group gave more than their baseline, with many individuals giving more than half, while the TD group gave less. Combined these results suggest that social motivation is sufficient for sharing and, in particular, generous sharing, as well as the self-focused form of fairness. Further, individuals with WS appear capable of both learning to be more generous and preventing disadvantageous outcomes, a more complex profile than previously known. CONCLUSIONS: In conclusion, the present study provides a snapshot into sharing and fairness-related behaviors in WS, contributing to our understanding of the intriguing social-behavioral phenotype associated with this developmental disorder. En ligne : https://dx.doi.org/10.1186/s11689-024-09568-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] The role of social motivation in sharing and fairness: insights from Williams syndrome [texte imprimé] / Francesca FOTI, Auteur ; Floriana COSTANZO, Auteur ; Carlo FABRIZIO, Auteur ; Andrea TERMINE, Auteur ; Deny MENGHINI, Auteur ; Tiziana IAQUINTA, Auteur ; Stefano VICARI, Auteur ; Laura PETROSINI, Auteur ; Peter R. BLAKE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Williams Syndrome/physiopathology/psychology  Motivation/physiology  Male  Female  Child  Social Behavior  Games, Experimental  Adult  Behavioral phenotype  Children  Developmental disorders  Dictator game  Fairness  Inequity aversion  Inequity game  Resource distribution  Social cognition  Social phenotype  Williams syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Sharing and fairness are important prosocial behaviors that help us navigate the social world. However, little is known about how and whether individuals with Williams Syndrome (WS) engage in these behaviors. The unique phenotype of individuals with WS, consisting of high social motivation and limited social cognition, can also offer insight into the role of social motivation in sharing and fairness when compared to typically developing (TD) individuals. The current study used established experimental paradigms to examine sharing and fairness in individuals with WS and TD individuals. METHODS: We compared a sample of patients with WS to TD children (6-year-olds) matched by mental age (MA) on two experimental tasks: the Dictator Game (DG, Experiment 1, N = 17 WS, 20 TD) with adults modeling giving behaviors used to test sharing and the Inequity Game (IG, Experiment 2, N = 14 WS, 17 TD) used to test fairness. RESULTS: Results showed that the WS group behaved similarly to the TD group for baseline giving in the DG and in the IG, rejecting disadvantageous offers but accepting advantageous ones. However, after viewing an adult model giving behavior, the WS group gave more than their baseline, with many individuals giving more than half, while the TD group gave less. Combined these results suggest that social motivation is sufficient for sharing and, in particular, generous sharing, as well as the self-focused form of fairness. Further, individuals with WS appear capable of both learning to be more generous and preventing disadvantageous outcomes, a more complex profile than previously known. CONCLUSIONS: In conclusion, the present study provides a snapshot into sharing and fairness-related behaviors in WS, contributing to our understanding of the intriguing social-behavioral phenotype associated with this developmental disorder. En ligne : https://dx.doi.org/10.1186/s11689-024-09568-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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