Attenuated processing of vowels in the left temporal cortex predicts speech-in-noise perception deficit in children with autism / Kirill A. FADEEV in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Attenuated processing of vowels in the left temporal cortex predicts speech-in-noise perception deficit in children with autism Type de document : texte imprimé Auteurs : Kirill A. FADEEV, Auteur ; Ilacai V. ROMERO REYES, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; Tatiana M. OVSIANNIKOVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Anna M. RYTIKOVA, Auteur ; Artem Y. NOVIKOV, Auteur ; Vladimir V. KOZUNOV, Auteur ; Tatiana A. STROGANOVA, Auteur ; Elena V. OREKHOVA, Auteur Langues : Anglais (eng) Mots-clés : Humans  Male  Speech Perception/physiology  Magnetoencephalography  Child  Temporal Lobe/physiopathology  Noise  Acoustic Stimulation  Evoked Potentials, Auditory/physiology  Autism Spectrum Disorder/physiopathology/complications  Adolescent  Auditory Cortex/physiopathology  Autistic Disorder/physiopathology/complications  Auditory processing disorder  Autism spectrum disorder (ASD)  Children  Formant structure  Magnetoencephalography (MEG)  Periodicity pitch  Speech-in-noise perception  Sustained processing negativity (SPN)  Vowels  of the Moscow State University of Psychology and Education approved this  investigation. All children gave verbal consent to participate in the study and  their caregivers gave written consent to participate. Consent for publication:  All children gave verbal consent to participate in the study and their caregivers  gave written consent for publication of anonymized data. Competing interests: The  authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory "object". METHODS: We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio. RESULTS: SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150-200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise. CONCLUSIONS: These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise. En ligne : https://dx.doi.org/10.1186/s11689-024-09585-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Attenuated processing of vowels in the left temporal cortex predicts speech-in-noise perception deficit in children with autism [texte imprimé] / Kirill A. FADEEV, Auteur ; Ilacai V. ROMERO REYES, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; Tatiana M. OVSIANNIKOVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Anna M. RYTIKOVA, Auteur ; Artem Y. NOVIKOV, Auteur ; Vladimir V. KOZUNOV, Auteur ; Tatiana A. STROGANOVA, Auteur ; Elena V. OREKHOVA, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Male  Speech Perception/physiology  Magnetoencephalography  Child  Temporal Lobe/physiopathology  Noise  Acoustic Stimulation  Evoked Potentials, Auditory/physiology  Autism Spectrum Disorder/physiopathology/complications  Adolescent  Auditory Cortex/physiopathology  Autistic Disorder/physiopathology/complications  Auditory processing disorder  Autism spectrum disorder (ASD)  Children  Formant structure  Magnetoencephalography (MEG)  Periodicity pitch  Speech-in-noise perception  Sustained processing negativity (SPN)  Vowels  of the Moscow State University of Psychology and Education approved this  investigation. All children gave verbal consent to participate in the study and  their caregivers gave written consent to participate. Consent for publication:  All children gave verbal consent to participate in the study and their caregivers  gave written consent for publication of anonymized data. Competing interests: The  authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory "object". METHODS: We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio. RESULTS: SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150-200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise. CONCLUSIONS: These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise. En ligne : https://dx.doi.org/10.1186/s11689-024-09585-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence / Viktoriya O. MANYUKHINA in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 20 p. Titre : Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence Type de document : texte imprimé Auteurs : Viktoriya O. MANYUKHINA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Ilia A. GALUTA, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; Justin F. SCHNEIDERMAN, Auteur ; Dmitrii I. ALTUKHOV, Auteur ; Tatiana A. STROGANOVA, Auteur ; Elena V. OREKHOVA, Auteur Article en page(s) : 20 p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Cognition/physiology  Humans  Intellectual Disability  Intelligence  Magnetoencephalography  Male  1/f power law  Autism spectrum disorders (ASDs)  Biomarkers  Excitation?inhibition balance  Power spectrum Index. décimale : PER Périodiques Résumé : BACKGROUND: Altered neuronal excitation-inhibition (E-I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E-I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E-I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability. METHODS: Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below-average (< 85) IQ. MEG was recorded at rest with eyes open/closed in 49 boys with ASD aged 6-15 years with IQ ranging from 54 to 128, and in 49 age-matched typically developing (TD) boys. The cortical source activity was estimated using the beamformer approach and individual brain models. We then extracted the 1/f slope by fitting a linear function to the log-log-scale power spectra in the high-frequency range. RESULTS: The global 1/f slope averaged over all cortical sources demonstrated high rank-order stability between the two conditions. Consistent with previous research, it was steeper in the eyes-closed than in the eyes-open condition and flattened with age. Regardless of condition, children with ASD and below-average IQ had flatter slopes than either TD or ASD children with average or above-average IQ. These group differences could not be explained by differences in signal-to-noise ratio or periodic (alpha and beta) activity. LIMITATIONS: Further research is needed to find out whether the observed changes in E-I ratios are characteristic of children with below-average IQ of other diagnostic groups. CONCLUSIONS: The atypically flattened spectral slope of aperiodic activity in children with ASD and below-average IQ suggests a shift of the global E-I balance toward hyper-excitation. The spectral slope can provide an accessible noninvasive biomarker of the E-I ratio for making objective judgments about treatment effectiveness in people with ASD and comorbid intellectual disability. En ligne : http://dx.doi.org/10.1186/s13229-022-00498-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence [texte imprimé] / Viktoriya O. MANYUKHINA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Ilia A. GALUTA, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; Justin F. SCHNEIDERMAN, Auteur ; Dmitrii I. ALTUKHOV, Auteur ; Tatiana A. STROGANOVA, Auteur ; Elena V. OREKHOVA, Auteur . - 20 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 20 p. Mots-clés : Autism Spectrum Disorder  Child  Cognition/physiology  Humans  Intellectual Disability  Intelligence  Magnetoencephalography  Male  1/f power law  Autism spectrum disorders (ASDs)  Biomarkers  Excitation?inhibition balance  Power spectrum Index. décimale : PER Périodiques Résumé : BACKGROUND: Altered neuronal excitation-inhibition (E-I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E-I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E-I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability. METHODS: Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below-average (< 85) IQ. MEG was recorded at rest with eyes open/closed in 49 boys with ASD aged 6-15 years with IQ ranging from 54 to 128, and in 49 age-matched typically developing (TD) boys. The cortical source activity was estimated using the beamformer approach and individual brain models. We then extracted the 1/f slope by fitting a linear function to the log-log-scale power spectra in the high-frequency range. RESULTS: The global 1/f slope averaged over all cortical sources demonstrated high rank-order stability between the two conditions. Consistent with previous research, it was steeper in the eyes-closed than in the eyes-open condition and flattened with age. Regardless of condition, children with ASD and below-average IQ had flatter slopes than either TD or ASD children with average or above-average IQ. These group differences could not be explained by differences in signal-to-noise ratio or periodic (alpha and beta) activity. LIMITATIONS: Further research is needed to find out whether the observed changes in E-I ratios are characteristic of children with below-average IQ of other diagnostic groups. CONCLUSIONS: The atypically flattened spectral slope of aperiodic activity in children with ASD and below-average IQ suggests a shift of the global E-I balance toward hyper-excitation. The spectral slope can provide an accessible noninvasive biomarker of the E-I ratio for making objective judgments about treatment effectiveness in people with ASD and comorbid intellectual disability. En ligne : http://dx.doi.org/10.1186/s13229-022-00498-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD / Tatiana A. STROGANOVA in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD Type de document : texte imprimé Auteurs : Tatiana A. STROGANOVA, Auteur ; K.S. KOMAROV, Auteur ; Olga V. SYSOEVA, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; T.M. OVSIANNIKOVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Elena V. OREKHOVA, Auteur Langues : Anglais (eng) Mots-clés : 40 Hz clicks  Auditory steady state response (ASSR)  Autism spectrum disorders (ASD)  Children  Magnetoencephalogram (MEG)  Pitch processing  Sustained field (SF) Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses-the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the 'pitch processing center' of the Heschl's gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD. METHODS: We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N = 35) and neurotypical (NT) boys (N = 35) aged 7-12-years. RESULTS: In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl's gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. LIMITATIONS: We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative. CONCLUSION: Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody. En ligne : http://dx.doi.org/10.1186/s13229-020-00408-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD [texte imprimé] / Tatiana A. STROGANOVA, Auteur ; K.S. KOMAROV, Auteur ; Olga V. SYSOEVA, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; T.M. OVSIANNIKOVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Elena V. OREKHOVA, Auteur. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : 40 Hz clicks  Auditory steady state response (ASSR)  Autism spectrum disorders (ASD)  Children  Magnetoencephalogram (MEG)  Pitch processing  Sustained field (SF) Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses-the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the 'pitch processing center' of the Heschl's gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD. METHODS: We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N = 35) and neurotypical (NT) boys (N = 35) aged 7-12-years. RESULTS: In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl's gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. LIMITATIONS: We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative. CONCLUSION: Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody. En ligne : http://dx.doi.org/10.1186/s13229-020-00408-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

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