Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders / T. A. STROGANOVA in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.21 Titre : Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : T. A. STROGANOVA, Auteur ; A. V. BUTORINA, Auteur ; O. V. SYSOEVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; A. Y. NIKOLAEVA, Auteur ; M. M. TSETLIN, Auteur ; Elena V. OREKHOVA, Auteur Article en page(s) : p.21 Langues : Anglais (eng) Mots-clés : Asd  Oblique line orientation threshold  Stimulus velocity  Visual gamma oscillation frequency Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50-120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of excitation of the fast-spiking inhibitory basket cells recruited by increasing strength of excitatory input. Therefore, the experimental manipulations affecting gamma frequency may throw light on inhibitory networks dysfunction in ASD. METHODS: Here, we used magnetoencephalography (MEG) to investigate modulation of visual gamma oscillation frequency by speed of drifting annular gratings (1.2, 3.6, 6.0 degrees /s) in 21 boys with ASD and 26 typically developing boys aged 7-15 years. Multitaper method was used for analysis of spectra of gamma power change upon stimulus presentation and permutation test was applied for statistical comparisons. We also assessed in our participants visual orientation discrimination thresholds, which are thought to depend on excitability of inhibitory networks in the visual cortex. RESULTS: Although frequency of the oscillatory gamma response increased with increasing velocity of visual motion in both groups of participants, the velocity effect was reduced in a substantial proportion of children with ASD. The range of velocity-related gamma frequency modulation correlated inversely with the ability to discriminate oblique line orientation in the ASD group, while no such correlation has been observed in the group of typically developing participants. CONCLUSIONS: Our findings suggest that abnormal velocity-related gamma frequency modulation in ASD may constitute a potential biomarker for reduced excitability of fast-spiking inhibitory neurons in a subset of children with ASD. En ligne : http://dx.doi.org/10.1186/s11689-015-9121-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders [Texte imprimé et/ou numérique] / T. A. STROGANOVA, Auteur ; A. V. BUTORINA, Auteur ; O. V. SYSOEVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; A. Y. NIKOLAEVA, Auteur ; M. M. TSETLIN, Auteur ; Elena V. OREKHOVA, Auteur . - p.21. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.21 Mots-clés : Asd  Oblique line orientation threshold  Stimulus velocity  Visual gamma oscillation frequency Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50-120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of excitation of the fast-spiking inhibitory basket cells recruited by increasing strength of excitatory input. Therefore, the experimental manipulations affecting gamma frequency may throw light on inhibitory networks dysfunction in ASD. METHODS: Here, we used magnetoencephalography (MEG) to investigate modulation of visual gamma oscillation frequency by speed of drifting annular gratings (1.2, 3.6, 6.0 degrees /s) in 21 boys with ASD and 26 typically developing boys aged 7-15 years. Multitaper method was used for analysis of spectra of gamma power change upon stimulus presentation and permutation test was applied for statistical comparisons. We also assessed in our participants visual orientation discrimination thresholds, which are thought to depend on excitability of inhibitory networks in the visual cortex. RESULTS: Although frequency of the oscillatory gamma response increased with increasing velocity of visual motion in both groups of participants, the velocity effect was reduced in a substantial proportion of children with ASD. The range of velocity-related gamma frequency modulation correlated inversely with the ability to discriminate oblique line orientation in the ASD group, while no such correlation has been observed in the group of typically developing participants. CONCLUSIONS: Our findings suggest that abnormal velocity-related gamma frequency modulation in ASD may constitute a potential biomarker for reduced excitability of fast-spiking inhibitory neurons in a subset of children with ASD. En ligne : http://dx.doi.org/10.1186/s11689-015-9121-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

EEG hyper-connectivity in high-risk infants is associated with later autism / Elena V. OREKHOVA in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.40 Titre : EEG hyper-connectivity in high-risk infants is associated with later autism Type de document : Texte imprimé et/ou numérique Auteurs : Elena V. OREKHOVA, Auteur ; M. ELSABBAGH, Auteur ; E. J. JONES, Auteur ; G. DAWSON, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur Article en page(s) : p.40 Langues : Anglais (eng) Mots-clés : Alpha  Autism spectrum disorders  Connectivity  Eeg  Infants  Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: It has been previously reported that structural and functional brain connectivity in individuals with autism spectrum disorders (ASD) is atypical and may vary with age. However, to date, no measures of functional connectivity measured within the first 2 years have specifically associated with a later ASD diagnosis. METHODS: In the present study, we analyzed functional brain connectivity in 14-month-old infants at high and low familial risk for ASD using electroencephalography (EEG). EEG was recorded while infants attended to videos. Connectivity was assessed using debiased weighted phase lag index (dbWPLI). At 36 months, the high-risk infants were assessed for symptoms of ASD. RESULTS: As a group, high-risk infants who were later diagnosed with ASD demonstrated elevated phase-lagged alpha-range connectivity as compared to both low-risk infants and high-risk infants who did not go on to ASD. Hyper-connectivity was most prominent over frontal and central areas. The degree of hyper-connectivity at 14 months strongly correlated with the severity of restricted and repetitive behaviors in participants with ASD at 3 years. These effects were not attributable to differences in behavior during the EEG session or to differences in spectral power. CONCLUSIONS: The results suggest that early hyper-connectivity in the alpha frequency range is an important feature of the ASD neurophysiological phenotype. En ligne : http://dx.doi.org/10.1186/1866-1955-6-40 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] EEG hyper-connectivity in high-risk infants is associated with later autism [Texte imprimé et/ou numérique] / Elena V. OREKHOVA, Auteur ; M. ELSABBAGH, Auteur ; E. J. JONES, Auteur ; G. DAWSON, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur . - p.40. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.40 Mots-clés : Alpha  Autism spectrum disorders  Connectivity  Eeg  Infants  Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: It has been previously reported that structural and functional brain connectivity in individuals with autism spectrum disorders (ASD) is atypical and may vary with age. However, to date, no measures of functional connectivity measured within the first 2 years have specifically associated with a later ASD diagnosis. METHODS: In the present study, we analyzed functional brain connectivity in 14-month-old infants at high and low familial risk for ASD using electroencephalography (EEG). EEG was recorded while infants attended to videos. Connectivity was assessed using debiased weighted phase lag index (dbWPLI). At 36 months, the high-risk infants were assessed for symptoms of ASD. RESULTS: As a group, high-risk infants who were later diagnosed with ASD demonstrated elevated phase-lagged alpha-range connectivity as compared to both low-risk infants and high-risk infants who did not go on to ASD. Hyper-connectivity was most prominent over frontal and central areas. The degree of hyper-connectivity at 14 months strongly correlated with the severity of restricted and repetitive behaviors in participants with ASD at 3 years. These effects were not attributable to differences in behavior during the EEG session or to differences in spectral power. CONCLUSIONS: The results suggest that early hyper-connectivity in the alpha frequency range is an important feature of the ASD neurophysiological phenotype. En ligne : http://dx.doi.org/10.1186/1866-1955-6-40 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence / Viktoriya O. MANYUKHINA in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 20 p. Titre : Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence Type de document : Texte imprimé et/ou numérique Auteurs : Viktoriya O. MANYUKHINA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Ilia A. GALUTA, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; Justin F. SCHNEIDERMAN, Auteur ; Dmitrii I. ALTUKHOV, Auteur ; Tatiana A. STROGANOVA, Auteur ; Elena V. OREKHOVA, Auteur Article en page(s) : 20 p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Cognition/physiology  Humans  Intellectual Disability  Intelligence  Magnetoencephalography  Male  1/f power law  Autism spectrum disorders (ASDs)  Biomarkers  Excitation?inhibition balance  Power spectrum Index. décimale : PER Périodiques Résumé : BACKGROUND: Altered neuronal excitation-inhibition (E-I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E-I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E-I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability. METHODS: Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below-average ( En ligne : http://dx.doi.org/10.1186/s13229-022-00498-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence [Texte imprimé et/ou numérique] / Viktoriya O. MANYUKHINA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Ilia A. GALUTA, Auteur ; Dzerassa E. GOIAEVA, Auteur ; Tatiana S. OBUKHOVA, Auteur ; Justin F. SCHNEIDERMAN, Auteur ; Dmitrii I. ALTUKHOV, Auteur ; Tatiana A. STROGANOVA, Auteur ; Elena V. OREKHOVA, Auteur . - 20 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 20 p. Mots-clés : Autism Spectrum Disorder  Child  Cognition/physiology  Humans  Intellectual Disability  Intelligence  Magnetoencephalography  Male  1/f power law  Autism spectrum disorders (ASDs)  Biomarkers  Excitation?inhibition balance  Power spectrum Index. décimale : PER Périodiques Résumé : BACKGROUND: Altered neuronal excitation-inhibition (E-I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E-I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E-I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability. METHODS: Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below-average ( En ligne : http://dx.doi.org/10.1186/s13229-022-00498-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD / T. A. STROGANOVA in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : T. A. STROGANOVA, Auteur ; K. S. KOMAROV, Auteur ; O. V. SYSOEVA, Auteur ; D. E. GOIAEVA, Auteur ; T. S. OBUKHOVA, Auteur ; T. M. OVSIANNIKOVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Elena V. OREKHOVA, Auteur Langues : Anglais (eng) Mots-clés : 40 Hz clicks  Auditory steady state response (ASSR)  Autism spectrum disorders (ASD)  Children  Magnetoencephalogram (MEG)  Pitch processing  Sustained field (SF) Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses-the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the 'pitch processing center' of the Heschl's gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD. METHODS: We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N?=?35) and neurotypical (NT) boys (N?=?35) aged 7-12-years. RESULTS: In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl's gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. LIMITATIONS: We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative. CONCLUSION: Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody. En ligne : http://dx.doi.org/10.1186/s13229-020-00408-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD [Texte imprimé et/ou numérique] / T. A. STROGANOVA, Auteur ; K. S. KOMAROV, Auteur ; O. V. SYSOEVA, Auteur ; D. E. GOIAEVA, Auteur ; T. S. OBUKHOVA, Auteur ; T. M. OVSIANNIKOVA, Auteur ; Andrey O. PROKOFYEV, Auteur ; Elena V. OREKHOVA, Auteur. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : 40 Hz clicks  Auditory steady state response (ASSR)  Autism spectrum disorders (ASD)  Children  Magnetoencephalogram (MEG)  Pitch processing  Sustained field (SF) Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses-the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the 'pitch processing center' of the Heschl's gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD. METHODS: We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N?=?35) and neurotypical (NT) boys (N?=?35) aged 7-12-years. RESULTS: In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl's gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. LIMITATIONS: We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative. CONCLUSION: Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody. En ligne : http://dx.doi.org/10.1186/s13229-020-00408-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

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