Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD - are we there yet? / Alessio BELLATO ; Valeria PARLATINI ; Madeleine J. GROOM ; Charlotte L. HALL ; Chris HOLLIS ; Emily SIMONOFF ; Anita THAPAR ; Samuele CORTESE in Journal of Child Psychology and Psychiatry, 66-2 (February 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.266-270 Titre : Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD - are we there yet? : Journal of Child Psychology and Psychiatry Type de document : texte imprimé Auteurs : Alessio BELLATO, Auteur ; Valeria PARLATINI, Auteur ; Madeleine J. GROOM, Auteur ; Charlotte L. HALL, Auteur ; Chris HOLLIS, Auteur ; Emily SIMONOFF, Auteur ; Anita THAPAR, Auteur ; Samuele CORTESE, Auteur Article en page(s) : p.266-270 Langues : Anglais (eng) Mots-clés : ADHD  activity level  biomarkers  continuous performance test  outcome  pharmacotherapy Index. décimale : PER Périodiques Résumé : Individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit varied responses to pharmacological treatments (e.g. stimulants and non-stimulants). Accurately and promptly detecting treatment-related improvements, response failure, or deterioration poses significant challenges, as current monitoring primarily relies on subjective ratings. In this commentary, we critically evaluate the evidence supporting the use of QbTest for objectively monitoring ADHD treatment response in clinical practice. We also offer recommendations for future research, advocating for rigorous clinical trials and longitudinal studies to further explore the potential utilisation of QbTest and other tools for monitoring treatment responses in individuals with ADHD. En ligne : https://doi.org/10.1111/jcpp.14071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD - are we there yet? : Journal of Child Psychology and Psychiatry [texte imprimé] / Alessio BELLATO, Auteur ; Valeria PARLATINI, Auteur ; Madeleine J. GROOM, Auteur ; Charlotte L. HALL, Auteur ; Chris HOLLIS, Auteur ; Emily SIMONOFF, Auteur ; Anita THAPAR, Auteur ; Samuele CORTESE, Auteur . - p.266-270. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.266-270 Mots-clés : ADHD  activity level  biomarkers  continuous performance test  outcome  pharmacotherapy Index. décimale : PER Périodiques Résumé : Individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit varied responses to pharmacological treatments (e.g. stimulants and non-stimulants). Accurately and promptly detecting treatment-related improvements, response failure, or deterioration poses significant challenges, as current monitoring primarily relies on subjective ratings. In this commentary, we critically evaluate the evidence supporting the use of QbTest for objectively monitoring ADHD treatment response in clinical practice. We also offer recommendations for future research, advocating for rigorous clinical trials and longitudinal studies to further explore the potential utilisation of QbTest and other tools for monitoring treatment responses in individuals with ADHD. En ligne : https://doi.org/10.1111/jcpp.14071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions / Alessio BELLATO in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4679-4691 Titre : Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions Type de document : texte imprimé Auteurs : Alessio BELLATO, Auteur ; Iti ARORA, Auteur ; Puja KOCHHAR, Auteur ; Danielle ROPAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur Article en page(s) : p.4679-4691 Langues : Anglais (eng) Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Autonomic Nervous System  Child  Heart Rate/physiology  Humans  Adhd  Autism  Cognitive function  Comorbidity  Heart rate variability Index. décimale : PER Périodiques Résumé : Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents with autism, ADHD, co-occurring autism/ADHD, and neurotypical controls. Heart rate variability was recorded during resting-state, a 'passive' auditory oddball task and an 'active' response conflict task. Autistic children showed hyper-arousal during the active task, while those with ADHD showed hypo-arousal during resting-state and the passive task. Irrespective of diagnosis, children characterised by hyper-arousal showed more severe autistic symptomatology, increased anxiety and reduced global functioning than those displaying hypo-arousal, suggesting the importance of considering individual autonomic arousal profiles for differential diagnosis of autism/ADHD and when developing personalised interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05244-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions [texte imprimé] / Alessio BELLATO, Auteur ; Iti ARORA, Auteur ; Puja KOCHHAR, Auteur ; Danielle ROPAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur . - p.4679-4691. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4679-4691 Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Autonomic Nervous System  Child  Heart Rate/physiology  Humans  Adhd  Autism  Cognitive function  Comorbidity  Heart rate variability Index. décimale : PER Périodiques Résumé : Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents with autism, ADHD, co-occurring autism/ADHD, and neurotypical controls. Heart rate variability was recorded during resting-state, a 'passive' auditory oddball task and an 'active' response conflict task. Autistic children showed hyper-arousal during the active task, while those with ADHD showed hypo-arousal during resting-state and the passive task. Irrespective of diagnosis, children characterised by hyper-arousal showed more severe autistic symptomatology, increased anxiety and reduced global functioning than those displaying hypo-arousal, suggesting the importance of considering individual autonomic arousal profiles for differential diagnosis of autism/ADHD and when developing personalised interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05244-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD / Elana J. FORBES in Journal of Autism and Developmental Disorders, 56-6 (June 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-6 (June 2026) . - p.2391-2407 Titre : Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD Type de document : texte imprimé Auteurs : Elana J. FORBES, Auteur ; Jeggan TIEGO, Auteur ; Joshua LANGMEAD, Auteur ; Kathryn E. UNRUH, Auteur ; Matthew W. MOSCONI, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Lydia MACLACHLAN, Auteur ; Mia MOSES, Auteur ; Kai CAPPEL, Auteur ; Rachael KNOTT, Auteur ; Tracey CHAU, Auteur ; Vishnu Priya Mohanakumar SINDHU, Auteur ; Alessio BELLATO, Auteur ; Madeleine J. GROOM, Auteur ; Rebecca KERESTES, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur Article en page(s) : p.2391-2407 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD. Four hundred and five (n = 405; 226 males) Australian children and adolescents aged 4 to 18 years (M = 9.64 years; SD = 3.20 years) with ADHD (n = 64), autism (n = 66), autism + ADHD (n = 146), or neurotypical individuals (n = 129) were compared across four different oculomotor tasks: visually guided saccade, anti-saccade, sinusoidal pursuit and step-ramp pursuit. Confirmatory analyses were conducted using separate datasets acquired from the University of Nottingham UK (n = 17 autism, n = 22 ADHD, n = 32 autism + ADHD, n = 30 neurotypical) and University of Kansas USA (n = 29 autism, n = 41 neurotypical). Linear mixed effect models controlling for sex, age and family revealed that children and adolescents with autism + ADHD exhibited increased variability in the accuracy of the final saccadic eye position compared to neurotypical children and adolescents. Autistic children and adolescents demonstrated a greater number of catch-up saccades during step-ramp pursuit compared to neurotypical children and adolescents. These findings suggest that select differences in saccadic precision are unique to autistic individuals with co-occurring ADHD, indicating that measuring basic sensorimotor processes may be useful for parsing neurodevelopment and clinical heterogeneity in autism. En ligne : https://doi.org/10.1007/s10803-024-06718-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD [texte imprimé] / Elana J. FORBES, Auteur ; Jeggan TIEGO, Auteur ; Joshua LANGMEAD, Auteur ; Kathryn E. UNRUH, Auteur ; Matthew W. MOSCONI, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Lydia MACLACHLAN, Auteur ; Mia MOSES, Auteur ; Kai CAPPEL, Auteur ; Rachael KNOTT, Auteur ; Tracey CHAU, Auteur ; Vishnu Priya Mohanakumar SINDHU, Auteur ; Alessio BELLATO, Auteur ; Madeleine J. GROOM, Auteur ; Rebecca KERESTES, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur . - p.2391-2407. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-6 (June 2026) . - p.2391-2407 Index. décimale : PER Périodiques Résumé : Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD. Four hundred and five (n = 405; 226 males) Australian children and adolescents aged 4 to 18 years (M = 9.64 years; SD = 3.20 years) with ADHD (n = 64), autism (n = 66), autism + ADHD (n = 146), or neurotypical individuals (n = 129) were compared across four different oculomotor tasks: visually guided saccade, anti-saccade, sinusoidal pursuit and step-ramp pursuit. Confirmatory analyses were conducted using separate datasets acquired from the University of Nottingham UK (n = 17 autism, n = 22 ADHD, n = 32 autism + ADHD, n = 30 neurotypical) and University of Kansas USA (n = 29 autism, n = 41 neurotypical). Linear mixed effect models controlling for sex, age and family revealed that children and adolescents with autism + ADHD exhibited increased variability in the accuracy of the final saccadic eye position compared to neurotypical children and adolescents. Autistic children and adolescents demonstrated a greater number of catch-up saccades during step-ramp pursuit compared to neurotypical children and adolescents. These findings suggest that select differences in saccadic precision are unique to autistic individuals with co-occurring ADHD, indicating that measuring basic sensorimotor processes may be useful for parsing neurodevelopment and clinical heterogeneity in autism. En ligne : https://doi.org/10.1007/s10803-024-06718-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? / Iti ARORA in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.600-616 Titre : What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? Type de document : texte imprimé Auteurs : Iti ARORA, Auteur ; Alessio BELLATO, Auteur ; Teodora GLIGA, Auteur ; Danielle ROPAR, Auteur ; Puja KOCHHAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur Article en page(s) : p.600-616 Langues : Anglais (eng) Mots-clés : Adolescent  Attentional Bias  Autism Spectrum Disorder  Autistic Disorder  Child  Humans  Autism  Autistic traits  Eye-tracking  Habituation  Information foraging Index. décimale : PER Périodiques Résumé : Slower habituation to repeating stimuli characterises Autism, but it is not known whether this is driven by difficulties with information processing or an attentional bias towards sameness. We conducted eye-tracking and presented looming geometrical shapes, clocks with moving arms and smiling faces, as two separate streams of stimuli (one repeating and one changing), to 7-15 years old children and adolescents (n = 103) with Autism, ADHD or co-occurring Autism+ADHD, and neurotypical children (Study-1); and to neurotypical children (n = 64) with varying levels of autistic traits (Study-2). Across both studies, autistic features were associated with longer looks to the repeating stimulus, and shorter looks to the changing stimulus, but only for more complex stimuli, indicating greater difficulty in processing complex or unpredictable information. En ligne : http://dx.doi.org/10.1007/s10803-021-04961-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? [texte imprimé] / Iti ARORA, Auteur ; Alessio BELLATO, Auteur ; Teodora GLIGA, Auteur ; Danielle ROPAR, Auteur ; Puja KOCHHAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur . - p.600-616. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.600-616 Mots-clés : Adolescent  Attentional Bias  Autism Spectrum Disorder  Autistic Disorder  Child  Humans  Autism  Autistic traits  Eye-tracking  Habituation  Information foraging Index. décimale : PER Périodiques Résumé : Slower habituation to repeating stimuli characterises Autism, but it is not known whether this is driven by difficulties with information processing or an attentional bias towards sameness. We conducted eye-tracking and presented looming geometrical shapes, clocks with moving arms and smiling faces, as two separate streams of stimuli (one repeating and one changing), to 7-15 years old children and adolescents (n = 103) with Autism, ADHD or co-occurring Autism+ADHD, and neurotypical children (Study-1); and to neurotypical children (n = 64) with varying levels of autistic traits (Study-2). Across both studies, autistic features were associated with longer looks to the repeating stimulus, and shorter looks to the changing stimulus, but only for more complex stimuli, indicating greater difficulty in processing complex or unpredictable information. En ligne : http://dx.doi.org/10.1007/s10803-021-04961-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

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