Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents / Barbara RUGGERI in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Titre : Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents Type de document : texte imprimé Auteurs : Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents [texte imprimé] / Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur . - p.650-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults / Debasish BASU in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.800-808 Titre : Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults Type de document : texte imprimé Auteurs : Debasish BASU, Auteur ; Abhishek GHOSH, Auteur ; Chandrima NASKAR, Auteur ; Srinivas BALACHANDER, Auteur ; Gwen FERNANDES, Auteur ; Nilakshi VAIDYA, Auteur ; Kalyanaraman KUMARAN, Auteur ; Murali KRISHNA, Auteur ; Gareth J. BARKER, Auteur ; Eesha SHARMA, Auteur ; Pratima MURTHY, Auteur ; Bharath HOLLA, Auteur ; Sanjeev JAIN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Kartik KALYANRAM, Auteur ; Meera PURUSHOTTAM, Auteur ; Rose Dawn BHARATH, Auteur ; Mathew VARGHESE, Auteur ; Kandavel THENNARASU, Auteur ; Amit CHAKRABARTI, Auteur ; Rajkumar Lenin SINGH, Auteur ; Roshan Lourembam SINGH, Auteur ; Subodh Bhagyalakshmi NANJAYYA, Auteur ; Chirag Kamal AHUJA, Auteur ; Kamakshi KARTIK, Auteur ; Ghattu KRISHNAVENI, Auteur ; Rebecca KURIYAN, Auteur ; Sunita Simon KURPAD, Auteur ; Sylvane DESRIVIERES, Auteur ; Udita IYENGAR, Auteur ; Yuning ZHANG, Auteur ; Matthew HICKMAN, Auteur ; Alex SPIERS, Auteur ; Mireille TOLEDANO, Auteur ; Gunter SCHUMANN, Auteur ; Vivek BENEGAL, Auteur Article en page(s) : p.800-808 Langues : Anglais (eng) Mots-clés : childhood experience  India  psychopathology  social deprivation  trauma Index. décimale : PER Périodiques Résumé : Developmental adversities early in life are associated with later psychopathology. Clustering may be a useful approach to group multiple diverse risks together and study their relation with psychopathology. To generate risk clusters of children, adolescents, and young adults, based on adverse environmental exposure and developmental characteristics, and to examine the association of risk clusters with manifest psychopathology. Participants (n = 8300) between 6 and 23 years were recruited from seven sites in India. We administered questionnaires to elicit history of previous exposure to adverse childhood environments, family history of psychiatric disorders in first-degree relatives, and a range of antenatal and postnatal adversities. We used these variables to generate risk clusters. Mini-International Neuropsychiatric Interview-5 was administered to evaluate manifest psychopathology. Two-step cluster analysis revealed two clusters designated as high-risk cluster (HRC) and low-risk cluster (LRC), comprising 4197 (50.5%) and 4103 (49.5%) participants, respectively. HRC had higher frequencies of family history of mental illness, antenatal and neonatal risk factors, developmental delays, history of migration, and exposure to adverse childhood experiences than LRC. There were significantly higher risks of any psychiatric disorder [Relative Risk (RR) = 2.0, 95% CI 1.8-2.3], externalizing (RR = 4.8, 95% CI 3.6-6.4) and internalizing disorders (RR = 2.6, 95% CI 2.2-2.9), and suicidality (2.3, 95% CI 1.8-2.8) in HRC. Social-environmental and developmental factors could classify Indian children, adolescents and young adults into homogeneous clusters at high or low risk of psychopathology. These biopsychosocial determinants of mental health may have practice, policy and research implications for people in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/S0954579422000050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults [texte imprimé] / Debasish BASU, Auteur ; Abhishek GHOSH, Auteur ; Chandrima NASKAR, Auteur ; Srinivas BALACHANDER, Auteur ; Gwen FERNANDES, Auteur ; Nilakshi VAIDYA, Auteur ; Kalyanaraman KUMARAN, Auteur ; Murali KRISHNA, Auteur ; Gareth J. BARKER, Auteur ; Eesha SHARMA, Auteur ; Pratima MURTHY, Auteur ; Bharath HOLLA, Auteur ; Sanjeev JAIN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Kartik KALYANRAM, Auteur ; Meera PURUSHOTTAM, Auteur ; Rose Dawn BHARATH, Auteur ; Mathew VARGHESE, Auteur ; Kandavel THENNARASU, Auteur ; Amit CHAKRABARTI, Auteur ; Rajkumar Lenin SINGH, Auteur ; Roshan Lourembam SINGH, Auteur ; Subodh Bhagyalakshmi NANJAYYA, Auteur ; Chirag Kamal AHUJA, Auteur ; Kamakshi KARTIK, Auteur ; Ghattu KRISHNAVENI, Auteur ; Rebecca KURIYAN, Auteur ; Sunita Simon KURPAD, Auteur ; Sylvane DESRIVIERES, Auteur ; Udita IYENGAR, Auteur ; Yuning ZHANG, Auteur ; Matthew HICKMAN, Auteur ; Alex SPIERS, Auteur ; Mireille TOLEDANO, Auteur ; Gunter SCHUMANN, Auteur ; Vivek BENEGAL, Auteur . - p.800-808. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.800-808 Mots-clés : childhood experience  India  psychopathology  social deprivation  trauma Index. décimale : PER Périodiques Résumé : Developmental adversities early in life are associated with later psychopathology. Clustering may be a useful approach to group multiple diverse risks together and study their relation with psychopathology. To generate risk clusters of children, adolescents, and young adults, based on adverse environmental exposure and developmental characteristics, and to examine the association of risk clusters with manifest psychopathology. Participants (n = 8300) between 6 and 23 years were recruited from seven sites in India. We administered questionnaires to elicit history of previous exposure to adverse childhood environments, family history of psychiatric disorders in first-degree relatives, and a range of antenatal and postnatal adversities. We used these variables to generate risk clusters. Mini-International Neuropsychiatric Interview-5 was administered to evaluate manifest psychopathology. Two-step cluster analysis revealed two clusters designated as high-risk cluster (HRC) and low-risk cluster (LRC), comprising 4197 (50.5%) and 4103 (49.5%) participants, respectively. HRC had higher frequencies of family history of mental illness, antenatal and neonatal risk factors, developmental delays, history of migration, and exposure to adverse childhood experiences than LRC. There were significantly higher risks of any psychiatric disorder [Relative Risk (RR) = 2.0, 95% CI 1.8-2.3], externalizing (RR = 4.8, 95% CI 3.6-6.4) and internalizing disorders (RR = 2.6, 95% CI 2.2-2.9), and suicidality (2.3, 95% CI 1.8-2.8) in HRC. Social-environmental and developmental factors could classify Indian children, adolescents and young adults into homogeneous clusters at high or low risk of psychopathology. These biopsychosocial determinants of mental health may have practice, policy and research implications for people in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/S0954579422000050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach / Tochukwu NWEZE in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175 Titre : Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach Type de document : texte imprimé Auteurs : Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L.W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÃœHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; IMAGEN CONSORTIUM, Auteur Article en page(s) : p.1159-1175 Langues : Anglais (eng) Mots-clés : Stress  cortical development  cognitive functioning  longitudinal models  bivariate latent change score model  longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach [texte imprimé] / Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L.W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÃœHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; IMAGEN CONSORTIUM, Auteur . - p.1159-1175. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175 Mots-clés : Stress  cortical development  cognitive functioning  longitudinal models  bivariate latent change score model  longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

---

1 (1 - 3 / 3) Par page : 25 50 100 200